{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:10:00Z","timestamp":1792033800731,"version":"4.4.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.chom.2026.08.015","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:44:40Z","timestamp":1788968680000},"page":"1981-1997.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microbial indole-3-acetamide alleviates polycystic ovary syndrome through HIF-2\u03b1-ceramide signaling"],"prefix":"10.1016","volume":"34","author":[{"given":"Weixuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyu","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingkai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejian","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changtao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1967-2416","authenticated-orcid":false,"given":"Yanli","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2026.08.015_bib1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41574-024-01057-w","article-title":"Polycystic ovary syndrome as a metabolic disease","volume":"21","author":"Helvaci","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.chom.2026.08.015_bib2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41572-024-00511-3","article-title":"Polycystic ovary syndrome","volume":"10","author":"Stener-Victorin","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.chom.2026.08.015_bib3","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.cmet.2025.08.002","article-title":"Polycystic ovary syndrome: A metabolic disorder with therapeutic opportunities","volume":"37","author":"Zhang","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.chom.2026.08.015_bib4","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12916-023-02975-8","article-title":"Perturbations in gut microbiota composition in patients with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"21","author":"Li","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.chom.2026.08.015_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1894070","article-title":"The impact of the gut microbiota on the reproductive and metabolic endocrine system","volume":"13","author":"Qi","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.chom.2026.08.015_bib6","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/s41591-019-0509-0","article-title":"Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome","volume":"25","author":"Qi","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2026.08.015_bib7","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/s42255-024-01041-8","article-title":"The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice","volume":"6","author":"Yun","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.chom.2026.08.015_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.chom.2024.12.006","article-title":"The intestinal fungus Aspergillus tubingensis promotes polycystic ovary syndrome through a secondary metabolite","volume":"33","author":"Wu","year":"2025","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2026.08.015_bib9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1210\/clinem\/dgad356","article-title":"Adipose Tissue Dysfunction in Polycystic Ovary Syndrome","volume":"109","author":"Bril","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.chom.2026.08.015_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.steroids.2017.12.009","article-title":"Enlarged adipocytes in subcutaneous adipose tissue associated to hyperandrogenism and visceral adipose tissue volume in women with polycystic ovary syndrome","volume":"130","author":"Echibur\u00fa","year":"2018","journal-title":"Steroids"},{"key":"10.1016\/j.chom.2026.08.015_bib11","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/cen.13931","article-title":"Adipocyte expression of glucose transporter 1 and 4 in PCOS: Relationship to insulin-mediated and non-insulin-mediated whole-body glucose uptake","volume":"90","author":"Ezeh","year":"2019","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.chom.2026.08.015_bib12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/humrep\/dey356","article-title":"Alterations in plasma non-esterified fatty acid (NEFA) kinetics and relationship with insulin resistance in polycystic ovary syndrome","volume":"34","author":"Ezeh","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.chom.2026.08.015_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12958-021-00878-y","article-title":"Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation","volume":"20","author":"Dumesic","year":"2022","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.chom.2026.08.015_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","year":"2004","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.chom.2026.08.015_bib15","doi-asserted-by":"crossref","first-page":"bnaa010","DOI":"10.1210\/endrev\/bnaa010","article-title":"Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome","volume":"41","author":"Stener-Victorin","year":"2020","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.chom.2026.08.015_bib16","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1136\/gutjnl-2020-323071","article-title":"Gut microbiota-derived metabolites as central regulators in metabolic disorders","volume":"70","author":"Agus","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.chom.2026.08.015_bib17","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/gutjnl-2021-326789","article-title":"Gut microbiome and health: mechanistic insights","volume":"71","author":"de Vos","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.chom.2026.08.015_bib18","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","article-title":"Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease","volume":"23","author":"Agus","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2026.08.015_bib19","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/humupd\/dmab004","article-title":"Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome","volume":"27","author":"de Medeiros","year":"2021","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.chom.2026.08.015_bib20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.metabol.2017.09.016","article-title":"Polycystic ovarian syndrome (PCOS): Long-term metabolic consequences","volume":"86","author":"Anagnostis","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.chom.2026.08.015_bib21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/physrev.00033.2011","article-title":"Pathophysiology of human visceral obesity: an update","volume":"93","author":"Tchernof","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.chom.2026.08.015_bib22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/joim.12540","article-title":"Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids","volume":"280","author":"Smith","year":"2016","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.chom.2026.08.015_bib23","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.chom.2024.04.017","article-title":"Candida albicans accelerates atherosclerosis by activating intestinal hypoxia-inducible factor2\u03b1 signaling","volume":"32","author":"Wang","year":"2024","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2026.08.015_bib24","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/j.cmet.2024.07.004","article-title":"A microbial metabolite inhibits the HIF-2\u03b1-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH","volume":"36","author":"Zhang","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.chom.2026.08.015_bib25","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.cmet.2019.09.016","article-title":"Adipocyte Hypoxia-Inducible Factor 2\u03b1 Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism","volume":"30","author":"Zhang","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.chom.2026.08.015_bib26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cmet.2011.02.005","article-title":"Transcriptional control of adipose lipid handling by IRF4","volume":"13","author":"Eguchi","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.chom.2026.08.015_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2014-1020","article-title":"Intraovarian control of early folliculogenesis","volume":"36","author":"Hsueh","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.chom.2026.08.015_bib28","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.3390\/microorganisms11082077","article-title":"Biosynthetic Pathways and Functions of Indole-3-Acetic Acid in Microorganisms","volume":"11","author":"Tang","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.chom.2026.08.015_bib29","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/abbi.1995.1034","article-title":"Purification and characterization of the flavoprotein tryptophan 2-monooxygenase expressed at high levels in Escherichia coli","volume":"316","author":"Emanuele","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.chom.2026.08.015_bib30","doi-asserted-by":"crossref","first-page":"122584","DOI":"10.1016\/j.biomaterials.2024.122584","article-title":"Engineered probiotics with sustained release of interleukin-2 for the treatment of inflammatory bowel disease after oral delivery","volume":"309","author":"Li","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.chom.2026.08.015_bib31","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.2337\/db14-0635","article-title":"Engineered commensal bacteria reprogram intestinal cells into glucose-responsive insulin-secreting cells for the treatment of diabetes","volume":"64","author":"Duan","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.chom.2026.08.015_bib32","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1126\/science.add7034","article-title":"Probiotic-guided CAR-T cells for solid tumor targeting","volume":"382","author":"Vincent","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.chom.2026.08.015_bib33","doi-asserted-by":"crossref","first-page":"13826","DOI":"10.1021\/bi035299n","article-title":"Analysis of the role of the active site residue Arg98 in the flavoprotein tryptophan 2-monooxygenase, a member of the L-amino oxidase family","volume":"42","author":"Sobrado","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.chom.2026.08.015_bib34","doi-asserted-by":"crossref","first-page":"100937","DOI":"10.1016\/j.molmet.2020.01.001","article-title":"Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies","volume":"35","author":"Sanchez-Garrido","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.chom.2026.08.015_bib35","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s12602-024-10223-5","article-title":"Gut Microbiota and Polycystic Ovary Syndrome (PCOS): Understanding the Pathogenesis and the Role of Probiotics as a Therapeutic Strategy","volume":"16","author":"Salehi","year":"2024","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.chom.2026.08.015_bib36","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.chom.2026.08.015_bib37","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1210\/jc.2009-1158","article-title":"Regulation of adiponectin secretion by adipocytes in the polycystic ovary syndrome: role of tumor necrosis factor-{alpha}","volume":"95","author":"Chazenbalk","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.chom.2026.08.015_bib38","doi-asserted-by":"crossref","first-page":"697223","DOI":"10.3389\/fendo.2021.697223","article-title":"Imaging-Based Body Fat Distribution in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.chom.2026.08.015_bib39","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1093\/humrep\/deae244","article-title":"Mendelian randomization and multi-omics approach analyses reveal impaired glucose metabolism and oxidative phosphorylation in visceral adipose tissue of women with polycystic ovary syndrome","volume":"39","author":"Zhang","year":"2024","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.chom.2026.08.015_bib40","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/cen.15302","article-title":"Nonobese PCOS Compared to Obese PCOS Have Similar Clinical Presentation, Hormonal Profile, and Insulin Resistance","volume":"103","author":"Patwari","year":"2025","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.chom.2026.08.015_bib41","doi-asserted-by":"crossref","first-page":"10535","DOI":"10.1039\/D3FO03585A","article-title":"Indole-3-acetamide from gut microbiota activated hepatic AhR and mediated the remission effect of Lactiplantibacillus plantarum P101 on alcoholic liver injury in mice","volume":"14","author":"Wang","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.chom.2026.08.015_bib42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.toxlet.2020.09.015","article-title":"Indole microbial intestinal metabolites expand the repertoire of ligands and agonists of the human pregnane X receptor","volume":"334","author":"Ill\u00e9s","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chom.2026.08.015_bib43","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.tem.2015.07.006","article-title":"Ceramides - Lipotoxic Inducers of Metabolic Disorders","volume":"26","author":"Chaurasia","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.chom.2026.08.015_bib44","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-physiol-031620-093815","article-title":"Ceramides in Metabolism: Key Lipotoxic Players","volume":"83","author":"Chaurasia","year":"2021","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.chom.2026.08.015_bib45","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.aav3722","article-title":"Targeting a ceramide double bond improves insulin resistance and hepatic steatosis","volume":"365","author":"Chaurasia","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.chom.2026.08.015_bib46","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.cmet.2025.03.002","article-title":"Ceramide-induced FGF13 impairs systemic metabolic health","volume":"37","author":"Naderi","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.chom.2026.08.015_bib47","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41586-024-07098-5","article-title":"IL-10 constrains sphingolipid metabolism to limit inflammation","volume":"627","author":"York","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.chom.2026.08.015_bib48","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3389\/fphys.2017.00787","article-title":"Brain Ceramide Metabolism in the Control of Energy Balance","volume":"8","author":"Cruciani-Guglielmacci","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.chom.2026.08.015_bib49","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tem.2024.06.007","article-title":"Ceramides in the central control of metabolism","volume":"36","author":"L\u00f3pez","year":"2025","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.chom.2026.08.015_bib50","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.celrep.2018.09.038","article-title":"Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress","volume":"25","author":"Gonz\u00e1lez-Garc\u00eda","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2026.08.015_bib51","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.2337\/db12-1451","article-title":"Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin","volume":"62","author":"Ram\u00edrez","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.chom.2026.08.015_bib52","doi-asserted-by":"crossref","first-page":"9691","DOI":"10.1073\/pnas.1103267108","article-title":"Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding","volume":"108","author":"Gao","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2026.08.015_bib53","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.cmet.2020.10.001","article-title":"Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty","volume":"32","author":"Heras","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.chom.2026.08.015_bib54","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1126\/science.adu8000","article-title":"Controlled colonization of the human gut with a genetically engineered microbial therapeutic","volume":"389","author":"Whitaker","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.chom.2026.08.015_bib55","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.tips.2022.02.002","article-title":"Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics","volume":"43","author":"Lynch","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.chom.2026.08.015_bib56","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s40168-021-01064-3","article-title":"Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank","volume":"9","author":"Liu","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.chom.2026.08.015_bib57","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.cell.2024.03.034","article-title":"Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway","volume":"187","author":"Nie","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.chom.2026.08.015_bib58","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cmet.2019.10.005","article-title":"Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis","volume":"31","author":"Das","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.chom.2026.08.015_bib59","doi-asserted-by":"crossref","first-page":"eadd5787","DOI":"10.1126\/science.add5787","article-title":"Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target","volume":"381","author":"Wang","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.chom.2026.08.015_bib60","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1128\/AEM.04023-14","article-title":"Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 system","volume":"81","author":"Jiang","year":"2015","journal-title":"Appl. Environ. Microbiol."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312826003574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312826003574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:12:45Z","timestamp":1791990765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312826003574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1931312826003574"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2026.08.015","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbial indole-3-acetamide alleviates polycystic ovary syndrome through HIF-2\u03b1-ceramide signaling","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2026.08.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}