{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:11:56Z","timestamp":1784355116330,"version":"3.55.0"},"reference-count":82,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":376,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.chom.2022.08.018","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T10:33:00Z","timestamp":1663669980000},"page":"1370-1381.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease"],"prefix":"10.1016","volume":"30","author":[{"given":"Isabella","family":"Fraschilla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajera","family":"Amatullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raza-Ur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate L.","family":"Jeffrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2022.08.018_bib1","doi-asserted-by":"crossref","first-page":"eabn6660","DOI":"10.1126\/sciimmunol.abn6660","article-title":"Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation","volume":"7","author":"Adiliaghdam","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.chom.2022.08.018_bib2","doi-asserted-by":"crossref","first-page":"15021","DOI":"10.1038\/nmicrobiol.2015.21","article-title":"The microenvironment of injured murine gut elicits a local pro-restitutive microbiota","volume":"1","author":"Alam","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2022.08.018_bib3","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1016\/j.cell.2022.06.048","article-title":"Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases","volume":"185","author":"Amatullah","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.chom.2022.08.018_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.mib.2020.08.005","article-title":"Epigenome-metabolome-microbiome axis in health and IBD","volume":"56","author":"Amatullah","year":"2020","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.chom.2022.08.018_bib5","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1126\/science.aaw7479","article-title":"Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis","volume":"364","author":"Ansaldo","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.chom.2022.08.018_bib6","doi-asserted-by":"crossref","first-page":"6766","DOI":"10.1038\/sj.onc.1210760","article-title":"Hox genes in hematopoiesis and leukemogenesis","volume":"26","author":"Argiropoulos","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.chom.2022.08.018_bib7","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nrd3674","article-title":"Epigenetic protein families: a new frontier for drug discovery","volume":"11","author":"Arrowsmith","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.chom.2022.08.018_bib8","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ni.2967","article-title":"Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice","volume":"15","author":"Bain","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2022.08.018_bib9","doi-asserted-by":"crossref","first-page":"10719","DOI":"10.1073\/pnas.1711233114","article-title":"Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice","volume":"114","author":"Berer","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2022.08.018_bib10","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nature10554","article-title":"Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination","volume":"479","author":"Berer","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.08.018_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.tibs.2005.11.001","article-title":"The PHD finger, a nuclear protein-interaction domain","volume":"31","author":"Bienz","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.chom.2022.08.018_bib12","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/ni.3780","article-title":"Regulation of inflammation by microbiota interactions with the host","volume":"18","author":"Blander","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2022.08.018_bib13","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/89675","article-title":"The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation","volume":"8","author":"Bottomley","year":"2001","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.chom.2022.08.018_bib14","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.immuni.2018.12.015","article-title":"Microbiotas from humans with inflammatory bowel disease alter the balance of gut Th17 and ROR\u03b3t+ regulatory T\u00a0cells and exacerbate colitis in mice","volume":"50","author":"Britton","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2022.08.018_bib15","doi-asserted-by":"crossref","first-page":"21536","DOI":"10.1073\/pnas.1922189117","article-title":"Defined microbiota transplant restores Th17\/RORgammat(+) regulatory T\u00a0cell balance in mice colonized with inflammatory bowel disease microbiotas","volume":"117","author":"Britton","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2022.08.018_bib16","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1128\/iai.65.8.3126-3131.1997","article-title":"Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus","volume":"65","author":"Cahill","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2022.08.018_bib17","doi-asserted-by":"crossref","first-page":"eaaw4341","DOI":"10.1126\/sciimmunol.aaw4341","article-title":"A specific gene-microbe interaction drives the development of Crohn's disease-like colitis in mice","volume":"4","author":"Caruso","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.chom.2022.08.018_bib18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.chom.2012.07.004","article-title":"Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice","volume":"12","author":"Carvalho","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2022.08.018_bib19","doi-asserted-by":"crossref","first-page":"10713","DOI":"10.1073\/pnas.1711235114","article-title":"Gut bacteria from multiple sclerosis patients modulate human T\u00a0cells and exacerbate symptoms in mouse models","volume":"114","author":"Cekanaviciute","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2022.08.018_bib20","doi-asserted-by":"crossref","first-page":"eaal5068","DOI":"10.1126\/sciimmunol.aal5068","article-title":"Helicobacter species are potent drivers of colonic T\u00a0cell responses in homeostasis and inflammation","volume":"2","author":"Chai","year":"2017","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.chom.2022.08.018_bib21","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1053\/j.gastro.2013.08.035","article-title":"Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice From salmonella infection","volume":"145","author":"Conway","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.chom.2022.08.018_bib22","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1126\/science.1152449","article-title":"Metal chelation and inhibition of bacterial growth in tissue abscesses","volume":"319","author":"Corbin","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.chom.2022.08.018_bib23","doi-asserted-by":"crossref","first-page":"11890","DOI":"10.1093\/nar\/gkaa828","article-title":"PML nuclear bodies and chromatin dynamics: catch me if you can!","volume":"48","author":"Corpet","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chom.2022.08.018_bib24","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1038\/s41591-020-1003-4","article-title":"Single-cell atlas of colonic CD8+ T\u00a0cells in ulcerative colitis","volume":"26","author":"Corridoni","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2022.08.018_bib25","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.cell.2007.08.019","article-title":"The histone H3 Lysine-27 demethylase Jmjd3 links inflammation to inhibition of Polycomb-mediated gene silencing","volume":"130","author":"De Santa","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.chom.2022.08.018_bib26","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1053\/j.gastro.2018.02.016","article-title":"Clinical and genomic correlates of neutrophil reactive oxygen species production in pediatric patients With Crohn\u2019s disease","volume":"154","author":"Denson","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.chom.2022.08.018_bib27","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2011.04.022","article-title":"NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis","volume":"145","author":"Elinav","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.chom.2022.08.018_bib28","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.cell.2012.02.013","article-title":"Histone recognition and large-scale structural analysis of the human bromodomain family","volume":"149","author":"Filippakopoulos","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.chom.2022.08.018_bib29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","article-title":"Gut microbiome structure and metabolic activity in inflammatory bowel disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2022.08.018_bib30","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.it.2020.04.007","article-title":"The speckled protein (SP) family: immunity\u2019s chromatin readers","volume":"41","author":"Fraschilla","year":"2020","journal-title":"Trends Immunol."},{"key":"10.1016\/j.chom.2022.08.018_bib31","doi-asserted-by":"crossref","first-page":"21469","DOI":"10.1074\/jbc.M708176200","article-title":"The PHD domain of plant PIAS proteins mediates SUMOylation of bromodomain GTE proteins","volume":"283","author":"Garcia-Dominguez","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2022.08.018_bib32","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.chom.2010.08.004","article-title":"Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis","volume":"8","author":"Garrett","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2022.08.018_bib33","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41586-020-2025-2","article-title":"Pathway paradigms revealed from the genetics of inflammatory bowel disease","volume":"578","author":"Graham","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.08.018_bib34","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fonc.2018.00125","article-title":"Multimodal light microscopy approaches to reveal structural and functional properties of promyelocytic leukemia nuclear bodies","volume":"8","author":"Hoischen","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.chom.2022.08.018_bib35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12016-009-8136-z","article-title":"Chronic granulomatous disease","volume":"38","author":"Holland","year":"2010","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.chom.2022.08.018_bib36","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1182\/blood-2011-03-341081","article-title":"Identification and characterization of Hoxa9 binding sites in hematopoietic cells","volume":"119","author":"Huang","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.chom.2022.08.018_bib37","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1038\/s41467-020-15448-w","article-title":"Dual functions of Aire CARD multimerization in the transcriptional regulation of T\u00a0cell tolerance","volume":"11","author":"Huoh","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2022.08.018_bib38","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1053\/j.gastro.2020.06.100","article-title":"Effects of intestinal fungi and viruses on immune responses and inflammatory bowel diseases","volume":"160","author":"Iliev","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.chom.2022.08.018_bib39","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.molcel.2007.11.012","article-title":"PHD domain-mediated E3 ligase activity directs intramolecular SUMOylation of an adjacent bromodomain required for gene silencing","volume":"28","author":"Ivanov","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chom.2022.08.018_bib40","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1038\/s41467-021-22164-6","article-title":"Single-cell analyses of Crohn\u2019s disease tissues reveal intestinal intraepithelial T\u00a0cells heterogeneity and altered subset distributions","volume":"12","author":"Jaeger","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2022.08.018_bib41","doi-asserted-by":"crossref","first-page":"e67290","DOI":"10.7554\/eLife.67290","article-title":"Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons","volume":"10","author":"Ji","year":"2021","journal-title":"ELife"},{"key":"10.1016\/j.chom.2022.08.018_bib42","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"Jostins","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.08.018_bib43","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.cell.2016.05.018","article-title":"The colonic crypt protects stem cells from microbiota-derived metabolites","volume":"165","author":"Kaiko","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chom.2022.08.018_bib44","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13073-014-0107-1","article-title":"Complex host genetics influence the microbiome in inflammatory bowel disease","volume":"6","author":"Knights","year":"2014","journal-title":"Genome Med."},{"key":"10.1016\/j.chom.2022.08.018_bib45","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nri3735","article-title":"Pattern recognition receptors: Curbing gut inflammation","volume":"14","author":"Kugelberg","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2022.08.018_bib46","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1128\/IAI.66.11.5157-5166.1998","article-title":"Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism","volume":"66","author":"Kullberg","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2022.08.018_bib47","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"Liu","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chom.2022.08.018_bib48","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41586-019-1237-9","article-title":"Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases","volume":"569","author":"Lloyd-Price","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.08.018_bib49","doi-asserted-by":"crossref","first-page":"11133","DOI":"10.1128\/JVI.76.21.11133-11138.2002","article-title":"Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus Type 1","volume":"76","author":"Madani","year":"2002","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2022.08.018_bib50","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.cell.2019.08.008","article-title":"Single-cell analysis of Crohn\u2019s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy","volume":"178","author":"Martin","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.chom.2022.08.018_bib51","doi-asserted-by":"crossref","first-page":"5619","DOI":"10.1093\/hmg\/ddv256","article-title":"A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis","volume":"24","author":"Matesanz","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.chom.2022.08.018_bib52","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1172\/jci.insight.146572","article-title":"The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice","volume":"6","author":"Matsushita","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.chom.2022.08.018_bib53","doi-asserted-by":"crossref","first-page":"eaag3160","DOI":"10.1126\/sciimmunol.aag3160","article-title":"Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140","volume":"2","author":"Mehta","year":"2017","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.chom.2022.08.018_bib54","doi-asserted-by":"crossref","first-page":"R79","DOI":"10.1186\/gb-2012-13-9-r79","article-title":"Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment","volume":"13","author":"Morgan","year":"2012","journal-title":"Genome Biol."},{"key":"10.1016\/j.chom.2022.08.018_bib55","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1136\/gutjnl-2011-300078","article-title":"NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2","volume":"61","author":"Muise","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.chom.2022.08.018_bib56","doi-asserted-by":"crossref","first-page":"eaah6888","DOI":"10.1126\/scitranslmed.aah6888","article-title":"A role for bacterial urease in gut dysbiosis and Crohn's disease","volume":"9","author":"Ni","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chom.2022.08.018_bib57","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2147\/CEG.S186235","article-title":"Fecal microbiota profiles in treatment-naive pediatric inflammatory bowel disease - associations with disease phenotype, treatment, and outcome","volume":"12","author":"Olbj\u00f8rn","year":"2019","journal-title":"Clin. Exp. Gastroenterol."},{"key":"10.1016\/j.chom.2022.08.018_bib58","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nature03419","article-title":"Ipr1 gene mediates innate immunity to tuberculosis","volume":"434","author":"Pan","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.08.018_bib59","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.tibs.2008.02.003","article-title":"It takes a PHD to SUMO","volume":"33","author":"Peng","year":"2008","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.chom.2022.08.018_bib60","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.2353\/ajpath.2009.081075","article-title":"Dominant role of the sst1 locus in pathogenesis of necrotizing lung granulomas during chronic tuberculosis infection and reactivation in genetically resistant hosts","volume":"174","author":"Pichugin","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.chom.2022.08.018_bib61","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.cell.2019.07.045","article-title":"Therapeutic opportunities in inflammatory bowel disease: mechanistic dissection of host-microbiome relationships","volume":"178","author":"Plichta","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.chom.2022.08.018_bib62","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.immuni.2014.06.015","article-title":"Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus","volume":"41","author":"Ramanan","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2022.08.018_bib63","doi-asserted-by":"crossref","first-page":"7274","DOI":"10.1038\/sj.onc.1204854","article-title":"Role and fate of PML nuclear bodies in response to interferon and viral infections","volume":"20","author":"Regad","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.chom.2022.08.018_bib64","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/ng.952","article-title":"Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease","volume":"43","author":"Rivas","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chom.2022.08.018_bib65","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/j.celrep.2019.04.023","article-title":"Comparison of co-housing and littermate methods for microbiota standardization in mouse models","volume":"27","author":"Robertson","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2022.08.018_bib66","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.immuni.2018.12.018","article-title":"The short chain fatty acid butyrate imprints an antimicrobial program in macrophages","volume":"50","author":"Schulthess","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2022.08.018_bib67","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.chom.2022.08.018_bib68","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1172\/JCI200519229","article-title":"Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity","volume":"115","author":"Smythies","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2022.08.018_bib69","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature18285","article-title":"Accounting for reciprocal host-microbiome interactions in experimental science","volume":"534","author":"Stappenbeck","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.08.018_bib70","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41586-019-0878-z","article-title":"A defined commensal consortium elicits CD8 T\u00a0cells and anti-cancer immunity","volume":"565","author":"Tanoue","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.08.018_bib71","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1182\/blood.V99.1.121","article-title":"Overexpression of the myeloid leukemia\u2013associatedHoxa9 gene in bone marrow cells induces stem cell expansion","volume":"99","author":"Thorsteinsdottir","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.chom.2022.08.018_bib72","doi-asserted-by":"crossref","first-page":"858","DOI":"10.3390\/nu3100858","article-title":"Regulation of inflammation by short chain fatty acids","volume":"3","author":"Vinolo","year":"2011","journal-title":"Nutrients"},{"key":"10.1016\/j.chom.2022.08.018_bib73","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1757-4749-6-22","article-title":"Characterization of bacterial community shift in human Ulcerative Colitis patients revealed by Illumina based 16S rRNA gene amplicon sequencing","volume":"6","author":"Walujkar","year":"2014","journal-title":"Gut Pathog."},{"key":"10.1016\/j.chom.2022.08.018_bib74","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/ni.2820","article-title":"The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance","volume":"15","author":"Waterfield","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2022.08.018_bib75","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41586-020-2604-2","article-title":"Microbiota-derived metabolite promotes HDAC3 activity in the gut","volume":"586","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.08.018_bib76","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/ng.2770","article-title":"Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis","volume":"45","author":"Xifara","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chom.2022.08.018_bib77","doi-asserted-by":"crossref","first-page":"e70783","DOI":"10.1371\/journal.pone.0070783","article-title":"Intestinal microbiota composition of interleukin-10 deficient C57BL\/6J mice and susceptibility to Helicobacter hepaticus-induced colitis","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2022.08.018_bib78","doi-asserted-by":"crossref","first-page":"107471","DOI":"10.1016\/j.celrep.2020.03.035","article-title":"Gut microbiota modulate CD8 T\u00a0cell responses to influence colitis-associated tumorigenesis","volume":"31","author":"Yu","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2022.08.018_bib79","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.4049\/jimmunol.1300016","article-title":"IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic","volume":"190","author":"Zenewicz","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2022.08.018_bib80","doi-asserted-by":"crossref","first-page":"12786","DOI":"10.1074\/jbc.M116.721159","article-title":"Multifaceted histone H3 methylation and phosphorylation readout by the plant homeodomain finger of human nuclear antigen Sp100C","volume":"291","author":"Zhang","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2022.08.018_bib81","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1038\/s41467-018-03914-5","article-title":"HOXA9 inhibits HIF-1\u03b1-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development","volume":"9","author":"Zhou","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2022.08.018_bib82","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.bbagen.2018.11.011","article-title":"Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent bromodomain","volume":"1863","author":"Zucchelli","year":"2019","journal-title":"Biochim. Biophys. Acta Gen. Subj."}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312822004176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312822004176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:30:43Z","timestamp":1761827443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312822004176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":82,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S1931312822004176"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2022.08.018","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.03.29.486273","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2022.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}