{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:20:15Z","timestamp":1793949615520,"version":"4.8.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA0806403"],"award-info":[{"award-number":["2022YFA0806403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011199","name":"State Key Laboratory of Microbial Resources, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371643"],"award-info":[{"award-number":["82371643"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341226"],"award-info":[{"award-number":["82341226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82288102"],"award-info":[{"award-number":["82288102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92357305"],"award-info":[{"award-number":["92357305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130022"],"award-info":[{"award-number":["82130022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31925021"],"award-info":[{"award-number":["31925021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82422017"],"award-info":[{"award-number":["82422017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82022028"],"award-info":[{"award-number":["82022028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370812"],"award-info":[{"award-number":["82370812"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.chom.2024.12.006","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T10:35:28Z","timestamp":1736332528000},"page":"119-136.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["The intestinal fungus Aspergillus tubingensis promotes polycystic ovary syndrome through a secondary metabolite"],"prefix":"10.1016","volume":"33","author":[{"given":"Jiayu","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meisong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixing","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengwei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyu","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-bing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-2372","authenticated-orcid":false,"given":"Changtao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2024.12.006_bib1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.chom.2024.12.006_bib2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","article-title":"Polycystic ovary syndrome","volume":"370","author":"Norman","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2024.12.006_bib3","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1093\/humrep\/dew218","article-title":"The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis","volume":"31","author":"Bozdag","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.chom.2024.12.006_bib4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cmet.2021.01.004","article-title":"Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process","volume":"33","author":"Mimouni","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.chom.2024.12.006_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nrendo.2016.193","article-title":"An updated view of hypothalamic-vascular-pituitary unit function and plasticity","volume":"13","author":"Le Tissier","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.chom.2024.12.006_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s40168-021-01046-5","article-title":"Androgen-induced gut dysbiosis disrupts glucolipid metabolism and endocrinal functions in polycystic ovary syndrome","volume":"9","author":"Han","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.chom.2024.12.006_bib7","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1210\/jc.2017-02153","article-title":"Gut Microbial Diversity in Women With Polycystic Ovary Syndrome Correlates With Hyperandrogenism","volume":"103","author":"Torres","year":"2018","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.chom.2024.12.006_bib8","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00017-19","article-title":"Probiotic Bifidobacterium lactis V9 Regulates the Secretion of Sex Hormones in Polycystic Ovary Syndrome Patients through the Gut-Brain Axis","volume":"4","author":"Zhang","year":"2019","journal-title":"mSystems"},{"key":"10.1016\/j.chom.2024.12.006_bib9","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/s41591-019-0509-0","article-title":"Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome","volume":"25","author":"Qi","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2024.12.006_bib10","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1016\/j.cell.2022.09.015","article-title":"A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors","volume":"185","author":"Dohlman","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.chom.2024.12.006_bib11","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nri.2017.55","article-title":"Fungal dysbiosis: immunity and interactions at mucosal barriers","volume":"17","author":"Iliev","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2024.12.006_bib12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s13205-022-03141-2","article-title":"Isomaltooligosaccharides utilization and genomic characterization of human infant anti-inflammatory Bifidobacterium longum and Bifidobacterium breve strains","volume":"12","author":"Sharma","year":"2022","journal-title":"3 Biotech"},{"key":"10.1016\/j.chom.2024.12.006_bib13","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/s42003-021-02753-3","article-title":"The gut commensal fungus, Candida parapsilosis, promotes high fat-diet induced obesity in mice","volume":"4","author":"Sun","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.chom.2024.12.006_bib14","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2020.1830693","article-title":"Therapeutic manipulation of gut microbiota by polysaccharides of Wolfiporia cocos reveals the contribution of the gut fungi-induced PGE2 to alcoholic hepatic steatosis","volume":"12","author":"Sun","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.chom.2024.12.006_bib15","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1053\/j.gastro.2020.09.014","article-title":"Population-Level Configurations of Gut Mycobiome Across 6 Ethnicities in Urban and Rural China","volume":"160","author":"Sun","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.chom.2024.12.006_bib16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41579-018-0121-1","article-title":"Fungal secondary metabolism: regulation, function and drug discovery","volume":"17","author":"Keller","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2024.12.006_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17132-4","article-title":"Culturomics and Amplicon-based Metagenomic Approaches for the Study of Fungal Population in Human Gut Microbiota","volume":"7","author":"Hamad","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chom.2024.12.006_bib18","doi-asserted-by":"crossref","first-page":"D490","DOI":"10.1093\/nar\/gkt1178","article-title":"The carbohydrate-active enzymes database (CAZy) in 2013","volume":"42","author":"Lombard","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chom.2024.12.006_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02583-16","article-title":"Drug Sensitivity and Resistance Mechanism in Aspergillus Section Nigri Strains from Japan","volume":"61","author":"Hashimoto","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chom.2024.12.006_bib20","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3852\/15-147","article-title":"The human gut mycobiome: pitfalls and potentials-a mycologist\u2019s perspective","volume":"107","author":"Suhr","year":"2015","journal-title":"Mycologia"},{"key":"10.1016\/j.chom.2024.12.006_bib21","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.mycmed.2018.02.013","article-title":"Identification of Aspergillus tubingensis in a primary skin infection","volume":"28","author":"Fr\u00edas-De-Le\u00f3n","year":"2018","journal-title":"J.\u00a0Mycol. Med."},{"key":"10.1016\/j.chom.2024.12.006_bib22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jiac.2019.10.022","article-title":"Fatal invasive pulmonary aspergillosis caused by voriconazole-resistant Aspergillus tubingensis in a patient with solid tumor","volume":"26","author":"Harada","year":"2020","journal-title":"J.\u00a0Infect. Chemother."},{"key":"10.1016\/j.chom.2024.12.006_bib23","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.freeradbiomed.2012.10.554","article-title":"Role of oxygen gradients in shaping redox relationships between the human intestine and its microbiota","volume":"55","author":"Espey","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.chom.2024.12.006_bib24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mib.2019.09.010","article-title":"Gut mycobiota under scrutiny: fungal symbionts or environmental transients?","volume":"50","author":"Fiers","year":"2019","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.chom.2024.12.006_bib25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/00275514.2019.1698246","article-title":"Carbon metabolic profiling of Trichoderma strains provides insight into potential ecological niches","volume":"112","author":"Wang","year":"2020","journal-title":"Mycologia"},{"key":"10.1016\/j.chom.2024.12.006_bib26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1530\/JOE-19-0589","article-title":"The therapeutic effect of interleukin-22 in high androgen-induced polycystic ovary syndrome","volume":"245","author":"Qi","year":"2020","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.chom.2024.12.006_bib27","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41586-019-0899-7","article-title":"Interleukin-22 protects intestinal stem cells against genotoxic stress","volume":"566","author":"Gronke","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.chom.2024.12.006_bib28","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1126\/science.1214914","article-title":"Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles","volume":"334","author":"Kiss","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.chom.2024.12.006_bib29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2011.11.011","article-title":"The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells","volume":"36","author":"Qiu","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2024.12.006_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-16431-1","article-title":"Intestinal fungi are causally implicated in microbiome assembly and immune development in mice","volume":"11","author":"van Tilburg Bernardes","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2024.12.006_bib31","series-title":"Fungal Physiology and Immunopathogenesis","first-page":"265","article-title":"Fungi as Part of the Microbiota and Interactions with Intestinal Bacteria","author":"Kapitan","year":"2019"},{"key":"10.1016\/j.chom.2024.12.006_bib32","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41586-022-04502-w","article-title":"Immune regulation by fungal strain diversity in inflammatory bowel disease","volume":"603","author":"Li","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.chom.2024.12.006_bib33","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/195502a0","article-title":"FONSECIN, A NAPHTHOPYRONE PIGMENT FROM A MUTANT OF ASPERGILLUS FONSECAEUS","volume":"195","author":"Galmarini","year":"1962","journal-title":"Nature"},{"key":"10.1016\/j.chom.2024.12.006_bib34","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1021\/jo01012a027","article-title":"FONSECIN A PIGMENT FROM AN ASPERGILLUS FONSECAEUS MUTANT","volume":"30","author":"Galmarin","year":"1965","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.chom.2024.12.006_bib35","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.chom.2019.12.005","article-title":"Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes","volume":"27","author":"Puyskens","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2024.12.006_bib36","first-page":"400","article-title":"Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis","volume":"9","author":"Sherman","year":"2018","journal-title":"Gut Microbes"},{"key":"10.1016\/j.chom.2024.12.006_bib37","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev-genet-120215-035203","article-title":"Regulation and Role of Fungal Secondary Metabolites","volume":"50","author":"Macheleidt","year":"2016","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.chom.2024.12.006_bib38","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.cell.2020.08.048","article-title":"Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption","volume":"183","author":"Chikina","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.chom.2024.12.006_bib39","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nature16460","article-title":"Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration","volume":"528","author":"Lindemans","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.chom.2024.12.006_bib40","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.immuni.2013.08.003","article-title":"Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22","volume":"39","author":"Zelante","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2024.12.006_bib41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1530\/JOE-20-0068","article-title":"Rat BAT xenotransplantation recovers the fertility and metabolic health of PCOS mice","volume":"248","author":"Du","year":"2021","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.chom.2024.12.006_bib42","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1073\/pnas.1523236113","article-title":"Brown adipose tissue transplantation ameliorates polycystic ovary syndrome","volume":"113","author":"Yuan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2024.12.006_bib43","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature13564","article-title":"Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes","volume":"514","author":"Wang","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chom.2024.12.006_bib44","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jcmgh.2021.04.014","article-title":"Inulin Fermentable Fiber Ameliorates Type I Diabetes via IL22 and Short-Chain Fatty Acids in Experimental Models","volume":"12","author":"Zou","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.chom.2024.12.006_bib45","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41577-019-0125-8","article-title":"The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease","volume":"19","author":"Rothhammer","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2024.12.006_bib46","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","article-title":"Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease","volume":"23","author":"Agus","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2024.12.006_bib47","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature13323","article-title":"Aryl hydrocarbon receptor control of a disease tolerance defence pathway","volume":"511","author":"Bessede","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chom.2024.12.006_bib48","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nm.4102","article-title":"CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands","volume":"22","author":"Lamas","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2024.12.006_bib49","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature10491","article-title":"An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor","volume":"478","author":"Opitz","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.chom.2024.12.006_bib50","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1172\/JCI0214097","article-title":"CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation","volume":"109","author":"Ma","year":"2002","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2024.12.006_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-25412-x","article-title":"AHR signaling is induced by infection with coronaviruses","volume":"12","author":"Giovannoni","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2024.12.006_bib52","doi-asserted-by":"crossref","first-page":"16677","DOI":"10.1073\/pnas.0404379101","article-title":"Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development","volume":"101","author":"Walisser","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2024.12.006_bib53","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.1096472","article-title":"Thymic origin of intestinal alphabeta T\u00a0cells revealed by fate mapping of ROR gammat+ cells","volume":"305","author":"Eberl","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.chom.2024.12.006_bib54","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0378-1119(87)90131-4","article-title":"A 10-MINUTE DNA PREPARATION FROM YEAST EFFICIENTLY RELEASES AUTONOMOUS PLASMIDS FOR TRANSFORMATION OF ESCHERICHIA COLI","volume":"57","author":"Hoffman","year":"1987","journal-title":"Gene"},{"key":"10.1016\/j.chom.2024.12.006_bib55","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/glycob\/cwq106","article-title":"CAZymes Analysis Toolkit (CAT): web service for searching and analyzing carbohydrate-active enzymes in a newly sequenced organism using CAZy database","volume":"20","author":"Park","year":"2010","journal-title":"Glycobiology"},{"key":"10.1016\/j.chom.2024.12.006_bib56","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00928-21","article-title":"High-Level Diversity of Basal Fungal Lineages and the Control of Fungal Community Assembly by Stochastic Processes in Mangrove Sediments","volume":"87","author":"Zhang","year":"2021","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.chom.2024.12.006_bib57","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41579-018-0116-y","article-title":"Mycobiome diversity: high-throughput sequencing and identification of fungi","volume":"17","author":"Nilsson","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2024.12.006_bib58","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/1758-2229.12438","article-title":"Fungal identification biases in microbiome projects","volume":"8","author":"Tedersoo","year":"2016","journal-title":"Environ. Microbiol. Rep."},{"key":"10.1016\/j.chom.2024.12.006_bib59","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1365-294X.1993.tb00005.x","article-title":"ITS PRIMERS WITH ENHANCED SPECIFICITY FOR BASIDIOMYCETES - APPLICATION TO THE IDENTIFICATION OF MYCORRHIZAE AND RUSTS","volume":"2","author":"Gardes","year":"1993","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.chom.2024.12.006_bib73","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3390\/biology1030895","article-title":"FLEXBAR\u2014flexible barcode and adapter processing for next-generation sequencing platforms","volume":"1","author":"Dodt","year":"2012","journal-title":"Biology"},{"key":"10.1016\/j.chom.2024.12.006_bib60","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/nph.14776","article-title":"PacBio metabarcoding of Fungi and other eukaryotes: errors, biases and perspectives","volume":"217","author":"Tedersoo","year":"2018","journal-title":"New Phytol."},{"key":"10.1016\/j.chom.2024.12.006_bib61","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","article-title":"UCHIME improves sensitivity and speed of chimera detection","volume":"27","author":"Edgar","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2024.12.006_bib62","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41596-019-0264-1","article-title":"Using MicrobiomeAnalyst for comprehensive statistical, functional, and meta-analysis of microbiome data","volume":"15","author":"Chong","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.chom.2024.12.006_bib63","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.chom.2024.12.006_bib64","doi-asserted-by":"crossref","first-page":"W242","DOI":"10.1093\/nar\/gkw290","article-title":"Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees","volume":"44","author":"Letunic","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chom.2024.12.006_bib65","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S1087-1845(02)00583-2","article-title":"Genetic and metabolic diversity of Trichoderma: a case study on South-East Asian isolates","volume":"38","author":"Kubicek","year":"2003","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.chom.2024.12.006_bib66","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1126\/science.1222804","article-title":"Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex","volume":"337","author":"Huang","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.chom.2024.12.006_bib67","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/s42255-021-00414-7","article-title":"GTTs and ITTs in mice: simple tests, complex answers","volume":"3","author":"Virtue","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.chom.2024.12.006_bib68","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.cell.2017.04.026","article-title":"Metabolic Phenotypes of Response to Vaccination in Humans","volume":"169","author":"Li","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.chom.2024.12.006_bib69","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/ni.3318","article-title":"Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment","volume":"17","author":"Zhong","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2024.12.006_bib70","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nprot.2014.006","article-title":"Full-length RNA-seq from single cells using Smart-seq2","volume":"9","author":"Picelli","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.chom.2024.12.006_bib71","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2024.12.006_bib72","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312824004736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312824004736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:23:11Z","timestamp":1767838991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312824004736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S1931312824004736"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2024.12.006","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The intestinal fungus Aspergillus tubingensis promotes polycystic ovary syndrome through a secondary metabolite","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2024.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}