{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:33:57Z","timestamp":1792647237294,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI053067"],"award-info":[{"award-number":["AI053067"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI114511"],"award-info":[{"award-number":["AI114511"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5 T32 AI7520-14"],"award-info":[{"award-number":["5 T32 AI7520-14"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.chom.2020.05.004","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T10:35:27Z","timestamp":1591698927000},"page":"41-53.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"title":["The Serotonin Neurotransmitter Modulates Virulence of Enteric Pathogens"],"prefix":"10.1016","volume":"28","author":[{"given":"Aman","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regan M.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reed","family":"Pifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelia","family":"Menezes-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Cuesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Narayanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"MacMillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Sperandio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2020.05.004_bib1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1073\/pnas.0906112107","article-title":"The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation","volume":"107","author":"Bansal","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.05.004_bib2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nature18849","article-title":"Interactions between the microbiota and pathogenic bacteria in the gut","volume":"535","author":"B\u00e4umler","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.chom.2020.05.004_bib3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/MOG.0b013e3282f2b0fb","article-title":"Utility of the Citrobacter rodentium infection model in laboratory mice","volume":"24","author":"Borenshtein","year":"2008","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.chom.2020.05.004_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/MED.0b013e32831e9c8e","article-title":"Serotonin in the gastrointestinal tract","volume":"16","author":"Camilleri","year":"2009","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.chom.2020.05.004_bib5","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01852-16","article-title":"Catabolite and oxygen regulation of enterohemorrhagic Escherichia coli virulence","volume":"7","author":"Carlson-Banning","year":"2016","journal-title":"mBio"},{"key":"10.1016\/j.chom.2020.05.004_bib6","doi-asserted-by":"crossref","first-page":"10420","DOI":"10.1073\/pnas.0604343103","article-title":"The QseC sensor kinase: a bacterial adrenergic receptor","volume":"103","author":"Clarke","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.05.004_bib7","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1111\/j.1365-2958.2005.04792.x","article-title":"Transcriptional regulation of flhDC by QseBC and sigma (FliA) in enterohaemorrhagic Escherichia coli","volume":"57","author":"Clarke","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2020.05.004_bib8","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.chom.2014.11.005","article-title":"The gut commensal Bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape","volume":"16","author":"Curtis","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2020.05.004_bib9","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"Datsenko","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.05.004_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fcimb.2016.00011","article-title":"The two-component system CpxRA negatively regulates the locus of enterocyte effacement of enterohemorrhagic Escherichia coli involving \u03c3 (32) and Lon protease","volume":"6","author":"De la Cruz","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.chom.2020.05.004_bib11","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1128\/IAI.66.9.4560-4563.1998","article-title":"Escherichia coli O157:H7 requires intimin for enteropathogenicity in calves","volume":"66","author":"Dean-Nystrom","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.05.004_bib12","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.0400326101","article-title":"Dissecting virulence: systematic and functional analyses of a pathogenicity island","volume":"101","author":"Deng","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.05.004_bib13","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1172\/JCI116717","article-title":"Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection","volume":"92","author":"Donnenberg","year":"1993","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2020.05.004_bib14","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1053\/j.gastro.2009.09.002","article-title":"Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression","volume":"137","author":"Esmaili","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.chom.2020.05.004_bib15","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1038\/s41564-019-0540-4","article-title":"Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut","volume":"4","author":"Fung","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2020.05.004_bib16","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3389\/fcimb.2018.00320","article-title":"The virulence effect of CpxRA in Citrobacter rodentium is independent of the auxiliary proteins NlpE and CpxP","volume":"8","author":"Giannakopoulou","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.chom.2020.05.004_bib17","doi-asserted-by":"crossref","first-page":"705","DOI":"10.7326\/0003-4819-109-9-705","article-title":"Illnesses associated with Escherichia coli O157:H7 infections. A broad clinical spectrum","volume":"109","author":"Griffin","year":"1988","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.chom.2020.05.004_bib18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1099\/00222615-47-2-151","article-title":"Secretory pathways in Salmonella Typhimurium-induced fluid accumulation in the porcine small intestine","volume":"47","author":"Gr\u00f8ndahl","year":"1998","journal-title":"J.\u00a0Med. Microbiol."},{"key":"10.1016\/j.chom.2020.05.004_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01025-13","article-title":"Posttranscriptional control of microbe-induced rearrangement of host cell actin","volume":"5","author":"Gruber","year":"2014","journal-title":"mBio"},{"key":"10.1016\/j.chom.2020.05.004_bib20","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1128\/IAI.02918-14","article-title":"Global analysis of posttranscriptional regulation by GlmY and GlmZ in enterohemorrhagic Escherichia coli O157:H7","volume":"83","author":"Gruber","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.05.004_bib21","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1365-2958.2009.06781.x","article-title":"Hfq affects the expression of the LEE pathogenicity island in enterohaemorrhagic Escherichia coli","volume":"73","author":"Hansen","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2020.05.004_bib22","first-page":"G1367","article-title":"Segment-specific effects of epinephrine on ion transport in the colon of the rat","volume":"275","author":"H\u00f6rger","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.chom.2020.05.004_bib23","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.cell.2013.11.024","article-title":"Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders","volume":"155","author":"Hsiao","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.chom.2020.05.004_bib24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3389\/fnins.2018.00216","article-title":"Indole, a signaling molecule produced by the gut microbiota, negatively impacts emotional behaviors in rats","volume":"12","author":"Jaglin","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.chom.2020.05.004_bib25","doi-asserted-by":"crossref","first-page":"39809","DOI":"10.1074\/jbc.M204482200","article-title":"Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in\u00a0vitro","volume":"277","author":"Janausch","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2020.05.004_bib26","doi-asserted-by":"crossref","first-page":"7996","DOI":"10.1073\/pnas.92.17.7996","article-title":"Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation","volume":"92","author":"Jarvis","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.05.004_bib27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.mib.2011.11.009","article-title":"Histidine kinases and response regulators in networks","volume":"15","author":"Jung","year":"2012","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.chom.2020.05.004_bib28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrmicro818","article-title":"Pathogenic Escherichia coli","volume":"2","author":"Kaper","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2020.05.004_bib29","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.micpath.2018.07.040","article-title":"New roles of fluoxetine in pharmacology: antibacterial effect and modulation of antibiotic activity","volume":"123","author":"Karine de Sousa","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.chom.2020.05.004_bib30","doi-asserted-by":"crossref","first-page":"6843","DOI":"10.1128\/JB.06141-11","article-title":"Hfq virulence regulation in enterohemorrhagic Escherichia coli O157:H7 strain 86-24","volume":"193","author":"Kendall","year":"2011","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chom.2020.05.004_bib31","doi-asserted-by":"crossref","first-page":"e01748","DOI":"10.1128\/mBio.01748-15","article-title":"What a dinner party! Mechanisms and functions of interkingdom signaling in host-pathogen associations","volume":"7","author":"Kendall","year":"2016","journal-title":"mBio"},{"key":"10.1016\/j.chom.2020.05.004_bib32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1021\/acscentsci.9b01076","article-title":"Characterization of the autoinducer-3 structure and biosynthesis in E. coli","volume":"6","author":"Kim","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.chom.2020.05.004_bib33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ebiom.2016.05.037","article-title":"Serotonin activates bacterial quorum sensing and enhances the virulence of Pseudomonas aeruginosa in the host","volume":"9","author":"Knecht","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.chom.2020.05.004_bib34","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1128\/iai.57.4.1290-1298.1989","article-title":"Actin accumulation at sites of bacterial adhesion to tissue culture cells: basis of a new diagnostic test for enteropathogenic and enterohemorrhagic Escherichia coli","volume":"57","author":"Knutton","year":"1989","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.05.004_bib35","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1136\/gut.2003.033563","article-title":"Serotonin and vasoactive intestinal peptide antagonists attenuate rotavirus diarrhoea","volume":"53","author":"Kordasti","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.chom.2020.05.004_bib36","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01031-19","article-title":"Indole signaling at the host-microbiota-pathogen interface","volume":"10","author":"Kumar","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.chom.2020.05.004_bib37","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1126\/science.1211057","article-title":"Intestinal microbiota promote enteric virus replication and systemic pathogenesis","volume":"334","author":"Kuss","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.chom.2020.05.004_bib38","first-page":"1167","article-title":"The ribosome binding site of a mini-ORF protects a T3SS mRNA from degradation by RNase","volume":"86","author":"Lodato","year":"2012","journal-title":"E.\u00a0Mol. Microbiol."},{"key":"10.1016\/j.chom.2020.05.004_bib39","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2958.2008.06530.x","article-title":"Post-transcriptional processing of the LEE4 operon in enterohaemorrhagic Escherichia coli","volume":"71","author":"Lodato","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2020.05.004_bib40","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S1286-4579(01)01387-9","article-title":"Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia","volume":"3","author":"Luperchio","year":"2001","journal-title":"Microbes Infect."},{"key":"10.1016\/j.chom.2020.05.004_bib41","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nature25979","article-title":"Extensive impact of non-antibiotic drugs on human gut bacteria","volume":"555","author":"Maier","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.chom.2020.05.004_bib42","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1172\/JCI62746","article-title":"A novel murine infection model for Shiga toxin-producing Escherichia coli","volume":"122","author":"Mallick","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2020.05.004_bib43","doi-asserted-by":"crossref","first-page":"15490","DOI":"10.1523\/JNEUROSCI.3299-14.2014","article-title":"Gut microbes and the brain: paradigm shift in neuroscience","volume":"34","author":"Mayer","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.chom.2020.05.004_bib44","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1073\/pnas.92.5.1664","article-title":"A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens","volume":"92","author":"McDaniel","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.05.004_bib45","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1128\/iai.63.9.3739-3744.1995","article-title":"Enterohemorrhagic Escherichia coli O157:H7 requires intimin to colonize the gnotobiotic pig intestine and to adhere to HEp-2 cells","volume":"63","author":"McKee","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.05.004_bib46","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1046\/j.1365-2958.1999.01473.x","article-title":"The per regulon of enteropathogenic Escherichia coli : identification of a regulatory cascade and a novel transcriptional activator, the locus of enterocyte effacement (LEE)-encoded regulator (Ler)","volume":"33","author":"Mellies","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2020.05.004_bib47","series-title":"Experiments in molecular genetics","author":"Miller","year":"1972"},{"key":"10.1016\/j.chom.2020.05.004_bib48","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1016\/j.vaccine.2010.04.099","article-title":"Neutralizing antibodies to Shiga toxin type 2 (Stx2) reduce colonization of mice by Stx2-expressing Escherichia coli O157:H7","volume":"28","author":"Mohawk","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.chom.2020.05.004_bib49","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.micpath.2010.01.003","article-title":"Pathogenesis of Escherichia coli O157:H7 strain 86-24 following oral infection of BALB\/c mice with an intact commensal flora","volume":"48","author":"Mohawk","year":"2010","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.chom.2020.05.004_bib50","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1128\/IAI.01038-09","article-title":"QseC mediates Salmonella enterica serovar typhimurium virulence in\u00a0vitro and in\u00a0vivo","volume":"78","author":"Moreira","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.05.004_bib51","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00280-12","article-title":"Virulence meets metabolism: cra and KdpE gene regulation in enterohemorrhagic Escherichia coli","volume":"3","author":"Njoroge","year":"2012","journal-title":"mBio"},{"key":"10.1016\/j.chom.2020.05.004_bib52","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1462-5822.2005.00657.x","article-title":"Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon","volume":"8","author":"O'Hara","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2020.05.004_bib53","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature11623","article-title":"Fucose sensing regulates bacterial intestinal colonization","volume":"492","author":"Pacheco","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.chom.2020.05.004_bib54","doi-asserted-by":"crossref","first-page":"E10712","DOI":"10.1073\/pnas.1813451115","article-title":"Redox, amino acid, and fatty acid metabolism intersect with bacterial virulence in the gut","volume":"115","author":"Pifer","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.05.004_bib55","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1160354","article-title":"Targeting QseC signaling and virulence for antibiotic development","volume":"321","author":"Rasko","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.chom.2020.05.004_bib56","doi-asserted-by":"crossref","first-page":"5889","DOI":"10.1073\/pnas.0811409106","article-title":"The two-component system QseEF and the membrane protein QseG link adrenergic and stress sensing to bacterial pathogenesis","volume":"106","author":"Reading","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.05.004_bib57","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1128\/JB.01848-06","article-title":"A novel two-component signaling system that activates transcription of an enterohemorrhagic Escherichia coli effector involved in remodeling of host actin","volume":"189","author":"Reading","year":"2007","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chom.2020.05.004_bib58","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1096\/fj.14-259598","article-title":"Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells","volume":"29","author":"Reigstad","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.chom.2020.05.004_bib59","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1056\/NEJM198303243081203","article-title":"Hemorrhagic colitis associated with a rare Escherichia coli serotype","volume":"308","author":"Riley","year":"1983","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2020.05.004_bib60","series-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"10.1016\/j.chom.2020.05.004_bib61","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.chom.2015.04.011","article-title":"Control of brain development, function, and behavior by the microbiome","volume":"17","author":"Sampson","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2020.05.004_bib62","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-2958.2009.06856.x","article-title":"Hfq negatively regulates type III secretion in EHEC and several other pathogens","volume":"74","author":"Shakhnovich","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2020.05.004_bib63","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1038\/s41598-019-38489-8","article-title":"Serotonin transporter deficiency is associated with dysbiosis and changes in metabolic function of the mouse intestinal microbiome","volume":"9","author":"Singhal","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chom.2020.05.004_bib64","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.EHEC-0007-2013","article-title":"The locus of enterocyte Effacement and associated virulence factors of enterohemorrhagic Escherichia coli","volume":"2","author":"Stevens","year":"2014","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.chom.2020.05.004_bib65","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1128\/IAI.00194-15","article-title":"The CpxRA two-component system is essential for Citrobacter rodentium virulence","volume":"83","author":"Thomassin","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.05.004_bib66","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1128\/IAI.00677-08","article-title":"CadA negatively regulates Escherichia coli O157:H7 adherence and intestinal colonization","volume":"76","author":"Vazquez-Juarez","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.05.004_bib67","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/mmi.14182","article-title":"Characterization of the Citrobacter rodentium Cpx regulon and its role in host infection","volume":"111","author":"Vogt","year":"2019","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2020.05.004_bib68","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1128\/JB.183.14.4210-4216.2001","article-title":"Indole can act as an extracellular signal in Escherichia coli","volume":"183","author":"Wang","year":"2001","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chom.2020.05.004_bib69","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.dib.2016.03.025","article-title":"Data supporting the rat brain sample preparation and validation assays for simultaneous determination of 8 neurotransmitters and their metabolites using liquid chromatography-tandem mass spectrometry","volume":"7","author":"Wojnicz","year":"2016","journal-title":"Data Brief"},{"key":"10.1016\/j.chom.2020.05.004_bib70","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1086\/338633","article-title":"Ferrets as a model system for renal disease secondary to intestinal infection with Escherichia coli O157:H7 and other Shiga toxin-producing E.\u00a0coli","volume":"185","author":"Woods","year":"2002","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2020.05.004_bib71","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","article-title":"Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312820302869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312820302869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:08:22Z","timestamp":1778832502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312820302869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S1931312820302869"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2020.05.004","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738114953.793576777","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.738114953.793577276","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.738114953.793575776","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Serotonin Neurotransmitter Modulates Virulence of Enteric Pathogens","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2020.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}