{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:23:14Z","timestamp":1790738594868,"version":"4.1.0"},"reference-count":98,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":373,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P51OD011132"],"award-info":[{"award-number":["P51OD011132"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI083019"],"award-info":[{"award-number":["U19AI083019"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2U19AI057266"],"award-info":[{"award-number":["2U19AI057266"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AI131566"],"award-info":[{"award-number":["U01AI131566"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008065","name":"Georgia Research Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016958","name":"Office of Research Infrastructure Programs, National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012423","name":"Children's Healthcare of Atlanta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000179","name":"Office of the Director","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000179","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.chom.2019.12.003","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T10:41:52Z","timestamp":1578480112000},"page":"14-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Cross-Reactive Antibodies during Zika Virus Infection: Protection, Pathogenesis, and Placental Seeding"],"prefix":"10.1016","volume":"27","author":[{"given":"Matthew G.","family":"Zimmerman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Wrammert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehul S.","family":"Suthar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2019.12.003_bib1","doi-asserted-by":"crossref","first-page":"eaao4163","DOI":"10.1126\/scitranslmed.aao4163","article-title":"Durability and correlates of vaccine protection against Zika virus in rhesus monkeys","volume":"9","author":"Abbink","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chom.2019.12.003_bib2","doi-asserted-by":"crossref","first-page":"eaat6114","DOI":"10.1126\/sciimmunol.aat6114","article-title":"Immune responses at the maternal-fetal interface","volume":"4","author":"Ander","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.chom.2019.12.003_bib3","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/s41467-019-08845-3","article-title":"Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika","volume":"10","author":"Andrade","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2019.12.003_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1126\/science.aal4365","article-title":"Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity","volume":"356","author":"Bardina","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.chom.2019.12.003_bib5","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.chom.2016.03.008","article-title":"Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection","volume":"19","author":"Bayer","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.12.003_bib6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.chom.2010.08.007","article-title":"The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity","volume":"8","author":"Beltramello","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.12.003_bib7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3201\/eid2303.161499","article-title":"Zika Virus RNA Replication and Persistence in Brain and Placental Tissue","volume":"23","author":"Bhatnagar","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib8","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.chom.2019.12.003_bib9","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika Virus Infection in Pregnant Women in Rio de Janeiro","volume":"375","author":"Brasil","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2019.12.003_bib10","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/S0140-6736(16)30058-7","article-title":"Guillain-Barr\u00e9 syndrome associated with Zika virus infection","volume":"387","author":"Brasil","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2019.12.003_bib11","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.immuni.2019.01.005","article-title":"Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy","volume":"50","author":"Brown","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2019.12.003_bib12","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1182\/blood-2012-01-380121","article-title":"Properties of mouse and human IgG receptors and their contribution to disease models","volume":"119","author":"Bruhns","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.chom.2019.12.003_bib13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4269\/ajtmh.1988.38.172","article-title":"A prospective study of dengue infections in Bangkok","volume":"38","author":"Burke","year":"1988","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.chom.2019.12.003_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1136\/archdischild-2018-314782","article-title":"Congenital Zika infection: neurology can occur without microcephaly","volume":"104","author":"Cardoso","year":"2019","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.chom.2019.12.003_bib15","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3389\/fimmu.2014.00290","article-title":"Human to mosquito transmission of dengue viruses","volume":"5","author":"Carrington","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chom.2019.12.003_bib16","doi-asserted-by":"crossref","first-page":"e1006537","DOI":"10.1371\/journal.ppat.1006537","article-title":"Zika virus preferentially replicates in the female reproductive tract after vaginal inoculation of rhesus macaques","volume":"13","author":"Carroll","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2019.12.003_bib17","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.celrep.2017.10.059","article-title":"Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action","volume":"21","author":"Chen","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2019.12.003_bib18","doi-asserted-by":"crossref","first-page":"e0005926","DOI":"10.1371\/journal.pntd.0005926","article-title":"Immune status alters the probability of apparent illness due to dengue virus infection: Evidence from a pooled analysis across multiple cohort and cluster studies","volume":"11","author":"Clapham","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.micinf.2008.12.006","article-title":"Human genetic determinants of dengue virus susceptibility","volume":"11","author":"Coffey","year":"2009","journal-title":"Microbes Infect."},{"key":"10.1016\/j.chom.2019.12.003_bib20","doi-asserted-by":"crossref","first-page":"124588","DOI":"10.1172\/jci.insight.124588","article-title":"Human antibody response to Zika targets type-specific quaternary structure epitopes","volume":"4","author":"Collins","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.chom.2019.12.003_bib21","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/infdis\/jiu481","article-title":"Preexisting neutralizing antibody responses distinguish clinically inapparent and apparent dengue virus infections in a Sri Lankan pediatric cohort","volume":"211","author":"Corbett","year":"2015","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib22","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nrmicro.2016.125","article-title":"Zika virus - reigniting the TORCH","volume":"14","author":"Coyne","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2019.12.003_bib23","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.7985020","article-title":"Implantation and the placenta: key pieces of the development puzzle","volume":"266","author":"Cross","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.chom.2019.12.003_bib24","doi-asserted-by":"crossref","first-page":"e1188","DOI":"10.1371\/journal.pntd.0001188","article-title":"In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection","volume":"5","author":"de Alwis","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib25","doi-asserted-by":"crossref","first-page":"7439","DOI":"10.1073\/pnas.1200566109","article-title":"Identification of human neutralizing antibodies that bind to complex\u00a0epitopes on dengue virions","volume":"109","author":"de Alwis","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2019.12.003_bib26","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S1473-3099(16)30318-8","article-title":"Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study","volume":"16","author":"de Ara\u00fajo","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib27","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S1473-3099(17)30727-2","article-title":"Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study","volume":"18","author":"de Ara\u00fajo","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib29","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.celrep.2016.07.049","article-title":"Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype","volume":"16","author":"Dowd","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2019.12.003_bib30","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1038\/s41467-019-11866-7","article-title":"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice","volume":"10","author":"Figueiredo","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2019.12.003_bib31","doi-asserted-by":"crossref","first-page":"e0003749","DOI":"10.1371\/journal.pntd.0003749","article-title":"The Complexity of a Dengue Vaccine: A\u00a0Review of the Human Antibody Response","volume":"9","author":"Flipse","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib32","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.chom.2018.09.015","article-title":"Maternally Acquired Zika Antibodies Enhance Dengue Disease Severity in Mice","volume":"24","author":"Fowler","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.12.003_bib33","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.aogh.2015.02.006","article-title":"The burden of dengue and chikungunya worldwide: implications for the southern United States and California","volume":"80","author":"Fredericks","year":"2014","journal-title":"Ann. Glob. Health"},{"key":"10.1016\/j.chom.2019.12.003_bib34","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1016\/j.ijid.2010.09.008","article-title":"Long-term persistence of clinical symptoms in dengue-infected persons and its association with immunological disorders","volume":"15","author":"Garc\u00eda","year":"2011","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib35","doi-asserted-by":"crossref","first-page":"10498","DOI":"10.1038\/s41598-017-10901-1","article-title":"Prior Exposure to Zika Virus Significantly Enhances Peak Dengue-2 Viremia in Rhesus Macaques","volume":"7","author":"George","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chom.2019.12.003_bib36","doi-asserted-by":"crossref","first-page":"e1002726","DOI":"10.1371\/journal.pmed.1002726","article-title":"Prior dengue virus infection and risk of Zika: A pediatric cohort in Nicaragua","volume":"16","author":"Gordon","year":"2019","journal-title":"PLoS Med."},{"key":"10.1016\/j.chom.2019.12.003_bib37","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.chom.2018.04.003","article-title":"An Immunocompetent Mouse Model of Zika Virus Infection","volume":"23","author":"Gorman","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.12.003_bib38","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2018.23.24.1800268","article-title":"Increased risk for autochthonous vector-borne infections transmitted by Aedes albopictus in continental Europe","volume":"23","author":"Gossner","year":"2018","journal-title":"Euro Surveill."},{"key":"10.1016\/j.chom.2019.12.003_bib39","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.chom.2016.05.009","article-title":"Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling","volume":"19","author":"Grant","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.12.003_bib40","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(14)60572-9","article-title":"Dengue","volume":"385","author":"Guzman","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2019.12.003_bib41","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/aje\/152.9.793","article-title":"Epidemiologic studies on Dengue in Santiago de Cuba, 1997","volume":"152","author":"Guzm\u00e1n","year":"2000","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.chom.2019.12.003_bib42","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/cid\/cix472","article-title":"Maternal Zika Virus Disease Severity, Virus Load, Prior Dengue Antibodies, and Their Relationship to Birth Outcomes","volume":"65","author":"Halai","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib43","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/infdis\/140.4.527","article-title":"In\u00a0vivo enhancement of dengue virus infection in rhesus monkeys by passively transferred antibody","volume":"140","author":"Halstead","year":"1979","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib44","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0065-3527(03)60011-4","article-title":"Neutralization and antibody-dependent enhancement of dengue viruses","volume":"60","author":"Halstead","year":"2003","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.chom.2019.12.003_bib45","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/265739a0","article-title":"Antibody-enhanced dengue virus infection in primate leukocytes","volume":"265","author":"Halstead","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.chom.2019.12.003_bib46","doi-asserted-by":"crossref","first-page":"e428","DOI":"10.3928\/19382359-20171025-01","article-title":"Zika Virus: A Review for Pediatricians","volume":"46","author":"Heald-Sargent","year":"2017","journal-title":"Pediatr. Ann."},{"key":"10.1016\/j.chom.2019.12.003_bib47","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41426-018-0199-6","article-title":"Zika virus infection in human placental tissue explants is enhanced in the presence of dengue virus antibodies in-vitro","volume":"7","author":"Hermanns","year":"2018","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.chom.2019.12.003_bib48","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41467-017-02499-9","article-title":"Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology","volume":"9","author":"Hirsch","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2019.12.003_bib49","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.chom.2017.08.012","article-title":"Gestational Stage and IFN-lambda Signaling Regulate ZIKV Infection In Utero","volume":"22","author":"Jagger","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.12.003_bib50","doi-asserted-by":"crossref","first-page":"e88461","DOI":"10.1172\/jci.insight.88461","article-title":"Zika virus productively infects primary human placenta-specific macrophages","volume":"1","author":"Jurado","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.chom.2019.12.003_bib51","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/jamapediatrics.2017.0002","article-title":"Bridging Knowledge Gaps to Understand How Zika Virus Exposure and Infection Affect Child Development","volume":"171","author":"Kapogiannis","year":"2017","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.chom.2019.12.003_bib52","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1126\/science.aan6836","article-title":"Antibody-dependent enhancement of severe dengue disease in humans","volume":"358","author":"Katzelnick","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.chom.2019.12.003_bib53","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.celrep.2018.10.031","article-title":"A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates","volume":"25","author":"Keeffe","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2019.12.003_bib54","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.4049\/jimmunol.0803247","article-title":"FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus","volume":"182","author":"Kim","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2019.12.003_bib55","doi-asserted-by":"crossref","first-page":"411","DOI":"10.4269\/ajtmh.1988.38.411","article-title":"Evidence that maternal dengue antibodies are important in the development of dengue hemorrhagic fever in infants","volume":"38","author":"Kliks","year":"1988","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.chom.2019.12.003_bib56","doi-asserted-by":"crossref","first-page":"e1007640","DOI":"10.1371\/journal.ppat.1007640","article-title":"The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis","volume":"15","author":"Langerak","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2019.12.003_bib57","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.chom.2019.10.001","article-title":"Adenovirus Vector-Based Vaccines Confer Maternal-Fetal Protection against Zika Virus Challenge in Pregnant IFN-alphabetaR(\u2212\/\u2212) Mice","volume":"26","author":"Larocca","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.12.003_bib58","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1369\/0022155417705095","article-title":"Distribution of FcRn Across Species and Tissues","volume":"65","author":"Latvala","year":"2017","journal-title":"J.\u00a0Histochem. Cytochem."},{"key":"10.1016\/j.chom.2019.12.003_bib59","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1056\/NEJMc1800098","article-title":"Neurodevelopment in Infants Exposed to Zika Virus In Utero","volume":"379","author":"Lopes Moreira","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2019.12.003_bib60","doi-asserted-by":"crossref","first-page":"eaan8184","DOI":"10.1126\/scitranslmed.aan8184","article-title":"Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques","volume":"9","author":"Magnani","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chom.2019.12.003_bib61","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1038\/s41467-018-04056-4","article-title":"Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques","volume":"9","author":"Magnani","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2019.12.003_bib62","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2353\/ajpath.2006.050482","article-title":"Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis","volume":"168","author":"Maidji","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.chom.2019.12.003_bib63","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1128\/iai.24.1.47-50.1979","article-title":"Effect of immune status on dengue 2 virus replication in cultured leukocytes from infants and children","volume":"24","author":"Marchette","year":"1979","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2019.12.003_bib64","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S0140-6736(16)30883-2","article-title":"Pathology of congenital Zika syndrome in Brazil: a case series","volume":"388","author":"Martines","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2019.12.003_bib65","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cell.2018.03.019","article-title":"Fetal Neuropathology in Zika Virus-Infected Pregnant Female Rhesus Monkeys","volume":"173","author":"Martinot","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.chom.2019.12.003_bib67","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.stem.2016.04.009","article-title":"Understanding How Zika Virus Enters and Infects Neural Target Cells","volume":"18","author":"Miner","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.chom.2019.12.003_bib68","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.chom.2017.01.004","article-title":"Zika Virus Pathogenesis and Tissue Tropism","volume":"21","author":"Miner","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.12.003_bib69","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pediatrneurol.2017.10.012","article-title":"Neuroimaging Findings in Normocephalic Newborns With Intrauterine Zika Virus Exposure","volume":"78","author":"Mulkey","year":"2018","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.chom.2019.12.003_bib70","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cmi.2017.11.004","article-title":"Adverse birth outcomes associated with Zika virus exposure during pregnancy in S\u00e3o Jos\u00e9 do Rio Preto, Brazil","volume":"24","author":"Nogueira","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.chom.2019.12.003_bib71","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/nn.4612","article-title":"Zika virus directly infects peripheral neurons and induces cell death","volume":"20","author":"Oh","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chom.2019.12.003_bib72","doi-asserted-by":"crossref","first-page":"15674","DOI":"10.1038\/ncomms15674","article-title":"Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus","volume":"8","author":"Pantoja","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2019.12.003_bib73","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature21428","article-title":"Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination","volume":"543","author":"Pardi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.chom.2019.12.003_bib74","doi-asserted-by":"crossref","first-page":"e0005554","DOI":"10.1371\/journal.pntd.0005554","article-title":"Dissecting the human serum antibody response to secondary dengue virus infections","volume":"11","author":"Patel","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib75","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.3201\/eid2508.190113","article-title":"Cross-Protection of Dengue Virus Infection against Congenital\u00a0Zika\u00a0Syndrome, Northeastern Brazil","volume":"25","author":"Pedroso","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib76","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/bdrb.20201","article-title":"An interspecies comparison of placental antibody transfer: new insights into developmental toxicity testing of monoclonal antibodies","volume":"86","author":"Pentsuk","year":"2009","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"key":"10.1016\/j.chom.2019.12.003_bib77","doi-asserted-by":"crossref","first-page":"7852","DOI":"10.1073\/pnas.1607931113","article-title":"Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus","volume":"113","author":"Priyamvada","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2019.12.003_bib78","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.chom.2016.05.015","article-title":"Zika Virus Infects Human Placental Macrophages","volume":"20","author":"Quicke","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.12.003_bib80","doi-asserted-by":"crossref","first-page":"eaav3208","DOI":"10.1126\/sciadv.aav3208","article-title":"Maternal immunity and antibodies to dengue virus promote infection and Zika virus-induced microcephaly in fetuses","volume":"5","author":"Rathore","year":"2019","journal-title":"Sci Adv"},{"key":"10.1016\/j.chom.2019.12.003_bib81","doi-asserted-by":"crossref","first-page":"636","DOI":"10.15585\/mmwr.mm6624a3","article-title":"Evaluation of Placental and Fetal Tissue Specimens for Zika Virus Infection - 50 States and District of Columbia, January-December, 2016","volume":"66","author":"Reagan-Steiner","year":"2017","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.chom.2019.12.003_bib82","doi-asserted-by":"crossref","first-page":"14408","DOI":"10.1073\/pnas.1618029113","article-title":"Zika virus cell tropism in the developing human brain and\u00a0inhibition\u00a0by azithromycin","volume":"113","author":"Retallack","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2019.12.003_bib83","doi-asserted-by":"crossref","first-page":"858","DOI":"10.15585\/mmwr.mm6731e1","article-title":"Vital Signs: Zika-Associated Birth Defects and Neurodevelopmental Abnormalities Possibly Associated with Congenital Zika Virus Infection - U.S. Territories and Freely Associated States, 2018","volume":"67","author":"Rice","year":"2018","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.chom.2019.12.003_bib84","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2017.03.016","article-title":"Modified mRNA Vaccines Protect against Zika Virus Infection","volume":"169","author":"Richner","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.chom.2019.12.003_bib85","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1084\/jem.20191061","article-title":"Risk of Zika microcephaly correlates with features of maternal antibodies","volume":"216","author":"Robbiani","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2019.12.003_bib86","doi-asserted-by":"crossref","first-page":"e1000732","DOI":"10.1371\/journal.ppat.1000732","article-title":"Placental syncytiotrophoblast constitutes a major barrier to vertical transmission of Listeria monocytogenes","volume":"6","author":"Robbins","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2019.12.003_bib87","doi-asserted-by":"crossref","first-page":"e0003564","DOI":"10.1371\/journal.pntd.0003564","article-title":"Antibodies against immature virions are not a discriminating factor for dengue disease severity","volume":"9","author":"Rodenhuis-Zybert","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib88","doi-asserted-by":"crossref","first-page":"eaan6809","DOI":"10.1126\/sciimmunol.aan6809","article-title":"Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors","volume":"2","author":"Rogers","year":"2017","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.chom.2019.12.003_bib89","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5858\/arpa.2016-0401-OA","article-title":"Placental Pathology of Zika Virus: Viral Infection of the Placenta Induces Villous Stromal Macrophage (Hofbauer Cell) Proliferation and Hyperplasia","volume":"141","author":"Rosenberg","year":"2017","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.chom.2019.12.003_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0378(97)00068-5","article-title":"Human placental Fc receptors and the transmission of antibodies from mother to fetus","volume":"37","author":"Simister","year":"1997","journal-title":"J.\u00a0Reprod. Immunol."},{"key":"10.1016\/j.chom.2019.12.003_bib91","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJMoa1800820","article-title":"Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy","volume":"379","author":"Sridhar","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2019.12.003_bib92","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.aaf8505","article-title":"Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection","volume":"353","author":"Stettler","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.chom.2019.12.003_bib93","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.chom.2016.07.002","article-title":"Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission","volume":"20","author":"Tabata","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.12.003_bib94","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1365-2249.1994.tb06040.x","article-title":"Antibody-dependent enhancement of HIV-1 infection in human term syncytiotrophoblast cells cultured in\u00a0vitro","volume":"96","author":"T\u00f3th","year":"1994","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.chom.2019.12.003_bib95","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity","volume":"181","author":"Vaughn","year":"2000","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib96","doi-asserted-by":"crossref","first-page":"e0201495","DOI":"10.1371\/journal.pone.0201495","article-title":"Skills attained by infants with congenital Zika syndrome: Pilot data from Brazil","volume":"13","author":"Wheeler","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2019.12.003_bib97","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1086\/512680","article-title":"Severe dengue virus infection in travelers: risk factors and laboratory indicators","volume":"195","author":"Wichmann","year":"2007","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2019.12.003_bib98","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.chom.2018.09.008","article-title":"A Single-Dose\u00a0Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission","volume":"24","author":"Xie","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2019.12.003_bib99","doi-asserted-by":"crossref","first-page":"e01722-17","DOI":"10.1128\/JVI.01722-17","article-title":"Recombinant Chimpanzee Adenovirus Vaccine AdC7-M\/E Protects against Zika Virus Infection and Testis Damage","volume":"92","author":"Xu","year":"2018","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2019.12.003_bib100","doi-asserted-by":"crossref","first-page":"e1003821","DOI":"10.1371\/journal.ppat.1003821","article-title":"Placental syncytium forms a biophysical barrier against pathogen invasion","volume":"9","author":"Zeldovich","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2019.12.003_bib101","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.chom.2018.10.008","article-title":"Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages","volume":"24","author":"Zimmerman","year":"2018","journal-title":"Cell Host Microbe"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312819306328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312819306328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:07:54Z","timestamp":1778832474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312819306328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":98,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S1931312819306328"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2019.12.003","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cross-Reactive Antibodies during Zika Virus Infection: Protection, Pathogenesis, and Placental Seeding","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2019.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}