{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:30:30Z","timestamp":1793532630751,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014576","name":"University of California Office of the President","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014576","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010296","name":"James B Pendleton Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010296","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006235","name":"E O Lawrence Berkeley National Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006235","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.chom.2025.10.018","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:09:09Z","timestamp":1764086949000},"page":"2043-2051.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Divergent viral phosphodiesterases for immune signaling evasion"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1555-4124","authenticated-orcid":false,"given":"Erin E.","family":"Doherty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Nomburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurashau","family":"Blount","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Doudna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2025.10.018_bib1","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1016\/j.cell.2023.05.038","article-title":"cGLRs are a diverse family of pattern recognition receptors in innate immunity","volume":"186","author":"Li","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.chom.2025.10.018_bib2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.sbi.2019.08.003","article-title":"cGAS and CD-NTase enzymes: structure, mechanism, and evolution","volume":"59","author":"Kranzusch","year":"2019","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.chom.2025.10.018_bib3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nri3719","article-title":"OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids","volume":"14","author":"Hornung","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2025.10.018_bib4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cell.2020.05.019","article-title":"CBASS Immunity Uses CARF-Related Effectors to Sense 3\u2032\u20135\u2032- and 2\u2032\u20135\u2032-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection","volume":"182","author":"Lowey","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.chom.2025.10.018_bib5","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/s41586-022-04716-y","article-title":"Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity","volume":"605","author":"Hobbs","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.10.018_bib6","doi-asserted-by":"crossref","first-page":"5229","DOI":"10.1093\/nar\/gkf645","article-title":"Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily","volume":"30","author":"Mazumder","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chom.2025.10.018_bib7","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/s41586-024-07809-y","article-title":"Birth of protein folds and functions in the virome","volume":"633","author":"Nomburg","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.10.018_bib8","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.1016\/j.cell.2024.07.057","article-title":"Animal and bacterial viruses share conserved mechanisms of immune evasion","volume":"187","author":"Hobbs","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.chom.2025.10.018_bib9","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41586-019-0953-5","article-title":"Bacterial cGAS-like enzymes synthesize diverse nucleotide signals","volume":"567","author":"Whiteley","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.10.018_bib10","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1016\/j.molcel.2022.11.006","article-title":"Bacterial origins of cyclic nucleotide-activated antiviral immune signaling","volume":"82","author":"Patel","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chom.2025.10.018_bib11","doi-asserted-by":"crossref","DOI":"10.1093\/femsml\/uqad015","article-title":"Recent advances and perspectives in nucleotide second messenger signaling in bacteria","volume":"4","author":"Hengge","year":"2023","journal-title":"Microlife"},{"key":"10.1016\/j.chom.2025.10.018_bib12","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1093\/bioinformatics\/btz536","article-title":"Benchmarking fold detection by DaliLite v.5","volume":"35","author":"Holm","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2025.10.018_bib13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/protein\/12.2.85","article-title":"Twilight zone of protein sequence alignments","volume":"12","author":"Rost","year":"1999","journal-title":"Protein Eng."},{"key":"10.1016\/j.chom.2025.10.018_bib14","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-11-431","article-title":"Hidden Markov model speed heuristic and iterative HMM search procedure","volume":"11","author":"Johnson","year":"2010","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.chom.2025.10.018_bib15","article-title":"Multiple Protein Structure Alignment at Scale with FoldMason","author":"Gilchrist","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.chom.2025.10.018_bib16","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1093\/molbev\/msaa015","article-title":"IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era","volume":"37","author":"Minh","year":"2020","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.chom.2025.10.018_bib17","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1038\/s41564-020-0777-y","article-title":"Diversity and classification of cyclic-oligonucleotide-based anti-phage signalling systems","volume":"5","author":"Millman","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2025.10.018_bib18","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature23467","article-title":"Type III CRISPR\u2013Cas systems produce cyclic oligoadenylate second messengers","volume":"548","author":"Niewoehner","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.10.018_bib19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1126\/science.aao0100","article-title":"A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems","volume":"357","author":"Kazlauskiene","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.chom.2025.10.018_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-025-09569-9","article-title":"A miniature CRISPR\u2013Cas10 enzyme confers immunity by inhibitory signalling","author":"Doherty","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.10.018_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-025-09557-z","article-title":"The Panoptes system uses decoy cyclic nucleotides to defend against phage","author":"Sullivan","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.10.018_bib22","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.1016\/j.cell.2021.09.031","article-title":"Cyclic CMP and cyclic UMP mediate bacterial immunity against phages","volume":"184","author":"Tal","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.chom.2025.10.018_bib23","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00208-21","article-title":"Cellular Effects of 2\u2032,3\u2032-Cyclic Nucleotide Monophosphates in Gram-Negative Bacteria","volume":"204","author":"Duggal","year":"2022","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.chom.2025.10.018_bib24","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1093\/nar\/gkaa112","article-title":"Cyclic di-AMP, a second messenger of primary importance: tertiary structures and binding mechanisms","volume":"48","author":"He","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chom.2025.10.018_bib25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-micro-020518-115555","article-title":"Multiple Roles of c-di-GMP Signaling in Bacterial Pathogenesis","volume":"73","author":"Valentini","year":"2019","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.chom.2025.10.018_bib26","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/s41586-023-06620-5","article-title":"Antiviral type III CRISPR signalling via conjugation of ATP and SAM","volume":"622","author":"Chi","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.10.018_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/science.ads6055","article-title":"Base-modified nucleotides mediate immune signaling in bacteria","volume":"388","author":"Zeng","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.chom.2025.10.018_bib28","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1126\/science.adu2262","article-title":"TIR signaling activates caspase-like immunity in bacteria","volume":"387","author":"Rousset","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.chom.2025.10.018_bib29","article-title":"Bacterial cGAS-like enzymes produce 2\u2032,3\u2032-cGAMP to activate an ion channel that restricts phage replication","author":"Tak","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.chom.2025.10.018_bib31","first-page":"214","article-title":"INfrastructure for a PHAge REference Database: Identification of Large-Scale Biases in the Current Collection of Cultured Phage Genomes","volume":"2","author":"Cook","year":"2021","journal-title":"Phage (New Rochelle)"},{"key":"10.1016\/j.chom.2025.10.018_bib30","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41586-020-2007-4","article-title":"Clades of huge phages from across Earth\u2019s ecosystems","volume":"578","author":"Al-Shayeb","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.chom.2025.10.018_bib33","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","article-title":"ColabFold: making protein folding accessible to all","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2025.10.018_bib32","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/nbt.3988","article-title":"MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets","volume":"35","author":"Steinegger","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chom.2025.10.018_bib35","doi-asserted-by":"crossref","first-page":"D348","DOI":"10.1093\/nar\/gkae1087","article-title":"CATH v4.4: major expansion of CATH by experimental and predicted structural data","volume":"53","author":"Waman","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chom.2025.10.018_bib36","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1107\/S2059798317016035","article-title":"CCP4i2: the new graphical user interface to the CCP4 program suite","volume":"74","author":"Potterton","year":"2018","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.chom.2025.10.018_bib40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr., D"},{"key":"10.1016\/j.chom.2025.10.018_bib41","doi-asserted-by":"crossref","first-page":"W83","DOI":"10.1093\/nar\/gkae410","article-title":"The Galaxy platform for accessible, reproducible, and collaborative data analyses: 2024 update","volume":"52","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chom.2025.10.018_bib42","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41587-023-01690-2","article-title":"Integrative analysis of multimodal mass spectrometry data in MZmine 3","volume":"41","author":"Schmid","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chom.2025.10.018_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btae296","article-title":"Chainsaw: protein domain segmentation with fully convolutional neural networks","volume":"40","author":"Wells","year":"2024","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2025.10.018_bib37","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1107\/S2059798322004399","article-title":"xia2.multiplex: a multi-crystal data-analysis pipeline","volume":"78","author":"Gildea","year":"2022","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.chom.2025.10.018_bib38","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1107\/S0907444905036693","article-title":"Scaling and assessment of data quality","volume":"62","author":"Evans","year":"2006","journal-title":"Acta Crystallogr., D"},{"key":"10.1016\/j.chom.2025.10.018_bib39","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1107\/S0907444913000061","article-title":"How good are my data and what is the resolution?","volume":"69","author":"Evans","year":"2013","journal-title":"Acta Crystallogr., D"}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312825004524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312825004524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:11:48Z","timestamp":1765383108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312825004524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1931312825004524"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2025.10.018","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Divergent viral phosphodiesterases for immune signaling evasion","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2025.10.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}