{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:03:22Z","timestamp":1792490602210,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":371,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004897","name":"Pennsylvania Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.chom.2020.09.007","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T10:35:49Z","timestamp":1602066949000},"page":"509-515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":132,"title":["The Biology of the Intestinal Intracellular Parasite Cryptosporidium"],"prefix":"10.1016","volume":"28","author":[{"given":"Amandine","family":"Gu\u00e9rin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Striepen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2020.09.007_bib1","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.1073\/pnas.1814685116","article-title":"Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis","volume":"116","author":"Baraga\u00f1a","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.09.007_bib2","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1128\/AAC.02460-12","article-title":"Drug repurposing screen reveals FDA-approved inhibitors of human HMG-CoA reductase and isoprenoid synthesis that block Cryptosporidium parvum growth","volume":"57","author":"Bessoff","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chom.2020.09.007_bib3","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1462-5822.2011.01597.x","article-title":"The moving junction of apicomplexan parasites: a key structure for invasion","volume":"13","author":"Besteiro","year":"2011","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2020.09.007_bib4","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2217\/fmb.09.128","article-title":"Human immune responses in cryptosporidiosis","volume":"5","author":"Borad","year":"2010","journal-title":"Future Microbiol."},{"key":"10.1016\/j.chom.2020.09.007_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1473-3099(14)70772-8","article-title":"A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium","volume":"15","author":"Checkley","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chom.2020.09.007_bib6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0016-5085(03)00662-0","article-title":"Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src","volume":"125","author":"Chen","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.chom.2020.09.007_bib7","doi-asserted-by":"crossref","first-page":"31671","DOI":"10.1074\/jbc.M401592200","article-title":"Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42","volume":"279","author":"Chen","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2020.09.007_bib8","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1073\/pnas.0408563102","article-title":"Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion","volume":"102","author":"Chen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.09.007_bib9","doi-asserted-by":"crossref","first-page":"e0008252","DOI":"10.1371\/journal.pntd.0008252","article-title":"Cryptosporidiosis should be designated as a tropical disease by the US Food and Drug Administration","volume":"14","author":"Choy","year":"2020","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.chom.2020.09.007_bib10","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.1128\/IAI.69.9.5940-5942.2001","article-title":"Cryptosporidium parvum infection requires host cell actin polymerization","volume":"69","author":"Elliott","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.09.007_bib11","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.pt.2018.07.009","article-title":"Genetic Diversity and Population Structure of Cryptosporidium","volume":"34","author":"Feng","year":"2018","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.chom.2020.09.007_bib12","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1128\/IAI.67.2.844-852.1999","article-title":"A role for host phosphoinositide 3-kinase and cytoskeletal remodeling during Cryptosporidium parvum infection","volume":"67","author":"Forney","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.09.007_bib13","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41564-018-0177-8","article-title":"Modelling Cryptosporidium infection in human small intestinal and lung organoids","volume":"3","author":"Heo","year":"2018","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2020.09.007_bib14","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1038\/s41467-018-05240-2","article-title":"Cryopreservation of infectious Cryptosporidium parvum oocysts","volume":"9","author":"Jaskiewicz","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2020.09.007_bib15","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1038\/s41467-019-09880-w","article-title":"A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors","volume":"10","author":"Jumani","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2020.09.007_bib16","doi-asserted-by":"crossref","first-page":"e758","DOI":"10.1016\/S2214-109X(18)30283-3","article-title":"Morbidity, mortality, and long-term consequences associated with diarrhoea from Cryptosporidium infection in children younger than 5 years: a meta-analyses study","volume":"6","author":"Khalil","year":"2018","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.chom.2020.09.007_bib17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0140-6736(13)60844-2","article-title":"Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study","volume":"382","author":"Kotloff","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2020.09.007_bib18","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1017\/S0031182014000237","article-title":"Cryptosporidium infections: molecular advances","volume":"141","author":"Lendner","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/j.chom.2020.09.007_bib19","doi-asserted-by":"crossref","first-page":"e0005373","DOI":"10.1371\/journal.pntd.0005373","article-title":"A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis","volume":"11","author":"Love","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.chom.2020.09.007_bib20","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature22337","article-title":"A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis","volume":"546","author":"Manjunatha","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.chom.2020.09.007_bib21","doi-asserted-by":"crossref","first-page":"e3000364","DOI":"10.1371\/journal.pbio.3000364","article-title":"Intestinal delta-6-desaturase activity determines host range for Toxoplasma sexual reproduction","volume":"17","author":"Martorelli Di Genova","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.chom.2020.09.007_bib22","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/s41564-019-0377-x","article-title":"Evolutionary genomics of anthroponosis in Cryptosporidium","volume":"4","author":"Nader","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2020.09.007_bib23","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1111\/j.1462-5822.2006.00759.x","article-title":"Cryptosporidium parvum infects human cholangiocytes via sphingolipid-enriched membrane microdomains","volume":"8","author":"Nelson","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2020.09.007_bib24","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/BF00931092","article-title":"Cryptosporidium sp. of the starred lizard Agame stellio:ultrastructure and life cycle","volume":"76","author":"Ostrovska","year":"1990","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.chom.2020.09.007_bib25","doi-asserted-by":"crossref","first-page":"21160","DOI":"10.1073\/pnas.1908239116","article-title":"Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell","volume":"116","author":"Pawlowic","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.09.007_bib26","doi-asserted-by":"crossref","first-page":"e564","DOI":"10.1016\/S2214-109X(15)00151-5","article-title":"Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED)","volume":"3","author":"Platts-Mills","year":"2015","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.chom.2020.09.007_bib27","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1128\/EC.00213-13","article-title":"Strategies to discover the structural components of cyst and oocyst walls","volume":"12","author":"Samuelson","year":"2013","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.chom.2020.09.007_bib28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.chom.2019.05.006","article-title":"A Genetically Tractable, Natural Mouse Model of Cryptosporidiosis Offers Insights into Host Protective Immunity","volume":"26","author":"Sateriale","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2020.09.007_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/503189a","article-title":"Parasitic infections: Time to tackle cryptosporidiosis","volume":"503","author":"Striepen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.chom.2020.09.007_bib30","doi-asserted-by":"crossref","first-page":"eaax7161","DOI":"10.1126\/scitranslmed.aax7161","article-title":"Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection","volume":"11","author":"Swale","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chom.2020.09.007_bib31","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1038\/s41564-019-0539-x","article-title":"Life cycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum","volume":"4","author":"Tandel","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2020.09.007_bib32","first-page":"487","article-title":"An extracellular Coccidium, Cryptosporidium Muris (Gen. Et Sp. Nov.), of the gastric Glands of the Common Mouse","volume":"23","author":"Tyzzer","year":"1910","journal-title":"J.\u00a0Med. Res."},{"key":"10.1016\/j.chom.2020.09.007_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aba8412","article-title":"Bicyclic azetidines cure infection with the diarrheal pathogen Cryptosporidium by inhibiting parasite phenylalanyl-tRNA synthetase in mice","volume":"12","author":"Vinayak","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chom.2020.09.007_bib33","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature14651","article-title":"Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum","volume":"523","author":"Vinayak","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.chom.2020.09.007_bib35","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1017\/S0031182013000838","article-title":"Sex and Eimeria: a molecular perspective","volume":"140","author":"Walker","year":"2013","journal-title":"Parasitology"},{"key":"10.1016\/j.chom.2020.09.007_bib36","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1128\/IAI.73.9.5379-5387.2005","article-title":"Gliding motility leads to active cellular invasion by Cryptosporidium parvum sporozoites","volume":"73","author":"Wetzel","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.09.007_bib37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ijpara.2020.01.005","article-title":"Cryptosporidium hominis infections in non-human animal species: revisiting the concept of host specificity","volume":"50","author":"Widmer","year":"2020","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.chom.2020.09.007_bib38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1128\/mSphere.00124-18","article-title":"Monoclonal Antibodies to Intracellular Stages of Cryptosporidium parvum Define Life Cycle Progression In\u00a0Vitro","volume":"3","author":"Wilke","year":"2018","journal-title":"MSphere"},{"key":"10.1016\/j.chom.2020.09.007_bib39","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.chom.2019.05.007","article-title":"A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In\u00a0Vitro and Genetic Tractability","volume":"26","author":"Wilke","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2020.09.007_bib40","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.ijpara.2017.05.002","article-title":"Targeted gene knockdown validates the essential role of lactate dehydrogenase in Cryptosporidium parvum","volume":"47","author":"Witola","year":"2017","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.chom.2020.09.007_bib41","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/s12864-019-5788-9","article-title":"Comparative analysis reveals conservation in genome organization among intestinal Cryptosporidium species and sequence divergence in potential secreted pathogenesis determinants among major human-infecting species","volume":"20","author":"Xu","year":"2019","journal-title":"BMC Genomics"},{"key":"10.1016\/j.chom.2020.09.007_bib42","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1128\/IAI.05862-11","article-title":"Involvement of host cell integrin \u03b12 in Cryptosporidium parvum infection","volume":"80","author":"Zhang","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2020.09.007_bib43","doi-asserted-by":"crossref","first-page":"e1005250","DOI":"10.1371\/journal.ppat.1005250","article-title":"Cryptosporidium Lactate Dehydrogenase Is Associated with the Parasitophorous Vacuole Membrane and Is a Potential Target for Developing Therapeutics","volume":"11","author":"Zhang","year":"2015","journal-title":"PLoS Pathog."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312820305084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312820305084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:24:17Z","timestamp":1761827057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312820305084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S1931312820305084"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2020.09.007","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738811335.793588243","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Biology of the Intestinal Intracellular Parasite Cryptosporidium","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2020.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}