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Res."},{"key":"10.1016\/j.chom.2026.08.018_bib88","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature13528","article-title":"Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia","volume":"513","author":"Kir","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chom.2026.08.018_bib89","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41586-022-04518-2","article-title":"A single-cell atlas of human and mouse white adipose tissue","volume":"603","author":"Emont","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.chom.2026.08.018_bib90","unstructured":"Emont, M.P., Jacobs, C., Essene, A.L., Pant, D., Tenen, D., Colleluori, G., Di Vincenzo, A., Jorgensen, A.M., Dashti, H., Stefek, A., et al. (2022). A single-cell atlas of human and mouse white adipose tissue. Broad Institute Single Cell Portal. Dataset SCP1376. https:\/\/singlecell.broadinstitute.org\/single_cell\/study\/SCP1376."},{"key":"10.1016\/j.chom.2026.08.018_bib91","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.27669","article-title":"Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice","volume":"6","author":"Hepler","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.chom.2026.08.018_bib94","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.cell.2012.04.037","article-title":"Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota","volume":"149","author":"Chung","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.chom.2026.08.018_bib104","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mimet.2009.05.004","article-title":"A modular system for Clostridium shuttle plasmids","volume":"78","author":"Heap","year":"2009","journal-title":"J. Microbiol. 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