{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:07:58Z","timestamp":1790762878415,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":373,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.chom.2019.03.012","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T11:37:37Z","timestamp":1556624257000},"page":"706-718.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Nutrient Sensing by the Intestinal Epithelium Orchestrates Mucosal Antimicrobial Defense via Translational Control of Hes1"],"prefix":"10.1016","volume":"25","author":[{"given":"Shaonan","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Kun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayao","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeonseok","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuerui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2019.03.012_bib1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2013a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2019.03.012_bib2","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1074\/jbc.M109410200","article-title":"Activation of Paneth cell alpha-defensins in mouse small intestine","volume":"277","author":"Ayabe","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2019.03.012_bib3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature08698","article-title":"FOXO-dependent regulation of innate immune homeostasis","volume":"463","author":"Becker","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.chom.2019.03.012_bib4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.chom.2013.05.004","article-title":"Intestinal epithelial autophagy is essential for host defense against invasive bacteria","volume":"13","author":"Benjamin","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.03.012_bib5","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nrmicro2546","article-title":"Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis","volume":"9","author":"Bevins","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2019.03.012_bib6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nri3198","article-title":"Regulation and function of mTOR signalling in T\u00a0cell fate decisions","volume":"12","author":"Chi","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2019.03.012_bib7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/gut.48.2.176","article-title":"Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease","volume":"48","author":"Cunliffe","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.chom.2019.03.012_bib8","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nri3532","article-title":"Autophagy in infection, inflammation and immunity","volume":"13","author":"Deretic","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2019.03.012_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2019.03.012_bib10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nri3228","article-title":"Epithelial antimicrobial defence of the skin and intestine","volume":"12","author":"Gallo","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2019.03.012_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.gfs.2018.03.004","article-title":"The global burden of chronic and hidden hunger: trends and determinants","volume":"17","author":"G\u00f6decke","year":"2018","journal-title":"Glob. Food Sec."},{"key":"10.1016\/j.chom.2019.03.012_bib12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4049\/jimmunol.1303356","article-title":"Repression of mammalian target of rapamycin complex 1 inhibits intestinal regeneration in acute inflammatory bowel disease models","volume":"195","author":"Guan","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2019.03.012_bib13","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/mi.2017.111","article-title":"Epithelial Hes1 maintains gut homeostasis by preventing microbial dysbiosis","volume":"11","author":"Guo","year":"2018","journal-title":"Mucosal. Immunol."},{"key":"10.1016\/j.chom.2019.03.012_bib14","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nri2449","article-title":"Nutrient sensing and inflammation in metabolic diseases","volume":"8","author":"Hotamisligil","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2019.03.012_bib15","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.immuni.2008.08.016","article-title":"Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways","volume":"29","author":"Hu","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2019.03.012_bib16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using David bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.chom.2019.03.012_bib17","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.cell.2016.05.044","article-title":"mTORC1 and SIRT1 cooperate to foster expansion of gut adult stem cells during calorie restriction","volume":"166","author":"Igarashi","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chom.2019.03.012_bib18","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.1074\/jbc.270.12.6691","article-title":"Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. Activation of the precursor, interaction with other matrix metalloproteinases and enzymic properties","volume":"270","author":"Imai","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2019.03.012_bib19","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/nprot.2012.086","article-title":"The ribosome profiling strategy for monitoring translation in\u00a0vivo by deep sequencing of ribosome-protected mRNA fragments","volume":"7","author":"Ingolia","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.chom.2019.03.012_bib20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrm3522","article-title":"Amino acid signalling upstream of mTOR","volume":"14","author":"Jewell","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chom.2019.03.012_bib21","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.immuni.2017.04.028","article-title":"MenTORing immunity: mTOR signaling in the development and function of tissue-resident immune cells","volume":"46","author":"Jones","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2019.03.012_bib22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2019.03.012_bib23","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nature12903","article-title":"Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity","volume":"506","author":"Kim","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chom.2019.03.012_bib24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/B978-0-12-405943-6.00007-5","article-title":"Expression dynamics and functions of Hes factors in development and diseases","volume":"110","author":"Kobayashi","year":"2014","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.chom.2019.03.012_bib25","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2019.03.012_bib26","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"10.1016\/j.chom.2019.03.012_bib27","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"MTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.chom.2019.03.012_bib28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.chom.2019.03.012_bib29","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/29795","article-title":"Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression","volume":"394","author":"Lord","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.chom.2019.03.012_bib30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet.journal"},{"key":"10.1016\/j.chom.2019.03.012_bib31","doi-asserted-by":"crossref","first-page":"11205","DOI":"10.1074\/jbc.M111.333559","article-title":"Alternative luminal activation mechanisms for paneth cell alpha-defensins","volume":"287","author":"Mastroianni","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2019.03.012_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbpa.2010.01.002","article-title":"Starvation physiology: reviewing the different strategies animals use to survive a common challenge","volume":"156","author":"McCue","year":"2010","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.chom.2019.03.012_bib33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.immuni.2014.12.028","article-title":"Antimicrobial defense of the intestine","volume":"42","author":"Mukherjee","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2019.03.012_bib34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-physiol-030212-183741","article-title":"Notch in the intestine: regulation of homeostasis and pathogenesis","volume":"75","author":"Noah","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.chom.2019.03.012_bib35","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/MOG.0b013e32833dccde","article-title":"Paneth cells and innate mucosal immunity","volume":"26","author":"Ouellette","year":"2010","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.chom.2019.03.012_bib36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2019.03.012_bib37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-immunol-020711-075024","article-title":"Regulation of immune responses by mTOR","volume":"30","author":"Powell","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.chom.2019.03.012_bib38","doi-asserted-by":"crossref","first-page":"e12204","DOI":"10.7554\/eLife.12204","article-title":"Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis","volume":"5","author":"Ro","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.chom.2019.03.012_bib39","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1096\/fj.15-278606","article-title":"mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice","volume":"30","author":"Sampson","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.chom.2019.03.012_bib40","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in\u00a0vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.chom.2019.03.012_bib41","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/ni1206","article-title":"Mammalian defensins in the antimicrobial immune response","volume":"6","author":"Selsted","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2019.03.012_bib42","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/ni.3486","article-title":"The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation","volume":"17","author":"Shang","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2019.03.012_bib43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s13238-016-0250-0","article-title":"Role of Notch signaling in regulating innate immunity and inflammation in health and disease","volume":"7","author":"Shang","year":"2016","journal-title":"Protein Cell"},{"key":"10.1016\/j.chom.2019.03.012_bib44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature18846","article-title":"Diet-microbiota interactions as moderators of human metabolism","volume":"535","author":"Sonnenburg","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.chom.2019.03.012_bib45","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ni.3205","article-title":"Interferon-gamma regulates cellular metabolism and mRNA translation to potentiate macrophage activation","volume":"16","author":"Su","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2019.03.012_bib46","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1242\/dev.069070","article-title":"The role of Hes genes in intestinal development, homeostasis and tumor formation","volume":"139","author":"Ueo","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.chom.2019.03.012_bib47","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev.physiol.010908.163145","article-title":"Stem cells, self-renewal, and differentiation in the intestinal epithelium","volume":"71","author":"van der Flier","year":"2009","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.chom.2019.03.012_bib48","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.physiol.68.040104.105739","article-title":"The comparative physiology of food deprivation: from feast to famine","volume":"68","author":"Wang","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.chom.2019.03.012_bib49","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nri3901","article-title":"Regulation of innate immune cell function by mTOR","volume":"15","author":"Weichhart","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2019.03.012_bib50","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.286.5437.113","article-title":"Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense","volume":"286","author":"Wilson","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.chom.2019.03.012_bib51","doi-asserted-by":"crossref","first-page":"11194","DOI":"10.1038\/ncomms11194","article-title":"Genome-wide assessment of differential translations with ribosome profiling data","volume":"7","author":"Xiao","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2019.03.012_bib52","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nature11163","article-title":"mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake","volume":"486","author":"Yilmaz","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.chom.2019.03.012_bib53","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/415389a","article-title":"Antimicrobial peptides of multicellular organisms","volume":"415","author":"Zasloff","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.chom.2019.03.012_bib54","doi-asserted-by":"crossref","first-page":"9770","DOI":"10.1021\/bi101512j","article-title":"The membrane-bound structure and topology of a human alpha-defensin indicate a dimer pore mechanism for membrane disruption","volume":"49","author":"Zhang","year":"2010","journal-title":"Biochemistry"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312819301647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312819301647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:16:32Z","timestamp":1761826592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312819301647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S1931312819301647"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2019.03.012","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nutrient Sensing by the Intestinal Epithelium Orchestrates Mucosal Antimicrobial Defense via Translational Control of Hes1","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2019.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}