{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:17:49Z","timestamp":1792844269280,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":373,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100004897","name":"Pennsylvania Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI112427"],"award-info":[{"award-number":["R01AI112427"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI148249"],"award-info":[{"award-number":["R01AI148249"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF 58-2018"],"award-info":[{"award-number":["ALTF 58-2018"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.chom.2021.07.002","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T11:23:41Z","timestamp":1627989821000},"page":"1407-1420.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7"],"prefix":"10.1016","volume":"29","author":[{"given":"Amandine","family":"Gu\u00e9rin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan H.","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily M.","family":"Kugler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis K.","family":"Burkhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Bum","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Striepen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2021.07.002_bib1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1126\/science.1094786","article-title":"Complete genome sequence of the apicomplexan, Cryptosporidium parvum","volume":"304","author":"Abrahamsen","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.chom.2021.07.002_bib2","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nm1350","article-title":"Quantitative imaging of Plasmodium transmission from mosquito to mammal","volume":"12","author":"Amino","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2021.07.002_bib3","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1083\/jcb.201610098","article-title":"The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis","volume":"217","author":"Beati","year":"2018","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2021.07.002_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012354","article-title":"Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii","volume":"5","author":"Behnke","year":"2010","journal-title":"Plos One"},{"key":"10.1016\/j.chom.2021.07.002_bib5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/mmi.14674","article-title":"Biogenesis and discharge of the rhoptries: key organelles for entry and hijack of host cells by the Apicomplexa","volume":"115","author":"Ben Chaabene","year":"2021","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2021.07.002_bib6","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1462-5822.2011.01597.x","article-title":"The moving junction of apicomplexan parasites: a key structure for invasion","volume":"13","author":"Besteiro","year":"2011","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2021.07.002_bib7","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1186\/s12915-014-0108-y","article-title":"The toxoplasma-host cell junction is anchored to the cell cortex to sustain parasite invasive force","volume":"12","author":"Bichet","year":"2014","journal-title":"BMC Biol"},{"key":"10.1016\/j.chom.2021.07.002_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1473-3099(14)70772-8","article-title":"A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium","volume":"15","author":"Checkley","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chom.2021.07.002_bib9","doi-asserted-by":"crossref","first-page":"6806","DOI":"10.1128\/IAI.72.12.6806-6816.2004","article-title":"Apical organelle discharge by Cryptosporidium parvum is temperature, cytoskeleton, and intracellular calcium dependent and required for host cell invasion","volume":"72","author":"Chen","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2021.07.002_bib10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0016-5085(03)00662-0","article-title":"Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src","volume":"125","author":"Chen","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.chom.2021.07.002_bib11","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1128\/IAI.72.5.3011-3021.2004","article-title":"Cdc42 and the actin-related protein\/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum","volume":"72","author":"Chen","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2021.07.002_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008252","article-title":"Cryptosporidiosis should be designated as a tropical disease by the US Food and Drug Administration","volume":"14","author":"Choy","year":"2020","journal-title":"PloS Negl. Trop. Dis."},{"key":"10.1016\/j.chom.2021.07.002_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fcimb.2016.00107","article-title":"Hijacking host cell highways: manipulation of the host actin cytoskeleton by obligate intracellular bacterial pathogens","volume":"6","author":"Colonne","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.chom.2021.07.002_bib14","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/s41467-019-09074-4","article-title":"LMO7 deficiency reveals the significance of the cuticular plate for hearing function","volume":"10","author":"Du","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2021.07.002_bib15","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0020-7519(98)00076-9","article-title":"Apical organelles and host-cell invasion by Apicomplexa","volume":"28","author":"Dubremetz","year":"1998","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.chom.2021.07.002_bib16","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1128\/IAI.68.4.2315-2322.2000","article-title":"Cryptosporidium parvum induces host cell actin accumulation at the host-parasite interface","volume":"68","author":"Elliott","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2021.07.002_bib17","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.1128\/IAI.69.9.5940-5942.2001","article-title":"Cryptosporidium parvum infection requires host cell actin polymerization","volume":"69","author":"Elliott","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2021.07.002_bib18","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1128\/IAI.67.2.844-852.1999","article-title":"A role for host phosphoinositide 3-kinase and cytoskeletal remodeling during Cryptosporidium parvum infection","volume":"67","author":"Forney","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2021.07.002_bib19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrmicro3184","article-title":"Cell division in apicomplexan parasites","volume":"12","author":"Francia","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2021.07.002_bib20","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nrmicro.2017.86","article-title":"Gliding motility powers invasion and egress in Apicomplexa","volume":"15","author":"Fr\u00e9nal","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2021.07.002_bib21","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s11033-008-9281-9","article-title":"Alternative splicing for members of human mosaic domain superfamilies. I. The CH and LIM domains containing group of proteins","volume":"36","author":"Friedberg","year":"2009","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.chom.2021.07.002_bib22","first-page":"4183","article-title":"A novel gene containing PDZ and LIM domains, PCD1, is overexpressed in human colorectal cancer","volume":"22","author":"Furuya","year":"2002","journal-title":"Anticancer Res"},{"key":"10.1016\/j.chom.2021.07.002_bib23","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1091\/mbc.e05-01-0042","article-title":"Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules","volume":"16","author":"Gatfield","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.chom.2021.07.002_bib24","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1128\/iai.62.10.4506-4514.1994","article-title":"Cryptosporidium parvum infection of Caco-2 cell monolayers induces an apical monolayer defect, selectively increases transmonolayer permeability, and causes epithelial cell death","volume":"62","author":"Griffiths","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2021.07.002_bib25","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1128\/JCM.36.9.2503-2508.1998","article-title":"The gamma interferon gene knockout mouse: a highly sensitive model for evaluation of therapeutic agents against Cryptosporidium parvum","volume":"36","author":"Griffiths","year":"1998","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.chom.2021.07.002_bib26","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/s41564-017-0018-1","article-title":"Efficient invasion by Toxoplasma depends on the subversion of host protein networks","volume":"2","author":"Gu\u00e9rin","year":"2017","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2021.07.002_bib27","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.chom.2020.09.007","article-title":"The biology of the intestinal intracellular parasite cryptosporidium","volume":"28","author":"Gu\u00e9rin","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2021.07.002_bib28","first-page":"56S","article-title":"Cryptosporidium parvum: synchronized excystation in\u00a0vitro and evaluation of sporozoite infectivity with a new lectin-based assay","volume":"46","author":"Gut","year":"1999","journal-title":"J.\u00a0Eukaryot. Microbiol."},{"key":"10.1016\/j.chom.2021.07.002_bib29","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.bbamem.2008.10.028","article-title":"Tight junctions as targets of infectious agents","volume":"1788","author":"Guttman","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chom.2021.07.002_bib30","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1091\/mbc.10.11.3539","article-title":"Time-lapse video microscopy of gliding motility in Toxoplasma gondii reveals a novel, biphasic mechanism of cell locomotion","volume":"10","author":"H\u00e5kansson","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.chom.2021.07.002_bib31","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1128\/CMR.00005-17","article-title":"Toxoplasma effectors targeting host signaling and transcription","volume":"30","author":"Hakimi","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.chom.2021.07.002_bib32","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1128\/IAI.01479-06","article-title":"Enteropathogenic Escherichia coli, Shigella flexneri, and Listeria monocytogenes recruit a junctional protein, zonula occludens-1, to actin tails and pedestals","volume":"75","author":"Hanajima-Ozawa","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2021.07.002_bib33","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1111\/ajt.14956","article-title":"Outbreaks associated with treated recreational water - United States, 2000\u20132014","volume":"18","author":"Hlavsa","year":"2018","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.chom.2021.07.002_bib34","first-page":"5296","article-title":"PCD1, a novel gene containing PDZ and LIM domains, is overexpressed in several human cancers","volume":"60","author":"Kang","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.chom.2021.07.002_bib35","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/1574-6976.12013","article-title":"Subversion of host cellular functions by the apicomplexan parasites","volume":"37","author":"Kemp","year":"2013","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.chom.2021.07.002_bib36","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0092-8674(00)80437-7","article-title":"Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells","volume":"91","author":"Kenny","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.chom.2021.07.002_bib37","doi-asserted-by":"crossref","first-page":"e758","DOI":"10.1016\/S2214-109X(18)30283-3","article-title":"Morbidity, mortality, and long-term consequences associated with diarrhoea from Cryptosporidium infection in children younger than 5 years: a meta-analyses study","volume":"6","author":"Khalil","year":"2018","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.chom.2021.07.002_bib38","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0140-6736(13)60844-2","article-title":"Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study","volume":"382","author":"Kotloff","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2021.07.002_bib39","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12830","article-title":"Cryptosporidium parvum disrupts intestinal epithelial barrier function via altering expression of key tight junction and adherens junction proteins","volume":"20","author":"Kumar","year":"2018","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2021.07.002_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032457","article-title":"Identification of a new rhoptry neck complex RON9\/RON10 in the Apicomplexa parasite Toxoplasma gondii","volume":"7","author":"Lamarque","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2021.07.002_bib41","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1128\/iai.51.2.715-717.1986","article-title":"Plasmids coding for drug resistance and localized adherence to HeLa cells in enteropathogenic Escherichia coli O55:H- and O55:H6","volume":"51","author":"Laporta","year":"1986","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2021.07.002_bib42","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.1087025","article-title":"Discovery of gene function by expression profiling of the malaria parasite life cycle","volume":"301","author":"Le Roch","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.chom.2021.07.002_bib43","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1017\/S0031182014000237","article-title":"Cryptosporidium infections: molecular advances","volume":"141","author":"Lendner","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/j.chom.2021.07.002_bib44","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fcimb.2019.00103","article-title":"Mechanisms of human innate immune evasion by Toxoplasma gondii","volume":"9","author":"Lima","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.chom.2021.07.002_bib45","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1091\/mbc.e15-04-0218","article-title":"LIMCH1 regulates nonmuscle myosin-II activity and suppresses cell migration","volume":"28","author":"Lin","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.chom.2021.07.002_bib46","doi-asserted-by":"crossref","first-page":"647387","DOI":"10.3389\/fcell.2021.647387","article-title":"LMO7 as an unrecognized factor promoting pancreatic cancer progression and metastasis","volume":"9","author":"Liu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.chom.2021.07.002_bib47","doi-asserted-by":"crossref","first-page":"12350","DOI":"10.1038\/srep12350","article-title":"Identification of Drosophila mutants affecting defense to an entomopathogenic fungus","volume":"5","author":"Lu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chom.2021.07.002_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031715","article-title":"The Cryptosporidium parvum transcriptome during in\u00a0vitro development","volume":"7","author":"Mauzy","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2021.07.002_bib49","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.micinf.2018.04.006","article-title":"Inflammasome components caspase-1 and adaptor protein apoptosis-associated speck-like proteins are important in resistance to Cryptosporidium parvum","volume":"20","author":"McNair","year":"2018","journal-title":"Microbes Infect"},{"key":"10.1016\/j.chom.2021.07.002_bib50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.chom.2013.02.001","article-title":"The toxoplasma protein ARO mediates the apical positioning of rhoptry organelles, a prerequisite for host cell invasion","volume":"13","author":"Mueller","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2021.07.002_bib51","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1242\/jcs.177386","article-title":"Structural and functional dissection of Toxoplasma gondii armadillo repeats only protein","volume":"129","author":"Mueller","year":"2016","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.chom.2021.07.002_bib52","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.canlet.2004.07.023","article-title":"Transforming growth factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells","volume":"220","author":"Nakamura","year":"2005","journal-title":"Cancer Lett"},{"key":"10.1016\/j.chom.2021.07.002_bib53","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S1286-4579(99)00246-4","article-title":"Caspase-dependent apoptosis during infection with Cryptosporidium parvum","volume":"1","author":"Ojcius","year":"1999","journal-title":"Microbes Infect"},{"key":"10.1016\/j.chom.2021.07.002_bib54","doi-asserted-by":"crossref","first-page":"31365","DOI":"10.1074\/jbc.M401957200","article-title":"Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells","volume":"279","author":"Ooshio","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2021.07.002_bib55","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/BF00931092","article-title":"Cryptosporidium sp. of the starred lizardAgama stellio: ultrastructure and life cycle","volume":"76","author":"Ostrovska","year":"1990","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.chom.2021.07.002_bib56","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2017.03.016","article-title":"NAIP-NLRC4 inflammasomes coordinate intestinal epithelial cell expulsion with eicosanoid and IL-18 release via activation of caspase-1 and -8","volume":"46","author":"Rauch","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2021.07.002_bib57","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.micinf.2015.01.004","article-title":"How bacterial pathogens colonize their hosts and invade deeper tissues","volume":"17","author":"Ribet","year":"2015","journal-title":"Microbes Infect"},{"key":"10.1016\/j.chom.2021.07.002_bib58","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nmeth.1220","article-title":"Lifeact: a versatile marker to visualize F-actin","volume":"5","author":"Riedl","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2021.07.002_bib59","first-page":"2717","article-title":"PCD1, a novel gene containing PDZ and LIM domains, is overexpressed in human breast cancer and linked to lymph node metastasis","volume":"23","author":"Sasaki","year":"2003","journal-title":"Anticancer Res"},{"key":"10.1016\/j.chom.2021.07.002_bib60","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2007807118","article-title":"The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6","volume":"118","author":"Sateriale","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2021.07.002_bib61","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/978-1-4939-9748-0_13","article-title":"Genetic manipulation of Cryptosporidium parvum with CRISPR\/Cas9","volume":"2052","author":"Sateriale","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.chom.2021.07.002_bib62","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.chom.2019.05.006","article-title":"A genetically tractable, natural mouse model of Cryptosporidiosis Offers insights into host protective immunity","volume":"26","author":"Sateriale","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2021.07.002_bib63","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0960-9822(98)70135-6","article-title":"Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells","volume":"8","author":"Stauffer","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.chom.2021.07.002_bib64","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1021\/jm001101a","article-title":"Experimental and computational screening models for the prediction of intestinal drug absorption","volume":"44","author":"Stenberg","year":"2001","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.chom.2021.07.002_bib65","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1038\/s41467-019-11979-z","article-title":"A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites","volume":"10","author":"Suarez","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2021.07.002_bib66","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.gene.2018.10.056","article-title":"Role of the smallish gene during Drosophila eye development","volume":"684","author":"Tanaka","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.chom.2021.07.002_bib67","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1038\/s41564-019-0539-x","article-title":"Life cycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum","volume":"4","author":"Tandel","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2021.07.002_bib68","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1099\/00221287-144-12-3249","article-title":"Ultrastructural analysis of the sporozoite of Cryptosporidium parvum","volume":"144","author":"Tetley","year":"1998","journal-title":"Microbiology (Reading)"},{"key":"10.1016\/j.chom.2021.07.002_bib69","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1126\/science.1204988","article-title":"Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide","volume":"333","author":"Tonkin","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.chom.2021.07.002_bib70","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fcimb.2016.00087","article-title":"Tight junction disruption induced by type 3 secretion system effectors injected by enteropathogenic and enterohemorrhagic Escherichia coli","volume":"6","author":"Ugalde-Silva","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.chom.2021.07.002_bib71","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.molbiopara.2012.02.004","article-title":"Molecular characterisation of a Cryptosporidium parvum rhoptry protein candidate related to the rhoptry neck proteins TgRON1 of Toxoplasma gondii and PfASP of Plasmodium falciparum","volume":"183","author":"Valentini","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.chom.2021.07.002_bib72","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature14651","article-title":"Genetic modification of the diarrheal pathogen Cryptosporidium parvum","volume":"523","author":"Vinayak","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.chom.2021.07.002_bib73","article-title":"Identification of novel O-linked glycosylated toxoplasma proteins by Vicia villosa lectin chromatography","volume":"11","author":"Wang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2021.07.002_bib74","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1128\/IAI.73.9.5379-5387.2005","article-title":"Gliding motility leads to active cellular invasion by Cryptosporidium parvum sporozoites","volume":"73","author":"Wetzel","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2021.07.002_bib75","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nmeth.1638","article-title":"A public genome-scale lentiviral expression library of human ORFs","volume":"8","author":"Yang","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2021.07.002_bib76","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1128\/IAI.05862-11","article-title":"Involvement of host cell integrin alpha2 in Cryptosporidium parvum infection","volume":"80","author":"Zhang","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2021.07.002_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005250","article-title":"Cryptosporidium lactate dehydrogenase is associated with the parasitophorous vacuole membrane and is a potential target for developing therapeutics","volume":"11","author":"Zhang","year":"2015","journal-title":"PLoS Pathog"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312821003036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312821003036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:27:06Z","timestamp":1761827226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312821003036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":77,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1931312821003036"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2021.07.002","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740589169.793593915","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2021.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}