{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:44:53Z","timestamp":1792507493048,"version":"4.5.0"},"reference-count":92,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000875","name":"The Pew Charitable Trusts","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000875","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000884","name":"Cancer Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014185","name":"Searle Scholars Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001710","name":"The Branco Weiss Fellowship","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.chom.2026.04.009","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:41:31Z","timestamp":1778078491000},"page":"1050-1066.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Maternal helminths rewire the microbiota to promote offspring antiviral immunity"],"prefix":"10.1016","volume":"34","author":[{"given":"Krist","family":"Antunes Fernandes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Cafiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jojo","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8834-3136","authenticated-orcid":false,"given":"Ai Ing","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2026.04.009_bib1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0140-6736(17)31930-X","article-title":"Soil-transmitted helminth infections","volume":"391","author":"Jourdan","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2026.04.009_bib2","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1146\/annurev-immunol-093019-122827","article-title":"Immune System Investigation Using Parasitic Helminths","volume":"39","author":"Douglas","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.chom.2026.04.009_bib3","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jaci.2016.07.007","article-title":"Regulation of the host immune system by helminth parasites","volume":"138","author":"Maizels","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.chom.2026.04.009_bib4","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/imr.13315","article-title":"Maternal-driven immune education in offspring","volume":"323","author":"Fernandes","year":"2024","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.chom.2026.04.009_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/science.abf3002","article-title":"Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring","volume":"373","author":"Lim","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.chom.2026.04.009_bib6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.pt.2020.10.013","article-title":"Toxoplasma Effectors that Affect Pregnancy Outcome","volume":"37","author":"Arranz-Sol\u00eds","year":"2021","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.chom.2026.04.009_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/v15010220","article-title":"Maternal Immune Response to ZIKV Triggers High-Inflammatory Profile in Congenital Zika Syndrome","volume":"15","author":"Fialho","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.chom.2026.04.009_bib8","doi-asserted-by":"crossref","first-page":"6256","DOI":"10.4049\/jimmunol.177.9.6256","article-title":"Mechanisms of neonatal mucosal antibody protection","volume":"177","author":"Harris","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2026.04.009_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aav3058","article-title":"Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring","volume":"5","author":"Darby","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.chom.2026.04.009_bib10","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2026.04.009_bib11","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-021-04580-1","article-title":"Dissection of the gut microbiota in mothers and children with chronic Trichuris trichiura infection in Pemba Island, Tanzania","volume":"14","author":"Chen","year":"2021","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.chom.2026.04.009_bib12","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.chom.2023.02.008","article-title":"Networking between helminths, microbes, and mammals","volume":"31","author":"Loke","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2026.04.009_bib13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijpara.2019.09.005","article-title":"Infection with a small intestinal helminth, Heligmosomoides polygyrus bakeri, consistently alters microbial communities throughout the murine small and large intestine","volume":"50","author":"Rapin","year":"2020","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.chom.2026.04.009_bib14","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-020-02020-4","article-title":"Lifestyle and the presence of helminths is associated with gut microbiome composition in Cameroonians","volume":"21","author":"Rubel","year":"2020","journal-title":"Genome Biol."},{"key":"10.1016\/j.chom.2026.04.009_bib15","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-022-01385-x","article-title":"Gut microbiome of helminth-infected indigenous Malaysians is context dependent","volume":"10","author":"Tee","year":"2022","journal-title":"Microbiome"},{"key":"10.1016\/j.chom.2026.04.009_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/nu16234023","article-title":"Interplay Between Helminth Infections, Malnutrition, and Gut Microbiota in Children and Mothers from Pemba, Tanzania: Potential of Microbiota-Directed Interventions","volume":"16","author":"Toussaint Ngu\u00e9l\u00e9","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.chom.2026.04.009_bib17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41385-018-0102-8","article-title":"Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites","volume":"12","author":"Filbey","year":"2019","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.chom.2026.04.009_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.phrs.2018.04.008","article-title":"Helminth infection in mice improves insulin sensitivity via modulation of gut microbiota and fatty acid metabolism","volume":"132","author":"Pace","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.chom.2026.04.009_bib19","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.immuni.2015.09.012","article-title":"The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation","volume":"43","author":"Zaiss","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2026.04.009_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002490","article-title":"IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease","volume":"8","author":"Fairfax","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2026.04.009_bib21","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.chom.2023.01.018","article-title":"Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites","volume":"31","author":"Bogaert","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2026.04.009_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanmic.2024.101042","article-title":"Clinical implications of maternal multikingdom transmissions and early-life microbiota","volume":"6","author":"Zeng","year":"2025","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.chom.2026.04.009_bib23","doi-asserted-by":"crossref","DOI":"10.3791\/52412","article-title":"Cultivation of Heligmosomoides polygyrus: an immunomodulatory nematode parasite and its secreted products","author":"Johnston","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.chom.2026.04.009_bib24","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00281-012-0347-3","article-title":"Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus","volume":"34","author":"Reynolds","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.chom.2026.04.009_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2024.103144","article-title":"A simplified protocol for deriving sterile, infectious murine Heligmosomoides polygyrus bakeri larvae","volume":"5","author":"Blackwell","year":"2024","journal-title":"Star Protoc."},{"key":"10.1016\/j.chom.2026.04.009_bib26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.exppara.2011.08.011","article-title":"Immune modulation and modulators in Heligmosomoides polygyrus infection","volume":"132","author":"Maizels","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.chom.2026.04.009_bib27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/mi.2016.36","article-title":"Primary Heligmosomoides polygyrus bakeri infection induces myeloid-derived suppressor cells that suppress CD4+ Th2 responses and promote chronic infection","volume":"10","author":"Valanparambil","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.chom.2026.04.009_bib28","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.immuni.2009.01.006","article-title":"Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus","volume":"30","author":"Wojciechowski","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2026.04.009_bib29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature17173","article-title":"High-fat diet enhances stemness and tumorigenicity of intestinal progenitors","volume":"531","author":"Beyaz","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.chom.2026.04.009_bib30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.tcb.2023.10.008","article-title":"Multiplicity of stem cell memories of inflammation and tissue repair in epithelia","volume":"34","author":"Levra Levron","year":"2024","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.chom.2026.04.009_bib31","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature24271","article-title":"Inflammatory memory sensitizes skin epithelial stem cells to tissue damage","volume":"550","author":"Naik","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.chom.2026.04.009_bib32","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41586-018-0449-8","article-title":"Allergic inflammatory memory in human respiratory epithelial progenitor cells","volume":"560","author":"Ordovas-Montanes","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.chom.2026.04.009_bib33","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0140-6736(24)01716-1","article-title":"Severe respiratory syncytial virus infection in children: burden, management, and emerging therapies","volume":"404","author":"Mazur","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2026.04.009_bib34","doi-asserted-by":"crossref","DOI":"10.1186\/1743-422X-2-46","article-title":"Respiratory syncytial virus-induced acute and chronic airway disease is independent of genetic background: an experimental murine model","volume":"2","author":"Ch\u00e1vez-Bueno","year":"2005","journal-title":"Virol. J."},{"key":"10.1016\/j.chom.2026.04.009_bib35","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.4049\/jimmunol.1101789","article-title":"Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins","volume":"187","author":"Bera","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2026.04.009_bib36","doi-asserted-by":"crossref","first-page":"10946","DOI":"10.1128\/JVI.01295-13","article-title":"Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice","volume":"87","author":"Durant","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2026.04.009_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2018.07.012","article-title":"Cytokines and CD8 T cell immunity during respiratory syncytial virus infection","volume":"133","author":"Schmidt","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.chom.2026.04.009_bib38","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1164\/rccm.201812-2366OC","article-title":"Elevated Levels of Type 2 Respiratory Innate Lymphoid Cells in Human Infants with Severe Respiratory Syncytial Virus Bronchiolitis","volume":"200","author":"Vu","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.chom.2026.04.009_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-39569-0","article-title":"High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection","volume":"14","author":"Nagai","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2026.04.009_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00259","article-title":"Type I Interferons as Regulators of Lung Inflammation","volume":"8","author":"Makris","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chom.2026.04.009_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103891","article-title":"Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis","volume":"77","author":"Antunes","year":"2022","journal-title":"EBiomedicine"},{"key":"10.1016\/j.chom.2026.04.009_bib42","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210235","article-title":"Maternal gut microbiome regulates immunity to RSV infection in offspring","volume":"218","author":"Fonseca","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.chom.2026.04.009_bib43","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.immuni.2024.05.019","article-title":"Longitudinal humoral analysis in RSV-infected infants identifies pre-existing RSV strain-specific G and evolving cross-reactive F antibodies","volume":"57","author":"Nziza","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2026.04.009_bib44","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2020.04.030","article-title":"An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint","volume":"181","author":"Ramanan","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.chom.2026.04.009_bib45","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.cell.2024.02.022","article-title":"Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer","volume":"187","author":"Jia","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.chom.2026.04.009_bib46","article-title":"Bifidobacteria with indole-3-lactic acid-producing capacity exhibit psychobiotic potential via reducing neuroinflammation","volume":"5","author":"Qian","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.chom.2026.04.009_bib47","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41586-022-04884-x","article-title":"The gut metabolite indole-3 propionate promotes nerve regeneration and repair","volume":"607","author":"Serger","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.chom.2026.04.009_bib48","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-024-01750-y","article-title":"Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding","volume":"12","author":"Wang","year":"2024","journal-title":"Microbiome"},{"key":"10.1016\/j.chom.2026.04.009_bib49","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-3024.1985.tb00073.x","article-title":"Genetic control of immunity to Nematospiroides dubius: a 9-day anthelmintic abbreviated immunizing regime which separates weak and strong responder strains of mice","volume":"7","author":"Behnke","year":"1985","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.chom.2026.04.009_bib50","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0014-4894(84)90105-X","article-title":"Heligmosomoides polygyrus: time of anthelmintic treatment and infection parameters in mice exposed to increasing doses of larvae","volume":"57","author":"Kerboeuf","year":"1984","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.chom.2026.04.009_bib51","article-title":"Type 2 immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis","volume":"3","author":"Fricke","year":"2015","journal-title":"Microbiome"},{"key":"10.1016\/j.chom.2026.04.009_bib52","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1016\/j.cell.2023.05.046","article-title":"Ultra-deep sequencing of Hadza hunter-gatherers recovers vanishing gut microbes","volume":"186","author":"Carter","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.chom.2026.04.009_bib53","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.abj2972","article-title":"Robust variation in infant gut microbiome assembly across a spectrum of lifestyles","volume":"376","author":"Olm","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.chom.2026.04.009_bib54","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.stem.2024.10.003","article-title":"Maternal gut microbiota influence stem cell function in offspring","volume":"32","author":"Dang","year":"2025","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.chom.2026.04.009_bib55","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202217241","article-title":"Maternal diet and gut microbiome composition modulate early-life immune development","volume":"15","author":"Grant","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.chom.2026.04.009_bib56","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw8429","article-title":"Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice","volume":"367","author":"Kimura","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.chom.2026.04.009_bib57","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2206505","article-title":"Maternal microbe-specific modulation of the offspring microbiome and development during pregnancy and lactation","volume":"15","author":"Tian","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.chom.2026.04.009_bib58","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2442526","article-title":"Maternal probiotic exposure enhances CD8 T cell protective neonatal immunity and modulates offspring metabolome to control influenza virus infection","volume":"17","author":"Valentin","year":"2025","journal-title":"Gut Microbes"},{"key":"10.1016\/j.chom.2026.04.009_bib59","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41586-020-2745-3","article-title":"The maternal microbiome modulates fetal neurodevelopment in mice","volume":"586","author":"Vuong","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.chom.2026.04.009_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abh3816","article-title":"Maternal gut microbiome-induced IgG regulates neonatal gut microbiome and immunity","volume":"7","author":"Sanidad","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.chom.2026.04.009_bib61","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.immuni.2021.11.005","article-title":"Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells","volume":"55","author":"Kim","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2026.04.009_bib62","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2325067","article-title":"Shotgun metagenomics and systemic targeted metabolomics highlight indole-3-propionic acid as a protective gut microbial metabolite against influenza infection","volume":"16","author":"Heumel","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.chom.2026.04.009_bib63","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.immuni.2024.06.010","article-title":"Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood","volume":"57","author":"Perdijk","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2026.04.009_bib64","article-title":"Maternal consumption of ultra-processed foods and subsequent risk of offspring overweight or obesity: results from three prospective cohort studies","volume":"379","author":"Wang","year":"2022","journal-title":"BMJ"},{"key":"10.1016\/j.chom.2026.04.009_bib65","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-018-0416-5","article-title":"Differential human gut microbiome assemblages during soil-transmitted helminth infections in Indonesia and Liberia","volume":"6","author":"Rosa","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.chom.2026.04.009_bib66","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.jaci.2017.01.016","article-title":"Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota","volume":"140","author":"McFarlane","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.chom.2026.04.009_bib67","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.jcmgh.2020.06.010","article-title":"Helminth-Induced and Th2-Dependent Alterations of the Gut Microbiota Attenuate Obesity Caused by High-Fat Diet","volume":"10","author":"Su","year":"2020","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.chom.2026.04.009_bib68","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.4049\/jimmunol.2400158","article-title":"Maternal Helminth Infection Causes Dysfunctional B Cell Development in Male Offspring","volume":"213","author":"Gibbs","year":"2024","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2026.04.009_bib69","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jaci.2014.05.034","article-title":"Maternal immune response to helminth infection during pregnancy determines offspring susceptibility to allergic airway inflammation","volume":"134","author":"Straubinger","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.chom.2026.04.009_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009260","article-title":"Maternal schistosomiasis impairs offspring Interleukin-4 production and B cell expansion","volume":"17","author":"Cort\u00e9s-Selva","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2026.04.009_bib71","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2147\/JIR.S348079","article-title":"Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives","volume":"15","author":"Shi","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.chom.2026.04.009_bib72","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.pt.2019.04.009","article-title":"Helminth Therapy - From the Parasite Perspective","volume":"35","author":"Sobotkov\u00e1","year":"2019","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.chom.2026.04.009_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.575586","article-title":"Indole Propionic Acid, an Unusual Antibiotic Produced by the Gut Microbiota, With Anti-inflammatory and Antioxidant Properties","volume":"11","author":"Negatu","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.chom.2026.04.009_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/s41387-018-0046-9","article-title":"Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals","volume":"8","author":"Tuomainen","year":"2018","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.chom.2026.04.009_bib75","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jare.2025.05.051","article-title":"Prenatal supplementation with the gut-derived tryptophan metabolite indole-3-propionic acid alleviates colitis susceptibility in maternal immune-activated offspring mice","volume":"81","author":"He","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.chom.2026.04.009_bib76","article-title":"Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against \u03b1PD1-induced cardiotoxicity in mice","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2026.04.009_bib77","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbi.2022.08.003","article-title":"Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP\/PS1 mice","volume":"106","author":"Sun","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.chom.2026.04.009_bib78","doi-asserted-by":"crossref","DOI":"10.1186\/s10020-023-00614-9","article-title":"Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR\/NF-\u03baB axis","volume":"29","author":"Zhuang","year":"2023","journal-title":"Mol. Med."},{"key":"10.1016\/j.chom.2026.04.009_bib79","article-title":"Generation of Mouse Lung Epithelial Cells","volume":"3","author":"Kasinski","year":"2013","journal-title":"Bio Protoc."},{"key":"10.1016\/j.chom.2026.04.009_bib80","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.4049\/jimmunol.1004140","article-title":"Heligmosomoides polygyrus elicits a dominant nonprotective antibody response directed against restricted glycan and peptide epitopes","volume":"187","author":"Hewitson","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2026.04.009_bib81","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1086\/386341","article-title":"Timing of infection and prior immunization with respiratory syncytial virus (RSV) in RSV-enhanced allergic inflammation","volume":"189","author":"Barends","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.chom.2026.04.009_bib82","doi-asserted-by":"crossref","first-page":"11651","DOI":"10.1128\/JVI.01387-06","article-title":"In vitro and in vivo fitness of respiratory syncytial virus monoclonal antibody escape mutants","volume":"80","author":"Zhao","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2026.04.009_bib83","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-36323-4","article-title":"Microbiota-derived acetate enhances host antiviral response via NLRP3","volume":"14","author":"Niu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2026.04.009_bib84","article-title":"High Resolution Mass Spectrometry Improves Data Quantity and Quality as Compared to Unit Mass Resolution Mass Spectrometry in High-Throughput Profiling Metabolomics","volume":"4","author":"Evans","year":"2014","journal-title":"Metabolomics."},{"key":"10.1016\/j.chom.2026.04.009_bib85","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/jalm\/jfz026","article-title":"Precision of a Clinical Metabolomics Profiling Platform for Use in the Identification of Inborn Errors of Metabolism","volume":"5","author":"Ford","year":"2020","journal-title":"J. Appl. Lab. Med."},{"key":"10.1016\/j.chom.2026.04.009_bib86","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/ismej.2012.8","article-title":"Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms","volume":"6","author":"Caporaso","year":"2012","journal-title":"ISME J."},{"key":"10.1016\/j.chom.2026.04.009_bib87","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1016\/j.cell.2022.07.020","article-title":"Gut bacterial nutrient preferences quantified in vivo","volume":"185","author":"Zeng","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.chom.2026.04.009_bib88","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","article-title":"PICRUSt2 for prediction of metagenome functions","volume":"38","author":"Douglas","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chom.2026.04.009_bib89","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btad470","article-title":"ggpicrust2: an R package for PICRUSt2 predicted functional profile analysis and visualization","volume":"39","author":"Yang","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2026.04.009_bib90","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00125-22","article-title":"Indole-3-Propionic Acid as a Potential Therapeutic Agent for Sepsis-Induced Gut Microbiota Disturbance","volume":"10","author":"Fang","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.chom.2026.04.009_bib91","doi-asserted-by":"crossref","DOI":"10.1126\/science.aax9176","article-title":"A metagenomic strategy for harnessing the chemical repertoire of the human microbiome","volume":"366","author":"Sugimoto","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.chom.2026.04.009_bib92","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65088","article-title":"Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3","volume":"10","author":"Beghini","year":"2021","journal-title":"eLife"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312826001654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312826001654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:17:07Z","timestamp":1783163827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312826001654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":92,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S1931312826001654"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2026.04.009","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal helminths rewire the microbiota to promote offspring antiviral immunity","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2026.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}