{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:44:58Z","timestamp":1793321098347,"version":"4.5.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004815","name":"Isaac Newton Trust","doi-asserted-by":"publisher","award":["ECF-2015-562"],"award-info":[{"award-number":["ECF-2015-562"]}],"id":[{"id":"10.13039\/501100004815","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI112427"],"award-info":[{"award-number":["R01AI112427"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI148249"],"award-info":[{"award-number":["R01AI148249"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF 58-2018"],"award-info":[{"award-number":["ALTF 58-2018"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004897","name":"Pennsylvania Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214298\/Z\/18\/Z"],"award-info":[{"award-number":["214298\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000275","name":"Leverhulme Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.chom.2023.03.001","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T11:08:36Z","timestamp":1679483316000},"page":"650-664.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":114,"title":["Cryptosporidium uses multiple distinct secretory organelles to interact with and modify its host cell"],"prefix":"10.1016","volume":"31","author":[{"given":"Amandine","family":"Gu\u00e9rin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Strelau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Barylyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethan A.","family":"Wallbank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver M.","family":"Crook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn S.","family":"Lilley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross F.","family":"Waller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7426-432X","authenticated-orcid":false,"given":"Boris","family":"Striepen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2023.03.001_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0140-6736(13)60844-2","article-title":"Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study","volume":"382","author":"Kotloff","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2023.03.001_bib2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1473-3099(14)70772-8","article-title":"A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium","volume":"15","author":"Checkley","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chom.2023.03.001_bib3","doi-asserted-by":"crossref","first-page":"e0008252","DOI":"10.1371\/journal.pntd.0008252","article-title":"Cryptosporidiosis should be designated as a tropical disease by the US Food and Drug Administration","volume":"14","author":"Choy","year":"2020","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.chom.2023.03.001_bib4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/503189a","article-title":"Parasitic infections: time to tackle cryptosporidiosis","volume":"503","author":"Striepen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.chom.2023.03.001_bib5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.chom.2020.09.007","article-title":"The biology of the intestinal intracellular parasite cryptosporidium","volume":"28","author":"Gu\u00e9rin","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2023.03.001_bib6","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.chom.2021.07.002","article-title":"Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7","volume":"29","author":"Gu\u00e9rin","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2023.03.001_bib7","article-title":"Live imaging of the Cryptosporidium parvum lifecycle reveals direct development of male and female gametes from type one meronts","volume":"18","author":"English","year":"2022","journal-title":"PLoS Biol."},{"key":"10.1016\/j.chom.2023.03.001_bib8","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1038\/s41564-019-0539-x","article-title":"Life cycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum","volume":"4","author":"Tandel","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2023.03.001_bib9","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1128\/IAI.68.4.2315-2322.2000","article-title":"Cryptosporidium parvum induces host cell actin accumulation at the host-parasite interface","volume":"68","author":"Elliott","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2023.03.001_bib10","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/BF00931092","article-title":"Cryptosporidium sp. of the starred lizard Agama stellio: ultrasturcture an life cycle","volume":"76","author":"Ostrovska","year":"1990","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.chom.2023.03.001_bib11","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1126\/science.1094786","article-title":"Complete genome sequence of the apicomplexan, Cryptosporidium parvum","volume":"304","author":"Abrahamsen","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.chom.2023.03.001_bib12","first-page":"57","article-title":"Biochemistry. In Cryptosporidium and Cryptosporidiosis","author":"Zhu","year":"2007"},{"key":"10.1016\/j.chom.2023.03.001_bib13","doi-asserted-by":"crossref","first-page":"21160","DOI":"10.1073\/pnas.1908239116","article-title":"Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell","volume":"116","author":"Pawlowic","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2023.03.001_bib14","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/mmi.14674","article-title":"Biogenesis and discharge of the rhoptries: key organelles for entry and hijack of host cells by the Apicomplexa","volume":"115","author":"Ben Chaabene","year":"2021","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2023.03.001_bib15","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nrmicro.2017.86","article-title":"Gliding motility powers invasion and egress in Apicomplexa","volume":"15","author":"Fr\u00e9nal","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2023.03.001_bib16","doi-asserted-by":"crossref","first-page":"e20201314","DOI":"10.1084\/jem.20201314","article-title":"Lessons from Toxoplasma: host responses that mediate parasite control and the microbial effectors that subvert them","volume":"218","author":"Frickel","year":"2021","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2023.03.001_bib17","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1128\/CMR.00005-17","article-title":"Toxoplasma effectors targeting Host Signaling and Transcription","volume":"30","author":"Hakimi","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.chom.2023.03.001_bib18","doi-asserted-by":"crossref","first-page":"e13018","DOI":"10.1111\/cmi.13018","article-title":"Biogenesis and secretion of micronemes in Toxoplasma gondii","volume":"21","author":"Dubois","year":"2019","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2023.03.001_bib19","doi-asserted-by":"crossref","first-page":"e12904","DOI":"10.1111\/jeu.12904","article-title":"Dense granule biogenesis, secretion, and function in Toxoplasma gondii","volume":"69","author":"Griffith","year":"2022","journal-title":"J.\u00a0Eukaryot. Microbiol."},{"key":"10.1016\/j.chom.2023.03.001_bib20","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.pt.2014.12.002","article-title":"Toxoplasma secretory granules: one population or more?","volume":"31","author":"Mercier","year":"2015","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.chom.2023.03.001_bib21","doi-asserted-by":"crossref","first-page":"e70451","DOI":"10.7554\/eLife.70451","article-title":"The enteric pathogen Cryptosporidium parvum exports proteins into the cytosol of the infected host cell","volume":"10","author":"Dumaine","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.chom.2023.03.001_bib22","doi-asserted-by":"crossref","first-page":"8992","DOI":"10.1038\/ncomms9992","article-title":"A draft map of the mouse pluripotent stem cell spatial proteome","volume":"7","author":"Christoforou","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2023.03.001_bib23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature14651","article-title":"Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum","volume":"523","author":"Vinayak","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.chom.2023.03.001_bib24","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1002\/pmic.201000359","article-title":"Improved sub-cellular resolution via simultaneous analysis of organelle proteomics data across varied experimental conditions","volume":"10","author":"Trotter","year":"2010","journal-title":"Proteomics"},{"key":"10.1016\/j.chom.2023.03.001_bib25","first-page":"339","article-title":"Visualizing data using t-SNE","volume":"9","author":"Van der Maaten","year":"2008","journal-title":"J.\u00a0Mach. Learn. Res."},{"key":"10.1016\/j.chom.2023.03.001_bib26","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41587-019-0036-z","article-title":"SignalP 5.0 improves signal peptide predictions using deep neural networks","volume":"37","author":"Almagro Armenteros","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chom.2023.03.001_bib27","doi-asserted-by":"crossref","first-page":"e1008288","DOI":"10.1371\/journal.pcbi.1008288","article-title":"A semi-supervised Bayesian approach for simultaneous protein sub-cellular localisation assignment and novelty detection","volume":"16","author":"Crook","year":"2020","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.chom.2023.03.001_bib28","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1017\/S0031182096008761","article-title":"Cloning of the entire COWP gene of Cryptosporidium parvum and ultrastructural localization of the protein during sexual parasite development","volume":"114","author":"Spano","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/j.chom.2023.03.001_bib29","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1128\/IAI.72.2.980-987.2004","article-title":"The Cryptosporidium oocyst wall protein is a member of a multigene family and has a homolog in Toxoplasma","volume":"72","author":"Templeton","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2023.03.001_bib31","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1128\/EC.00213-13","article-title":"Strategies to discover the structural components of cyst and oocyst walls","volume":"12","author":"Samuelson","year":"2013","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.chom.2023.03.001_bib30","first-page":"56S","article-title":"Cryptosporidium parvum: synchronized excystation in\u00a0vitro and evaluation of sporozoite infectivity with a new lectin-based assay","volume":"46","author":"Gut","year":"1999","journal-title":"J.\u00a0Eukaryot. Microbiol."},{"key":"10.1016\/j.chom.2023.03.001_bib32","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1186\/s12936-018-2617-6","article-title":"Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes","volume":"17","author":"Jenwithisuk","year":"2018","journal-title":"Malar. J."},{"key":"10.1016\/j.chom.2023.03.001_bib33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1017\/S0031182011002034","article-title":"Crystalloid body, refractile body and virus-like particles in Apicomplexa: what is in there?","volume":"139","author":"Lemgruber","year":"2012","journal-title":"Parasitology"},{"key":"10.1016\/j.chom.2023.03.001_bib34","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1099\/00221287-144-12-3249","article-title":"Ultrastructural analysis of the sporozoite of Cryptosporidium parvum","volume":"144","author":"Tetley","year":"1998","journal-title":"Microbiology (Reading)"},{"key":"10.1016\/j.chom.2023.03.001_bib35","doi-asserted-by":"crossref","first-page":"103925","DOI":"10.1016\/j.jprot.2020.103925","article-title":"Plasmodium berghei LAPs form an extended protein complex that facilitates crystalloid targeting and biogenesis","volume":"227","author":"Tremp","year":"2020","journal-title":"J.\u00a0Proteomics"},{"key":"10.1016\/j.chom.2023.03.001_bib36","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.molbiopara.2003.11.014","article-title":"A new modular protein of Cryptosporidium parvum, with ricin B and LCCL domains, expressed in the sporozoite invasive stage","volume":"134","author":"Tosini","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.chom.2023.03.001_bib37","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1128\/IAI.68.9.5167-5175.2000","article-title":"Mediation of Cryptosporidium parvum infection in\u00a0vitro by mucin-like glycoproteins defined by a neutralizing monoclonal antibody","volume":"68","author":"Cevallos","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2023.03.001_bib39","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.molbiopara.2012.02.004","article-title":"Molecular characterisation of a Cryptosporidium parvum rhoptry protein candidate related to the rhoptry neck proteins TgRON1 of Toxoplasma gondii and PfASP of Plasmodium falciparum","volume":"183","author":"Valentini","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.chom.2023.03.001_bib40","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.molbiopara.2007.09.004","article-title":"The thrombospondin-related protein CpMIC1 (CpTSP8) belongs to the repertoire of micronemal proteins of Cryptosporidium parvum","volume":"157","author":"Putignani","year":"2008","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.chom.2023.03.001_bib38","doi-asserted-by":"crossref","first-page":"e31715","DOI":"10.1371\/journal.pone.0031715","article-title":"The Cryptosporidium parvum transcriptome during in\u00a0vitro development","volume":"7","author":"Mauzy","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2023.03.001_bib41","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.chom.2020.09.011","article-title":"A comprehensive subcellular atlas of the toxoplasma proteome via hyperLOPIT provides spatial context for protein functions","volume":"28","author":"Barylyuk","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2023.03.001_bib42","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1550-7408.1995.tb01601.x","article-title":"Monoclonal antibodies identify a subset of dense granules in Cryptosporidium parvum zoites and gamonts","volume":"42","author":"Bonnin","year":"1995","journal-title":"J.\u00a0Eukaryot. Microbiol."},{"key":"10.1016\/j.chom.2023.03.001_bib43","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/nature08104","article-title":"A newly discovered protein export machine in malaria parasites","volume":"459","author":"de Koning-Ward","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.chom.2023.03.001_bib44","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jmb.2010.09.051","article-title":"The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum","volume":"404","author":"El Bakkouri","year":"2010","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.chom.2023.03.001_bib45","doi-asserted-by":"crossref","first-page":"e1005250","DOI":"10.1371\/journal.ppat.1005250","article-title":"Cryptosporidium lactate dehydrogenase is associated with the parasitophorous vacuole membrane and is a potential target for developing therapeutics","volume":"11","author":"Zhang","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2023.03.001_bib46","doi-asserted-by":"crossref","first-page":"e49662","DOI":"10.7554\/eLife.49662","article-title":"Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles","volume":"8","author":"Janou\u0161kovec","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.chom.2023.03.001_bib47","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1016\/j.cub.2019.07.019","article-title":"Multiple independent origins of apicomplexan-like parasites","volume":"29","author":"Mathur","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.chom.2023.03.001_bib48","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1186\/s12864-022-08700-8","article-title":"Marine gregarine genomes reveal the breadth of apicomplexan diversity with a partially conserved glideosome machinery","volume":"23","author":"Boisard","year":"2022","journal-title":"BMC Genomics"},{"key":"10.1016\/j.chom.2023.03.001_bib49","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1016\/j.cub.2021.04.028","article-title":"Parallel functional reduction in the mitochondria of apicomplexan parasites","volume":"31","author":"Mathur","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.chom.2023.03.001_bib50","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.ijpara.2012.09.009","article-title":"Evolution of apicomplexan secretory organelles","volume":"42","author":"Gubbels","year":"2012","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.chom.2023.03.001_bib51","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1550-7408.2007.00291.x","article-title":"An ultrastructural comparison of the attachment sites between Gregarina steini and Cryptosporidium muris","volume":"54","author":"Valigurov\u00e1","year":"2007","journal-title":"J.\u00a0Eukaryot. Microbiol."},{"key":"10.1016\/j.chom.2023.03.001_bib52","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s41576-020-0269-1","article-title":"Host-parasite co-evolution and its genomic signature","volume":"21","author":"Ebert","year":"2020","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.chom.2023.03.001_bib53","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev-micro-041320-021425","article-title":"How Apicomplexa parasites secrete and build their invasion machinery","volume":"76","author":"Cova","year":"2022","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.chom.2023.03.001_bib54","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1128\/IAI.67.2.844-852.1999","article-title":"A role for host phosphoinositide 3-kinase and cytoskeletal remodeling during Cryptosporidium parvum infection","volume":"67","author":"Forney","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2023.03.001_bib55","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1128\/IAI.73.9.5379-5387.2005","article-title":"Gliding motility leads to active cellular invasion by Cryptosporidium parvum sporozoites","volume":"73","author":"Wetzel","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2023.03.001_bib56","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.cell.2016.08.019","article-title":"A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan Genes","volume":"166","author":"Sidik","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chom.2023.03.001_bib57","doi-asserted-by":"crossref","first-page":"778560","DOI":"10.3389\/fvets.2021.778560","article-title":"Discovery of new microneme proteins in Cryptosporidium parvum and implication of the roles of a rhomboid membrane protein (CpROM1) in host-parasite interaction","volume":"8","author":"Gao","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.chom.2023.03.001_bib58","doi-asserted-by":"crossref","first-page":"6987","DOI":"10.1128\/IAI.70.12.6987-6995.2002","article-title":"Cryptosporidium parvum genes containing thrombospondin type 1 domains","volume":"70","author":"Deng","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2023.03.001_bib59","doi-asserted-by":"crossref","first-page":"e1003213","DOI":"10.1371\/journal.ppat.1003213","article-title":"An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes","volume":"9","author":"Kremer","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2023.03.001_bib60","doi-asserted-by":"crossref","first-page":"e12870","DOI":"10.1111\/cmi.12870","article-title":"A proteomic analysis unravels novel CORVET and HOPS proteins involved in Toxoplasma gondii secretory organelles biogenesis","volume":"20","author":"Morlon-Guyot","year":"2018","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2023.03.001_bib61","doi-asserted-by":"crossref","first-page":"7617","DOI":"10.3390\/ijms23147617","article-title":"Characterization of dense granule metalloproteinase INS-16 in Cryptosporidium parvum","volume":"23","author":"Cui","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chom.2023.03.001_bib62","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nature13574","article-title":"PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes","volume":"511","author":"Beck","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chom.2023.03.001_bib63","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.chom.2013.03.002","article-title":"Host cell subversion by toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression","volume":"13","author":"Bougdour","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2023.03.001_bib64","doi-asserted-by":"crossref","first-page":"e1000767","DOI":"10.1371\/journal.ppat.1000767","article-title":"Universal features of post-transcriptional gene regulation are critical for plasmodium zygote development","volume":"6","author":"Mair","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2023.03.001_bib65","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.tibs.2021.12.005","article-title":"Structural advances in sterol-sensing domain-containing proteins","volume":"47","author":"Wu","year":"2022","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.chom.2023.03.001_bib66","doi-asserted-by":"crossref","first-page":"e0326122","DOI":"10.1128\/mbio.03261-22","article-title":"Genetic ablation of a female specific Apetala 2 transcription factor blocks oocyst shedding in Cryptosporidium parvum","author":"Tandel","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.chom.2023.03.001_bib75","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.molbiopara.2006.12.010","article-title":"The immunological selection of recombinant peptides from Cryptosporidium parvum reveals 14 proteins expressed at the sporozoite stage, 7 of which are conserved in other Apicomplexa","volume":"152","author":"Trasarti","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.chom.2023.03.001_bib72","series-title":"Density-Based Clustering Based on Hierarchical Density Estimates","first-page":"160","author":"Campello","year":"2013"},{"key":"10.1016\/j.chom.2023.03.001_bib74","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s13059-019-1832-y","article-title":"OrthoFinder: phylogenetic orthology inference for comparative genomics","volume":"20","author":"Emms","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.chom.2023.03.001_bib73","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"Krogh","year":"2001","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.chom.2023.03.001_bib67","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/978-1-4939-9748-0_13","article-title":"Genetic manipulation of Cryptosporidium parvum with CRISPR\/Cas9","volume":"2052","author":"Sateriale","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.chom.2023.03.001_bib68","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-1-0716-1681-9_8","article-title":"Coupling auxin-inducible Degron system with ultrastructure expansion microscopy to accelerate the discovery of gene function in Toxoplasma gondii","volume":"2369","author":"Dos Santos Pacheco","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.chom.2023.03.001_bib69","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/nprot.2017.026","article-title":"Using hyperLOPIT to perform high-resolution mapping of the spatial proteome","volume":"12","author":"Mulvey","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.chom.2023.03.001_bib70","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1586\/epr.12.15","article-title":"High-pH reversed-phase chromatography with fraction concatenation for 2D proteomic analysis","volume":"9","author":"Yang","year":"2012","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.chom.2023.03.001_bib71","doi-asserted-by":"crossref","first-page":"D898","DOI":"10.1093\/nar\/gkab929","article-title":"VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center","volume":"50","author":"Amos","year":"2022","journal-title":"Nucleic Acids Res."}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312823001051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312823001051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:34:42Z","timestamp":1761827682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312823001051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":75,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S1931312823001051"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2023.03.001","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cryptosporidium uses multiple distinct secretory organelles to interact with and modify its host cell","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2023.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}