{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:10:26Z","timestamp":1790565026582,"version":"4.1.0"},"reference-count":110,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK034854"],"award-info":[{"award-number":["P30DK034854"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["AI169795"],"award-info":[{"award-number":["AI169795"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["AI155634"],"award-info":[{"award-number":["AI155634"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["AI072429"],"award-info":[{"award-number":["AI072429"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["AI075039"],"award-info":[{"award-number":["AI075039"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["AI075039"],"award-info":[{"award-number":["AI075039"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["AI072429"],"award-info":[{"award-number":["AI072429"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.chom.2025.08.001","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T14:36:52Z","timestamp":1756478212000},"page":"1535-1549.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-\u03b3"],"prefix":"10.1016","volume":"33","author":[{"given":"Kevin D.","family":"Eislmayr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte A.","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fitty L.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudyut","family":"Yuvaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet Peace","family":"Babirye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin L.","family":"Roncaioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Vickery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cammie F.","family":"Lesser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6686-3912","authenticated-orcid":false,"given":"Russell E.","family":"Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2025.08.001_bib1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0140-6736(17)33296-8","article-title":"Shigellosis","volume":"391","author":"Kotloff","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2025.08.001_bib2","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S1473-3099(18)30475-4","article-title":"Morbidity and mortality due to Shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990\u20132016","volume":"18","author":"Khalil","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chom.2025.08.001_bib3","doi-asserted-by":"crossref","first-page":"e255","DOI":"10.1016\/S2214-109X(18)30045-7","article-title":"Global disability-adjusted life-year estimates of long-term health burden and undernutrition attributable to diarrhoeal diseases in children younger than 5 years","volume":"6","author":"Troeger","year":"2018","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.chom.2025.08.001_bib4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ijid.2023.01.034","article-title":"Consequences of Shigella infection in young children: a systematic review","volume":"129","author":"Libby","year":"2023","journal-title":"Int. J. Infect Dis."},{"key":"10.1016\/j.chom.2025.08.001_bib5","doi-asserted-by":"crossref","DOI":"10.1128\/ecosalplus.esp-0006-2017","article-title":"A Brief History of Shigella","volume":"8","author":"Lampel","year":"2018","journal-title":"EcoSal Plus"},{"key":"10.1016\/j.chom.2025.08.001_bib6","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1128\/iai.64.7.2752-2764.1996","article-title":"Infection of rabbit Peyer\u2019s patches by Shigella flexneri: effect of adhesive or invasive bacterial phenotypes on follicle-associated epithelium","volume":"64","author":"Sansonetti","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2025.08.001_bib7","article-title":"Shigella Pathogenesis: New Insights through Advanced Methodologies","volume":"7","author":"Schnupf","year":"2019","journal-title":"Microbiol. Spec."},{"key":"10.1016\/j.chom.2025.08.001_bib8","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1128\/CMR.00032-07","article-title":"Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion","volume":"21","author":"Schroeder","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.chom.2025.08.001_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2015.00219","article-title":"Shigella Manipulates host immune responses by delivering effector proteins with specific roles","volume":"6","author":"Ashida","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chom.2025.08.001_bib10","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1073\/pnas.86.10.3867","article-title":"Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin","volume":"86","author":"Bernardini","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2025.08.001_bib11","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1073\/pnas.92.14.6572","article-title":"Shigella flexneri surface protein IcsA is sufficient to direct actin-based motility","volume":"92","author":"Goldberg","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2025.08.001_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2017.00064","article-title":"How do the virulence factors of Shigella work together to cause disease?","volume":"7","author":"Mattock","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.chom.2025.08.001_bib13","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1093\/infdis\/159.6.1126","article-title":"Inoculum Size in Shigellosis and Implications For Expected Mode of Transmission","volume":"159","author":"DuPont","year":"1989","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.chom.2025.08.001_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2023.102399","article-title":"Animal models of shigellosis: a historical overview","volume":"85","author":"Alphonse","year":"2023","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.chom.2025.08.001_bib15","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.59022","article-title":"NAIP-NLRC4-deficient mice are susceptible to shigellosis","volume":"9","author":"Mitchell","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.chom.2025.08.001_bib16","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.83639","article-title":"A hierarchy of cell death pathways confers layered resistance to shigellosis in mice","volume":"12","author":"Roncaioli","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.chom.2025.08.001_bib17","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nature10394","article-title":"Innate immune recognition of bacterial ligands by NAIPs dictates inflammasome specificity","volume":"477","author":"Kofoed","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.08.001_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003926","article-title":"Shigella Type III Secretion Protein MxiI Is Recognized by Naip2 to Induce Nlrc4 Inflammasome Activation Independently of Pkc\u03b4","volume":"10","author":"Suzuki","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2025.08.001_bib19","doi-asserted-by":"crossref","first-page":"14408","DOI":"10.1073\/pnas.1306376110","article-title":"Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation","volume":"110","author":"Yang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2025.08.001_bib20","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.08.001_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.mib.2013.11.008","article-title":"Detection of cytosolic bacteria by inflammatory caspases","volume":"17","author":"Hagar","year":"2014","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.chom.2025.08.001_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102910","article-title":"Shigella OspC3 suppresses murine cytosolic LPS sensing","volume":"24","author":"Oh","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.chom.2025.08.001_bib23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41586-021-04020-1","article-title":"Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11","volume":"599","author":"Li","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.08.001_bib24","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1128\/IAI.01104-10","article-title":"Antibiotic Treatment Alters the Colonic Mucus Layer and Predisposes the host to exacerbated Citrobacter rodentium-induced colitis","volume":"79","author":"Wlodarska","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2025.08.001_bib25","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1084\/jem.20170495","article-title":"Commensal microbes provide first line defense against Listeria monocytogenes infection","volume":"214","author":"Becattini","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.chom.2025.08.001_bib26","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1128\/IAI.71.5.2839-2858.2003","article-title":"Pretreatment of Mice with Streptomycin Provides a Salmonella enterica Serovar Typhimurium Colitis Model That Allows Analysis of Both Pathogen and Host","volume":"71","author":"Barthel","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2025.08.001_bib27","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2017.03.016","article-title":"NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8","volume":"46","author":"Rauch","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2025.08.001_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.chom.2014.07.001","article-title":"Epithelium-Intrinsic NAIP\/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa","volume":"16","author":"Sellin","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2025.08.001_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00663-21","article-title":"Salmonella enterica Serovar Typhimurium Induces NAIP\/NLRC4- and NLRP3\/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells","volume":"90","author":"Naseer","year":"2022","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2025.08.001_bib30","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.chom.2021.08.010","article-title":"Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection","volume":"29","author":"Luchetti","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2025.08.001_bib31","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.chom.2013.04.012","article-title":"The Shigella OspC3 Effector Inhibits Caspase-4, Antagonizes Inflammatory Cell Death, and Promotes Epithelial Infection","volume":"13","author":"Kobayashi","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2025.08.001_bib32","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1073\/pnas.1801310115","article-title":"Synthetic bottom-up approach reveals the complex interplay of Shigella effectors in regulation of epithelial cell death","volume":"115","author":"Mou","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2025.08.001_bib33","article-title":"Shigella OspF blocks rapid p38-dependent priming of the NAIP\u2013NLRC4 inflammasome","author":"Turcotte","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.chom.2025.08.001_bib34","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1128\/iai.65.12.5165-5170.1997","article-title":"The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages","volume":"65","author":"Hilbi","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2025.08.001_bib35","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/infdis\/171.2.376","article-title":"Cytokine secretion in acute shigellosis is correlated to disease activity and directed more to stool than to plasma","volume":"171","author":"Raqib","year":"1995","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.chom.2025.08.001_bib36","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrmicro1662","article-title":"Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road","volume":"5","author":"Levine","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2025.08.001_bib37","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/0016-5085(86)91120-0","article-title":"Rectal histology in acute bacillary dysentery","volume":"90","author":"Anand","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1016\/j.chom.2025.08.001_bib38","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2271597","article-title":"Ascorbate deficiency increases progression of shigellosis in guinea pigs and mice infection models","volume":"15","author":"Skerniskyte","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.chom.2025.08.001_bib39","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.4049\/jimmunol.178.4.2476","article-title":"New Animal Model of Shigellosis in the Guinea Pig: Its Usefulness for Protective Efficacy Studies","volume":"178","author":"Shim","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2025.08.001_bib40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/358167a0","article-title":"Shigella flexneri induces apoptosis in infected macrophages","volume":"358","author":"Zychlinsky","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.08.001_bib41","doi-asserted-by":"crossref","first-page":"5357","DOI":"10.1128\/iai.64.12.5357-5365.1996","article-title":"In vivo apoptosis in Shigella flexneri infections","volume":"64","author":"Zychlinsky","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2025.08.001_bib42","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1002\/j.1460-2075.1996.tb00759.x","article-title":"A bacterial invasin induces macrophage apoptosis by binding directly to ICE","volume":"15","author":"Chen","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.chom.2025.08.001_bib43","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1083\/jcb.201108081","article-title":"Cell death and infection: a double-edged sword for host and pathogen survival","volume":"195","author":"Ashida","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.chom.2025.08.001_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002809","article-title":"IFN\u03b3 Inhibits the Cytosolic Replication of Shigella flexneri via the Cytoplasmic RNA Sensor RIG-I","volume":"8","author":"Jehl","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2025.08.001_bib110","unstructured":"Eislmayr, K. (2025). Graphical Abstract. Created in BioRender. https:\/\/BioRender.com\/64uv53d."},{"key":"10.1016\/j.chom.2025.08.001_bib111","unstructured":"Eislmayr, K. (2025). Figure 3. The responsiveness of non-hematopoietic cells to IFN-\u03b3 is crucial for controlling Shigella infection. Created in BioRender. https:\/\/BioRender.com\/1dzqp93."},{"key":"10.1016\/j.chom.2025.08.001_bib45","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020104926","article-title":"Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions","volume":"39","author":"Kutsch","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.chom.2025.08.001_bib46","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2216028120","article-title":"LPS-aggregating proteins GBP1 and GBP2 are each sufficient to enhance caspase-4 activation both in cellulo and in vitro","volume":"120","author":"Dickinson","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2025.08.001_bib47","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41586-024-07134-4","article-title":"Universal recording of immune cell interactions in vivo","volume":"627","author":"Nakandakari-Higa","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.08.001_bib48","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nature24467","article-title":"Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence","volume":"551","author":"Li","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.08.001_bib49","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cell.2004.10.010","article-title":"JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells","volume":"119","author":"Passegu\u00e9","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.chom.2025.08.001_bib50","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.immuni.2018.07.004","article-title":"The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages","volume":"49","author":"Scott","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2025.08.001_bib51","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.immuni.2018.07.016","article-title":"A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns","volume":"49","author":"Price","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2025.08.001_bib52","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.chom.2014.01.013","article-title":"Toll-like receptor-deficient mice reveal how innate immune signaling influences Salmonella virulence strategies","volume":"15","author":"Sivick","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2025.08.001_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00847","article-title":"Interferon-gamma at the crossroads of tumor immune surveillance or evasion","volume":"9","author":"Castro","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chom.2025.08.001_bib54","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1084\/jem.20160880","article-title":"Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection","volume":"214","author":"Lee","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.chom.2025.08.001_bib55","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ni.1715","article-title":"Cytokine-secreting follicular T cells shape the antibody repertoire","volume":"10","author":"Reinhardt","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2025.08.001_bib56","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.4049\/jimmunol.1401992","article-title":"A Novel Model for IFN-\u03b3\u2013Mediated Autoinflammatory Syndromes","volume":"194","author":"Reinhardt","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2025.08.001_bib57","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41385-021-00381-y","article-title":"Epithelium-autonomous NAIP\/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice","volume":"14","author":"Fattinger","year":"2021","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.chom.2025.08.001_bib58","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2013963118","article-title":"Bacterial detection by NAIP\/NLRC4 elicits prompt contractions of intestinal epithelial cell layers","volume":"118","author":"Samperio Ventayol","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2025.08.001_bib59","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0167-5699(98)01321-8","article-title":"Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria","volume":"19","author":"Ottenhoff","year":"1998","journal-title":"Immunol. Today"},{"key":"10.1016\/j.chom.2025.08.001_bib60","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1128\/IAI.70.6.3026-3032.2002","article-title":"Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis","volume":"70","author":"Vordermeier","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2025.08.001_bib61","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1084\/jem.178.6.2249","article-title":"An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection","volume":"178","author":"Flynn","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.chom.2025.08.001_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2014.00050","article-title":"The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons","volume":"4","author":"Dussurget","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.chom.2025.08.001_bib63","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/JLB.4MA1019-152R","article-title":"Interferon \u03b3 receptor downregulation facilitates Legionella survival in alveolar macrophages","volume":"107","author":"Yang","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.chom.2025.08.001_bib64","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1172\/JCI114038","article-title":"Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron","volume":"83","author":"Byrd","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.chom.2025.08.001_bib65","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/mi.2015.95","article-title":"IFN-\u03b3 induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense","volume":"9","author":"Cai","year":"2016","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.chom.2025.08.001_bib66","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/s41590-020-0697-2","article-title":"Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms","volume":"21","author":"Wandel","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2025.08.001_bib67","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1128\/IAI.66.4.1342-1348.1998","article-title":"An essential role for gamma interferon in innate resistance to Shigella flexneri infection","volume":"66","author":"Way","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2025.08.001_bib68","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.chom.2017.09.007","article-title":"GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8.","volume":"22","author":"Wandel","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2025.08.001_bib69","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2218469120","article-title":"Shigella IpaH9.8 limits GBP1-dependent LPS release from intracytosolic bacteria to suppress caspase-4 activation","volume":"120","author":"Goers","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2025.08.001_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52130-8","article-title":"The interferon stimulated gene viperin, restricts Shigella. flexneri in vitro","volume":"9","author":"Helbig","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chom.2025.08.001_bib71","article-title":"The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation","author":"Saavedra-Sanchez","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.chom.2025.08.001_bib72","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01979-17","article-title":"Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility","volume":"8","author":"Piro","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.chom.2025.08.001_bib73","doi-asserted-by":"crossref","DOI":"10.1126\/science.abf8113","article-title":"A human apolipoprotein L with detergent-like activity kills intracellular pathogens","volume":"373","author":"Gaudet","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.chom.2025.08.001_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-16889-z","article-title":"Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria","volume":"11","author":"Santos","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2025.08.001_bib75","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1126\/science.1233028","article-title":"Cellular self-defense: How cell-autonomous immunity protects against pathogens","volume":"340","author":"Randow","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.chom.2025.08.001_bib77","article-title":"Shigella flexneri evades LPS ubiquitylation through IpaH1.4-mediated degradation of RNF213","author":"Naydenova","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.chom.2025.08.001_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.624094","article-title":"Interferons: Tug of War Between Bacteria and Their Host","volume":"11","author":"Alphonse","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.chom.2025.08.001_bib79","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1128\/IAI.68.3.1289-1296.2000","article-title":"Induction of Necrosis in Human Neutrophils by Shigella flexneri Requires Type III Secretion, IpaB and IpaC Invasins, and Actin Polymerization","volume":"68","author":"Fran\u00e7ois","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2025.08.001_bib80","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/j.1462-5822.2010.01459.x","article-title":"Neutrophil antimicrobial proteins enhance Shigella flexneri adhesion and invasion","volume":"12","author":"Eilers","year":"2010","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2025.08.001_bib81","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/mi.2012.24","article-title":"The role of neutrophils during intestinal inflammation","volume":"5","author":"Fournier","year":"2012","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.chom.2025.08.001_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0030111","article-title":"Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages","volume":"3","author":"Suzuki","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2025.08.001_bib83","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1128\/IAI.01483-15","article-title":"Macrophage Apoptosis Triggered by IpaD from Shigella flexneri","volume":"84","author":"Arizmendi","year":"2016","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2025.08.001_bib84","article-title":"Shigella induces pro-inflammatory macrophages that cooperate with neutrophils to protect from secondary infection","author":"Gomes","year":"2024","journal-title":"Social Science Research Network"},{"key":"10.1016\/j.chom.2025.08.001_bib85","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.62320","article-title":"Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response","volume":"10","author":"Maculins","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.chom.2025.08.001_bib86","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/embo-reports\/kve155","article-title":"CARD4\/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri","volume":"2","author":"Girardin","year":"2001","journal-title":"EMBO Rep."},{"key":"10.1016\/j.chom.2025.08.001_bib87","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201846943","article-title":"ADP-heptose is a newly identified pathogen-associated molecular pattern of Shigella flexneri","volume":"19","author":"Garc\u00eda-Weber","year":"2018","journal-title":"EMBO Rep."},{"key":"10.1016\/j.chom.2025.08.001_bib88","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1074-7613(00)00070-4","article-title":"Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12","volume":"13","author":"Oppmann","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2025.08.001_bib89","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037311","article-title":"Homeostatic Regulation of Salmonella-Induced Mucosal Inflammation and Injury by IL-23","volume":"7","author":"Awoniyi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2025.08.001_bib90","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/ni.2031","article-title":"The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF","volume":"12","author":"El-Behi","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2025.08.001_bib91","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature05505","article-title":"Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis","volume":"445","author":"Zheng","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.08.001_bib92","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature09447","article-title":"Generation of Pathogenic Th17 Cells in the Absence of TGF-\u03b2 Signaling","volume":"467","author":"Ghoreschi","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.08.001_bib93","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41575-018-0084-8","article-title":"IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting","volume":"16","author":"Moschen","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.chom.2025.08.001_bib94","doi-asserted-by":"crossref","DOI":"10.3390\/cells9102184","article-title":"IL-12 and IL-23\u2014Close Relatives with Structural Homologies but Distinct Immunological Functions","volume":"9","author":"Floss","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.chom.2025.08.001_bib95","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nm.3895","article-title":"IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases","volume":"21","author":"Teng","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2025.08.001_bib96","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191736","article-title":"NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma","volume":"217","author":"Tenthorey","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.chom.2025.08.001_bib104","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"Datsenko","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2025.08.001_bib109","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1111\/j.1600-0854.2008.00830.x","article-title":"Dynamic behavior of Salmonella-induced membrane tubules in epithelial cells","volume":"9","author":"Drecktrah","year":"2008","journal-title":"Traffic"},{"key":"10.1016\/j.chom.2025.08.001_bib108","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00065-13","article-title":"Identification of Salmonella Pathogenicity Island-2 Type III Secretion System Effectors Involved in Intramacrophage Replication of S. enterica Serovar Typhimurium: Implications for Rational Vaccine Design","volume":"4","author":"Figueira","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.chom.2025.08.001_bib106","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.chom.2025.08.001_bib97","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgen. Res."},{"key":"10.1016\/j.chom.2025.08.001_bib98","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nmeth762","article-title":"A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration","volume":"2","author":"Buch","year":"2005","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2025.08.001_bib99","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1126\/science.8456301","article-title":"Immune response in mice that lack the interferon-gamma receptor","volume":"259","author":"Huang","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.chom.2025.08.001_bib100","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S1074-7613(00)80413-6","article-title":"IL-12-Deficient Mice Are Defective in IFN\u03b3 Production and Type 1 Cytokine Responses","volume":"4","author":"Magram","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2025.08.001_bib101","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1084\/jem.20112675","article-title":"Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage","volume":"209","author":"Meredith","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.chom.2025.08.001_bib102","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nbt822","article-title":"High-throughput engineering of the mouse genome coupled with high-resolution expression analysis","volume":"21","author":"Valenzuela","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chom.2025.08.001_bib103","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00438-004-0982-z","article-title":"The novel mutation K87E in ribosomal protein S12 enhances protein synthesis activity during the late growth phase in Escherichia coli","volume":"271","author":"Hosaka","year":"2004","journal-title":"Mol. Genet. Genomics"},{"key":"10.1016\/j.chom.2025.08.001_bib105","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-1-61779-815-3_6","article-title":"Identification, isolation, and culture of intestinal epithelial stem cells from murine intestine","volume":"879","author":"Gracz","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.chom.2025.08.001_bib107","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1053\/j.gastro.2011.07.050","article-title":"Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett\u2019s Epithelium","volume":"141","author":"Sato","year":"2011","journal-title":"Gastroenterology"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312825002975?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312825002975?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:40:50Z","timestamp":1781185250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312825002975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":110,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1931312825002975"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2025.08.001","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.01.20.633976","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-\u03b3","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2025.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}