{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:55:09Z","timestamp":1793505309506,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI110941-01A1"],"award-info":[{"award-number":["AI110941-01A1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R37 AI048071"],"award-info":[{"award-number":["R37 AI048071"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.chom.2021.08.009","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T10:31:51Z","timestamp":1630924311000},"page":"1496-1506.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Single-genome sequencing reveals within-host evolution of human malaria parasites"],"prefix":"10.1016","volume":"29","author":[{"given":"Aliou","family":"Dia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Jett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon G.","family":"Trevino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy S.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanlaya","family":"Sriprawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.C.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Nosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Cheeseman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2021.08.009_bib1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature12876","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum malaria","volume":"505","author":"Ariey","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chom.2021.08.009_bib2","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1038\/s41467-018-04965-4","article-title":"Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics","volume":"9","author":"Auburn","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2021.08.009_bib3","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1093\/infdis\/jiz016","article-title":"Genomic analysis of Plasmodium vivax in southern Ethiopia reveals selective pressures in multiple parasite mechanisms","volume":"220","author":"Auburn","year":"2019","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2021.08.009_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/nar\/30.1.87","article-title":"PlasmoDB: the Plasmodium genome resource. An integrated database providing tools for accessing, analyzing and mapping expression and sequence data (both finished and unfinished)","volume":"30","author":"Bahl","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.chom.2021.08.009_bib5","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/nar\/gkg081","article-title":"PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational data","volume":"31","author":"Bahl","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.chom.2021.08.009_bib6","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0140-6736(19)31096-7","article-title":"Mapping the global endemicity and clinical burden of Plasmodium vivax, 2000\u201317: a spatial and temporal modelling study","volume":"394","author":"Battle","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2021.08.009_bib7","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/s41588-019-0366-2","article-title":"Linked-read analysis identifies mutations in single-cell DNA-sequencing data","volume":"51","author":"Bohrson","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chom.2021.08.009_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003293","article-title":"Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families","volume":"9","author":"Bopp","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.chom.2021.08.009_bib9","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/nrmicro3364","article-title":"Asymptomatic malaria infections: detectability, transmissibility and public health relevance","volume":"12","author":"Bousema","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2021.08.009_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002882","article-title":"A high resolution case study of a patient with recurrent Plasmodium vivax infections shows that relapses were caused by meiotic siblings","volume":"8","author":"Bright","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.chom.2021.08.009_bib11","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1534\/genetics.104.035212","article-title":"The genomes of recombinant inbred lines","volume":"169","author":"Broman","year":"2005","journal-title":"Genetics"},{"key":"10.1016\/j.chom.2021.08.009_bib12","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1146\/annurev-genet-110711-155534","article-title":"Identity by descent between distant relatives: detection and applications","volume":"46","author":"Browning","year":"2012","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.chom.2021.08.009_bib13","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1093\/cid\/ciy319","article-title":"Comparison of the cumulative efficacy and safety of chloroquine, artesunate, and chloroquine-primaquine in Plasmodium vivax Malaria","volume":"67","author":"Chu","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.chom.2021.08.009_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004812","article-title":"Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosis","volume":"10","author":"Claessens","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.chom.2021.08.009_bib15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1126\/science.aan4472","article-title":"Mapping the malaria parasite druggable genome by using in\u00a0vitro evolution and chemogenomics","volume":"359","author":"Cowell","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.chom.2021.08.009_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.806","article-title":"A framework for variation discovery and genotyping using next-generation DNA sequencing data","volume":"43","author":"DePristo","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chom.2021.08.009_bib17","doi-asserted-by":"crossref","first-page":"20045","DOI":"10.1073\/pnas.1003776107","article-title":"Whole-genome sequencing and microarray analysis of ex\u00a0vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes","volume":"107","author":"Dharia","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2021.08.009_bib18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nmeth.4227","article-title":"Accurate identification of single-nucleotide variants in whole-genome-amplified single cells","volume":"14","author":"Dong","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2021.08.009_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006358","article-title":"A spatio-temporal assessment of simian\/human immunodeficiency virus (SHIV) evolution reveals a highly dynamic process within the host","volume":"13","author":"Feder","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.chom.2021.08.009_bib20","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1534\/genetics.108.090019","article-title":"Clonal interference, multiple mutations and adaptation in large asexual populations","volume":"180","author":"Fogle","year":"2008","journal-title":"Genetics"},{"key":"10.1016\/j.chom.2021.08.009_bib21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1179\/135100003225002961","article-title":"PlasmoDB: exploring genomics and post-genomics data of the malaria parasite, Plasmodium falciparum","volume":"8","author":"Fraunholz","year":"2003","journal-title":"Redox Rep"},{"key":"10.1016\/j.chom.2021.08.009_bib22","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/molbev\/msaa278","article-title":"Common adaptive strategies underlie within-host evolution of bacterial pathogens","volume":"38","author":"Gatt","year":"2021","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.chom.2021.08.009_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw2619","article-title":"The Malaria Cell Atlas: single parasite transcriptomes across the complete Plasmodium life cycle","volume":"365","author":"Howick","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.chom.2021.08.009_bib24","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1101\/gr.115972.110","article-title":"Maximum-likelihood estimation of recent shared ancestry (ERSA)","volume":"21","author":"Huff","year":"2011","journal-title":"Genome Res"},{"key":"10.1016\/j.chom.2021.08.009_bib25","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1086\/512241","article-title":"Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites","volume":"195","author":"Imwong","year":"2007","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2021.08.009_bib26","article-title":"Rapid emergence of clonal interference during malaria parasite cultivation","author":"Jett","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.chom.2021.08.009_bib27","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.cell.2018.03.041","article-title":"Chemoresistance evolution in triple-negative breast cancer delineated by single-cell sequencing","volume":"173","author":"Kim","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.chom.2021.08.009_bib28","article-title":"Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM","author":"Li","year":"2013","journal-title":"arXiv"},{"key":"10.1016\/j.chom.2021.08.009_bib29","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1101\/gr.1224503","article-title":"OrthoMCL: identification of ortholog groups for eukaryotic genomes","volume":"13","author":"Li","year":"2003","journal-title":"Genome Res"},{"key":"10.1016\/j.chom.2021.08.009_bib30","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/ng.2848","article-title":"Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures","volume":"46","author":"Lieberman","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chom.2021.08.009_bib31","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/ng.997","article-title":"Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes","volume":"43","author":"Lieberman","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chom.2021.08.009_bib32","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/nm.4205","article-title":"Genomic diversity in autopsy samples reveals within-host dissemination of HIV-associated Mycobacterium tuberculosis","volume":"22","author":"Lieberman","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2021.08.009_bib33","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/infdis\/jiv142","article-title":"Using amplicon deep sequencing to detect genetic signatures of Plasmodium vivax relapse","volume":"212","author":"Lin","year":"2015","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2021.08.009_bib34","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1126\/science.aao4426","article-title":"Aging and neurodegeneration are associated with increased mutations in single human neurons","volume":"359","author":"Lodato","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.chom.2021.08.009_bib35","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.aab1785","article-title":"Somatic mutation in single human neurons tracks developmental and transcriptional history","volume":"350","author":"Lodato","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.chom.2021.08.009_bib36","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1126\/science.aau3879","article-title":"Somatic mutant clones colonize the human esophagus with age","volume":"362","author":"Martincorena","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.chom.2021.08.009_bib37","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.cell.2017.09.042","article-title":"Universal patterns of selection in cancer and somatic tissues","volume":"171","author":"Martincorena","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.chom.2021.08.009_bib38","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1093\/gbe\/evz140","article-title":"Mode and tempo of microsatellite length change in a malaria parasite mutation accumulation experiment","volume":"11","author":"McDew-White","year":"2019","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.chom.2021.08.009_bib39","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1101\/gr.203711.115","article-title":"Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum","volume":"26","author":"Miles","year":"2016","journal-title":"Genome Res"},{"key":"10.1016\/j.chom.2021.08.009_bib40","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1101\/gr.168286.113","article-title":"Single-cell genomics for dissection of complex malaria infections","volume":"24","author":"Nair","year":"2014","journal-title":"Genome Res"},{"key":"10.1016\/j.chom.2021.08.009_bib41","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature09807","article-title":"Tumour evolution inferred by single-cell sequencing","volume":"472","author":"Navin","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.chom.2021.08.009_bib42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.chom.2019.12.001","article-title":"Co-transmission of related malaria parasite lineages shapes within-host parasite diversity","volume":"27","author":"Nkhoma","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2021.08.009_bib43","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/embor.2012.165","article-title":"Genomic evidence for elevated mutation rates in highly expressed genes","volume":"13","author":"Park","year":"2012","journal-title":"EMBO Rep"},{"key":"10.1016\/j.chom.2021.08.009_bib44","doi-asserted-by":"crossref","first-page":"E8096","DOI":"10.1073\/pnas.1608828113","article-title":"Selective sweep suggests transcriptional regulation may underlie Plasmodium vivax resilience to malaria control measures in Cambodia","volume":"113","author":"Parobek","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2021.08.009_bib45","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/ng.3599","article-title":"Genomic analysis of local variation and recent evolution in Plasmodium vivax","volume":"48","author":"Pearson","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chom.2021.08.009_bib46","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01888-17","article-title":"Genomic analyses reveal the common occurrence and complexity of Plasmodium vivax relapses in Cambodia","volume":"9","author":"Popovici","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.chom.2021.08.009_bib47","series-title":"R: a language and environment for statistical computing","author":"Developement Core Team","year":"2017"},{"key":"10.1016\/j.chom.2021.08.009_bib48","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1038\/s41467-021-23434-z","article-title":"A single-cell atlas of Plasmodium falciparum transmission through the mosquito","volume":"12","author":"Real","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2021.08.009_bib49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1475-2875-7-45","article-title":"Concentration and purification by magnetic separation of the erythrocytic stages of all human Plasmodium species","volume":"7","author":"Ribaut","year":"2008","journal-title":"Malar. J."},{"key":"10.1016\/j.chom.2021.08.009_bib50","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s12936-018-2349-7","article-title":"hmmIBD: software to infer pairwise identity by descent between haploid genotypes","volume":"17","author":"Schaffner","year":"2018","journal-title":"Malar. J."},{"key":"10.1016\/j.chom.2021.08.009_bib51","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1475-2875-7-94","article-title":"Plasmodium vivax trophozoites insensitive to chloroquine","volume":"7","author":"Sharrock","year":"2008","journal-title":"Malar. J."},{"key":"10.1016\/j.chom.2021.08.009_bib52","doi-asserted-by":"crossref","first-page":"5595","DOI":"10.1038\/s41467-019-13412-x","article-title":"Resolving the cause of recurrent Plasmodium vivax malaria probabilistically","volume":"10","author":"Taylor","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2021.08.009_bib53","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/1475-2875-12-275","article-title":"Microsatellite genotyping of Plasmodium vivax infections and their relapses in pregnant and non-pregnant patients on the Thai-Myanmar border","volume":"12","author":"Thanapongpichat","year":"2013","journal-title":"Malar. J."},{"key":"10.1016\/j.chom.2021.08.009_bib54","doi-asserted-by":"crossref","first-page":"e1007420","DOI":"10.1371\/journal.pgen.1007420","article-title":"Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIV","volume":"14","author":"Theys","year":"2018","journal-title":"PLoS Genet"},{"key":"10.1016\/j.chom.2021.08.009_bib55","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1093\/gbe\/evx256","article-title":"High-resolution single-cell sequencing of malaria parasites","volume":"9","author":"Trevino","year":"2017","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.chom.2021.08.009_bib56","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nrg3187","article-title":"Harnessing genomics and genome biology to understand malaria biology","volume":"13","author":"Volkman","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.chom.2021.08.009_bib57","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.29605","article-title":"A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi","volume":"6","author":"Voorberg-van der Wel","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.chom.2021.08.009_bib58","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nature13600","article-title":"Clonal evolution in breast cancer revealed by single nucleus genome sequencing","volume":"512","author":"Wang","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chom.2021.08.009_bib59","doi-asserted-by":"crossref","DOI":"10.1126\/science.aap7847","article-title":"Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis","volume":"360","author":"Zhang","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.chom.2021.08.009_bib60","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1093\/bioinformatics\/btx145","article-title":"SeqArray-a storage-efficient high-performance data format for WGS variant calls","volume":"33","author":"Zheng","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2021.08.009_bib61","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.40845","article-title":"The origins and relatedness structure of mixed i.nfections vary with local prevalence of P. falciparum malaria","volume":"8","author":"Zhu","year":"2019","journal-title":"eLife"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312821003851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312821003851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:27:57Z","timestamp":1761827277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312821003851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S1931312821003851"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2021.08.009","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740761193.793588641","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-genome sequencing reveals within-host evolution of human malaria parasites","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2021.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}