{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:36:12Z","timestamp":1790141772286,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":373,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.chom.2019.11.011","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T10:33:47Z","timestamp":1577356427000},"page":"54-67.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":138,"title":["Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection"],"prefix":"10.1016","volume":"27","author":[{"given":"Trung H.M.","family":"Pham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Thurston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana M.","family":"Massis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Honeycutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyler","family":"Lugo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda R.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose G.","family":"Vilches-Moure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan","family":"Hamblin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Helaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise M.","family":"Monack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2019.11.011_bib1","doi-asserted-by":"crossref","first-page":"6846","DOI":"10.4049\/jimmunol.172.11.6846","article-title":"TNF influences chemokine expression of macrophages in\u00a0vitro and that of CD11b+ cells in\u00a0vivo during Mycobacterium tuberculosis infection","volume":"172","author":"Algood","year":"2004","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2019.11.011_bib2","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1038\/srep01809","article-title":"Prominent role for T\u00a0cell-derived tumour necrosis factor for sustained control of Mycobacterium tuberculosis infection","volume":"3","author":"Allie","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chom.2019.11.011_bib3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.chom.2016.10.007","article-title":"The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation","volume":"20","author":"Bayer-Santos","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.11.011_bib4","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.4049\/jimmunol.166.11.6728","article-title":"TNF-alpha controls intracellular mycobacterial growth by both inducible nitric oxide synthase-dependent and inducible nitric oxide synthase-independent pathways","volume":"166","author":"Bekker","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2019.11.011_bib5","doi-asserted-by":"crossref","first-page":"e1005986","DOI":"10.1371\/journal.ppat.1005986","article-title":"Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking","volume":"12","author":"Bernut","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2019.11.011_bib6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.immuni.2008.06.011","article-title":"Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death","volume":"29","author":"Clay","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2019.11.011_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fimmu.2014.00255","article-title":"Dendritic cell-targeted vaccines","volume":"5","author":"Cohn","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chom.2019.11.011_bib8","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2019.11.011_bib9","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.smim.2014.04.003","article-title":"Tumor necrosis factor alpha in mycobacterial infection","volume":"26","author":"Dorhoi","year":"2014","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.chom.2019.11.011_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.chom.2013.07.010","article-title":"Salmonella require the fatty acid regulator PPAR\u03b4 for the establishment of a metabolic environment essential for long-term persistence","volume":"14","author":"Eisele","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.11.011_bib11","doi-asserted-by":"crossref","first-page":"e00065","DOI":"10.1128\/mBio.00065-13","article-title":"Identification of salmonella pathogenicity island-2 type III secretion system effectors involved in intramacrophage replication of S. enterica serovar typhimurium: implications for rational vaccine design","volume":"4","author":"Figueira","year":"2013","journal-title":"MBio"},{"key":"10.1016\/j.chom.2019.11.011_bib12","doi-asserted-by":"crossref","first-page":"e1413","DOI":"10.1542\/peds.2007-1897","article-title":"Beyond cat scratch disease: widening spectrum of Bartonella henselae infection","volume":"121","author":"Florin","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.chom.2019.11.011_bib13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/imr.12258","article-title":"Immunology studies in non-human primate models of tuberculosis","volume":"264","author":"Flynn","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.chom.2019.11.011_bib14","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.immuni.2018.10.009","article-title":"Salmonella Persist in Activated Macrophages in T Cell-Sparse Granulomas but Are Contained by Surrounding CXCR3 Ligand-Positioned Th1 Cells","volume":"49","author":"Goldberg","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2019.11.011_bib15","doi-asserted-by":"crossref","first-page":"e1003408","DOI":"10.1371\/journal.ppat.1003408","article-title":"The systemic immune state of super-shedder mice is characterized by a unique neutrophil-dependent blunting of TH1 responses","volume":"9","author":"Gopinath","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2019.11.011_bib16","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.3389\/fimmu.2019.01893","article-title":"The Mononuclear Phagocytic System. Generation of Diversity","volume":"10","author":"Gordon","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chom.2019.11.011_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellimm.2017.04.005","article-title":"Tumor promoting role of anti-tumor macrophages in tumor microenvironment","volume":"316","author":"Goswami","year":"2017","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.chom.2019.11.011_bib18","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20172020","article-title":"Growth of Mycobacterium tuberculosis in\u00a0vivo segregates with host macrophage metabolism and ontogeny","volume":"215","author":"Huang","year":"2018","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2019.11.011_bib19","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/jcp.20.3.267","article-title":"Histological findings in human brucellosis","volume":"20","author":"Hunt","year":"1967","journal-title":"J.\u00a0Clin. Pathol."},{"key":"10.1016\/j.chom.2019.11.011_bib20","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1016\/j.celrep.2018.05.072","article-title":"Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10","volume":"23","author":"Jaslow","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2019.11.011_bib21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.chom.2017.07.009","article-title":"Salmonella SPI-2 Type III Secretion System Effectors: Molecular Mechanisms And Physiological Consequences","volume":"22","author":"Jennings","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.11.011_bib22","doi-asserted-by":"crossref","first-page":"e00458-17","DOI":"10.1128\/IAI.00458-17","article-title":"Utilization of host polyamines in alternatively activated macrophages promotes chronic infection by Brucella abortus","volume":"86","author":"Kerrinnes","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2019.11.011_bib23","doi-asserted-by":"crossref","first-page":"39804","DOI":"10.1038\/srep39804","article-title":"A late-lineage murine neutrophil precursor population exhibits dynamic changes during demand-adapted granulopoiesis","volume":"7","author":"Kim","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chom.2019.11.011_bib24","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/j.celrep.2015.08.033","article-title":"TNF Counterbalances the Emergence of M2 Tumor Macrophages","volume":"12","author":"Kratochvill","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2019.11.011_bib25","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1371\/journal.ppat.0020011","article-title":"Genome-wide screen for Salmonella genes required for long-term systemic infection of the mouse","volume":"2","author":"Lawley","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2019.11.011_bib26","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/art.27271","article-title":"Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model","volume":"62","author":"Lin","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.chom.2019.11.011_bib27","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1084\/jem.3.6.611","article-title":"A Histological Study of Typhoid Fever","volume":"3","author":"Mallory","year":"1898","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2019.11.011_bib28","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1128\/IAI.02494-14","article-title":"Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection","volume":"83","author":"Marino","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2019.11.011_bib29","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1128\/iai.63.9.3674-3682.1995","article-title":"Effect of anti-tumor necrosis factor alpha antibodies on histopathology of primary Salmonella infections","volume":"63","author":"Mastroeni","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2019.11.011_bib30","doi-asserted-by":"crossref","first-page":"773","DOI":"10.4049\/jimmunol.1300113","article-title":"Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms","volume":"191","author":"Mattila","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2019.11.011_bib31","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/imr.12273","article-title":"Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma","volume":"264","author":"Matty","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.chom.2019.11.011_bib32","doi-asserted-by":"crossref","first-page":"e1000671","DOI":"10.1371\/journal.ppat.1000671","article-title":"The Salmonella SPI2 effector SseI mediates long-term systemic infection by modulating host cell migration","volume":"5","author":"McLaughlin","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2019.11.011_bib33","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1128\/IAI.69.3.1847-1855.2001","article-title":"Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology","volume":"69","author":"Mohan","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2019.11.011_bib34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1084\/jem.20031319","article-title":"Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+\/+ mice and can be reactivated by IFNgamma neutralization","volume":"199","author":"Monack","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2019.11.011_bib35","first-page":"63","article-title":"Enteric fever: a clinicopathologic study of 104 cases","volume":"69","author":"Nasrallah","year":"1978","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.chom.2019.11.011_bib36","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1146\/annurev-immunol-032712-100022","article-title":"The Formation and Function of Granulomas","volume":"36","author":"Pag\u00e1n","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.chom.2019.11.011_bib37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fimmu.2013.00120","article-title":"The role of the innate immune system in granulomatous disorders","volume":"4","author":"Petersen","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chom.2019.11.011_bib38","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1086\/517519","article-title":"Neutralization of tumor necrosis factor (TNF) by antibody but not TNF receptor fusion molecule exacerbates chronic murine tuberculosis","volume":"195","author":"Plessner","year":"2007","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2019.11.011_bib39","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.smim.2015.10.003","article-title":"Molecular and epigenetic basis of macrophage polarized activation","volume":"27","author":"Porta","year":"2015","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.chom.2019.11.011_bib40","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nri3211","article-title":"Revisiting the role of the granuloma in tuberculosis","volume":"12","author":"Ramakrishnan","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2019.11.011_bib41","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3389\/fcimb.2018.00327","article-title":"Mycobacterium tuberculosis Virulent Factor ESAT-6 Drives Macrophage Differentiation Toward the Pro-inflammatory M1 Phenotype and Subsequently Switches It to the Anti-inflammatory M2 Phenotype","volume":"8","author":"Refai","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.chom.2019.11.011_bib42","doi-asserted-by":"crossref","first-page":"e1006410","DOI":"10.1371\/journal.ppat.1006410","article-title":"MicroRNA 26a (miR-26a)\/KLF4 and CREB-C\/EBP\u03b2 regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection","volume":"13","author":"Sahu","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2019.11.011_bib43","doi-asserted-by":"crossref","first-page":"16206","DOI":"10.1038\/nmicrobiol.2016.206","article-title":"Single-cell RNA-seq ties macrophage polarization to growth rate of intracellular Salmonella","volume":"2","author":"Saliba","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2019.11.011_bib50","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2019.11.011_bib44","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.aat7148","article-title":"Salmonella persisters undermine host immune defenses during antibiotic treatment","volume":"362","author":"Stapels","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.chom.2019.11.011_bib45","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/imr.12289","article-title":"Bacterial recognition pathways that lead to inflammasome activation","volume":"265","author":"Storek","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.chom.2019.11.011_bib46","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1128\/IAI.01590-13","article-title":"CD11b+ Ly6Chi Ly6G- immature myeloid cells recruited in response to Salmonella enterica serovar Typhimurium infection exhibit protective and immunosuppressive properties","volume":"82","author":"Tam","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2019.11.011_bib47","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.4049\/jimmunol.147.9.3161","article-title":"The involvement of tumor necrosis factor in immunity to Salmonella infection","volume":"147","author":"Tite","year":"1991","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2019.11.011_bib48","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1126\/science.1179663","article-title":"Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium","volume":"327","author":"Volkman","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.chom.2019.11.011_bib49","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.imbio.2014.08.007","article-title":"Monocytes and infection: modulator, messenger and effector","volume":"220","author":"Xiong","year":"2015","journal-title":"Immunobiology"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312819305931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312819305931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:20:08Z","timestamp":1761826808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312819305931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S1931312819305931"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2019.11.011","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2019.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2019.11.002","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}