{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:20:59Z","timestamp":1783081259583,"version":"3.54.6"},"reference-count":10,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 DK120515"],"award-info":[{"award-number":["P30 DK120515"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005347","name":"American Association for the Study of Liver Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R00AA031328"],"award-info":[{"award-number":["R00AA031328"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["CTORA23-208366"],"award-info":[{"award-number":["CTORA23-208366"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.chom.2026.05.011","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:05:07Z","timestamp":1781103907000},"page":"975-977","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineered probiotic for hepatic encephalopathy"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2604-1340","authenticated-orcid":false,"given":"Cynthia L.","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2026.05.011_bib1","doi-asserted-by":"crossref","DOI":"10.1007\/s00535-026-02425-1","article-title":"Covert hepatic encephalopathy as a multi-organ syndrome: the gut-liver-muscle-brain axis, diagnosis, treatment, and multidisciplinary care","author":"Miwa","year":"2026","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.chom.2026.05.011_bib2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.14309\/ajg.0000000000003899","article-title":"ACG Clinical Guideline: Hepatic Encephalopathy","volume":"121","author":"Bajaj","year":"2026","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.chom.2026.05.011_bib3","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/s41467-025-67326-y","article-title":"Increased risk of antimicrobial resistance in patients with cirrhosis and hepatic encephalopathy using rifaximin","volume":"17","author":"Kuo","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2026.05.011_bib4","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrgastro.2013.99","article-title":"The liver-brain axis in liver failure: neuroinflammation and encephalopathy","volume":"10","author":"Butterworth","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.chom.2026.05.011_bib5","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1038\/nm.3400","article-title":"Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering","volume":"19","author":"Rangroo Thrane","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2026.05.011_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2026.03.048","article-title":"Engineered commensals for metabolic modulation of the gut-liver-brain axis","volume":"189","author":"Aggarwal","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.chom.2026.05.011_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau7975","article-title":"An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans","volume":"11","author":"Kurtz","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chom.2026.05.011_bib8","doi-asserted-by":"crossref","first-page":"723","DOI":"10.14309\/ajg.0000000000000343","article-title":"Ammonia Levels Do Not Guide Clinical Management of Patients With Hepatic Encephalopathy Caused by Cirrhosis","volume":"115","author":"Haj","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.chom.2026.05.011_bib9","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","article-title":"The gut-liver axis and gut microbiota in health and liver disease","volume":"21","author":"Hsu","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2026.05.011_bib10","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.jhep.2016.06.004","article-title":"Metabolic adaptation of skeletal muscle to hyperammonemia drives the beneficial effects of l-leucine in cirrhosis","volume":"65","author":"Davuluri","year":"2016","journal-title":"J. Hepatol."}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312826002040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312826002040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:42:17Z","timestamp":1783078937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312826002040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S1931312826002040"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2026.05.011","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineered probiotic for hepatic encephalopathy","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2026.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2026.03.048","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}