{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:21:54Z","timestamp":1793319714574,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003803","name":"University of Hong Kong","doi-asserted-by":"publisher","award":["104006476"],"award-info":[{"award-number":["104006476"]}],"id":[{"id":"10.13039\/501100003803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003803","name":"University of Hong Kong","doi-asserted-by":"publisher","award":["109001217"],"award-info":[{"award-number":["109001217"]}],"id":[{"id":"10.13039\/501100003803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32030003"],"award-info":[{"award-number":["32030003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31600099"],"award-info":[{"award-number":["31600099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31300424"],"award-info":[{"award-number":["31300424"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670979"],"award-info":[{"award-number":["81670979"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019558","name":"Qingdao Key Health Discipline Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014761","name":"Natural Science Foundation of Qingdao Municipality","doi-asserted-by":"publisher","award":["24-4-4-zrjj-158-jch"],"award-info":[{"award-number":["24-4-4-zrjj-158-jch"]}],"id":[{"id":"10.13039\/501100014761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MH235"],"award-info":[{"award-number":["ZR2024MH235"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.chom.2025.05.006","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T14:37:41Z","timestamp":1748615861000},"page":"1019-1032.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Single-tooth resolved, whole-mouth prediction of early childhood caries via spatiotemporal variations of plaque microbiota"],"prefix":"10.1016","volume":"33","author":[{"given":"Fang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-8477","authenticated-orcid":false,"given":"Jian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7529-2269","authenticated-orcid":false,"given":"Shi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2025.05.006_bib1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tim.2014.10.010","article-title":"Solving the etiology of dental caries","volume":"23","author":"Sim\u00f3n-Soro","year":"2015","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.chom.2025.05.006_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(07)60031-2","article-title":"Dental caries","volume":"369","author":"Selwitz","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2025.05.006_bib3","first-page":"40","article-title":"Policy on early childhood caries (ECC): classifications, consequences, and preventive strategies","volume":"30","year":"2008","journal-title":"Pediatr. Dent."},{"key":"10.1016\/j.chom.2025.05.006_bib4","series-title":"Report on the First Oral Health Epidemiological Survey in Qingdao City","article-title":"Survey Report","author":"Wang","year":"2022"},{"key":"10.1016\/j.chom.2025.05.006_bib5","first-page":"161","article-title":"The 4th National Oral Health Survey in the Mainland of China: Background and Methodology","volume":"21","author":"Lu","year":"2018","journal-title":"Chin. J. Dent. Res."},{"key":"10.1016\/j.chom.2025.05.006_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41368-022-00186-0","article-title":"Expert consensus on early childhood caries management","volume":"14","author":"Zou","year":"2022","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.chom.2025.05.006_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0140-6736(08)61933-9","article-title":"Oral health: prevention is key","volume":"373","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2025.05.006_bib8","doi-asserted-by":"crossref","first-page":"566","DOI":"10.14219\/jada.archive.2012.0235","article-title":"Length of tooth survival in older adults with complex medical, functional and dental backgrounds","volume":"143","author":"Chen","year":"2012","journal-title":"J. Am. Dent. Assoc."},{"key":"10.1016\/j.chom.2025.05.006_bib9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1365-263X.2012.01222.x","article-title":"Impact of caries onset on number and distribution of new lesions in preschool children","volume":"23","author":"Leroy","year":"2013","journal-title":"Int. J. Paediatr. Dent."},{"key":"10.1016\/j.chom.2025.05.006_bib10","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.chom.2015.08.005","article-title":"Prediction of Early Childhood Caries via Spatial-Temporal Variations of Oral Microbiota","volume":"18","author":"Teng","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2025.05.006_bib11","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s00248-014-0372-y","article-title":"Pyrosequencing Analysis of Oral Microbiota Shifting in Various Caries States in Childhood","volume":"67","author":"Jiang","year":"2014","journal-title":"Microb. Ecol."},{"key":"10.1016\/j.chom.2025.05.006_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-02900-1","article-title":"A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow","volume":"9","author":"Proctor","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2025.05.006_bib13","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1126\/science.1177486","article-title":"Bacterial community variation in human body habitats across space and time","volume":"326","author":"Costello","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.chom.2025.05.006_bib14","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1177\/0022034513488119","article-title":"Microbial geography of the oral cavity","volume":"92","author":"Sim\u00f3n-Soro","year":"2013","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.chom.2025.05.006_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.02009","article-title":"Oral Microbiome Shifts From Caries-Free to Caries-Affected Status in 3-Year-Old Chinese Children: A Longitudinal Study","volume":"9","author":"Xu","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.chom.2025.05.006_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2018.00423","article-title":"The Predictive Potentiality of Salivary Microbiome for the Recurrence of Early Childhood Caries","volume":"8","author":"Zhu","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.chom.2025.05.006_bib17","doi-asserted-by":"crossref","first-page":"E791","DOI":"10.1073\/pnas.1522149113","article-title":"Biogeography of a human oral microbiome at the micron scale","volume":"113","author":"Mark Welch","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2025.05.006_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41579-023-00963-6","article-title":"The oral microbiome: diversity, biogeography and human health","volume":"22","author":"Baker","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2025.05.006_bib19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1600-0528.1984.tb01408.x","article-title":"Measurement of dental caries experience--modification of the DMFT index","volume":"12","author":"Anaise","year":"1984","journal-title":"Community Dent. Oral Epidemiol."},{"key":"10.1016\/j.chom.2025.05.006_bib20","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-020-07307-1","article-title":"Meta-Apo improves accuracy of 16S-amplicon-based prediction of microbiome function","volume":"22","author":"Jing","year":"2021","journal-title":"BMC Genomics"},{"key":"10.1016\/j.chom.2025.05.006_bib21","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","article-title":"PICRUSt2 for prediction of metagenome functions","volume":"38","author":"Douglas","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chom.2025.05.006_bib22","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature13421","article-title":"Persistent gut microbiota immaturity in malnourished Bangladeshi children","volume":"510","author":"Subramanian","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.05.006_bib23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.05.006_bib24","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.chom.2014.02.005","article-title":"The treatment-naive microbiome in new-onset Crohn's disease","volume":"15","author":"Gevers","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2025.05.006_bib25","doi-asserted-by":"crossref","DOI":"10.3402\/jom.v6.25443","article-title":"Metatranscriptomics reveals overall active bacterial composition in caries lesions","volume":"6","author":"Sim\u00f3n-Soro","year":"2014","journal-title":"J. Oral Microbiol."},{"key":"10.1016\/j.chom.2025.05.006_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047722","article-title":"Beyond Streptococcus mutans: dental caries onset linked to multiple species by 16S rRNA community analysis","volume":"7","author":"Gross","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2025.05.006_bib27","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1128\/JCM.01232-10","article-title":"Bacterial 16S sequence analysis of severe caries in young permanent teeth","volume":"48","author":"Gross","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.chom.2025.05.006_bib28","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00284-013-0393-7","article-title":"Pyrosequencing analysis of oral microbiota in children with severe early childhood dental caries","volume":"67","author":"Jiang","year":"2013","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.chom.2025.05.006_bib29","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/s41592-018-0176-y","article-title":"Species-level functional profiling of metagenomes and metatranscriptomes","volume":"15","author":"Franzosa","year":"2018","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2025.05.006_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00050-22","article-title":"Compositionally Aware Phylogenetic Beta-Diversity Measures Better Resolve Microbiomes Associated with Phenotype","volume":"7","author":"Martino","year":"2022","journal-title":"mSystems"},{"key":"10.1016\/j.chom.2025.05.006_bib31","doi-asserted-by":"crossref","first-page":"e00016","DOI":"10.1128\/msystems.00016-19","article-title":"A Novel Sparse Compositional Technique Reveals Microbial Perturbations","volume":"4","author":"Martino","year":"2019","journal-title":"mSystems"},{"key":"10.1016\/j.chom.2025.05.006_bib33","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chom.2025.05.006_bib32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.5005\/jp-journals-10005-1089","article-title":"International Caries Detection and Assessment System (ICDAS): A New Concept","volume":"4","author":"Gugnani","year":"2011","journal-title":"Int. J. Clin. Pediatr. Dent."},{"key":"10.1016\/j.chom.2025.05.006_bib34","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1654-1103.2003.tb02228.x","article-title":"VEGAN, a package of R functions for community ecology","volume":"14","author":"Dixon","year":"2003","journal-title":"J. Veg. Sci."},{"key":"10.1016\/j.chom.2025.05.006_bib35","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.chom.2025.05.006_bib36","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"10.1016\/j.chom.2025.05.006_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v077.i01","article-title":"ranger: A Fast Implementation of Random Forests for High Dimensional Data in C plus plus and R","volume":"77","author":"Wright","year":"2017","journal-title":"J. Stat. Softw."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312825001854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312825001854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:27:58Z","timestamp":1762561678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312825001854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1931312825001854"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2025.05.006","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-tooth resolved, whole-mouth prediction of early childhood caries via spatiotemporal variations of plaque microbiota","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2025.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}