{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:39:28Z","timestamp":1791941968623,"version":"4.3.4"},"reference-count":66,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI005284"],"award-info":[{"award-number":["AI005284"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI117922"],"award-info":[{"award-number":["AI117922"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["AI005284"],"award-info":[{"award-number":["AI005284"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2016217834"],"award-info":[{"award-number":["2016217834"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001447","name":"Rita Allen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000042","name":"Amgen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["I-2013-20190330"],"award-info":[{"award-number":["I-2013-20190330"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.chom.2020.09.014","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T10:35:41Z","timestamp":1603794941000},"page":"712-723.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["RTP4 Is a Potent IFN-Inducible Anti-flavivirus Effector Engaged in a Host-Virus Arms Race in Bats and Other Mammals"],"prefix":"10.1016","volume":"28","author":[{"given":"Ian N.","family":"Boys","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina B.","family":"Mar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela C.","family":"De La Cruz-Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Eitson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Schoggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2020.09.014_bib1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41564-019-0371-3","article-title":"Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host","volume":"4","author":"Ahn","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2020.09.014_bib2","doi-asserted-by":"crossref","first-page":"W580","DOI":"10.1093\/nar\/gks498","article-title":"FastML: a web server for probabilistic reconstruction of ancestral sequences","volume":"40","author":"Ashkenazy","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chom.2020.09.014_bib3","first-page":"440","article-title":"Stability of two hierarchical grouping techniques case I: sensitivity to data errors","volume":"69","author":"Baker","year":"1974","journal-title":"J.\u00a0Am. Stat. Assoc."},{"key":"10.1016\/j.chom.2020.09.014_bib4","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1128\/JVI.01606-16","article-title":"IRAV (FLJ11286), an interferon-stimulated gene with antiviral activity against dengue virus, interacts with MOV10","volume":"91","author":"Balinsky","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2020.09.014_bib5","doi-asserted-by":"crossref","first-page":"100958","DOI":"10.1016\/j.isci.2020.100958","article-title":"Positive selection of a serine residue in bat IRF3 confers enhanced antiviral protection","volume":"23","author":"Banerjee","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.chom.2020.09.014_bib6","doi-asserted-by":"crossref","first-page":"20650","DOI":"10.1074\/jbc.M513637200","article-title":"Members of RTP and REEP gene families influence functional bitter taste receptor expression","volume":"281","author":"Behrens","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2020.09.014_bib7","article-title":"Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain","volume":"3","author":"Benfield","year":"2020","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.chom.2020.09.014_bib8","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1128\/CMR.00017-06","article-title":"Bats: important reservoir hosts of emerging viruses","volume":"19","author":"Calisher","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.chom.2020.09.014_bib9","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/oxfordjournals.molbev.a026334","article-title":"Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis","volume":"17","author":"Castresana","year":"2000","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.chom.2020.09.014_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ydbio.2012.06.012","article-title":"Xenopus laevis zygote arrest 2 (zar2) encodes a zinc finger RNA-binding protein that binds to the translational control sequence in the maternal Wee1 mRNA and regulates translation","volume":"369","author":"Charlesworth","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.chom.2020.09.014_bib11","doi-asserted-by":"crossref","first-page":"e3000181","DOI":"10.1371\/journal.pbio.3000181","article-title":"Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins","volume":"17","author":"Col\u00f3n-Thillet","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.chom.2020.09.014_bib12","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0076-6879(08)02415-4","article-title":"Chapter 15. Co-immunoprecipitation techniques for assessing RNA-protein interactions in\u00a0vivo","volume":"449","author":"Conrad","year":"2008","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.chom.2020.09.014_bib13","doi-asserted-by":"crossref","first-page":"e8266","DOI":"10.1371\/journal.pone.0008266","article-title":"Establishment, immortalisation and characterisation of pteropid bat cell lines","volume":"4","author":"Crameri","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2020.09.014_bib14","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev-genet-110711-155522","article-title":"Rules of engagement: molecular insights from host-virus arms races","volume":"46","author":"Daugherty","year":"2012","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.chom.2020.09.014_bib15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4049\/jimmunol.1701214","article-title":"The IFN response in bats displays distinctive IFN-stimulated gene expression kinetics with atypical RNaseL induction","volume":"200","author":"De La Cruz-Rivera","year":"2018","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2020.09.014_bib16","doi-asserted-by":"crossref","first-page":"16045","DOI":"10.1073\/pnas.0804106105","article-title":"Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4","volume":"105","author":"D\u00e9caillot","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.09.014_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2020.09.014_bib18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1128\/MMBR.05023-11","article-title":"Viral quasispecies evolution","volume":"76","author":"Domingo","year":"2012","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.chom.2020.09.014_bib19","doi-asserted-by":"crossref","first-page":"e00211","DOI":"10.1128\/JVI.00211-19","article-title":"A CRISPR activation screen identifies genes that protect against Zika virus infection","volume":"93","author":"Dukhovny","year":"2019","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2020.09.014_bib20","doi-asserted-by":"crossref","first-page":"18828","DOI":"10.1073\/pnas.0605777103","article-title":"Artificial evolution extends the spectrum of viruses that are targeted by a disease-resistance gene from potato","volume":"103","author":"Farnham","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.09.014_bib21","doi-asserted-by":"crossref","first-page":"e00361-17","DOI":"10.1128\/JVI.00361-17","article-title":"Evolution and antiviral specificities of interferon-induced Mx proteins of bats against Ebola, influenza, and other RNA viruses","volume":"91","author":"Fuchs","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2020.09.014_bib22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1124\/mol.118.112987","article-title":"Regulation of an opioid receptor chaperone protein, RTP4, by morphine","volume":"95","author":"Fujita","year":"2019","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.chom.2020.09.014_bib23","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1093\/bioinformatics\/btv428","article-title":"dendextend: an R package for visualizing, adjusting and comparing trees of hierarchical clustering","volume":"31","author":"Galili","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2020.09.014_bib24","doi-asserted-by":"crossref","first-page":"10438","DOI":"10.1128\/JVI.00986-10","article-title":"The endoplasmic reticulum provides the membrane platform for biogenesis of the Flavivirus replication complex","volume":"84","author":"Gillespie","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2020.09.014_bib25","doi-asserted-by":"crossref","first-page":"W14","DOI":"10.1093\/nar\/gkq321","article-title":"ALTER: program-oriented conversion of DNA and protein alignments","volume":"38","author":"Glez-Pe\u00f1a","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chom.2020.09.014_bib26","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1099\/0022-1317-81-8-1927","article-title":"Isolation of Hendra virus from pteropid bats: a natural reservoir of Hendra virus","volume":"81","author":"Halpin","year":"2000","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.chom.2020.09.014_bib27","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.celrep.2016.05.075","article-title":"Western Zika virus in human fetal neural progenitors persists long term with partial cytopathic and limited immunogenic effects","volume":"15","author":"Hanners","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2020.09.014_bib28","doi-asserted-by":"crossref","first-page":"11351","DOI":"10.1073\/pnas.1814995116","article-title":"A metaanalysis of bat phylogenetics and positive selection based on genomes and transcriptomes from 18 species","volume":"116","author":"Hawkins","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.09.014_bib29","doi-asserted-by":"crossref","first-page":"19465","DOI":"10.1073\/pnas.2006492117","article-title":"RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology","volume":"117","author":"He","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.09.014_bib30","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/s00018-019-03242-x","article-title":"Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia","volume":"77","author":"Irving","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.chom.2020.09.014_bib31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.virol.2004.10.034","article-title":"Construction and applications of yellow fever virus replicons","volume":"331","author":"Jones","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.chom.2020.09.014_bib32","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.chom.2016.08.005","article-title":"Identification of interferon-stimulated genes with antiretroviral activity","volume":"20","author":"Kane","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2020.09.014_bib33","doi-asserted-by":"crossref","first-page":"e226","DOI":"10.1371\/journal.pbio.0060226","article-title":"SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum","volume":"6","author":"Knoops","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.chom.2020.09.014_bib34","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/molbev\/msy096","article-title":"MEGA X: molecular evolutionary genetics analysis across computing platforms","volume":"35","author":"Kumar","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.chom.2020.09.014_bib35","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1093\/molbev\/msx116","article-title":"TimeTree: a resource for timelines, Timetrees, and divergence times","volume":"34","author":"Kumar","year":"2017","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.chom.2020.09.014_bib36","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00385-13","article-title":"A short hairpin RNA screen of interferon-stimulated genes identifies a novel negative regulator of the cellular antiviral response","volume":"4","author":"Li","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.chom.2020.09.014_bib37","doi-asserted-by":"crossref","first-page":"9608","DOI":"10.1128\/jvi.71.12.9608-9617.1997","article-title":"trans-Complementation of yellow fever virus NS1 reveals a role in early RNA replication","volume":"71","author":"Lindenbach","year":"1997","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2020.09.014_bib38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0065-3527(03)59002-9","article-title":"Molecular biology of flaviviruses","volume":"59","author":"Lindenbach","year":"2003","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.chom.2020.09.014_bib39","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/hep.22550","article-title":"Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells","volume":"48","author":"Marukian","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.chom.2020.09.014_bib40","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.chom.2012.09.005","article-title":"Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA","volume":"12","author":"Mitchell","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2020.09.014_bib41","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1093\/bioinformatics\/btu743","article-title":"CRISPRdirect: software for designing CRISPR\/Cas guide RNA with reduced off-target sites","volume":"31","author":"Naito","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2020.09.014_bib42","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nature22975","article-title":"Host and viral traits predict zoonotic spillover from mammals","volume":"546","author":"Olival","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.chom.2020.09.014_bib43","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.cell.2018.03.070","article-title":"The Egyptian rousette genome reveals unexpected features of bat antiviral immunity","volume":"173","author":"Pavlovich","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.chom.2020.09.014_bib44","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/s41564-018-0244-1","article-title":"A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks Flavivirus replication","volume":"3","author":"Richardson","year":"2018","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2020.09.014_bib45","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2020.09.014_bib46","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/wrna.1191","article-title":"Regulation of Flavivirus RNA synthesis and capping","volume":"4","author":"Saeedi","year":"2013","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.chom.2020.09.014_bib47","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2004.11.021","article-title":"RTP family members induce functional expression of mammalian odorant receptors","volume":"119","author":"Saito","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.chom.2020.09.014_bib48","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2020.09.014_bib49","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1073\/pnas.0409853102","article-title":"Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain","volume":"102","author":"Sawyer","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2020.09.014_bib66","doi-asserted-by":"crossref","first-page":"14610","DOI":"10.1073\/pnas.1212379109","article-title":"Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro","volume":"109","author":"Schoggins","year":"2012","journal-title":"PNAS"},{"key":"10.1016\/j.chom.2020.09.014_bib50","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nature12862","article-title":"Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity","volume":"505","author":"Schoggins","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chom.2020.09.014_bib51","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature09907","article-title":"A diverse range of gene products are effectors of the type I interferon antiviral response","volume":"472","author":"Schoggins","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.chom.2020.09.014_bib52","doi-asserted-by":"crossref","first-page":"e00246-16","DOI":"10.1128\/mSphere.00246-16","article-title":"Rescue of the 1947 Zika virus prototype strain with a Cytomegalovirus promoter-driven cDNA clone","author":"Schwarz","year":"2016","journal-title":"mSphere"},{"key":"10.1016\/j.chom.2020.09.014_bib53","doi-asserted-by":"crossref","first-page":"e2004086","DOI":"10.1371\/journal.pbio.2004086","article-title":"Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses","volume":"15","author":"Shaw","year":"2017","journal-title":"PLoS Biol."},{"key":"10.1016\/j.chom.2020.09.014_bib54","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1099\/jgv.0.000672","article-title":"ICTV virus taxonomy profile: Flaviviridae","volume":"98","author":"Simmonds","year":"2017","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.chom.2020.09.014_bib55","doi-asserted-by":"crossref","first-page":"e1005357","DOI":"10.1371\/journal.ppat.1005357","article-title":"Characterization of RyDEN (C19orf66) as an interferon-stimulated cellular inhibitor against dengue virus replication","volume":"12","author":"Suzuki","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2020.09.014_bib56","first-page":"15G.1.1","article-title":"Influenza: propagation, quantification, and storage","volume":"29","author":"Szretter","year":"2006","journal-title":"Curr. Protoc. Microbiol."},{"key":"10.1016\/j.chom.2020.09.014_bib57","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4269\/ajtmh.2009.81.457","article-title":"Transmission of Japanese encephalitis virus from the black flying fox, Pteropus alecto, to Culex annulirostris mosquitoes, despite the absence of detectable viremia","volume":"81","author":"van den Hurk","year":"2009","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.chom.2020.09.014_bib58","first-page":"1","article-title":"A new evolutionary law","volume":"1","author":"Van Valen","year":"1973","journal-title":"Evol. Theor."},{"key":"10.1016\/j.chom.2020.09.014_bib59","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.cell.2018.12.030","article-title":"Regulation of HIV-1 gag-pol expression by shiftless, an inhibitor of programmed \u22121 ribosomal frameshifting","volume":"176","author":"Wang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.chom.2020.09.014_bib60","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fnmol.2011.00008","article-title":"A molecular toolbox for rapid generation of viral vectors to up- or down-regulate neuronal gene expression in\u00a0vivo","volume":"4","author":"White","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.chom.2020.09.014_bib61","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.chom.2018.01.006","article-title":"Dampened STING-dependent interferon activation in bats","volume":"23","author":"Xie","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2020.09.014_bib62","first-page":"1396","article-title":"Maximum-likelihood estimation of phylogeny from DNA sequences when substitution rates differ over sites","volume":"10","author":"Yang","year":"1993","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.chom.2020.09.014_bib63","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/molbev\/msm088","article-title":"PAML 4: phylogenetic analysis by maximum likelihood","volume":"24","author":"Yang","year":"2007","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.chom.2020.09.014_bib64","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1230835","article-title":"Comparative analysis of bat genomes provides insight into the evolution of flight and immunity","volume":"339","author":"Zhang","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.chom.2020.09.014_bib65","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1073\/pnas.1518240113","article-title":"Contraction of the type I IFN locus and unusual constitutive expression of IFN-alpha in bats","volume":"113","author":"Zhou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312820305199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312820305199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:08:39Z","timestamp":1778832519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312820305199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S1931312820305199"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2020.09.014","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RTP4 Is a Potent IFN-Inducible Anti-flavivirus Effector Engaged in a Host-Virus Arms Race in Bats and Other Mammals","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2020.09.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}