{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:41:34Z","timestamp":1792856494920,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["09203466"],"award-info":[{"award-number":["09203466"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001839","name":"University Grants Committee","doi-asserted-by":"publisher","award":["14117122"],"award-info":[{"award-number":["14117122"]}],"id":[{"id":"10.13039\/501100001839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["8601370"],"award-info":[{"award-number":["8601370"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173999"],"award-info":[{"award-number":["82173999"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8423003"],"award-info":[{"award-number":["8423003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022720","name":"Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022720","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["SGDX20210823103534005"],"award-info":[{"award-number":["SGDX20210823103534005"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.chom.2024.11.013","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T10:46:04Z","timestamp":1734605164000},"page":"104-118.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Roseburia intestinalis-derived butyrate alleviates neuropathic pain"],"prefix":"10.1016","volume":"33","author":[{"given":"Yanjun","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idy Hiu Ting","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenfen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaomin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songbin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Likai","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huarong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Gin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew Tak Vai","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Ka Kei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2024.11.013_bib1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/WCO.0000000000000092","article-title":"Neurological complications of varicella zoster virus reactivation","volume":"27","author":"Nagel","year":"2014","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.chom.2024.11.013_bib2","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1080\/21645515.2020.1847582","article-title":"A systematic literature review of herpes zoster incidence worldwide","volume":"17","author":"van Oorschot","year":"2021","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.chom.2024.11.013_bib3","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-004833","article-title":"Systematic review of incidence and complications of herpes zoster: towards a global perspective","volume":"4","author":"Kawai","year":"2014","journal-title":"BMJ Open"},{"key":"10.1016\/j.chom.2024.11.013_bib4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0885-3924(00)00218-9","article-title":"Antidepressants and anticonvulsants for diabetic neuropathy and postherpetic neuralgia: a quantitative systematic review","volume":"20","author":"Collins","year":"2000","journal-title":"J.\u00a0Pain Symptom Manag."},{"key":"10.1016\/j.chom.2024.11.013_bib5","article-title":"Antiviral treatment for preventing postherpetic neuralgia","volume":"2014","author":"Chen","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.chom.2024.11.013_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-15342-5","article-title":"Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease","volume":"11","author":"Ryan","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2024.11.013_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1053\/j.gastro.2019.03.049","article-title":"Gut microbiota in patients with irritable bowel syndrome-A systematic review","volume":"157","author":"Pittayanon","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.chom.2024.11.013_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104055","article-title":"Gut dysbiosis in rheumatic diseases: A systematic review and meta-analysis of 92 observational studies","volume":"80","author":"Wang","year":"2022","journal-title":"EBiomedicine"},{"key":"10.1016\/j.chom.2024.11.013_bib9","first-page":"778","article-title":"Faecal microbiota composition associates with abdominal pain in the general population","volume":"67","author":"Hadizadeh","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.chom.2024.11.013_bib10","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1097\/j.pain.0000000000001640","article-title":"Altered microbiome composition in individuals with fibromyalgia","volume":"160","author":"Minerbi","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.chom.2024.11.013_bib11","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nn.4606","article-title":"Gut microbiota is critical for the induction of chemotherapy-induced pain","volume":"20","author":"Shen","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chom.2024.11.013_bib12","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-022-02523-w","article-title":"Gut microbiota depletion by antibiotics ameliorates somatic neuropathic pain induced by nerve injury, chemotherapy, and diabetes in mice","volume":"19","author":"Ma","year":"2022","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.chom.2024.11.013_bib13","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/jgh.14536","article-title":"Beneficial effect of butyrate-producing Lachnospiraceae on\u00a0stress-induced visceral hypersensitivity in rats","volume":"34","author":"Zhang","year":"2019","journal-title":"J.\u00a0Gastroenterol. Hepatol."},{"key":"10.1016\/j.chom.2024.11.013_bib14","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/abbs\/gmx138","article-title":"Clostridium butyricum regulates visceral hypersensitivity of irritable bowel syndrome by inhibiting colonic mucous low grade inflammation through its action on NLRP6","volume":"50","author":"Zhao","year":"2018","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.chom.2024.11.013_bib15","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1136\/gutjnl-2021-325177","article-title":"Two microbiota subtypes identified in irritable bowel syndrome with distinct responses to the low FODMAP diet","volume":"71","author":"Vervier","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.chom.2024.11.013_bib16","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","article-title":"Gut microbiome structure and metabolic activity in inflammatory bowel disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2024.11.013_bib17","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.neuron.2021.12.020","article-title":"Internal senses of the vagus nerve","volume":"110","author":"Prescott","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.chom.2024.11.013_bib18","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41586-022-05139-5","article-title":"A brainstem map for visceral sensations","volume":"609","author":"Ran","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.chom.2024.11.013_bib19","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.neuron.2016.01.040","article-title":"DREADDs for neuroscientists","volume":"89","author":"Roth","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.chom.2024.11.013_bib20","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.3748\/wjg.v25.i40.6077","article-title":"Nucleus tractus solitarius mediates hyperalgesia induced by chronic pancreatitis in rats","volume":"25","author":"Bai","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.chom.2024.11.013_bib21","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1128\/AEM.69.7.4320-4324.2003","article-title":"Oligonucleotide probes that detect quantitatively significant groups of butyrate-producing bacteria in human feces","volume":"69","author":"Hold","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.chom.2024.11.013_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.757718","article-title":"Roseburia intestinalis: A Beneficial Gut Organism from the Discoveries in Genus and Species","volume":"11","author":"Nie","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.chom.2024.11.013_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/1462-2920.13589","article-title":"Formation of propionate and butyrate by the human colonic microbiota","volume":"19","author":"Louis","year":"2017","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.chom.2024.11.013_bib24","article-title":"Vaginal dysbiosis associated-bacteria Megasphaera elsdenii and Prevotella timonensis induce immune activation via dendritic cells","volume":"138","author":"van Teijlingen","year":"2020","journal-title":"J.\u00a0Reprod. Immunol."},{"key":"10.1016\/j.chom.2024.11.013_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00379","article-title":"Oral administration of Flavonifractor plautii strongly suppresses Th2 immune responses in mice","volume":"11","author":"Ogita","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chom.2024.11.013_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104834","article-title":"The microbial metabolite desaminotyrosine enhances T-cell priming and cancer immunotherapy with immune checkpoint inhibitors","volume":"97","author":"Joachim","year":"2023","journal-title":"EBiomedicine"},{"key":"10.1016\/j.chom.2024.11.013_bib27","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jmoldx.2019.01.006","article-title":"Leveraging human microbiome features to diagnose and stratify children with irritable bowel syndrome","volume":"21","author":"Hollister","year":"2019","journal-title":"J.\u00a0Mol. Diagn."},{"key":"10.1016\/j.chom.2024.11.013_bib28","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.chom.2014.02.005","article-title":"The treatment-naive microbiome in new-onset Crohn's disease","volume":"15","author":"Gevers","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2024.11.013_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-018-0603-4","article-title":"A comparative study of the gut microbiota in immune-mediated inflammatory diseases-does a common dysbiosis exist?","volume":"6","author":"Forbes","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.chom.2024.11.013_bib30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/gutjnl-2015-309800","article-title":"Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer","volume":"66","author":"Yu","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.chom.2024.11.013_bib31","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1158\/1078-0432.CCR-16-1599","article-title":"Fecal bacteria act as novel biomarkers for noninvasive diagnosis of colorectal cancer","volume":"23","author":"Liang","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.chom.2024.11.013_bib32","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.3945\/ajcn.112.046607","article-title":"Decreased dietary fiber intake and structural alteration of gut microbiota in patients with advanced colorectal adenoma","volume":"97","author":"Chen","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.chom.2024.11.013_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.chom.2024.11.013_bib34","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/mds.26307","article-title":"Colonic bacterial composition in Parkinson's disease","volume":"30","author":"Keshavarzian","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.chom.2024.11.013_bib35","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/mp.2016.44","article-title":"Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism","volume":"21","author":"Zheng","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.chom.2024.11.013_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2018.00049","article-title":"The vagus nerve at the interface of the microbiota-gut-brain axis","volume":"12","author":"Bonaz","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.chom.2024.11.013_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105893","article-title":"An NTS-CeA projection modulates depression-like behaviors in a mouse model of chronic pain","volume":"174","author":"He","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.chom.2024.11.013_bib38","doi-asserted-by":"crossref","first-page":"7041","DOI":"10.1523\/JNEUROSCI.5128-14.2015","article-title":"Distinct brainstem and forebrain circuits receiving tracheal sensory neuron inputs revealed using a novel conditional anterograde transsynaptic viral tracing system","volume":"35","author":"McGovern","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.chom.2024.11.013_bib39","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1053\/j.gastro.2016.10.046","article-title":"The vagus\u00a0nerve in appetite regulation, mood, and intestinal inflammation","volume":"152","author":"Browning","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.chom.2024.11.013_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2018.00044","article-title":"Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders","volume":"9","author":"Breit","year":"2018","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.chom.2024.11.013_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.668337","article-title":"Optogenetic manipulations of amygdala neurons modulate spinal nociceptive processing and behavior under normal conditions and in an arthritis pain model","volume":"12","author":"Mazzitelli","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.chom.2024.11.013_bib42","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41386-023-01673-6","article-title":"The parabrachial to central amygdala pathway is critical to injury-induced pain sensitization in mice","volume":"49","author":"Torres-Rodriguez","year":"2024","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.chom.2024.11.013_bib43","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.78610","article-title":"Cellular mechanisms underlying central sensitization in a mouse model of chronic muscle pain","volume":"11","author":"Lin","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.chom.2024.11.013_bib44","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.celrep.2019.09.011","article-title":"Dual and opposing functions of the central amygdala in the modulation of pain","volume":"29","author":"Wilson","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2024.11.013_bib45","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cell.2015.05.057","article-title":"Elucidating an affective pain circuit that creates a threat memory","volume":"162","author":"Han","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.chom.2024.11.013_bib46","article-title":"Neuronal cell types, projections, and spatial organization of the central amygdala","volume":"25","author":"O'Leary","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.chom.2024.11.013_bib47","doi-asserted-by":"crossref","first-page":"26482","DOI":"10.1073\/pnas.2006065117","article-title":"Fecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice","volume":"117","author":"Bonomo","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2024.11.013_bib48","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jfma.2013.05.013","article-title":"Attenuation of neuropathic pain by sodium butyrate in an experimental model of chronic constriction injury in rats","volume":"113","author":"Kukkar","year":"2014","journal-title":"J.\u00a0Formos. Med. Assoc."},{"key":"10.1016\/j.chom.2024.11.013_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56132-4","article-title":"Butyrate inhibits visceral allodynia and colonic hyperpermeability in rat models of irritable bowel syndrome","volume":"9","author":"Nozu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chom.2024.11.013_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004226","article-title":"Sparse and compositionally robust inference of microbial ecological networks","volume":"11","author":"Kurtz","year":"2015","journal-title":"PLOS Comput. Biol."},{"key":"10.1016\/j.chom.2024.11.013_bib51","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-019-1758-4","article-title":"Cytoscape Automation: empowering workflow-based network analysis","volume":"20","author":"Otasek","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.chom.2024.11.013_bib52","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65088","article-title":"Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3","volume":"10","author":"Beghini","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.chom.2024.11.013_bib53","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1080\/01621459.1965.10480843","article-title":"The up-and-down method for small samples","volume":"60","author":"Dixon","year":"1965","journal-title":"J.\u00a0Am.\u00a0Stat. Assoc."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193131282400444X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193131282400444X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T13:17:19Z","timestamp":1764163039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193131282400444X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S193131282400444X"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2024.11.013","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roseburia intestinalis-derived butyrate alleviates neuropathic pain","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2024.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}