{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:01:04Z","timestamp":1792116064888,"version":"4.4.0"},"reference-count":89,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI118861"],"award-info":[{"award-number":["R01AI118861"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI123243"],"award-info":[{"award-number":["R01AI123243"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007928","name":"Perelman School of Medicine, University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.chom.2020.07.019","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T10:31:20Z","timestamp":1598265080000},"page":"683-698.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial Inflammation"],"prefix":"10.1016","volume":"28","author":[{"given":"Xin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia M.","family":"Holmgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunny","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2020.07.019_bib1","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1084\/jem.20170689","article-title":"The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes","volume":"214","author":"Anzai","year":"2017","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2020.07.019_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004229","article-title":"The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines","volume":"10","author":"Asrat","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.chom.2020.07.019_bib3","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.4049\/jimmunol.1300100","article-title":"IL-1alpha signaling initiates the inflammatory response to virulent Legionella pneumophila in\u00a0vivo","volume":"190","author":"Barry","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib4","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.22707","article-title":"Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen","volume":"6","author":"Barry","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.chom.2020.07.019_bib5","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.immuni.2016.10.026","article-title":"GM-CSF: from growth factor to central mediator of tissue inflammation","volume":"45","author":"Becher","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2020.07.019_bib6","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1128\/JB.01798-07","article-title":"Lgt: a family of cytotoxic glucosyltransferases produced by Legionella pneumophila","volume":"190","author":"Belyi","year":"2008","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chom.2020.07.019_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2958.1993.tb01092.x","article-title":"Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila","volume":"7","author":"Berger","year":"1993","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2020.07.019_bib8","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00281-016-0569-x","article-title":"Macrophage-epithelial interactions in pulmonary alveoli","volume":"38","author":"Bhattacharya","year":"2016","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.chom.2020.07.019_bib9","first-page":"L148","article-title":"Secretion of cytokines by rat alveolar epithelial cells: possible regulatory role for SP-A","volume":"266","author":"Blau","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.chom.2020.07.019_bib10","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.immuni.2009.08.010","article-title":"Origin of the lamina propria dendritic cell network","volume":"31","author":"Bogunovic","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2020.07.019_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1128\/IAI.66.1.65-69.1998","article-title":"In\u00a0vivo regulation of replicative Legionella pneumophila lung infection by endogenous interleukin-12","volume":"66","author":"Brieland","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.07.019_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005691","article-title":"Cooperation between monocyte-derived cells and lymphoid cells in the acute response to a bacterial lung pathogen","volume":"12","author":"Brown","year":"2016","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.chom.2020.07.019_bib13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/978-1-4615-8852-8_15","article-title":"Hexokinase: the direct link between mitochondrial and glycolytic reactions in rapidly growing cancer cells","volume":"92","author":"Bustamente","year":"1977","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.chom.2020.07.019_bib14","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1073\/pnas.1211521110","article-title":"Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila","volume":"110","author":"Case","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.07.019_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003400","article-title":"Caspase-11 activation in response to bacterial secretion systems that access the host cytosol","volume":"9","author":"Casson","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.chom.2020.07.019_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006309","article-title":"Neutrophils and Ly6Chi monocytes collaborate in generating an optimal cytokine response that protects against pulmonary Legionella pneumophila infection","volume":"13","author":"Casson","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.chom.2020.07.019_bib17","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.cell.2013.05.016","article-title":"Posttranscriptional control of T\u00a0cell effector function by aerobic glycolysis","volume":"153","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.chom.2020.07.019_bib18","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jaci.2009.12.980","article-title":"Overview of the immune response","volume":"125","author":"Chaplin","year":"2010","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib19","doi-asserted-by":"crossref","first-page":"7557","DOI":"10.1073\/pnas.1501289112","article-title":"IL-1R signaling enables bystander cells to overcome bacterial blockade of host protein synthesis","volume":"112","author":"Copenhaver","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.07.019_bib20","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1128\/IAI.01891-14","article-title":"Alveolar macrophages and neutrophils are the primary reservoirs for Legionella pneumophila and mediate cytosolic surveillance of type IV secretion","volume":"82","author":"Copenhaver","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.07.019_bib21","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1164\/ajrccm\/150.5_Pt_2.S50","article-title":"Regulation of interleukin-5 and granulocyte-macrophage colony-stimulating factor expression","volume":"150","author":"Cousins","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.chom.2020.07.019_bib22","first-page":"332","article-title":"Cell number and cell characteristics of the normal human lung","volume":"126","author":"Crapo","year":"1982","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.chom.2020.07.019_bib23","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.immuni.2015.08.010","article-title":"The cytokine GM-CSF drives the inflammatory signature of CCR2+ monocytes and licenses autoimmunity","volume":"43","author":"Croxford","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2020.07.019_bib24","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1523\/JNEUROSCI.12-03-01101.1992","article-title":"In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse","volume":"12","author":"Cunningham","year":"1992","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.chom.2020.07.019_bib25","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/j.celrep.2017.10.088","article-title":"Positive and negative regulation of the master metabolic regulator mTORC1 by two families of Legionella pneumophila effectors","volume":"21","author":"De Leon","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.chom.2020.07.019_bib26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3109\/08830189809043005","article-title":"Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist","volume":"16","author":"Dinarello","year":"1998","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib27","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1126\/science.8171324","article-title":"Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis","volume":"264","author":"Dranoff","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.chom.2020.07.019_bib28","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.4049\/jimmunol.1202368","article-title":"GM-CSF produced by nonhematopoietic cells is required for early epithelial cell proliferation and repair of injured colonic mucosa","volume":"190","author":"Egea","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/ni.2833","article-title":"TLR-driven early glycolytic reprogramming via the kinases TBK1-IKK\u03b5 supports the anabolic demands of dendritic cell activation","volume":"15","author":"Everts","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001289","article-title":"Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila","volume":"7","author":"Fontana","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.chom.2020.07.019_bib31","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJM197712012972201","article-title":"Legionnaires' disease: description of an epidemic of pneumonia","volume":"297","author":"Fraser","year":"1977","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2020.07.019_bib32","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.4049\/jimmunol.159.7.3364","article-title":"Phenotypic and functional characterization of mice that lack the type I receptor for IL-1","volume":"159","author":"Glaccum","year":"1997","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib33","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.immuni.2012.03.027","article-title":"GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells","volume":"36","author":"Greter","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2020.07.019_bib34","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1084\/jem.20131199","article-title":"Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF","volume":"210","author":"Guilliams","year":"2013","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2020.07.019_bib35","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1128\/iai.64.12.5151-5160.1996","article-title":"Effector mechanisms responsible for gamma interferon-mediated host resistance to Legionella pneumophila lung infection: the role of endogenous nitric oxide differs in susceptible and resistant murine hosts","volume":"64","author":"Heath","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.07.019_bib36","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.chom.2018.02.011","article-title":"Lung epithelial cells coordinate innate lymphocytes and immunity against pulmonary fungal infection","volume":"23","author":"Hernandez-Santos","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2020.07.019_bib37","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1084\/jem.187.9.1463","article-title":"Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha\/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion","volume":"187","author":"Horai","year":"1998","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2020.07.019_bib38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201012-2036OC","article-title":"GM-CSF in the lung protects against lethal influenza infection","volume":"184","author":"Huang","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.chom.2020.07.019_bib39","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI118461","article-title":"Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice","volume":"97","author":"Huffman","year":"1996","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2020.07.019_bib40","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.176.6.1693","article-title":"Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor","volume":"176","author":"Inaba","year":"1992","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2020.07.019_bib41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrmicro1967","article-title":"The Legionella pneumophila replication vacuole: making a cosy niche inside host cells","volume":"7","author":"Isberg","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2020.07.019_bib42","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ni.3123","article-title":"Control of adaptive immunity by the innate immune system","volume":"16","author":"Iwasaki","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib43","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI117676","article-title":"A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion","volume":"95","author":"Jung","year":"1995","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2020.07.019_bib44","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/infdis\/jiw054","article-title":"Role of granulocyte-macrophage colony-stimulating factor signaling in regulating neutrophil antifungal activity and the oxidative burst during respiratory fungal challenge","volume":"213","author":"Kasahara","year":"2016","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2020.07.019_bib45","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kappaB by toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.chom.2020.07.019_bib46","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1182\/blood-2009-10-249540","article-title":"Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation","volume":"115","author":"Krawczyk","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.chom.2020.07.019_bib47","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fimmu.2017.00061","article-title":"Metabolism supports macrophage activation","volume":"8","author":"Langston","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib48","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.4049\/jimmunol.1003565","article-title":"Nonhematopoietic cells are key players in innate control of bacterial airway infection","volume":"186","author":"LeibundGut-Landmann","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib49","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1016\/j.jmb.2019.07.028","article-title":"Viewing Legionella pneumophila pathogenesis through an immunological lens","volume":"431","author":"Liu","year":"2019","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.chom.2020.07.019_bib50","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1523\/JNEUROSCI.3199-14.2015","article-title":"Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types","volume":"35","author":"Liu","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.chom.2020.07.019_bib51","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1056\/NEJM197712012972202","article-title":"Legionnaires' disease: isolation of a bacterium and demonstration of its role in other respiratory disease","volume":"297","author":"McDade","year":"1977","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2020.07.019_bib52","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages","volume":"167","author":"Mills","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chom.2020.07.019_bib53","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1084\/jem.20051659","article-title":"Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection","volume":"203","author":"Molofsky","year":"2006","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2020.07.019_bib54","doi-asserted-by":"crossref","first-page":"1249288","DOI":"10.1126\/science.1249288","article-title":"Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis","volume":"343","author":"Mortha","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.chom.2020.07.019_bib55","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.chom.2019.01.006","article-title":"A Legionella pneumophila kinase phosphorylates the Hsp70 chaperone family to inhibit eukaryotic protein synthesis","volume":"25","author":"Moss","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2020.07.019_bib56","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/j.1460-2075.1995.tb07100.x","article-title":"Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs","volume":"14","author":"Mui","year":"1995","journal-title":"EMBO J"},{"key":"10.1016\/j.chom.2020.07.019_bib57","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.4049\/jimmunol.1600745","article-title":"GM-CSF induces inflammatory macrophages by regulating glycolysis and lipid metabolism","volume":"197","author":"Na","year":"2016","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib58","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fmicb.2011.00136","article-title":"Type IVB secretion systems of Legionella and other Gram-negative bacteria","volume":"2","author":"Nagai","year":"2011","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.chom.2020.07.019_bib59","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/stem.5530130402","article-title":"Regulation of granulocyte-macrophage colony-stimulating factor and interleukin 3 expression","volume":"13","author":"Nimer","year":"1995","journal-title":"Stem Cells"},{"key":"10.1016\/j.chom.2020.07.019_bib60","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ni.2514","article-title":"IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8+ T\u00a0cell responses to influenza A virus","volume":"14","author":"Pang","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4049\/jimmunol.178.1.39","article-title":"GM-CSF production by autoreactive T\u00a0cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis","volume":"178","author":"Ponomarev","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib62","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrmicro.2017.67","article-title":"Legionella and Coxiella effectors: strength in diversity and activity","volume":"15","author":"Qiu","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2020.07.019_bib63","first-page":"4335","article-title":"JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region","volume":"14","author":"Quelle","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.chom.2020.07.019_bib64","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1371\/journal.ppat.0020018","article-title":"Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity","volume":"2","author":"Ren","year":"2006","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.chom.2020.07.019_bib65","doi-asserted-by":"crossref","first-page":"9565","DOI":"10.1073\/pnas.92.21.9565","article-title":"Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5","volume":"92","author":"Robb","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.07.019_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150068","article-title":"Generation and characterization of mice expressing a conditional allele of the interleukin-1 receptor Type 1","volume":"11","author":"Robson","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2020.07.019_bib67","doi-asserted-by":"crossref","first-page":"E1475","DOI":"10.1073\/pnas.1117988108","article-title":"Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition","volume":"108","author":"Rock","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.07.019_bib68","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4049\/jimmunol.0901698","article-title":"Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation","volume":"185","author":"Rodr\u00edguez-Prados","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003805","article-title":"iNKT cell production of GM-CSF controls Mycobacterium tuberculosis","volume":"10","author":"Rothchild","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.chom.2020.07.019_bib70","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1046\/j.1365-2958.1998.00841.x","article-title":"Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake","volume":"28","author":"Roy","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2020.07.019_bib71","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1128\/iai.61.12.5361-5373.1993","article-title":"Identification of Legionella pneumophila genes required for growth within and killing of human macrophages","volume":"61","author":"Sadosky","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.07.019_bib72","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/ni.3005","article-title":"Induction of the nuclear receptor PPAR-gamma by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages","volume":"15","author":"Schneider","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib73","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1462-5822.2009.01301.x","article-title":"Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response","volume":"11","author":"Shen","year":"2009","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2020.07.019_bib74","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-micro-102215-095557","article-title":"Autophagy evasion and endoplasmic reticulum subversion: the yin and yang of Legionella intracellular infection","volume":"70","author":"Sherwood","year":"2016","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.chom.2020.07.019_bib75","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S1074-7613(01)00218-7","article-title":"GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1","volume":"15","author":"Shibata","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2020.07.019_bib76","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1086\/516530","article-title":"Antibody-mediated depletion of tumor necrosis factor-alpha impairs pulmonary host defenses to Legionella pneumophila","volume":"176","author":"Skerrett","year":"1997","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2020.07.019_bib77","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1084\/jem.20071119","article-title":"GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival","volume":"205","author":"Sonderegger","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2020.07.019_bib78","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1073\/pnas.91.12.5592","article-title":"Granulocyte\/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology","volume":"91","author":"Stanley","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.07.019_bib79","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.chom.2020.07.019_bib80","doi-asserted-by":"crossref","first-page":"463","DOI":"10.4049\/jimmunol.178.1.463","article-title":"Differential regulation of cytokine release and leukocyte migration by lipopolysaccharide-stimulated primary human lung alveolar type II epithelial cells and macrophages","volume":"178","author":"Thorley","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib81","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat8410","article-title":"Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells","volume":"10","author":"Tugues","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chom.2020.07.019_bib82","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.4049\/jimmunol.0803961","article-title":"IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia","volume":"182","author":"Ueda","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2020.07.019_bib83","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1126\/science.279.5352.873","article-title":"Conjugative transfer by the virulence system of Legionella pneumophila","volume":"279","author":"Vogel","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.chom.2020.07.019_bib84","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cmet.2018.08.012","article-title":"Glycolytic stimulation is not a requirement for M2 macrophage differentiation","volume":"28","author":"Wang","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/j.chom.2020.07.019_bib85","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1073\/pnas.1003428107","article-title":"Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity","volume":"107","author":"Weinberg","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.07.019_bib86","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature12902","article-title":"Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity","volume":"506","author":"Westphalen","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chom.2020.07.019_bib87","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0021-9258(18)64988-9","article-title":"Localization of the primary metabolic block produced by 2-deoxyglucose","volume":"224","author":"Wick","year":"1957","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2020.07.019_bib88","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1084\/jem.20112691","article-title":"Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33","volume":"209","author":"Willart","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2020.07.019_bib89","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ni1305","article-title":"The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection","volume":"7","author":"Zamboni","year":"2006","journal-title":"Nat. Immunol."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312820304224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312820304224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:08:29Z","timestamp":1778832509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312820304224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":89,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S1931312820304224"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2020.07.019","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.02.29.970004","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial Inflammation","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2020.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}