{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:28:59Z","timestamp":1785338939415,"version":"3.55.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.chom.2026.03.010","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:24:45Z","timestamp":1775665485000},"page":"545-547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microbes as architects of colonic patterning"],"prefix":"10.1016","volume":"34","author":[{"given":"Dena","family":"Lyras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Hei","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3792-4023","authenticated-orcid":false,"given":"Helen E.","family":"Abud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2026.03.010_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.20","article-title":"Clostridium difficile infection","volume":"2","author":"Smits","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.chom.2026.03.010_bib2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nature07450","article-title":"Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis","volume":"456","author":"Bouskra","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.chom.2026.03.010_bib3","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.chom.2015.10.007","article-title":"Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization","volume":"18","author":"Johansson","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2026.03.010_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.108941","article-title":"Effects of flora deficiency on the structure and function of the large intestine","volume":"27","author":"Chai","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.chom.2026.03.010_bib5","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1242\/dev.097386","article-title":"How to make an intestine","volume":"141","author":"Wells","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.chom.2026.03.010_bib6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41580-020-0278-0","article-title":"Cell fate specification and differentiation in the adult mammalian intestine","volume":"22","author":"Beumer","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chom.2026.03.010_bib7","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1242\/dev.121.10.3163","article-title":"Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut","volume":"121","author":"Roberts","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.chom.2026.03.010_bib8","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.devcel.2009.02.010","article-title":"Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2","volume":"16","author":"Gao","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.chom.2026.03.010_bib9","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41556-023-01337-z","article-title":"Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains","volume":"26","author":"Zwick","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.chom.2026.03.010_bib10","article-title":"Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility","volume":"189","author":"Rispal","year":"2026","journal-title":"Cell"}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312826001186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312826001186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:27:05Z","timestamp":1776284825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312826001186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1931312826001186"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2026.03.010","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbes as architects of colonic patterning","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2026.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2026.02.007","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}