{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:14:27Z","timestamp":1792214067300,"version":"4.4.0"},"reference-count":92,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"am","delay-in-days":378,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003194","name":"New York Stem Cell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000008","name":"David and Lucile Packard Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000008","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.chom.2025.04.009","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T10:34:55Z","timestamp":1746095695000},"page":"621-631.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["An engineered gut bacterium protects against dietary methylmercury exposure in pregnant mice"],"prefix":"10.1016","volume":"33","author":[{"given":"Kristie B.","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franciscus","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena J.","family":"Coley-O\u2019Rourke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik T.","family":"Paulson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Novoselov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delanie","family":"Finnigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Paramo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene","family":"Lopez-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien S.","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina T.","family":"Schartup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1633-588X","authenticated-orcid":false,"given":"Elaine Y.","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2025.04.009_bib1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41586-019-1468-9","article-title":"Climate change and overfishing increase neurotoxicant in marine predators","volume":"572","author":"Schartup","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.04.009_bib2","doi-asserted-by":"crossref","DOI":"10.1088\/1748-9326\/ab281f","article-title":"Five hundred years of anthropogenic mercury: spatial and temporal release profiles","volume":"14","author":"Streets","year":"2019","journal-title":"Environ. Res. Lett."},{"key":"10.1016\/j.chom.2025.04.009_bib3","series-title":"Treatise on Geochemistry","first-page":"91","article-title":"11.4 - Geochemistry of Mercury in the Environment","author":"Fitzgerald","year":"2014"},{"key":"10.1016\/j.chom.2025.04.009_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.136827","article-title":"Understanding mercury methylation in the changing environment: Recent advances in assessing microbial methylators and mercury bioavailability","volume":"714","author":"Tang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chom.2025.04.009_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110462","article-title":"Mercury methylation in rice paddy and accumulation in rice plant: A review","volume":"195","author":"Zhao","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chom.2025.04.009_bib6","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1289\/ehp.1104494","article-title":"Evidence on the Human Health Effects of Low-Level Methylmercury Exposure","volume":"120","author":"Karagas","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chom.2025.04.009_bib7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0892-0362(97)00097-4","article-title":"Cognitive Deficit in 7-Year-Old Children with Prenatal Exposure to Methylmercury","volume":"19","author":"Grandjean","year":"1997","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chom.2025.04.009_bib8","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.scitotenv.2017.10.014","article-title":"Prenatal mercury exposure, fish intake and neurocognitive development during first three years of life: Prospective cohort mothers and Children\u2019s environmental health (MOCEH) study","volume":"615","author":"Kim","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chom.2025.04.009_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108682","article-title":"Combined prenatal exposure to mercury and LCPUFA on newborn\u2019s brain measures and neurodevelopment at the age of 18 months","volume":"178","author":"Ni\u0161evi\u0107","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.chom.2025.04.009_bib10","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1007\/s00204-023-03580-7","article-title":"Effects of low doses of methylmercury (MeHg) exposure on definitive endoderm cell differentiation in human embryonic stem cells","volume":"97","author":"Li","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chom.2025.04.009_bib11","series-title":"Toxicology","first-page":"137","article-title":"Methylmercury, oxidative stress, and neurodegeneration","author":"Bittencourt","year":"2021"},{"key":"10.1016\/j.chom.2025.04.009_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125586","article-title":"Toxicity of mercury: Molecular evidence","volume":"245","author":"Yang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.chom.2025.04.009_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.resconrec.2024.107858","article-title":"Trends and drivers of global dietary methylmercury exposure during 1995\u20132020","volume":"211","author":"Zhou","year":"2024","journal-title":"Resour. Conserv. Recy."},{"key":"10.1016\/j.chom.2025.04.009_bib14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s13181-013-0344-5","article-title":"The Role of Chelation in the Treatment of Arsenic and Mercury Poisoning","volume":"9","author":"Kosnett","year":"2013","journal-title":"J. Med. Toxicol."},{"key":"10.1016\/j.chom.2025.04.009_bib15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/24734306.2020.1870077","article-title":"Rethinking treatment of mercury poisoning: the roles of selenium, acetylcysteine, and thiol chelators in the treatment of mercury poisoning: a narrative review","volume":"5","author":"Spiller","year":"2021","journal-title":"Toxicol. Commun."},{"key":"10.1016\/j.chom.2025.04.009_bib16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40557-015-0086-8","article-title":"Evaluation of mercury exposure level, clinical diagnosis and treatment for mercury intoxication","volume":"28","author":"Ye","year":"2016","journal-title":"Ann. Occup. Environ. Med."},{"key":"10.1016\/j.chom.2025.04.009_bib17","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/clpt.2010.132","article-title":"Chelation for Heavy Metals (Arsenic, Lead, and Mercury): Protective or Perilous?","volume":"88","author":"Kosnett","year":"2010","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.chom.2025.04.009_bib18","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1007\/s00204-020-02847-7","article-title":"Heavy metal chelation tests: the misleading and hazardous promise","volume":"94","author":"Hoet","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chom.2025.04.009_bib19","doi-asserted-by":"crossref","first-page":"e01580","DOI":"10.1128\/mBio.01580-14","article-title":"Randomized Open-Label Pilot Study of the Influence of Probiotics and the Gut Microbiome on Toxic Metal Levels in Tanzanian Pregnant Women and School Children","volume":"5","author":"Bisanz","year":"2014","journal-title":"mBio"},{"key":"10.1016\/j.chom.2025.04.009_bib20","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.scitotenv.2018.12.406","article-title":"Hg2+-binding peptide decreases mercury ion accumulation in fish through a cell surface display system","volume":"659","author":"Liu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chom.2025.04.009_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113937","article-title":"Synthetic symbiotic bacteria reduces the toxicity of mercury ingested via contaminated food","volume":"178","author":"Chen","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.chom.2025.04.009_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114461","article-title":"Protective effects of oral administration of lactic acid bacteria strains against methylmercury-induced intestinal toxicity in a murine model","volume":"185","author":"Rodr\u00edguez-Viso","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.chom.2025.04.009_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.123016","article-title":"Tailored bacteria tackling with environmental mercury: Inspired by natural mercuric detoxification operons","volume":"341","author":"Hui","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chom.2025.04.009_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.682605","article-title":"Expanded Diversity and Phylogeny of mer Genes Broadens Mercury Resistance Paradigms and Reveals an Origin for MerA Among Thermophilic Archaea","volume":"12","author":"Christakis","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.chom.2025.04.009_bib25","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1007\/s00204-023-03548-7","article-title":"Assessing the role of the gut microbiome in methylmercury demethylation and elimination in humans and gnotobiotic mice","volume":"97","author":"Coe","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chom.2025.04.009_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2022.102178","article-title":"Engineering the human gut commensal Bacteroides thetaiotaomicron with synthetic biology","volume":"70","author":"Lai","year":"2022","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.chom.2025.04.009_bib27","first-page":"45","article-title":"Potential of Organic Mercury-resistant Bacteria Isolated from Mercury Contaminated Sites for Organic Mercury Remediation","volume":"22","author":"Fatimawali","year":"2019","journal-title":"Pak. J. Biol. Sci."},{"key":"10.1016\/j.chom.2025.04.009_bib28","doi-asserted-by":"crossref","DOI":"10.1088\/1757-899X\/1115\/1\/012080","article-title":"Overproduction and Purification of Organomercuric Lyase (MerB) from Mercury-resistant Bacteria Pseudomonas aeruginosa Isolate 4B2","volume":"1115","author":"Fatimawali","year":"2021","journal-title":"IOP Conf. Ser.: Mater. Sci. Eng."},{"key":"10.1016\/j.chom.2025.04.009_bib29","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.cell.2017.03.041","article-title":"Tunable Expression Tools Enable Single-Cell Strain Distinction in the Gut Microbiome","volume":"169","author":"Whitaker","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.chom.2025.04.009_bib30","series-title":"The State of World Fisheries and Aquaculture 2022. Towards Blue Transformation","year":"2022"},{"key":"10.1016\/j.chom.2025.04.009_bib31","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1038\/s41559-022-01878-w","article-title":"Safeguarding nutrients from coral reefs under climate change","volume":"6","author":"Mellin","year":"2022","journal-title":"Nat. Ecol. Evol."},{"key":"10.1016\/j.chom.2025.04.009_bib32","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s002040050279","article-title":"Methylmercury transport across the placenta via neutral amino acid carrier","volume":"70","author":"Kajiwara","year":"1996","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chom.2025.04.009_bib33","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/toxsci\/kfl199","article-title":"Developmental Exposure to Methylmercury Alters Learning and Induces Depression-like Behavior in Male Mice","volume":"97","author":"Onishchenko","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chom.2025.04.009_bib34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbr.2008.03.008","article-title":"Chronic, low-dose prenatal exposure to methylmercury impairs motor and mnemonic function in adult C57\/B6 mice","volume":"191","author":"Montgomery","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.chom.2025.04.009_bib35","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1289\/ehp.02110523","article-title":"Inorganic mercury and methylmercury in placentas of Swedish women","volume":"110","author":"Ask","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chom.2025.04.009_bib36","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1016\/j.scitotenv.2010.07.079","article-title":"Perinatal lead and mercury exposure in Austria","volume":"408","author":"Gundacker","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chom.2025.04.009_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/enrs.2002.4349","article-title":"Neurodevelopmental Investigations among Methylmercury-Exposed Children in French Guiana","volume":"89","author":"Cordier","year":"2002","journal-title":"Environ. Res."},{"key":"10.1016\/j.chom.2025.04.009_bib38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-069X-2-8","article-title":"Low level methylmercury exposure affects neuropsychological function in adults","volume":"2","author":"Yokoo","year":"2003","journal-title":"Environ. Health"},{"key":"10.1016\/j.chom.2025.04.009_bib39","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuro.2004.12.005","article-title":"Low-Level Methylmercury Exposure as a Risk Factor for Neurologic Abnormalities in Adults","volume":"26","author":"Auger","year":"2005","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.chom.2025.04.009_bib40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.envint.2013.01.005","article-title":"Long term neurocognitive impact of low dose prenatal methylmercury exposure in Hong Kong","volume":"54","author":"Lam","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.chom.2025.04.009_bib41","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1039\/C4TX00205A","article-title":"Participation of b0,+ and B0,+ systems in the transport of mercury bound to cysteine in intestinal cells","volume":"4","author":"V\u00e1zquez","year":"2015","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.chom.2025.04.009_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22063101","article-title":"Cellular and Molecular Mechanisms Mediating Methylmercury Neurotoxicity and Neuroinflammation","volume":"22","author":"Novo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chom.2025.04.009_bib43","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/taap.1999.8685","article-title":"Induction of the Cell Cycle Regulatory Gene p21 (Waf1, Cip1) Following Methylmercury Exposure in Vitro and in Vivo","volume":"157","author":"Ou","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chom.2025.04.009_bib44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/taap.2001.9267","article-title":"p21WAF1\/CIP1 Inhibits Cell Cycle Progression but Not G2\/M-Phase Transition Following Methylmercury Exposure","volume":"178","author":"Mendoza","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chom.2025.04.009_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27123878","article-title":"Activation of IGF-1\/GLP-1 Signalling via 4-Hydroxyisoleucine Prevents Motor Neuron Impairments in Experimental ALS-Rats Exposed to Methylmercury-Induced Neurotoxicity","volume":"27","author":"Shandilya","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.chom.2025.04.009_bib46","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.neuro.2022.04.006","article-title":"Ferroptosis contributes to methylmercury-induced cytotoxicity in rat primary astrocytes and Buffalo rat liver cells","volume":"90","author":"Dong","year":"2022","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.chom.2025.04.009_bib47","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-020-2496-1","article-title":"A single-cell transcriptomic atlas characterizes ageing tissues in the mouse","volume":"583","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.04.009_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232213837","article-title":"Chronic Methylmercury Intoxication Induces Systemic Inflammation, Behavioral, and Hippocampal Amino Acid Changes in C57BL6J Adult Mice","volume":"23","author":"Nascimento","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chom.2025.04.009_bib49","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1039\/C8MT00297E","article-title":"Proteomic approach underlying the hippocampal neurodegeneration caused by low doses of methylmercury after long-term exposure in adult rats","volume":"11","author":"Bittencourt","year":"2019","journal-title":"Metallomics"},{"key":"10.1016\/j.chom.2025.04.009_bib50","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/glia.21153","article-title":"Comparative Study on the Response of Rat Primary Astrocytes and Microglia to Methylmercury Toxicity","volume":"59","author":"Ni","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.chom.2025.04.009_bib51","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.chemosphere.2003.11.011","article-title":"Interactions between mercury and dissolved organic matter--a review","volume":"55","author":"Ravichandran","year":"2004","journal-title":"Chemosphere"},{"key":"10.1016\/j.chom.2025.04.009_bib52","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/glia.23801","article-title":"The intellectual disability protein Oligophrenin-1 controls astrocyte morphology and migration","volume":"68","author":"Pillet","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.chom.2025.04.009_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.115019","article-title":"Nucleophosmin 1 overexpression enhances neuroprotection by attenuating cellular stress in traumatic brain injury","volume":"383","author":"Zhao","year":"2025","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.chom.2025.04.009_bib54","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neulet.2017.05.044","article-title":"Quantitative proteomic analysis revealed changes in protein synthesis and mitochondrial functions after acute DNA damage in mouse neural stem cells","volume":"653","author":"Wang","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.chom.2025.04.009_bib55","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/jnc.14817","article-title":"Microglial ROCK is essential for chronic methylmercury-induced neurodegeneration","volume":"151","author":"Shinozaki","year":"2019","journal-title":"J. Neurochem."},{"key":"10.1016\/j.chom.2025.04.009_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1003663","article-title":"Necrotic-like BV-2 microglial cell death due to methylmercury exposure","volume":"13","author":"Martins","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.chom.2025.04.009_bib57","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1053\/j.gastro.2013.01.047","article-title":"Complex Interactions Among Diet, Gastrointestinal Transit, and Gut Microbiota in Humanized Mice","volume":"144","author":"Kashyap","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.chom.2025.04.009_bib58","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3181\/00379727-157-39990","article-title":"Absorption of Mercury from Ligated Segments of the Rat Gastrointestinal Tract","volume":"157","author":"Sasser","year":"1978","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.chom.2025.04.009_bib59","article-title":"A Double-Blind, Placebo-Controlled Trial to Assess Safety and Tolerability of (Thetanix) Bacteroides thetaiotaomicron in Adolescent Crohn\u2019s Disease","volume":"12","author":"Hansen","year":"2020","journal-title":"Clin. Transl. Gastroenterol."},{"key":"10.1016\/j.chom.2025.04.009_bib60","article-title":"Controlled colonization of the human gut with a genetically engineered microbial medicine","author":"Whitaker","year":"2024","journal-title":"medRxiv"},{"key":"10.1016\/j.chom.2025.04.009_bib61","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-56145-w","article-title":"Methylmercury demethylation and volatilization by animals expressing microbial enzymes","volume":"16","author":"Tepper","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2025.04.009_bib62","article-title":"Global health effects of future atmospheric mercury emissions","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2025.04.009_bib63","unstructured":"FDA. (2024). Technical Information on Development of FDA\/EPA Advice about Eating Fish for Those Who Might Become or Are Pregnant or Breastfeeding and Children Ages 1-11 Years. FDA.gov. https:\/\/www.fda.gov\/food\/environmental-contaminants-food\/technical-information-development-fdaepa-advice-about-eating-fish-those-who-might-become-or-are."},{"key":"10.1016\/j.chom.2025.04.009_bib64","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1021\/acsenvironau.1c00022","article-title":"Demethylation\u2500The Other Side of the Mercury Methylation Coin: A Critical Review","volume":"2","author":"Barkay","year":"2022","journal-title":"ACS Environ."},{"key":"10.1016\/j.chom.2025.04.009_bib65","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00204-016-1803-y","article-title":"Mechanisms involved in the transport of mercuric ions in target tissues","volume":"91","author":"Bridges","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chom.2025.04.009_bib66","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/toxsci\/kfaa192","article-title":"Variation in Methylmercury Metabolism and Elimination in Humans: Physiological Pharmacokinetic Modeling Highlights the Role of Gut Biotransformation, Skeletal Muscle, and Hair","volume":"180","author":"Pope","year":"2021","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chom.2025.04.009_bib67","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2131\/jts.43.717","article-title":"Monomethylmercury degradation by the human gut microbiota is stimulated by protein amendments","volume":"43","author":"Guo","year":"2018","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.chom.2025.04.009_bib68","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0006-8993(02)02964-5","article-title":"Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate dose exposure throughout gestation and lactation periods","volume":"949","author":"Sakamoto","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.chom.2025.04.009_bib69","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.envint.2012.02.007","article-title":"Mercury and docosahexaenoic acid levels in maternal and cord blood in relation to segmental maternal hair mercury concentrations at parturition","volume":"44","author":"Sakamoto","year":"2012","journal-title":"Environ. Int."},{"key":"10.1016\/j.chom.2025.04.009_bib70","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/S0140-6736(03)13371-5","article-title":"Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study","volume":"361","author":"Myers","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2025.04.009_bib71","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1289\/ehp.1408554","article-title":"Relation of Prenatal Methylmercury Exposure from Environmental Sources to Childhood IQ","volume":"123","author":"Jacobson","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chom.2025.04.009_bib72","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1021\/acsomega.3c07047","article-title":"The Toxicity of Mercury and Its Chemical Compounds: Molecular Mechanisms and Environmental and Human Health Implications: A Comprehensive Review","volume":"9","author":"Wu","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.chom.2025.04.009_bib73","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-018-0092-4","article-title":"An exclusive metabolic niche enables strain engraftment in the gut microbiota","volume":"557","author":"Shepherd","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.04.009_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-94174-9","article-title":"Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability","volume":"11","author":"Bolan","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chom.2025.04.009_bib75","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2025.04.009_bib76","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2025.04.009_bib77","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.7563.1","article-title":"Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences","volume":"4","author":"Soneson","year":"2015","journal-title":"F1000Res"},{"key":"10.1016\/j.chom.2025.04.009_bib78","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.chom.2025.04.009_bib79","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.chom.2025.04.009_bib80","doi-asserted-by":"crossref","first-page":"D870","DOI":"10.1093\/nar\/gkac947","article-title":"CellMarker 2.0: an updated database of manually curated cell markers in human\/mouse and web tools based on scRNA-seq data","volume":"51","author":"Hu","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chom.2025.04.009_bib81","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2105-13-134","article-title":"Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction","volume":"13","author":"Ye","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.chom.2025.04.009_bib82","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00544-19","article-title":"Genetic Manipulation of Wild Human Gut Bacteroides","volume":"202","author":"Bencivenga-Barry","year":"2020","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.chom.2025.04.009_bib83","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/s41596-018-0119-1","article-title":"INFOGEST static in vitro simulation of gastrointestinal food digestion","volume":"14","author":"Brodkorb","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.chom.2025.04.009_bib84","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/BF01189726","article-title":"Measurement of Hg methylation in sediments using high specific-activity203Hg and ambient incubation","volume":"80","author":"Gilmour","year":"1995","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.chom.2025.04.009_bib85","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1002\/etc.5620190909","article-title":"Constants of mercury methylation and demethylation rates in sediments and comparison of tracer and ambient mercury availability","volume":"19","author":"Hintelmann","year":"2000","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chom.2025.04.009_bib86","series-title":"Biogeochemistry of Environmentally Important Trace Elements ACS Symposium Series","first-page":"321","article-title":"Determination of Stable Mercury Isotopes by ICP\/MS and Their Application in Environmental Studies","author":"Hintelmann","year":"2002"},{"key":"10.1016\/j.chom.2025.04.009_bib87","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1021\/ac010366+","article-title":"Validation of methylmercury determinations in aquatic systems by alkyl derivatization methods for GC analysis using ICP-IDMS","volume":"73","author":"Demuth","year":"2001","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chom.2025.04.009_bib88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4319\/lom.2014.12.1","article-title":"Determination of monomethylmercury from seawater with ascorbic acid-assisted direct ethylation","volume":"12","author":"Munson","year":"2014","journal-title":"Limnol. Oceanogr.: Methods"},{"key":"10.1016\/j.chom.2025.04.009_bib89","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3748\/wjg.v19.i11.1683","article-title":"Molecular mechanisms of liver ischemia reperfusion injury: Insights from transgenic knockout models","volume":"19","author":"Datta","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.chom.2025.04.009_bib90","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1039\/c3ja30332b","article-title":"Rare earth element analysis in natural waters by multiple isotope dilution \u2013 sector field ICP-MS","volume":"28","author":"Rousseau","year":"2013","journal-title":"J. Anal. At. Spectrom."},{"key":"10.1016\/j.chom.2025.04.009_bib91","doi-asserted-by":"crossref","DOI":"10.1038\/srep10318","article-title":"Shallow methylmercury production in the marginal sea ice zone of the central Arctic Ocean","volume":"5","author":"Heimb\u00fcrger","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chom.2025.04.009_bib92","doi-asserted-by":"crossref","first-page":"G607","DOI":"10.1152\/ajpgi.00303.2023","article-title":"Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii served as key components of fecal microbiota transplantation to alleviate colitis","volume":"326","author":"Xu","year":"2024","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312825001428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312825001428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T10:42:50Z","timestamp":1747219370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312825001428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":92,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1931312825001428"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2025.04.009","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An engineered gut bacterium protects against dietary methylmercury exposure in pregnant mice","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2025.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}