{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:03:13Z","timestamp":1781186593024,"version":"3.54.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100021914","name":"Grand Challenges","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007901","name":"Microbiology Society","doi-asserted-by":"publisher","award":["GA002322"],"award-info":[{"award-number":["GA002322"]}],"id":[{"id":"10.13039\/501100007901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["204457\/Z\/16\/Z"],"award-info":[{"award-number":["204457\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["197083"],"award-info":[{"award-number":["197083"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1189062"],"award-info":[{"award-number":["OPP1189062"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-003570"],"award-info":[{"award-number":["INV-003570"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["206194"],"award-info":[{"award-number":["206194"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.chom.2025.08.005","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T14:41:47Z","timestamp":1756824107000},"page":"1473-1483.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Naturally acquired promoter variation influences Streptococcus pneumoniae infection outcomes"],"prefix":"10.1016","volume":"33","author":[{"given":"Thomas E.","family":"Barton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angharad E.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate C.","family":"Mellor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail E.","family":"McKnight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Bacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Newbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Pohler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal S.","family":"Monshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Bryson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Dube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Zar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Nicol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Bentley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hilty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason W.","family":"Rosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-8153","authenticated-orcid":false,"given":"Daniel R.","family":"Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2025.08.005_bib1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.chom.2016.07.019","article-title":"Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR","volume":"20","author":"Hentrich","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2025.08.005_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009158","article-title":"Neuraminidase B controls neuraminidase A-dependent mucus production and evasion","volume":"17","author":"Hammond","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2025.08.005_bib3","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1021\/ja110733q","article-title":"Three Streptococcus pneumoniae sialidases: three different products","volume":"133","author":"Xu","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.chom.2025.08.005_bib4","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.2041-1014.2012.00658.x","article-title":"Pneumococcal neuraminidase A: an essential upper airway colonization factor for Streptococcus pneumoniae","volume":"27","author":"Brittan","year":"2012","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.chom.2025.08.005_bib5","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1080\/21505594.2018.1520545","article-title":"Assessing the function of pneumococcal neuraminidases NanA, NanB and NanC in in vitro and in vivo lung infection models using monoclonal antibodies","volume":"9","author":"Janesch","year":"2018","journal-title":"Virulence"},{"key":"10.1016\/j.chom.2025.08.005_bib6","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1128\/AEM.00499-15","article-title":"Sialic acid-mediated gene expression in Streptococcus pneumoniae and role of NanR as a transcriptional activator of the nan gene cluster","volume":"81","author":"Afzal","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.chom.2025.08.005_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.666504","article-title":"Recognition of Streptococcal Promoters by the Pneumococcal SigA Protein","volume":"8","author":"Solano-Collado","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.chom.2025.08.005_bib8","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1128\/IAI.02944-14","article-title":"Sequence elements upstream of the core promoter are necessary for full transcription of the capsule gene operon in Streptococcus pneumoniae strain D39","volume":"83","author":"Wen","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2025.08.005_bib9","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1128\/IAI.01289-13","article-title":"The core promoter of the capsule operon of Streptococcus pneumoniae is necessary for colonization and invasive disease","volume":"82","author":"Shainheit","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2025.08.005_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-43241-y","article-title":"Synthetic genetic oscillators demonstrate the functional importance of phenotypic variation in pneumococcal-host interactions","volume":"14","author":"Rueff","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2025.08.005_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/srep30176","article-title":"Allelic Variation of the Capsule Promoter Diversifies Encapsulation and Virulence In Streptococcus pneumoniae","volume":"6","author":"Wen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chom.2025.08.005_bib12","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1093\/molbev\/msab018","article-title":"Pneumococcal Colonization and Virulence Factors Identified Via Experimental Evolution in Infection Models","volume":"38","author":"Green","year":"2021","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.chom.2025.08.005_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003495","article-title":"High-Resolution Transcriptome Maps Reveal Strain-Specific Regulatory Features of Multiple Campylobacter jejuni Isolates","volume":"9","author":"Dugar","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.chom.2025.08.005_bib14","doi-asserted-by":"crossref","first-page":"D366","DOI":"10.1093\/nar\/gkp911","article-title":"phiSITE: database of gene regulation in bacteriophages","volume":"38","author":"Klucar","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chom.2025.08.005_bib15","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1006\/jmbi.1993.1202","article-title":"Structure of the maltodextrin-uptake locus of Streptococcus pneumoniae. Correlation to the Escherichia coli maltose regulon","volume":"230","author":"Puyet","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.chom.2025.08.005_bib16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/jmbi.1995.0366","article-title":"An extended -10 promoter alone directs transcription of the DpnII operon of Streptococcus pneumoniae","volume":"250","author":"Sabelnikov","year":"1995","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.chom.2025.08.005_bib17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.mimet.2010.08.004","article-title":"Novel plasmid-based genetic tools for the study of promoters and terminators in Streptococcus pneumoniae and Enterococcus faecalis","volume":"83","author":"Ruiz-Cruz","year":"2010","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.chom.2025.08.005_bib18","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.1021\/bi990206g","article-title":"Protein-nucleic acid interactions during open complex formation investigated by systematic alteration of the protein and DNA binding partners","volume":"38","author":"Helmann","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.chom.2025.08.005_bib19","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1128\/IAI.00587-12","article-title":"Increased chain length promotes pneumococcal adherence and colonization","volume":"80","author":"Rodriguez","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2025.08.005_bib20","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41579-018-0001-8","article-title":"Streptococcus pneumoniae: transmission, colonization and invasion","volume":"16","author":"Weiser","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2025.08.005_bib21","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00989-17","article-title":"Capsule Type and Amount Affect Shedding and Transmission of Streptococcus pneumoniae","volume":"8","author":"Zafar","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.chom.2025.08.005_bib22","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ebiom.2019.04.021","article-title":"International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact","volume":"43","author":"Gladstone","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.chom.2025.08.005_bib23","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.1093\/nar\/gkf606","article-title":"Vanadate inhibits the ATPase activity and DNA binding capability of bacterial MutS. A structural model for the vanadate-MutS interaction at the Walker A motif","volume":"30","author":"Pezza","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chom.2025.08.005_bib24","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/j.1365-2958.2004.04076.x","article-title":"Encoded errors: mutations and rearrangements mediated by misalignment at repetitive DNA sequences","volume":"52","author":"Lovett","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2025.08.005_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-03817-4","article-title":"The bacterial promoter spacer modulates promoter strength and timing by length, TG-motifs and DNA supercoiling sensitivity","volume":"11","author":"Klein","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chom.2025.08.005_bib26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrmicro1912","article-title":"Advances in bacterial promoter recognition and its control by factors that do not bind DNA","volume":"6","author":"Haugen","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2025.08.005_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-28747-1","article-title":"Xenogeneic silencing strategies in bacteria are dictated by RNA polymerase promiscuity","volume":"13","author":"Forrest","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2025.08.005_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/816713","article-title":"Unified theory of bacterial sialometabolism: how and why bacteria metabolize host sialic acids","volume":"2013","author":"Vimr","year":"2013","journal-title":"ISRN Microbiol."},{"key":"10.1016\/j.chom.2025.08.005_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02579-24","article-title":"Neuraminidase-mediated enhancement of Streptococcus pneumoniae colonization is associated with altered mucus characteristics and distribution","volume":"16","author":"Montgomery","year":"2025","journal-title":"mBio"},{"key":"10.1016\/j.chom.2025.08.005_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-49619-w","article-title":"Environmental and genetic regulation of Streptococcus pneumoniae galactose catabolic pathways","volume":"15","author":"Kareem","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2025.08.005_bib31","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/440435a","article-title":"Avian flu: influenza virus receptors in the human airway","volume":"440","author":"Shinya","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.08.005_bib32","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1038\/s41396-023-01509-7","article-title":"Regulatory fine-tuning of mcr-1 increases bacterial fitness and stabilises antibiotic resistance in agricultural settings","volume":"17","author":"Ogunlana","year":"2023","journal-title":"ISME J."},{"key":"10.1016\/j.chom.2025.08.005_bib33","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03103-22","article-title":"Influence of Streptococcus pneumoniae Within-Strain Population Diversity on Virulence and Pathogenesis","volume":"11","author":"Jacques","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.chom.2025.08.005_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-25862-3","article-title":"The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops","volume":"12","author":"Ottema","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2025.08.005_bib35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. J."},{"key":"10.1016\/j.chom.2025.08.005_bib36","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2025.08.005_bib37","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"GigaScience"},{"key":"10.1016\/j.chom.2025.08.005_bib38","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2025.08.005_bib39","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.chom.2025.08.005_bib40","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2025.08.005_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/nmicrobiol.2016.77","article-title":"MicrobeJ, a tool for high throughput bacterial cell detection and quantitative analysis","volume":"1","author":"Ducret","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2025.08.005_bib42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2105-13-31","article-title":"PANDAseq: paired-end assembler for illumina sequences","volume":"13","author":"Masella","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.chom.2025.08.005_bib43","article-title":"SeroBA: rapid high-throughput serotyping of Streptococcus pneumoniae from whole genome sequence data","volume":"4","author":"Epping","year":"2018","journal-title":"Microb. Genom."},{"key":"10.1016\/j.chom.2025.08.005_bib44","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1101\/gr.241455.118","article-title":"Fast and flexible bacterial genomic epidemiology with PopPUNK","volume":"29","author":"Lees","year":"2019","journal-title":"Genome Res."},{"key":"10.1016\/j.chom.2025.08.005_bib45","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3390\/genes11090965","article-title":"Advancing Genetic Tools in Streptococcus pneumoniae","volume":"11","author":"Echlin","year":"2020","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.chom.2025.08.005_bib46","article-title":"CLIMB (the Cloud Infrastructure for Microbial Bioinformatics): an online resource for the medical microbiology community","volume":"2","author":"Connor","year":"2016","journal-title":"Microb. Genom."},{"key":"10.1016\/j.chom.2025.08.005_bib47","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2025.08.005_bib48","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1128\/IAI.00416-16","article-title":"Infant Mouse Model for the Study of Shedding and Transmission during Streptococcus pneumoniae Monoinfection","volume":"84","author":"Zafar","year":"2016","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2025.08.005_bib49","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.chom.2019.04.012","article-title":"Bacterial Factors Required for Transmission of Streptococcus pneumoniae in Mammalian Hosts","volume":"25","author":"Rowe","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2025.08.005_bib50","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.chom.2016.12.005","article-title":"Host-to-Host Transmission of Streptococcus pneumoniae Is Driven by Its Inflammatory Toxin, Pneumolysin","volume":"21","author":"Zafar","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2025.08.005_bib51","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12866-014-0210-x","article-title":"A point mutation in cpsE renders Streptococcus pneumoniae nonencapsulated and enhances its growth, adherence and competence","volume":"14","author":"Schaffner","year":"2014","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.chom.2025.08.005_bib52","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1136\/thoraxjnl-2014-206242","article-title":"Investigating the early-life determinants of illness in Africa: the Drakenstein Child Health Study","volume":"70","author":"Zar","year":"2015","journal-title":"Thorax"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312825003312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312825003312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:40:17Z","timestamp":1781185217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312825003312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1931312825003312"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2025.08.005","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Naturally acquired promoter variation influences Streptococcus pneumoniae infection outcomes","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2025.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}