{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:51:58Z","timestamp":1789519918700,"version":"build-2803163510"},"reference-count":90,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22fk0108146"],"award-info":[{"award-number":["JP22fk0108146"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP223fa727002"],"award-info":[{"award-number":["JP223fa727002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21fk0108494"],"award-info":[{"award-number":["JP21fk0108494"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21fk0108493"],"award-info":[{"award-number":["JP21fk0108493"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22fk0108617"],"award-info":[{"award-number":["JP22fk0108617"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21fk0108574"],"award-info":[{"award-number":["JP21fk0108574"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21fk0108465"],"award-info":[{"award-number":["JP21fk0108465"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005946","name":"Hokkaido University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005946","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016845","name":"Institute for Frontier Life and Medical Sciences, Kyoto University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JPMJCR20H4"],"award-info":[{"award-number":["JPMJCR20H4"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JPMJCR20H8"],"award-info":[{"award-number":["JPMJCR20H8"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011313","name":"Tokyo Biochemical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008899","name":"Waksman Foundation of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K15767"],"award-info":[{"award-number":["20K15767"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K07089"],"award-info":[{"award-number":["22K07089"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20H05873"],"award-info":[{"award-number":["JP20H05873"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K16375"],"award-info":[{"award-number":["22K16375"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20H05773"],"award-info":[{"award-number":["JP20H05773"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K07103"],"award-info":[{"award-number":["22K07103"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JPJSCCA20190008"],"award-info":[{"award-number":["JPJSCCA20190008"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H02736"],"award-info":[{"award-number":["21H02736"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22J11578"],"award-info":[{"award-number":["22J11578"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004091","name":"Kumamoto University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.chom.2022.10.003","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T12:47:26Z","timestamp":1666097246000},"page":"1540-1555.e15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":161,"title":["Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant"],"prefix":"10.1016","volume":"30","author":[{"given":"Akatsuki","family":"Saito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomokazu","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Zahradnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Deguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshiro","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Anraku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumpei","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Yamasoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"Nasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mako","family":"Toyoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiya","family":"Uriu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kosugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Shofa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MST","family":"Monira Begum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rigel","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naganori","family":"Nao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumi","family":"Tsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Yoshimatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Kuramochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Kita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Sasaki-Tabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Maenaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuharu","family":"Nagamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Asakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Nagashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Sadamasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamasa","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akifumi","family":"Takaori-Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Shirakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Sawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Irie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Hashiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Matsuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terumasa","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takasuke","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4431-1380","authenticated-orcid":false,"given":"Kei","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2022.10.003_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"Phenix: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.chom.2022.10.003_bib2","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S1473-3099(22)00422-4","article-title":"Augmented neutralisation resistance of emerging omicron subvariants BA.2.12.1, BA.4, and BA.5","volume":"22","author":"Arora","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chom.2022.10.003_bib3","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s41586-020-2852-1","article-title":"SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies","volume":"588","author":"Barnes","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.10.003_bib4","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/s41591-022-01792-5","article-title":"Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies","volume":"28","author":"Bruel","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2022.10.003_bib5","article-title":"Characterizations of enhanced infectivity and antibody evasion of Omicron BA.2.75","author":"Cao","year":"2022","journal-title":"Preprint at bioRxiv"},{"key":"10.1016\/j.chom.2022.10.003_bib6","article-title":"Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies","author":"Cao","year":"2021","journal-title":"Preprint at bioRxiv"},{"key":"10.1016\/j.chom.2022.10.003_bib7","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41586-022-04980-y","article-title":"BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection","volume":"608","author":"Cao","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.10.003_bib8","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1093\/bioinformatics\/btp348","article-title":"trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses","volume":"25","author":"Capella-Guti\u00e9rrez","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2022.10.003_bib9","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jsb.2013.08.002","article-title":"One number does not fit all: mapping local variations in resolution in cryo-EM reconstructions","volume":"184","author":"Cardone","year":"2013","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.chom.2022.10.003_bib10","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41586-021-04387-1","article-title":"Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization","volume":"602","author":"Cele","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.10.003_bib11","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.chom.2021.03.005","article-title":"Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single Supersite","volume":"29","author":"Cerutti","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2022.10.003_bib12","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1126\/science.abc0870","article-title":"Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2","volume":"369","author":"Chan","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.chom.2022.10.003_bib13","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2022.10.003_bib14","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1126\/science.abc6952","article-title":"A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2","volume":"369","author":"Chi","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.chom.2022.10.003_bib15","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4161\/fly.19695","article-title":"A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3","volume":"6","author":"Cingolani","year":"2012","journal-title":"Fly (Austin)"},{"key":"10.1016\/j.chom.2022.10.003_bib16","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1021\/acsbiomaterials.1c00642","article-title":"Usability of polydimethylsiloxane-based microfluidic devices in pharmaceutical research using human hepatocytes","volume":"7","author":"Deguchi","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.chom.2022.10.003_bib17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cell.2021.12.046","article-title":"SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses","volume":"185","author":"Dejnirattisai","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.chom.2022.10.003_bib18","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/s41564-021-00972-2","article-title":"Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail","volume":"6","author":"Dong","year":"2021","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2022.10.003_bib19","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.chom.2022.10.003_bib20","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/infdis\/jiab368","article-title":"SARS-CoV-2 B.1.617 Mutations L452R and E484Q Are Not Synergistic for Antibody Evasion","volume":"224","author":"Ferreira","year":"2021","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2022.10.003_bib21","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1016\/j.cell.2021.03.013","article-title":"Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity","volume":"184","author":"Garcia-Beltran","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.chom.2022.10.003_bib23","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/pro.3235","article-title":"UCSF ChimeraX: meeting modern challenges in visualization and analysis","volume":"27","author":"Goddard","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.chom.2022.10.003_bib24","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.stemcr.2014.07.005","article-title":"Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells","volume":"3","author":"Gotoh","year":"2014","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.chom.2022.10.003_bib25","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.chom.2022.07.002","article-title":"SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns","volume":"30","author":"Gruell","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2022.10.003_bib26","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1056\/NEJMc2206576","article-title":"Neutralization escape by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5","volume":"387","author":"Hachmann","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2022.10.003_bib27","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41579-021-00573-0","article-title":"SARS-CoV-2 variants, spike mutations and immune escape","volume":"19","author":"Harvey","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2022.10.003_bib28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nsmb.1969","article-title":"Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM","volume":"18","author":"Hashiguchi","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.chom.2022.10.003_bib29","doi-asserted-by":"crossref","first-page":"eabo6783","DOI":"10.1126\/sciadv.abo6783","article-title":"SARS-CoV-2 disrupts the respiratory vascular barrier by suppressing Claudin-5 expression","volume":"8","author":"Hashimoto","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.chom.2022.10.003_bib30","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.abd0826","article-title":"Structure-based design of prefusion-stabilized SARS-CoV-2 spikes","volume":"369","author":"Hsieh","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.chom.2022.10.003_bib31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41580-021-00418-x","article-title":"Mechanisms of SARS-CoV-2 entry into cells","volume":"23","author":"Jackson","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chom.2022.10.003_bib32","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/pro.3280","article-title":"Improvements to the APBS biomolecular solvation software suite","volume":"27","author":"Jurrus","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.chom.2022.10.003_bib33","article-title":"Omicron sub-lineages BA.4\/BA.5 escape BA.1 infection elicited neutralizing immunity","author":"Khan","year":"2022","journal-title":"Preprint at medRxiv"},{"key":"10.1016\/j.chom.2022.10.003_bib34","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.46234\/ccdcw2021.255","article-title":"GISAID's role in pandemic response","volume":"3","author":"Khare","year":"2021","journal-title":"China CDC Wkly."},{"key":"10.1016\/j.chom.2022.10.003_bib35","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41467-020-20602-5","article-title":"A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein","volume":"12","author":"Kim","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2022.10.003_bib36","doi-asserted-by":"crossref","first-page":"110218","DOI":"10.1016\/j.celrep.2021.110218","article-title":"The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance","volume":"38","author":"Kimura","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2022.10.003_bib37","article-title":"SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant","author":"Kimura","year":"2022","journal-title":"Preprint at bioRxiv"},{"key":"10.1016\/j.chom.2022.10.003_bib38","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/j.cell.2022.09.018","article-title":"Virological characteristics of the novel SARS-CoV-2 Omicron variants including BA.4 and BA.5","volume":"185","author":"Kimura","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.chom.2022.10.003_bib39","article-title":"SARS-CoV-2 BA.5 vaccine breakthrough risk and severity compared with BA.2: a case-case and cohort study using electronic health records in Portugal","author":"Kislaya","year":"2022","journal-title":"Preprint at medRxiv"},{"key":"10.1016\/j.chom.2022.10.003_bib40","article-title":"Monitoring viral-mediated membrane fusion using fluorescent reporter methods","volume":"Chapter","author":"Kondo","year":"2011","journal-title":"Curr. Protoc. Cell Biol."},{"key":"10.1016\/j.chom.2022.10.003_bib41","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.stemcr.2015.11.010","article-title":"Directed induction of functional multi-ciliated cells in proximal airway epithelial spheroids from human pluripotent stem cells","volume":"6","author":"Konishi","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.chom.2022.10.003_bib43","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41586-020-2180-5","article-title":"Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor","volume":"581","author":"Lan","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.10.003_bib44","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1093\/bioinformatics\/bty191","article-title":"Minimap2: pairwise alignment for nucleotide sequences","volume":"34","author":"Li","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2022.10.003_bib45","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2022.10.003_bib46","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2022.10.003_bib47","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41586-021-04388-0","article-title":"Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2","volume":"602","author":"Liu","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.10.003_bib48","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41586-020-2571-7","article-title":"Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike","volume":"584","author":"Liu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.10.003_bib49","article-title":"The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines","author":"Liu","year":"2021","journal-title":"Preprint at bioRxiv"},{"key":"10.1016\/j.chom.2022.10.003_bib50","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.chom.2021.04.010","article-title":"An NTD Supersite of attack","volume":"29","author":"Lok","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2022.10.003_bib51","doi-asserted-by":"crossref","first-page":"100679","DOI":"10.1016\/j.xcrm.2022.100679","article-title":"Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant","volume":"3","author":"Lyke","year":"2022","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.chom.2022.10.003_bib52","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1073\/pnas.2002589117","article-title":"Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells","volume":"117","author":"Matsuyama","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2022.10.003_bib53","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1016\/j.cell.2021.03.028","article-title":"N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2","volume":"184","author":"McCallum","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.chom.2022.10.003_bib54","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41586-022-04474-x","article-title":"Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity","volume":"603","author":"Meng","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.10.003_bib55","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","article-title":"ColabFold: making protein folding accessible to all","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2022.10.003_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010260","article-title":"Structural and antigenic variations in the spike protein of emerging SARS-CoV-2 variants","volume":"18","author":"Mittal","year":"2022","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.chom.2022.10.003_bib57","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.chom.2021.06.006","article-title":"SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity","volume":"29","author":"Motozono","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2022.10.003_bib58","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","article-title":"Efficient selection for high-expression transfectants with a novel eukaryotic vector","volume":"108","author":"Niwa","year":"1991","journal-title":"Gene"},{"key":"10.1016\/j.chom.2022.10.003_bib59","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/s41467-021-21118-2","article-title":"SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity","volume":"12","author":"Ozono","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2022.10.003_bib60","doi-asserted-by":"crossref","first-page":"13023","DOI":"10.1074\/jbc.RA120.013887","article-title":"Super-rapid quantitation of the production of HIV-1 harboring a luminescent peptide tag","volume":"295","author":"Ozono","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2022.10.003_bib61","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.chom.2022.10.003_bib62","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41586-020-2349-y","article-title":"Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody","volume":"583","author":"Pinto","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.10.003_bib63","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41586-021-04389-z","article-title":"Considerable escape of SARS-CoV-2 Omicron to antibody neutralization","volume":"602","author":"Planas","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.10.003_bib64","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2022.10.003_bib65","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1056\/NEJMc2206725","article-title":"Neutralization of the SARS-CoV-2 omicron BA.4\/5 and BA.2.12.1 Subvariants","volume":"386","author":"Qu","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2022.10.003_bib66","first-page":"493","article-title":"A simple method of estimating fifty percent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Hyg."},{"key":"10.1016\/j.chom.2022.10.003_bib93","doi-asserted-by":"crossref","first-page":"13419","DOI":"10.1073\/pnas.212519299","article-title":"Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line","volume":"99","author":"Reeves","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2022.10.003_bib67","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41586-021-04266-9","article-title":"Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation","volume":"602","author":"Saito","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.10.003_bib68","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s42003-022-03499-2","article-title":"Cell response analysis in SARS-CoV-2 infected bronchial organoids","volume":"5","author":"Sano","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.chom.2022.10.003_bib69","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1056\/NEJMc2210648","article-title":"Neutralization of SARS-CoV-2 omicron BA.2.75 after mRNA-1273 Vaccination","volume":"387","author":"Shen","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2022.10.003_bib70","doi-asserted-by":"crossref","first-page":"111009","DOI":"10.1016\/j.celrep.2022.111009","article-title":"Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike","volume":"39","author":"Stalls","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2022.10.003_bib71","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/bioinformatics\/btu033","article-title":"RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies","volume":"30","author":"Stamatakis","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2022.10.003_bib72","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1016\/j.cell.2021.03.029","article-title":"Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein","volume":"184","author":"Suryadevara","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.chom.2022.10.003_bib73","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41586-022-04462-1","article-title":"Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant","volume":"603","author":"Suzuki","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.10.003_bib74","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1056\/NEJMc2119407","article-title":"Efficacy of antibodies and antiviral drugs against Covid-19 Omicron variant","volume":"386","author":"Takashita","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2022.10.003_bib75","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1056\/NEJMc2201933","article-title":"Efficacy of antiviral agents against the SARS-CoV-2 Omicron subvariant BA.2","volume":"386","author":"Takashita","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2022.10.003_bib76","article-title":"Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5","author":"Tamura","year":"2022","journal-title":"Preprint at bioRxiv"},{"key":"10.1016\/j.chom.2022.10.003_bib77","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1016\/j.cell.2022.06.005","article-title":"Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum","volume":"185","author":"Tuekprakhon","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.chom.2022.10.003_bib78","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1093\/infdis\/jiac053","article-title":"Characterization of the immune resistance of SARS-CoV-2 Mu variant and the robust immunity induced by Mu infection","volume":"226","author":"Uriu","year":"2022","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2022.10.003_bib79","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1056\/NEJMc2114706","article-title":"Neutralization of the SARS-CoV-2 Mu variant by convalescent and vaccine serum","volume":"385","author":"Uriu","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2022.10.003_bib80","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41591-021-01678-y","article-title":"An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies","volume":"28","author":"VanBlargan","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2022.10.003_bib81","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1126\/science.abg5268","article-title":"Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes","volume":"372","author":"Voss","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.chom.2022.10.003_bib82","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41586-022-05053-w","article-title":"Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5, & BA.5","volume":"608","author":"Wang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.chom.2022.10.003_bib83","doi-asserted-by":"crossref","first-page":"110812","DOI":"10.1016\/j.celrep.2022.110812","article-title":"LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants","volume":"39","author":"Westendorf","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2022.10.003_bib85","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/pro.3330","article-title":"MolProbity: more and better reference data for improved all-atom structure validation","volume":"27","author":"Williams","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.chom.2022.10.003_bib86","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41594-020-00549-3","article-title":"A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent","volume":"28","author":"Xiao","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.chom.2022.10.003_bib87","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3390\/v12060629","article-title":"The anticoagulant nafamostat potently inhibits SARS-CoV-2\u00a0S protein-mediated fusion in a cell fusion assay system and viral infection in\u00a0vitro in a cell-yype-dependent manner","volume":"12","author":"Yamamoto","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.chom.2022.10.003_bib88","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nmeth.4448","article-title":"Long-term expansion of alveolar stem cells derived from human iPS cells in organoids","volume":"14","author":"Yamamoto","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2022.10.003_bib89","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/j.cell.2022.04.035","article-title":"Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike","volume":"185","author":"Yamasoba","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.chom.2022.10.003_bib90","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S1473-3099(22)00365-6","article-title":"Neutralisation sensitivity of SARS-CoV-2 omicron subvariants to therapeutic monoclonal antibodies","volume":"22","author":"Yamasoba","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chom.2022.10.003_bib91","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1021\/acssynbio.1c00395","article-title":"A protein-engineered, enhanced yeast display platform for rapid evolution of challenging targets","volume":"10","author":"Zahradn\u00edk","year":"2021","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.chom.2022.10.003_bib92","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/s41564-021-00954-4","article-title":"SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in\u00a0vitro evolution","volume":"6","author":"Zahradn\u00edk","year":"2021","journal-title":"Nat. Microbiol."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312822005169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312822005169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:09:32Z","timestamp":1778832572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312822005169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":90,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S1931312822005169"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2022.10.003","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.08.07.503115","asserted-by":"object"},{"id-type":"doi","id":"10.1101\/2022.07.14.500041","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2022.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}