{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:53:43Z","timestamp":1793321623554,"version":"4.5.0"},"reference-count":79,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE025220"],"award-info":[{"award-number":["DE025220"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE023193"],"award-info":[{"award-number":["DE023193"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE026152"],"award-info":[{"award-number":["DE026152"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE031756"],"award-info":[{"award-number":["DE031756"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE031206"],"award-info":[{"award-number":["DE031206"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE025848"],"award-info":[{"award-number":["DE025848"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE012505"],"award-info":[{"award-number":["DE012505"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE029436"],"award-info":[{"award-number":["DE029436"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE028561"],"award-info":[{"award-number":["DE028561"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE011111"],"award-info":[{"award-number":["DE011111"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["11,504,414"],"award-info":[{"award-number":["11,504,414"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["62,115,968"],"award-info":[{"award-number":["62,115,968"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["10,668,135"],"award-info":[{"award-number":["10,668,135"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE031491"],"award-info":[{"award-number":["DE031491"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.chom.2023.02.009","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T11:19:03Z","timestamp":1679051943000},"page":"528-538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":236,"title":["Oral polymicrobial communities: Assembly, function, and impact on diseases"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7392-8852","authenticated-orcid":false,"given":"George","family":"Hajishengallis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Lamont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Koo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2023.02.009_bib1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.tim.2016.02.010","article-title":"Dancing with the stars: how choreographed bacterial interactions dictate nososymbiocity and give rise to keystone pathogens, accessory pathogens, and pathobionts","volume":"24","author":"Hajishengallis","year":"2016","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.chom.2023.02.009_bib2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1177\/0022034520912181","article-title":"Magnesium-dependent promotion of H2O2 production increases ecological competitiveness of oral commensal streptococci","volume":"99","author":"Cheng","year":"2020","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.chom.2023.02.009_bib3","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/s41396-020-00865-y","article-title":"A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in\u00a0vivo virulence of an oral pathogen","volume":"15","author":"Hoare","year":"2021","journal-title":"ISME J."},{"key":"10.1016\/j.chom.2023.02.009_bib4","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: dynamic communities and host interactions","volume":"16","author":"Lamont","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2023.02.009_bib5","doi-asserted-by":"crossref","first-page":"eaau3333","DOI":"10.1126\/sciadv.aau3333","article-title":"Porphyromonas gingivalis in Alzheimer's disease brains: evidence for disease causation and treatment with small-molecule inhibitors","volume":"5","author":"Dominy","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.chom.2023.02.009_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.05.048","article-title":"The intermucosal connection between the mouth and gut in commensal pathobiont-driven colitis","volume":"182","author":"Kitamoto","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.chom.2023.02.009_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2022.03.043","article-title":"Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities","volume":"185","author":"Li","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.chom.2023.02.009_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-micro-090817-062503","article-title":"Biogeography of the oral microbiome: the site-specialist hypothesis","volume":"73","author":"Mark Welch","year":"2019","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.chom.2023.02.009_bib9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tim.2017.09.008","article-title":"Oral biofilms: pathogens, matrix, and polymicrobial interactions in microenvironments","volume":"26","author":"Bowen","year":"2018","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.chom.2023.02.009_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.02.097","article-title":"Spatial ecology of the human tongue dorsum microbiome","volume":"30","author":"Wilbert","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2023.02.009_bib11","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.tim.2016.12.012","article-title":"Ecology of the oral microbiome: beyond bacteria","volume":"25","author":"Baker","year":"2017","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.chom.2023.02.009_bib12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.chom.2020.07.009","article-title":"Oral microbiome geography: micron-scale habitat and niche","volume":"28","author":"Mark Welch","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2023.02.009_bib13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/0022034519877387","article-title":"Searching deep and wide: advances in the molecular understanding of dental caries and periodontal disease","volume":"30","author":"Divaris","year":"2019","journal-title":"Adv. Dent. Res."},{"key":"10.1016\/j.chom.2023.02.009_bib14","doi-asserted-by":"crossref","first-page":"100126","DOI":"10.1016\/j.mcpro.2021.100126","article-title":"Proteomics, lipidomics, metabolomics, and 16S DNA sequencing of dental plaque from patients with diabetes and periodontal disease","volume":"20","author":"Overmyer","year":"2021","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.chom.2023.02.009_bib15","doi-asserted-by":"crossref","first-page":"12375","DOI":"10.1073\/pnas.1919099117","article-title":"Spatial mapping of polymicrobial communities reveals a precise biogeography associated with human dental caries","volume":"117","author":"Kim","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2023.02.009_bib16","doi-asserted-by":"crossref","first-page":"E791","DOI":"10.1073\/pnas.1522149113","article-title":"Biogeography of a human oral microbiome at the micron scale","volume":"113","author":"Mark Welch","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2023.02.009_bib17","doi-asserted-by":"crossref","first-page":"e9321","DOI":"10.1371\/journal.pone.0009321","article-title":"Oral biofilm architecture on natural teeth","volume":"5","author":"Zijnge","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2023.02.009_bib18","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.tim.2019.03.003","article-title":"Spatial, temporal, and phylogenetic scales of microbial ecology","volume":"27","author":"Ladau","year":"2019","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.chom.2023.02.009_bib19","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrmicro.2016.84","article-title":"Spatial structure, cooperation and competition in biofilms","volume":"14","author":"Nadell","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2023.02.009_bib20","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1177\/0022034520909313","article-title":"Spatial design of polymicrobial oral biofilm in its native disease state","volume":"99","author":"Kim","year":"2020","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.chom.2023.02.009_bib21","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41586-020-2983-4","article-title":"Highly multiplexed spatial mapping of microbial communities","volume":"588","author":"Shi","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.chom.2023.02.009_bib22","series-title":"Pathobiont-mediated spatial structuring enhances biofilm virulence in childhood oral disease","author":"Cho","year":"2022"},{"key":"10.1016\/j.chom.2023.02.009_bib23","doi-asserted-by":"crossref","first-page":"107939","DOI":"10.1016\/j.celrep.2020.107939","article-title":"Acquisition and adaptation of ultra-small parasitic reduced genome bacteria to mammalian Hosts","volume":"32","author":"McLean","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2023.02.009_bib24","doi-asserted-by":"crossref","first-page":"e0014021","DOI":"10.1128\/cmr.00140-21","article-title":"Candidate phyla radiation, an underappreciated division of the human microbiome, and its impact on health and disease","volume":"35","author":"Naud","year":"2022","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.chom.2023.02.009_bib25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1128\/IAI.00361-10","article-title":"Structural dissection and in\u00a0vivo effectiveness of a peptide inhibitor of Porphyromonas gingivalis adherence to Streptococcus gordonii","volume":"79","author":"Daep","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2023.02.009_bib26","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/s41564-017-0021-6","article-title":"Metabolic crosstalk regulates Porphyromonas gingivalis colonization and virulence during oral polymicrobial infection","volume":"2","author":"Kuboniwa","year":"2017","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2023.02.009_bib27","doi-asserted-by":"crossref","first-page":"100088","DOI":"10.1074\/jbc.REV120.011985","article-title":"Regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles","volume":"296","author":"Shetty","year":"2021","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2023.02.009_bib28","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3390\/nu8120803","article-title":"Potential links between impaired one-carbon metabolism due to polymorphisms, inadequate B-vitamin status, and the development of Alzheimer's disease","volume":"8","author":"Troesch","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.chom.2023.02.009_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02004-19","article-title":"Porphyromonas gingivalis tyrosine phosphatase Php1 promotes community development and pathogenicity","volume":"10","author":"Jung","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.chom.2023.02.009_bib30","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/omi.12354","article-title":"Phosphorylation of major Porphyromonas gingivalis virulence factors is crucial for their processing and secretion","volume":"36","author":"Nowakowska","year":"2021","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.chom.2023.02.009_bib31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/omi.12231","article-title":"Live and let die: hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome","volume":"33","author":"Redanz","year":"2018","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.chom.2023.02.009_bib32","doi-asserted-by":"crossref","first-page":"e1002012","DOI":"10.1371\/journal.ppat.1002012","article-title":"Metabolite cross-feeding enhances virulence in a model polymicrobial infection","volume":"7","author":"Ramsey","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2023.02.009_bib33","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1073\/pnas.0809533106","article-title":"Polymicrobial interactions stimulate resistance to host innate immunity through metabolite perception","volume":"106","author":"Ramsey","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2023.02.009_bib34","doi-asserted-by":"crossref","first-page":"7819","DOI":"10.1073\/pnas.1400586111","article-title":"Bacterial fight-and-flight responses enhance virulence in a polymicrobial infection","volume":"111","author":"Stacy","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2023.02.009_bib35","doi-asserted-by":"crossref","first-page":"40023","DOI":"10.1111\/1462-2920.13425","article-title":"Fine-tuned production of hydrogen peroxide promotes biofilm formation of Streptococcus parasanguinis by a pathogenic cohabitant Aggregatibacter actinomycetemcomitans","volume":"18","author":"Duan","year":"2016","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.chom.2023.02.009_bib36","doi-asserted-by":"crossref","first-page":"e00782-16","DOI":"10.1128\/mBio.00782-16","article-title":"A commensal bacterium promotes virulence of an opportunistic pathogen via cross-respiration","volume":"7","author":"Stacy","year":"2016","journal-title":"mBio"},{"key":"10.1016\/j.chom.2023.02.009_bib37","doi-asserted-by":"crossref","first-page":"6912","DOI":"10.1128\/JB.05791-11","article-title":"Hydrogen peroxide-dependent DNA release and transfer of antibiotic resistance genes in Streptococcus gordonii","volume":"193","author":"Itzek","year":"2011","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.chom.2023.02.009_bib38","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s41396-020-0592-8","article-title":"Pyruvate secretion by oral streptococci modulates hydrogen peroxide dependent antagonism","volume":"14","author":"Redanz","year":"2020","journal-title":"ISME J."},{"key":"10.1016\/j.chom.2023.02.009_bib39","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/s41396-021-01141-3","article-title":"Mechanisms underlying interactions between two abundant oral commensal bacteria","volume":"16","author":"Perera","year":"2022","journal-title":"ISME J."},{"key":"10.1016\/j.chom.2023.02.009_bib40","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1177\/0022034519877150","article-title":"Horizontal and vertical transfer of oral microbial dysbiosis and periodontal disease","volume":"98","author":"Payne","year":"2019","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.chom.2023.02.009_bib41","doi-asserted-by":"crossref","first-page":"e0030921","DOI":"10.1128\/IAI.00309-21","article-title":"Loss of neutrophil homing to the periodontal tissues modulates the composition and disease potential of the oral microbiota","volume":"89","author":"Hashim","year":"2021","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2023.02.009_bib42","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.chom.2014.05.012","article-title":"Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis","volume":"15","author":"Maekawa","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2023.02.009_bib43","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.chom.2011.10.006","article-title":"Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement","volume":"10","author":"Hajishengallis","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2023.02.009_bib44","doi-asserted-by":"crossref","first-page":"eaat0797","DOI":"10.1126\/scitranslmed.aat0797","article-title":"A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans","volume":"10","author":"Dutzan","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chom.2023.02.009_bib45","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/00220345211035775","article-title":"SMDI: an index for measuring subgingival microbial dysbiosis","volume":"101","author":"Chen","year":"2022","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.chom.2023.02.009_bib46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13073-015-0153-3","article-title":"Functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis","volume":"7","author":"Yost","year":"2015","journal-title":"Genome Med."},{"key":"10.1016\/j.chom.2023.02.009_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2021.09.009","article-title":"Episymbiotic Saccharibacteria suppresses gingival inflammation and bone loss in mice through host bacterial modulation","volume":"29","author":"Chipashvili","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2023.02.009_bib48","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.1038\/s41467-019-12505-x","article-title":"Gingival solitary chemosensory cells are immune sentinels for periodontitis","volume":"10","author":"Zheng","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2023.02.009_bib49","article-title":"Site-specific adaptation mechanisms of an oral pathobiont in the oral and gut mucosae","author":"Guo","year":"2022","journal-title":"Preprint at bioRxiv"},{"key":"10.1016\/j.chom.2023.02.009_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2017.08.013","article-title":"Host genetic control of the oral microbiome in health and disease","volume":"22","author":"Gomez","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2023.02.009_bib51","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00460-18","article-title":"Oral administration of Porphyromonas gingivalis alters the gut microbiome and serum metabolome","volume":"3","author":"Kato","year":"2018","journal-title":"mSphere"},{"key":"10.1016\/j.chom.2023.02.009_bib52","doi-asserted-by":"crossref","first-page":"120162","DOI":"10.1016\/j.lfs.2021.120162","article-title":"Ligature induced periodontitis in rats causes gut dysbiosis leading to hepatic injury through SCD1\/AMPK signalling pathway","volume":"288","author":"Xing","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.chom.2023.02.009_bib53","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/1744666X.2021.1935877","article-title":"The pathogenic oral-gut-liver axis: new understandings and clinical implications","volume":"17","author":"Imai","year":"2021","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.chom.2023.02.009_bib54","doi-asserted-by":"crossref","first-page":"766170","DOI":"10.3389\/fimmu.2021.766170","article-title":"Oral pathobiont-induced changes in gut microbiota aggravate the pathology of nonalcoholic fatty liver disease in mice","volume":"12","author":"Yamazaki","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chom.2023.02.009_bib55","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/prd.12356","article-title":"Impact of systemic factors in shaping the periodontal microbiome","volume":"85","author":"Teles","year":"2021","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.chom.2023.02.009_bib56","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2023.02.009_bib57","doi-asserted-by":"crossref","first-page":"577485","DOI":"10.3389\/fcimb.2020.577485","article-title":"Comparison of blood bacterial communities in periodontal health and periodontal disease","volume":"10","author":"Emery","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.chom.2023.02.009_bib58","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.GPP3-0042-2018","article-title":"Biology of oral streptococci","volume":"6","author":"Abranches","year":"2018","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.chom.2023.02.009_bib59","doi-asserted-by":"crossref","first-page":"816640","DOI":"10.3389\/fimmu.2022.816640","article-title":"Periodontal infection aggravates C1q-mediated microglial activation and synapse pruning in Alzheimer's mice","volume":"13","author":"Hao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chom.2023.02.009_bib60","doi-asserted-by":"crossref","first-page":"105282","DOI":"10.1016\/j.neuint.2022.105282","article-title":"Secreted gingipains from Porphyromonas gingivalis increase permeability in human cerebral microvascular endothelial cells through intracellular degradation of tight junction proteins","volume":"154","author":"Nonaka","year":"2022","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.chom.2023.02.009_bib61","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/prd.12301","article-title":"Oral-lung microbiome interactions in lung diseases","volume":"83","author":"Mammen","year":"2020","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.chom.2023.02.009_bib62","doi-asserted-by":"crossref","first-page":"e0077121","DOI":"10.1128\/mBio.00771-21","article-title":"Obesity-related gut microbiota aggravates alveolar bone destruction in experimental periodontitis through elevation of uric acid","volume":"12","author":"Sato","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.chom.2023.02.009_bib63","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/art.41511","article-title":"An autoimmunogenic and proinflammatory profile defined by the gut microbiota of patients with untreated systemic lupus erythematosus","volume":"73","author":"Chen","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.chom.2023.02.009_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2018.09.009","article-title":"Compositional and temporal changes in the gut microbiome of pediatric ulcerative colitis patients are linked to disease course","volume":"24","author":"Schirmer","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2023.02.009_bib65","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41591-019-0458-7","article-title":"Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer","volume":"25","author":"Yachida","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2023.02.009_bib66","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.chom.2014.02.005","article-title":"The treatment-naive microbiome in new-onset Crohn\u2019s disease","volume":"15","author":"Gevers","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2023.02.009_bib67","doi-asserted-by":"crossref","first-page":"111314","DOI":"10.1016\/j.celrep.2022.111314","article-title":"Pathobiont-responsive Th17 cells in gut-mouth axis provoke inflammatory oral disease and are modulated by intestinal microbiome","volume":"40","author":"Nagao","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2023.02.009_bib68","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1038\/s41564-022-01224-7","article-title":"Inflammation-associated nitrate facilitates ectopic colonization of oral bacterium Veillonella parvula in the intestine","volume":"7","author":"Rojas-Tapias","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2023.02.009_bib69","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/prd.12426","article-title":"Fusobacterium nucleatum and cancer","volume":"89","author":"Alon-Maimon","year":"2022","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.chom.2023.02.009_bib70","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1136\/gutjnl-2020-322780","article-title":"F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer","volume":"70","author":"Hong","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.chom.2023.02.009_bib71","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1089\/dna.2019.5064","article-title":"Fusobacterium nucleatum caused DNA damage and promoted cell proliferation by the Ku70\/p53 pathway in oral cancer cells","volume":"39","author":"Geng","year":"2020","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.chom.2023.02.009_bib72","doi-asserted-by":"crossref","first-page":"eaan2306","DOI":"10.1126\/scitranslmed.aan2306","article-title":"Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus","volume":"10","author":"Greiling","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chom.2023.02.009_bib73","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nrmicro.2017.99","article-title":"Targeting microbial biofilms: current and prospective therapeutic strategies","volume":"15","author":"Koo","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2023.02.009_bib74","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000510185","article-title":"Oral mouth rinses against supragingival biofilm and gingival inflammation","volume":"29","author":"Arweiler","year":"2021","journal-title":"Monogr. Oral Sci."},{"key":"10.1016\/j.chom.2023.02.009_bib75","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/prd.12315","article-title":"Periodontal therapeutics: current host-modulation agents and future directions","volume":"82","author":"Golub","year":"2020","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.chom.2023.02.009_bib76","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/prd.12331","article-title":"Current understanding of periodontal disease pathogenesis and targets for host-modulation therapy","volume":"84","author":"Hajishengallis","year":"2020","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.chom.2023.02.009_bib77","doi-asserted-by":"crossref","first-page":"9442","DOI":"10.1021\/acs.nanolett.1c02702","article-title":"Ferumoxytol nanoparticles target biofilms causing tooth decay in the human mouth","volume":"21","author":"Liu","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.chom.2023.02.009_bib78","doi-asserted-by":"crossref","first-page":"e152973","DOI":"10.1172\/JCI152973","article-title":"Phase IIa clinical trial of complement C3 inhibitor AMY-101 in adults with periodontal inflammation","volume":"131","author":"Hasturk","year":"2021","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2023.02.009_bib79","doi-asserted-by":"crossref","first-page":"eabi4882","DOI":"10.1126\/science.abi4882","article-title":"Spatial transcriptomics of planktonic and sessile bacterial populations at single-cell resolution","volume":"373","author":"Dar","year":"2021","journal-title":"Science"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312823000793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312823000793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:10:37Z","timestamp":1778832637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312823000793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":79,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S1931312823000793"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2023.02.009","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral polymicrobial communities: Assembly, function, and impact on diseases","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2023.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}