{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:05:28Z","timestamp":1791482728332,"version":"4.3.4"},"reference-count":70,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":376,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR002243"],"award-info":[{"award-number":["UL1 TR002243"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201400024C"],"award-info":[{"award-number":["HHSN272201400024C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19 AI117905"],"award-info":[{"award-number":["U19 AI117905"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P30 CA68485"],"award-info":[{"award-number":["P30 CA68485"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["TR000445"],"award-info":[{"award-number":["TR000445"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["RR024975"],"award-info":[{"award-number":["RR024975"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007208","name":"Vanderbilt-Ingram Cancer Center","doi-asserted-by":"publisher","award":["P30 CA68485"],"award-info":[{"award-number":["P30 CA68485"]}],"id":[{"id":"10.13039\/100007208","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013017","name":"Vanderbilt University Medical Center","doi-asserted-by":"publisher","award":["HHSN272201300023I"],"award-info":[{"award-number":["HHSN272201300023I"]}],"id":[{"id":"10.13039\/100013017","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014588","name":"Sanofi Pasteur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014588","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.chom.2019.10.003","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T10:44:02Z","timestamp":1574160242000},"page":"715-728.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice"],"prefix":"10.1016","volume":"26","author":[{"given":"Iuliia M.","family":"Gilchuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Bangaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlo","family":"Gilchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"Irving","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurgun","family":"Kose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin G.","family":"Bombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J.","family":"Thornburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Buddy","family":"Creech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah L.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew B.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"James E.","family":"Crowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2019.10.003_bib1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.molimm.2014.09.017","article-title":"Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A\/L235A and N297A Fc mutations engineered into mouse IgG2a","volume":"63","author":"Arduin","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.chom.2019.10.003_bib71","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1038\/s41467-018-04704-9","article-title":"A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA","volume":"9","author":"Bangaru","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2019.10.003_bib3","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/QCO.0000000000000496","article-title":"Treatment of influenza with neuraminidase inhibitors","volume":"31","author":"Beard","year":"2018","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.chom.2019.10.003_bib4","doi-asserted-by":"crossref","first-page":"e02293-e16","DOI":"10.1128\/JVI.02293-16","article-title":"Role of neuraminidase in influenza A(H7N9) virus receptor binding","volume":"91","author":"Benton","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2019.10.003_bib5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cell.2018.03.030","article-title":"Influenza infection in humans induces broadly cross-reactive and protective neuraminidase-reactive antibodies","volume":"173","author":"Chen","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.chom.2019.10.003_bib6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/326358a0","article-title":"Three-dimensional structure of a complex of antibody with influenza virus neuraminidase","volume":"326","author":"Colman","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.chom.2019.10.003_bib7","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/infdis\/jis935","article-title":"Antibody correlates and predictors of immunity to naturally occurring influenza in humans and the importance of antibody to the neuraminidase","volume":"207","author":"Couch","year":"2013","journal-title":"J.\u00a0Infect. Dis."},{"issue":"Suppl 6","key":"10.1016\/j.chom.2019.10.003_bib8","doi-asserted-by":"crossref","first-page":"G47","DOI":"10.1016\/j.vaccine.2009.10.124","article-title":"Recent advances in the study of human antibody responses to influenza virus using optimized human hybridoma approaches","volume":"27","author":"Crowe","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.chom.2019.10.003_bib9","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1080\/19420862.2017.1323159","article-title":"Affinity of human IgG subclasses to mouse Fc gamma receptors","volume":"9","author":"Dekkers","year":"2017","journal-title":"MAbs"},{"key":"10.1016\/j.chom.2019.10.003_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.biochem.76.061705.090740","article-title":"Molecular mechanisms of antibody somatic hypermutation","volume":"76","author":"Di Noia","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.chom.2019.10.003_bib11","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1172\/JCI84428","article-title":"Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in\u00a0vivo protection","volume":"126","author":"DiLillo","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2019.10.003_bib12","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1126\/science.1222908","article-title":"Highly conserved protective epitopes on influenza B viruses","volume":"337","author":"Dreyfus","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.chom.2019.10.003_bib13","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/infdis\/jiy103","article-title":"A universal influenza vaccine: the strategic plan for the national institute of allergy and infectious diseases","volume":"218","author":"Erbelding","year":"2018","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2019.10.003_bib14","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1128\/JVI.79.5.2814-2822.2005","article-title":"Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls","volume":"79","author":"Fouchier","year":"2005","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2019.10.003_bib15","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1056\/NEJMc1313186","article-title":"A recombinant viruslike particle influenza A (H7N9) vaccine","volume":"369","author":"Fries","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2019.10.003_bib16","doi-asserted-by":"crossref","first-page":"12274","DOI":"10.1128\/JVI.76.23.12274-12280.2002","article-title":"Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A\/Memphis\/31\/98)","volume":"76","author":"Gulati","year":"2002","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2019.10.003_bib17","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1038\/ncomms3854","article-title":"Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in\u00a0vivo virulence or transmissibility","volume":"4","author":"Hai","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2019.10.003_bib18","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.jmb.2004.05.042","article-title":"Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen\/deuterium exchange mass spectrometry (DXMS)","volume":"340","author":"Hamuro","year":"2004","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.chom.2019.10.003_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature06106","article-title":"Fc receptor but not complement binding is important in antibody protection against HIV","volume":"449","author":"Hessell","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.chom.2019.10.003_bib20","doi-asserted-by":"crossref","first-page":"9891","DOI":"10.1021\/bi9008853","article-title":"Structural insights into glucan phosphatase dynamics using amide hydrogen-deuterium exchange mass spectrometry","volume":"48","author":"Hsu","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.chom.2019.10.003_bib21","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41564-018-0303-7","article-title":"Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans","volume":"4","author":"Huang","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2019.10.003_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1001\/jama.2015.7916","article-title":"Effect of varying doses of a monovalent H7N9 influenza vaccine with and without AS03 and MF59 adjuvants on immune response: a randomized clinical trial","volume":"314","author":"Jackson","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.chom.2019.10.003_bib23","doi-asserted-by":"crossref","first-page":"e01584-e17","DOI":"10.1128\/JVI.01584-17","article-title":"Antibodies directed toward neuraminidase N1 control disease in a mouse model of influenza","volume":"92","author":"Job","year":"2018","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2019.10.003_bib24","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1080\/22221751.2019.1572433","article-title":"Serum anti-neuraminidase antibody responses in human influenza A(H1N1)pdm09 virus infections","volume":"8","author":"Karunarathna","year":"2019","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.chom.2019.10.003_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41541-018-0076-2","article-title":"AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization","volume":"3","author":"Khurana","year":"2018","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.chom.2019.10.003_bib26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-1-59745-196-3_6","article-title":"The polymerase incomplete primer extension (PIPE) method applied to high-throughput cloning and site-directed mutagenesis","volume":"498","author":"Klock","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.chom.2019.10.003_bib27","doi-asserted-by":"crossref","first-page":"e02332-e17","DOI":"10.1128\/mBio.02332-17","article-title":"NAction! How can neuraminidase-based immunity contribute to better influenza virus vaccines?","volume":"9","author":"Krammer","year":"2018","journal-title":"MBio"},{"key":"10.1016\/j.chom.2019.10.003_bib28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jsb.2009.01.002","article-title":"Appion: an integrated, database-driven pipeline to facilitate EM image processing","volume":"166","author":"Lander","year":"2009","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.chom.2019.10.003_bib29","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0042-6822(84)90223-X","article-title":"Influenza virus neuraminidase with hemagglutinin activity","volume":"137","author":"Laver","year":"1984","journal-title":"Virology"},{"key":"10.1016\/j.chom.2019.10.003_bib30","doi-asserted-by":"crossref","first-page":"17889","DOI":"10.1074\/jbc.M111.224535","article-title":"Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen\/deuterium exchange mass spectrometry (DXMS)","volume":"286","author":"Li","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2019.10.003_bib31","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/pro.2000","article-title":"The prohormone proenkephalin possesses differential conformational features of subdomains revealed by rapid H-D exchange mass spectrometry","volume":"21","author":"Lu","year":"2012","journal-title":"Protein Sci."},{"key":"10.1016\/j.chom.2019.10.003_bib32","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3201\/eid2404.171995","article-title":"Influenza A(H7N9) virus antibody responses in survivors 1 year after infection, China, 2017","volume":"24","author":"Ma","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.chom.2019.10.003_bib33","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1093\/infdis\/jiw414","article-title":"Immunogenicity and safety of an AS03-adjuvanted H7N9 pandemic influenza vaccine in a randomized trial in healthy adults","volume":"214","author":"Madan","year":"2016","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2019.10.003_bib34","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0969-2126(00)00074-5","article-title":"The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody","volume":"2","author":"Malby","year":"1994","journal-title":"Structure"},{"key":"10.1016\/j.chom.2019.10.003_bib35","doi-asserted-by":"crossref","first-page":"5419","DOI":"10.1128\/JVI.03513-14","article-title":"Neuraminidase mutations conferring resistance to oseltamivir in influenza A(H7N9) viruses","volume":"89","author":"Marjuki","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2019.10.003_bib36","doi-asserted-by":"crossref","first-page":"e00417-e16","DOI":"10.1128\/mBio.00417-16","article-title":"Evaluation of antihemagglutinin and antineuraminidase antibodies as correlates of protection in an influenza A\/H1N1 virus healthy human challenge model","volume":"7","author":"Memoli","year":"2016","journal-title":"MBio"},{"key":"10.1016\/j.chom.2019.10.003_bib37","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/infdis\/jiv195","article-title":"Antibody to influenza virus neuraminidase: an independent correlate of protection","volume":"212","author":"Monto","year":"2015","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2019.10.003_bib38","doi-asserted-by":"crossref","first-page":"E497","DOI":"10.3390\/v10090497","article-title":"Zoonotic potential of influenza A viruses: a comprehensive overview","volume":"10","author":"Mostafa","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.chom.2019.10.003_bib39","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/s41591-019-0463-x","article-title":"Novel correlates of protection against pandemic H1N1 influenza A virus infection","volume":"25","author":"Ng","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2019.10.003_bib40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jsb.2003.08.005","article-title":"Topology representing network enables highly accurate classification of protein images taken by cryo electron-microscope without masking","volume":"143","author":"Ogura","year":"2003","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.chom.2019.10.003_bib41","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.immuni.2017.09.007","article-title":"The pathway to a universal influenza vaccine","volume":"47","author":"Paules","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2019.10.003_bib42","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera--a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.chom.2019.10.003_bib43","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0304-3991(99)00043-1","article-title":"Leginon: a system for fully automated acquisition of 1000 electron micrographs a day","volume":"77","author":"Potter","year":"1999","journal-title":"Ultramicroscopy"},{"key":"10.1016\/j.chom.2019.10.003_bib44","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/nar\/28.1.219","article-title":"IMGT, the international ImMunoGeneTics database","volume":"28","author":"Ruiz","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chom.2019.10.003_bib45","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1128\/jvi.68.3.1790-1796.1994","article-title":"Antigenicity of the N8 influenza A virus neuraminidase: existence of an epitope at the subunit interface of the neuraminidase","volume":"68","author":"Saito","year":"1994","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2019.10.003_bib46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3201\/eid2201.151330","article-title":"Avian influenza A(H7N9) virus infection in 2 travelers returning from China to Canada, January 2015","volume":"22","author":"Skowronski","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.chom.2019.10.003_bib47","doi-asserted-by":"crossref","first-page":"AID-0027","DOI":"10.1128\/microbiolspec.AID-0027-2014","article-title":"Use of human hybridoma technology to isolate human monoclonal antibodies","volume":"3","author":"Smith","year":"2015","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.chom.2019.10.003_bib72","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1128\/JVI.06335-11","article-title":"Persistence of circulating memory B cell clones with potential for dengue virus disease enhancement for decades following infection","volume":"86","author":"Smith","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2019.10.003_bib48","doi-asserted-by":"crossref","first-page":"9197","DOI":"10.1128\/JVI.00805-14","article-title":"Structure of influenza virus N7: the last piece of the neuraminidase \u201cjigsaw\u201d puzzle","volume":"88","author":"Sun","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2019.10.003_bib49","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1172\/JCI69377","article-title":"Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses","volume":"123","author":"Thornburg","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2019.10.003_bib50","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1172\/JCI85317","article-title":"H7N9 influenza virus neutralizing antibodies that possess few somatic mutations","volume":"126","author":"Thornburg","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2019.10.003_bib51","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1073\/pnas.1116200109","article-title":"A distinct lineage of influenza A virus from bats","volume":"109","author":"Tong","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2019.10.003_bib52","doi-asserted-by":"crossref","first-page":"e1003657","DOI":"10.1371\/journal.ppat.1003657","article-title":"New world bats harbor diverse influenza A viruses","volume":"9","author":"Tong","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2019.10.003_bib53","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s00705-009-0393-x","article-title":"Functional significance of the hemadsorption activity of influenza virus neuraminidase and its alteration in pandemic viruses","volume":"154","author":"Uhlendorff","year":"2009","journal-title":"Arch. Virol."},{"key":"10.1016\/j.chom.2019.10.003_bib54","doi-asserted-by":"crossref","first-page":"11808","DOI":"10.1073\/pnas.94.22.11808","article-title":"Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases","volume":"94","author":"Varghese","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2019.10.003_bib55","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jsb.2009.01.004","article-title":"DoG Picker and TiltPicker: software tools to facilitate particle selection in single particle electron microscopy","volume":"166","author":"Voss","year":"2009","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.chom.2019.10.003_bib56","doi-asserted-by":"crossref","first-page":"e01006","DOI":"10.1128\/JVI.01006-18","article-title":"Neuraminidase-inhibiting antibody titers correlate with protection from heterologous influenza virus strains of the same neuraminidase subtype","volume":"92","author":"Walz","year":"2018","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2019.10.003_bib57","doi-asserted-by":"crossref","first-page":"6114","DOI":"10.1038\/ncomms7114","article-title":"Structural characterization of a protective epitope spanning A(H1N1)pdm09 influenza virus neuraminidase monomers","volume":"6","author":"Wan","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2019.10.003_bib58","doi-asserted-by":"crossref","first-page":"e01588-e17","DOI":"10.1128\/JVI.01588-17","article-title":"Comparison of the efficacy of N9 neuraminidase-specific monoclonal antibodies against influenza A(H7N9) virus infection","volume":"92","author":"Wan","year":"2018","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2019.10.003_bib59","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S1473-3099(17)30323-7","article-title":"Epidemiology of avian influenza A H7N9 virus in human beings across five epidemics in mainland China, 2013-17: an epidemiological study of laboratory-confirmed case series","volume":"17","author":"Wang","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chom.2019.10.003_bib60","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0042-6822(84)90114-4","article-title":"Antigenic and biological characterization of influenza virus neuraminidase (N2) with monoclonal antibodies","volume":"135","author":"Webster","year":"1984","journal-title":"Virology"},{"key":"10.1016\/j.chom.2019.10.003_bib61","first-page":"633","article-title":"Zoonotic influenza viruses: antigenic and genetic characteristics and development of candidate vaccine viruses for pandemic preparedness","volume":"92","year":"2017","journal-title":"Wkly. Epidemiol. Rec."},{"key":"10.1016\/j.chom.2019.10.003_bib63","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.antiviral.2016.10.001","article-title":"An influenza A virus (H7N9) anti-neuraminidase monoclonal antibody with prophylactic and therapeutic activity in\u00a0vivo","volume":"135","author":"Wilson","year":"2016","journal-title":"Antiviral Res."},{"key":"10.1016\/j.chom.2019.10.003_bib64","doi-asserted-by":"crossref","first-page":"e02556","DOI":"10.1128\/mBio.02556-14","article-title":"Vaccination with adjuvanted recombinant neuraminidase induces broad heterologous, but not heterosubtypic, cross-protection against influenza virus infection in mice","volume":"6","author":"Wohlbold","year":"2015","journal-title":"MBio"},{"key":"10.1016\/j.chom.2019.10.003_bib65","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s41564-019-0401-1","article-title":"Antigenic drift originating from changes to the lateral surface of the neuraminidase head of influenza A virus","volume":"4","author":"Yasuhara","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2019.10.003_bib66","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/pro.5560020404","article-title":"Determination of amide hydrogen exchange by mass spectrometry: a new tool for protein structure elucidation","volume":"2","author":"Zhang","year":"1993","journal-title":"Protein Sci."},{"key":"10.1016\/j.chom.2019.10.003_bib67","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1107\/S0907444908016648","article-title":"Structure determination of the 1918 H1N1 neuraminidase from a crystal with lattice-translocation defects","volume":"D64","author":"Zhu","year":"2008","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.chom.2019.10.003_bib68","doi-asserted-by":"crossref","first-page":"13371","DOI":"10.1128\/JVI.01426-12","article-title":"Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic Acid receptors","volume":"86","author":"Zhu","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2019.10.003_bib69","doi-asserted-by":"crossref","first-page":"30533","DOI":"10.2807\/1560-7917.ES.2017.22.19.30533","article-title":"Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017","volume":"22","author":"Zhu","year":"2017","journal-title":"Euro Surveill."},{"key":"10.1016\/j.chom.2019.10.003_bib70","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.chom.2019.10.002","article-title":"Structural basis of protection from H7N9 influenza virus by human anti-N9 neuraminidase antibodies","volume":"26","author":"Zhu","year":"2019","journal-title":"Cell Host Microbe"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193131281930527X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193131281930527X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:08:35Z","timestamp":1778832515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193131281930527X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":70,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S193131281930527X"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2019.10.003","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2019.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2019.10.002","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}