{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:15:44Z","timestamp":1790766944092,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["2018-02330"],"award-info":[{"award-number":["2018-02330"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["2020-06121"],"award-info":[{"award-number":["2020-06121"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["2021-01141"],"award-info":[{"award-number":["2021-01141"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["2021-04779"],"award-info":[{"award-number":["2021-04779"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["2021.0136"],"award-info":[{"award-number":["2021.0136"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["2022-01313"],"award-info":[{"award-number":["2022-01313"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007231","name":"Cancerf\u00f6reningen i Stockholm","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018713","name":"Center for Innovative Medicine","doi-asserted-by":"publisher","award":["FoUI-988204"],"award-info":[{"award-number":["FoUI-988204"]}],"id":[{"id":"10.13039\/501100018713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Stiftelse","doi-asserted-by":"publisher","award":["M20-0190"],"award-info":[{"award-number":["M20-0190"]}],"id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["2019-00969"],"award-info":[{"award-number":["2019-00969"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["2021-00513"],"award-info":[{"award-number":["2021-00513"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["2022-01719"],"award-info":[{"award-number":["2022-01719"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["496946670"],"award-info":[{"award-number":["496946670"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["22 2237 Pj"],"award-info":[{"award-number":["22 2237 Pj"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","award":["CG-22 0009"],"award-info":[{"award-number":["CG-22 0009"]}],"id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["101046016"],"award-info":[{"award-number":["101046016"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.chom.2023.12.010","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T10:28:06Z","timestamp":1704882486000},"page":"156-161.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Memory T\u00a0cells effectively recognize the SARS-CoV-2 hypermutated BA.2.86 variant"],"prefix":"10.1016","volume":"32","author":[{"given":"Thomas R.","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriana","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puran","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotta","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Mielke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Vesterbacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Akber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"S\u00f6derdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.I. Edvard","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Lor\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret S\u00e4llberg","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Ljungman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna M.","family":"Ingelman-Sundberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Gustaf","family":"Ljunggren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"\u00d6sterborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Grifoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo","family":"Aleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-1719","authenticated-orcid":false,"given":"Marcus","family":"Buggert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2023.12.010_bib1","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.15585\/mmwr.mm7243a2","article-title":"Early detection and surveillance of the SARS-CoV-2 variant BA.2.86\u00a0\u2013 Worldwide, July-October 2023","volume":"72","author":"Lambrou","year":"2023","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.chom.2023.12.010_bib2","doi-asserted-by":"crossref","first-page":"2300460","DOI":"10.2807\/1560-7917.ES.2023.28.36.2300460","article-title":"First cases of SARS-CoV-2 BA.2.86 in Denmark, 2023","volume":"28","author":"Rasmussen","year":"2023","journal-title":"Euro Surveill."},{"key":"10.1016\/j.chom.2023.12.010_bib3","doi-asserted-by":"crossref","first-page":"e457","DOI":"10.1016\/S1473-3099(23)00573-X","article-title":"Antigenicity and infectivity characterisation of SARS-CoV-2 BA.2.86","volume":"23","author":"Yang","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chom.2023.12.010_bib4","doi-asserted-by":"crossref","first-page":"2300489","DOI":"10.2807\/1560-7917.ES.2023.28.39.2300489","article-title":"High attack rate in a large care home outbreak of SARS-CoV-2 BA.2.86, East of England, August 2023","volume":"28","author":"Reeve","year":"2023","journal-title":"Euro Surveill."},{"key":"10.1016\/j.chom.2023.12.010_bib5","doi-asserted-by":"crossref","first-page":"e460","DOI":"10.1016\/S1473-3099(23)00575-3","article-title":"Transmissibility, infectivity, and immune evasion of the SARS-CoV-2 BA.2.86 variant","volume":"23","author":"Uriu","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chom.2023.12.010_bib6","doi-asserted-by":"crossref","first-page":"e462","DOI":"10.1016\/S1473-3099(23)00588-1","article-title":"Sensitivity of the SARS-CoV-2 BA.2.86 variant to prevailing neutralising antibody responses","volume":"23","author":"Sheward","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chom.2023.12.010_bib7","doi-asserted-by":"crossref","first-page":"2271089","DOI":"10.1080\/22221751.2023.2271089","article-title":"Less neutralization evasion of SARS-CoV-2 BA.2.86 than XBB sublineages and CH.1.1","volume":"12","author":"Hu","year":"2023","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.chom.2023.12.010_bib8","doi-asserted-by":"crossref","first-page":"6904","DOI":"10.1016\/j.vaccine.2023.10.051","article-title":"Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86","volume":"41","author":"Lasrado","year":"2023","journal-title":"Vaccine"},{"key":"10.1016\/j.chom.2023.12.010_bib9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41577-022-00716-1","article-title":"Disentangling the relative importance of T\u00a0cell responses in COVID-19: leading actors or supporting cast?","volume":"22","author":"Kent","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2023.12.010_bib10","doi-asserted-by":"crossref","first-page":"eabq7647","DOI":"10.1126\/sciimmunol.abq7647","article-title":"CD8 T\u00a0cells contribute to vaccine protection against SARS-CoV-2 in macaques","volume":"7","author":"Liu","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.chom.2023.12.010_bib11","doi-asserted-by":"crossref","first-page":"eabg5021","DOI":"10.1126\/sciimmunol.abg5021","article-title":"Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in COVID-19 patients","volume":"6","author":"Notarbartolo","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.chom.2023.12.010_bib12","doi-asserted-by":"crossref","first-page":"eadh4529","DOI":"10.1126\/scitranslmed.adh4529","article-title":"T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19","volume":"15","author":"Zonozi","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chom.2023.12.010_bib13","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/j.immuni.2022.07.005","article-title":"Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T\u00a0cells elicited by mRNA vaccination","volume":"55","author":"Gao","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2023.12.010_bib14","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1182\/blood.2020006965","article-title":"Outcomes of COVID-19 in patients with CLL: a multicenter international experience","volume":"136","author":"Mato","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.chom.2023.12.010_bib15","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.chom.2023.08.006","article-title":"Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV-specific CD4+ and CD8+ T\u00a0cells","volume":"31","author":"Dub\u00e9","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2023.12.010_bib16","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/s41591-022-01700-x","article-title":"Ancestral SARS-CoV-2-specific T\u00a0cells cross-recognize the Omicron variant","volume":"28","author":"Gao","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2023.12.010_bib17","doi-asserted-by":"crossref","first-page":"eadg9452","DOI":"10.1126\/scitranslmed.adg9452","article-title":"Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T\u00a0cell immunity across immunocompromised states","volume":"15","author":"M\u00fcller","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chom.2023.12.010_bib18","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.cell.2022.01.029","article-title":"T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals","volume":"185","author":"Naranbhai","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.chom.2023.12.010_bib19","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.cell.2022.01.015","article-title":"SARS-CoV-2 vaccination induces immunological T\u00a0cell memory able to cross-recognize variants from Alpha to Omicron","volume":"185","author":"Tarke","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.chom.2023.12.010_bib20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1001\/jamaneurol.2022.0245","article-title":"Omicron-specific cytotoxic T-cell responses after a third dose of mRNA COVID-19 vaccine among patients with multiple sclerosis treated with ocrelizumab","volume":"79","author":"Madelon","year":"2022","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.chom.2023.12.010_bib21","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S1473-3099(22)00801-5","article-title":"Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease: a systematic review and meta-regression","volume":"23","author":"Bobrovitz","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chom.2023.12.010_bib22","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.immuni.2023.02.017","article-title":"SARS-CoV-2 breakthrough infection induces rapid memory and de novo T\u00a0cell responses","volume":"56","author":"Koutsakos","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2023.12.010_bib23","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/s41590-023-01613-y","article-title":"Prior vaccination promotes early activation of memory T\u00a0cells and enhances immune responses during SARS-CoV-2 breakthrough infection","volume":"24","author":"Painter","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2023.12.010_bib24","article-title":"Pre-existing SARS-2-specific T\u00a0cells are predicted to cross-recognize BA.2.86","author":"Sette","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2023.12.010_bib25","doi-asserted-by":"crossref","first-page":"103705","DOI":"10.1016\/j.ebiom.2021.103705","article-title":"Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial","volume":"74","author":"Bergman","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.chom.2023.12.010_bib26","doi-asserted-by":"crossref","first-page":"104700","DOI":"10.1016\/j.ebiom.2023.104700","article-title":"Real-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a one-year follow-up of the prospective clinical trial COVAXID","volume":"94","author":"Chen","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.chom.2023.12.010_bib27","doi-asserted-by":"crossref","first-page":"eabk0894","DOI":"10.1126\/sciimmunol.abk0894","article-title":"Identification of resident memory CD8+ T\u00a0cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue","volume":"6","author":"Niessl","year":"2021","journal-title":"Sci. Immunol."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193131282300505X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193131282300505X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:33:45Z","timestamp":1761827625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193131282300505X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S193131282300505X"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2023.12.010","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Memory T\u00a0cells effectively recognize the SARS-CoV-2 hypermutated BA.2.86 variant","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2023.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2023.12.003","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}