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Sci."},{"key":"10.1016\/j.chom.2024.06.015_bib59","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature13087","article-title":"A predictive fitness model for influenza","volume":"507","author":"Luksza","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chom.2024.06.015_bib60","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1534\/genetics.106.067678","article-title":"Beneficial mutation selection balance and the effect of linkage on positive selection","volume":"176","author":"Desai","year":"2007","journal-title":"Genetics"},{"key":"10.1016\/j.chom.2024.06.015_bib61","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.aaz8432","article-title":"Influenza vaccine-induced human bone marrow plasma cells decline within a year after vaccination","volume":"370","author":"Davis","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.chom.2024.06.015_bib62","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nature07231","article-title":"Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors","volume":"455","author":"Yu","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.chom.2024.06.015_bib63","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1128\/JVI.03509-12","article-title":"H3N2 influenza virus infection induces broadly reactive hemagglutinin stalk antibodies in humans and mice","volume":"87","author":"Margine","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2024.06.015_bib64","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.vaccine.2014.06.052","article-title":"Waning vaccine protection against influenza A (H3N2) illness in children and older adults during a single season","volume":"33","author":"Belongia","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.chom.2024.06.015_bib65","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1056\/NEJMc0907256","article-title":"Older age and a reduced likelihood of 2009 H1N1 virus infection","volume":"361","author":"Fisman","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2024.06.015_bib66","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa0906453","article-title":"Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus","volume":"361","author":"Hancock","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2024.06.015_bib67","doi-asserted-by":"crossref","DOI":"10.2807\/ese.18.05.20390-en","article-title":"Low and decreasing vaccine effectiveness against influenza A(H3) in 2011\/12 among vaccination target groups in Europe: results from the I-MOVE multicentre case-control study","volume":"18","author":"Kissling","year":"2013","journal-title":"Euro Surveill."},{"key":"10.1016\/j.chom.2024.06.015_bib68","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1093\/infdis\/jiv313","article-title":"Persistence of antibodies to influenza hemagglutinin and neuraminidase following one or two years of influenza vaccination","volume":"212","author":"Petrie","year":"2015","journal-title":"J.\u00a0Infect. 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Dis."},{"key":"10.1016\/j.chom.2024.06.015_bib74","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/zph.12364","article-title":"Hepatitis E in southern Vietnam: seroepidemiology in humans and molecular epidemiology in pigs","volume":"65","author":"Berto","year":"2018","journal-title":"Zoonoses Public Health"},{"key":"10.1016\/j.chom.2024.06.015_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006246","article-title":"Evidence of previous but not current transmission of Chikungunya virus in southern and central Vietnam: results from a systematic review and a seroprevalence study in four locations","volume":"12","author":"Quan","year":"2018","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.chom.2024.06.015_bib76","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2019.0207","article-title":"Serological inference of past primary and secondary dengue infection: implications for vaccination","volume":"16","author":"Lam","year":"2019","journal-title":"J.\u00a0R. Soc. Interface"},{"key":"10.1016\/j.chom.2024.06.015_bib77","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-26948-8","article-title":"Age-seroprevalence curves for the multi-strain structure of influenza A virus","volume":"12","author":"Vinh","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2024.06.015_bib78","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1016\/j.vaccine.2023.02.036","article-title":"Seroprotection against tetanus in southern Vietnam","volume":"41","author":"Thwaites","year":"2023","journal-title":"Vaccine"},{"key":"10.1016\/j.chom.2024.06.015_bib79","doi-asserted-by":"crossref","DOI":"10.1186\/s12985-021-01504-4","article-title":"Packaging signal of influenza A virus","volume":"18","author":"Li","year":"2021","journal-title":"Virol. J."},{"key":"10.1016\/j.chom.2024.06.015_bib80","doi-asserted-by":"crossref","first-page":"15891","DOI":"10.1073\/pnas.0908897106","article-title":"Rewiring the RNAs of influenza virus to prevent reassortment","volume":"106","author":"Gao","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2024.06.015_bib81","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1006\/viro.2000.0228","article-title":"The cytoplasmic tails of the influenza virus spike glycoproteins are required for normal genome packaging","volume":"269","author":"Zhang","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.chom.2024.06.015_bib82","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.chom.2017.05.011","article-title":"Diversity of functionally permissive sequences in the receptor-binding site of influenza hemagglutinin","volume":"21","author":"Wu","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2024.06.015_bib83","doi-asserted-by":"crossref","first-page":"9345","DOI":"10.1073\/pnas.96.16.9345","article-title":"Generation of influenza A viruses entirely from cloned cDNAs","volume":"96","author":"Neumann","year":"1999","journal-title":"Proc. Natl. Acad. Sci. 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Evol."},{"key":"10.1016\/j.chom.2024.06.015_bib85","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.cell.2020.08.012","article-title":"Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding","volume":"182","author":"Starr","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.chom.2024.06.015_bib86","doi-asserted-by":"crossref","first-page":"12531","DOI":"10.1128\/JVI.01889-13","article-title":"A mutant influenza virus that uses an N1 neuraminidase as the receptor-binding protein","volume":"87","author":"Hooper","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2024.06.015_bib87","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03665-3","article-title":"How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin","volume":"9","author":"Doud","year":"2018","journal-title":"Nat. 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