{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:42:22Z","timestamp":1792395742730,"version":"4.4.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.chom.2026.09.014","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:03:20Z","timestamp":1792163000000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Akkermansia muciniphila attenuates macrophage efferocytosis to enhance anti-PD-1 efficacy in microsatellite-stable colorectal cancer"],"prefix":"10.1016","author":[{"given":"Yu-Ting","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Dong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Nuo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Meng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Si","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Yu","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Wen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Ping","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Qin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Rui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Gang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Sha","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia-Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Lei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2026.09.014_bib1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41575-019-0189-8","article-title":"Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies","volume":"16","author":"Keum","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.chom.2026.09.014_bib2","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1053\/j.gastro.2020.12.068","article-title":"An Update on the Epidemiology, Molecular Characterization, Diagnosis, and Screening Strategies for Early-Onset Colorectal Cancer","volume":"160","author":"Burnett-Hartman","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.chom.2026.09.014_bib3","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1200\/JCO.2017.76.9901","article-title":"Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient\/Microsatellite Instability-High Metastatic Colorectal Cancer","volume":"36","author":"Overman","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.chom.2026.09.014_bib4","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1158\/1078-0432.CCR-21-0557","article-title":"FDA Approval Summary: Pembrolizumab for the First-line Treatment of Patients with MSI-H\/dMMR Advanced Unresectable or Metastatic Colorectal Carcinoma","volume":"27","author":"Casak","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.chom.2026.09.014_bib5","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/s41571-024-00943-6","article-title":"Neoadjuvant immunotherapy for dMMR and pMMR colorectal cancers: therapeutic strategies and putative biomarkers of response","volume":"21","author":"Williams","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.chom.2026.09.014_bib6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41575-019-0126-x","article-title":"Immunotherapy in colorectal cancer: rationale, challenges and potential","volume":"16","author":"Ganesh","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.chom.2026.09.014_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2020.102030","article-title":"Immunotherapy in gastrointestinal cancer: The current scenario and future perspectives","volume":"88","author":"Abdul-Latif","year":"2020","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.chom.2026.09.014_bib8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature21349","article-title":"Elements of cancer immunity and the cancer-immune set point","volume":"541","author":"Chen","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.chom.2026.09.014_bib9","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ccell.2018.03.015","article-title":"The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy","volume":"33","author":"Gopalakrishnan","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.chom.2026.09.014_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.aan3706","article-title":"Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors","volume":"359","author":"Routy","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.chom.2026.09.014_bib11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41568-022-00513-x","article-title":"Targeting the gut microbiota for cancer therapy","volume":"22","author":"Fernandes","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.chom.2026.09.014_bib12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1126\/science.abf3363","article-title":"Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients","volume":"371","author":"Davar","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.chom.2026.09.014_bib13","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1158\/2159-8290.CD-24-1230","article-title":"Gut Microbiota Modulation through Akkermansia spp. Supplementation Increases CAR T-cell Potency","volume":"15","author":"Marcos-Kovandzic","year":"2025","journal-title":"Cancer Discov."},{"key":"10.1016\/j.chom.2026.09.014_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2022.01.008","article-title":"Hallmarks of response, resistance, and toxicity to immune checkpoint blockade","volume":"185","author":"Morad","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.chom.2026.09.014_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/ismejo\/wraf084","article-title":"Akkermansia muciniphila exacerbates acute radiation-induced intestinal injury by depleting mucin and enhancing inflammation","volume":"19","author":"Wang","year":"2025","journal-title":"ISME J."},{"key":"10.1016\/j.chom.2026.09.014_bib16","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1038\/s41591-023-02453-x","article-title":"Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial","volume":"29","author":"Routy","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2026.09.014_bib17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41591-021-01655-5","article-title":"Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer","volume":"28","author":"Derosa","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2026.09.014_bib18","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.2147\/IJN.S304515","article-title":"Extracellular Vesicles from Akkermansia muciniphila Elicit Antitumor Immunity Against Prostate Cancer via Modulation of CD8+ T Cells and Macrophages","volume":"16","author":"Luo","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.chom.2026.09.014_bib19","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1136\/gutjnl-2019-320105","article-title":"A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice","volume":"69","author":"Wang","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.chom.2026.09.014_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/1751-7915.14522","article-title":"Akkermansia muciniphila outer membrane protein regulates recruitment of CD8(+) T cells in lung adenocarcinoma and through JAK-STAT signalling pathway","volume":"17","author":"Xu","year":"2024","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.chom.2026.09.014_bib21","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202403295RR","article-title":"Amuc_1434 From Akkermansia muciniphila Enhances CD8+ T Cell-Mediated Anti-Tumor Immunity by Suppressing PD-L1 in Colorectal Cancer","volume":"39","author":"Zhu","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.chom.2026.09.014_bib22","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2249143","article-title":"Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell","volume":"15","author":"Zhu","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.chom.2026.09.014_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114306","article-title":"Landscape of tumoral ecosystem for enhanced anti-PD-1 immunotherapy by gut Akkermansia muciniphila","volume":"43","author":"Zhu","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2026.09.014_bib24","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41568-019-0210-0","article-title":"Context-dependent roles of complement in cancer","volume":"19","author":"Roumenina","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.chom.2026.09.014_bib25","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.trecan.2022.02.006","article-title":"C1q+ macrophages: passengers or drivers of cancer progression","volume":"8","author":"Revel","year":"2022","journal-title":"Trends Cancer"},{"key":"10.1016\/j.chom.2026.09.014_bib26","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-007441","article-title":"C1q+ tumor-associated macrophages contribute to immunosuppression through fatty acid metabolic reprogramming in malignant pleural effusion","volume":"11","author":"Zhang","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.chom.2026.09.014_bib27","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.7150\/ijbs.100607","article-title":"Complement C1q is a key player in tumor-associated macrophage-mediated CD8+ T cell and NK cell dysfunction in malignant pleural effusion","volume":"20","author":"Yi","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.chom.2026.09.014_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01711-0","article-title":"MafB is a critical regulator of complement component C1q","volume":"8","author":"Tran","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2026.09.014_bib29","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41577-019-0240-6","article-title":"Efferocytosis in health and disease","volume":"20","author":"Doran","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2026.09.014_bib30","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/s43018-024-00731-2","article-title":"Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis","volume":"5","author":"Astuti","year":"2024","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.chom.2026.09.014_bib31","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2021.2024941","article-title":"MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression","volume":"11","author":"Lin","year":"2022","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.chom.2026.09.014_bib32","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41590-023-01475-4","article-title":"TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer","volume":"24","author":"Park","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2026.09.014_bib33","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cell.2018.08.061","article-title":"LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance","volume":"175","author":"Cunha","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.chom.2026.09.014_bib34","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.immuni.2014.10.017","article-title":"STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors","volume":"41","author":"Woo","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2026.09.014_bib35","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.immuni.2021.04.019","article-title":"The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake","volume":"54","author":"de Mingo Pulido","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2026.09.014_bib36","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.immuni.2020.01.014","article-title":"Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP","volume":"52","author":"Zhou","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2026.09.014_bib37","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.immuni.2019.04.018","article-title":"Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology","volume":"50","author":"Morioka","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2026.09.014_bib38","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.83069","article-title":"Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis","volume":"12","author":"Yao","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.chom.2026.09.014_bib39","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nature18935","article-title":"CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis","volume":"536","author":"Kojima","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.chom.2026.09.014_bib40","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1194\/jlr.M056689","article-title":"Macrophage SR-BI mediates efferocytosis via Src\/PI3K\/Rac1 signaling and reduces atherosclerotic lesion necrosis","volume":"56","author":"Tao","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.chom.2026.09.014_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12331","article-title":"Extracellular vesicles from human plasma dampen inflammation and promote tissue repair functions in macrophages","volume":"12","author":"Adamczyk","year":"2023","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.chom.2026.09.014_bib42","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/CIRCRESAHA.123.323223","article-title":"CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis","volume":"134","author":"Lv","year":"2024","journal-title":"Circ. Res."},{"key":"10.1016\/j.chom.2026.09.014_bib43","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1021\/acsnano.4c12036","article-title":"Biomimetic \"Trojan Horse\" Fibers Modulate Innate Immunity Cascades for Nerve Regeneration","volume":"19","author":"Wu","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.chom.2026.09.014_bib44","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-025-03428-0","article-title":"Microglia efferocytosis: an emerging mechanism for the resolution of neuroinflammation in Alzheimer's disease","volume":"22","author":"Chen","year":"2025","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.chom.2026.09.014_bib45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nm.4236","article-title":"A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice","volume":"23","author":"Plovier","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2026.09.014_bib46","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41401-023-01186-4","article-title":"Amuc_1100 pretreatment alleviates acute pancreatitis in a mouse model through regulating gut microbiota and inhibiting inflammatory infiltration","volume":"45","author":"Wang","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.chom.2026.09.014_bib47","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04323-22","article-title":"Membrane Protein Amuc_1100 Derived from Akkermansia muciniphila Facilitates Lipolysis and Browning via Activating the AC3\/PKA\/HSL Pathway","volume":"11","author":"Zheng","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.chom.2026.09.014_bib48","doi-asserted-by":"crossref","DOI":"10.1186\/s12929-023-00935-1","article-title":"Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143\/145","volume":"30","author":"Wade","year":"2023","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.chom.2026.09.014_bib49","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1136\/gutjnl-2022-327853","article-title":"Acetyltransferase from Akkermansia muciniphila blunts colorectal tumourigenesis by reprogramming tumour microenvironment","volume":"72","author":"Jiang","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.chom.2026.09.014_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107278","article-title":"Akkermansia muciniphila-derived pentadecanoic acid enhances oxaliplatin sensitivity in gastric cancer by modulating glycolysis","volume":"206","author":"Xu","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.chom.2026.09.014_bib51","article-title":"Intestinal Akkermansia muciniphila complements the efficacy of PD1 therapy in MAFLD-related hepatocellular carcinoma","volume":"6","author":"Wu","year":"2025","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.chom.2026.09.014_bib52","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2555618","article-title":"Akkermansia muciniphila ameliorates chronic stress-induced colorectal tumor growth by releasing outer membrane vesicles","volume":"17","author":"Jin","year":"2025","journal-title":"Gut Microbes"},{"key":"10.1016\/j.chom.2026.09.014_bib53","article-title":"Extracellular Vesicles from Child Gut Microbiota Enter into Bone to Preserve Bone Mass and Strength","volume":"8","author":"Liu","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.chom.2026.09.014_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.282","article-title":"Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.chom.2026.09.014_bib55","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/35075603","article-title":"Phagocytosis and clearance of apoptotic cells is mediated by MER","volume":"411","author":"Scott","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.chom.2026.09.014_bib56","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1172\/JCI90520","article-title":"MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis","volume":"127","author":"Cai","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.chom.2026.09.014_bib57","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1161\/CIRCRESAHA.117.311327","article-title":"MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury","volume":"121","author":"DeBerge","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.chom.2026.09.014_bib58","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adv2106","article-title":"Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction-associated steatohepatitis","volume":"17","author":"Shi","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chom.2026.09.014_bib59","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20221388","article-title":"Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis","volume":"220","author":"Chakraborty","year":"2023","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.chom.2026.09.014_bib60","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1158\/2326-6066.CIR-20-1019","article-title":"A. Muciniphila Suppresses Colorectal Tumorigenesis by Inducing TLR2\/NLRP3-Mediated M1-Like TAMs","volume":"9","author":"Fan","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.chom.2026.09.014_bib61","article-title":"PD-1 Blockade in Tumors with Mismatch-Repair Deficiency","volume":"373","author":"Asaoka","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.chom.2026.09.014_bib62","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1200\/JCO.19.02107","article-title":"Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability-High\/Mismatch Repair-Deficient Metastatic Colorectal Cancer: KEYNOTE-164","volume":"38","author":"Le","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.chom.2026.09.014_bib63","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0140-6736(24)02848-4","article-title":"Nivolumab plus ipilimumab versus nivolumab in microsatellite instability-high metastatic colorectal cancer (CheckMate 8HW): a randomised, open-label, phase 3 trial","volume":"405","author":"Andr\u00e9","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2026.09.014_bib64","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S1470-2045(17)30422-9","article-title":"Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study","volume":"18","author":"Overman","year":"2017","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.chom.2026.09.014_bib65","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1200\/JCO.21.01015","article-title":"First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability-High\/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase II CheckMate 142 Study","volume":"40","author":"Lenz","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.chom.2026.09.014_bib66","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1056\/NEJMoa2017699","article-title":"Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer","volume":"383","author":"Andr\u00e9","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.chom.2026.09.014_bib67","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1056\/NEJMoa2400634","article-title":"Neoadjuvant Immunotherapy in Locally Advanced Mismatch Repair-Deficient Colon Cancer","volume":"390","author":"Chalabi","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.chom.2026.09.014_bib68","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.annonc.2022.06.008","article-title":"Nivolumab plus low-dose ipilimumab in previously treated patients with microsatellite instability-high\/mismatch repair-deficient metastatic colorectal cancer: 4-year follow-up from CheckMate 142","volume":"33","author":"Andr\u00e9","year":"2022","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.chom.2026.09.014_bib69","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S1470-2045(19)30027-0","article-title":"Atezolizumab with or without cobimetinib versus regorafenib in previously treated metastatic colorectal cancer (IMblaze370): a multicentre, open-label, phase 3, randomised, controlled trial","volume":"20","author":"Eng","year":"2019","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.chom.2026.09.014_bib70","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cmet.2024.12.010","article-title":"Akkermansia muciniphila supplementation in patients with overweight\/obese type 2 diabetes: Efficacy depends on its baseline levels in the gut","volume":"37","author":"Zhang","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.chom.2026.09.014_bib71","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41591-019-0495-2","article-title":"Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study","volume":"25","author":"Depommier","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2026.09.014_bib72","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cels.2018.11.005","article-title":"Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data","volume":"8","author":"Wolock","year":"2019","journal-title":"Cell Syst."}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312826004038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312826004038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:04:44Z","timestamp":1792393484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312826004038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":72,"alternative-id":["S1931312826004038"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2026.09.014","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Akkermansia muciniphila attenuates macrophage efferocytosis to enhance anti-PD-1 efficacy in microsatellite-stable colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2026.09.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}