{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:14:04Z","timestamp":1786986844567,"version":"build-2736575974"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.chroma.2014.06.069","type":"journal-article","created":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T19:18:30Z","timestamp":1404242310000},"page":"85-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Quantification of target analytes in various biofluids using a postcolumn infused-internal standard method combined with matrix normalization factors in liquid chromatography\u2013electrospray ionization mass spectrometry"],"prefix":"10.1016","volume":"1358","author":[{"given":"Hsiao-Wei","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Lin","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Shen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hua","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2014.06.069_bib0005","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.clinbiochem.2005.01.014","article-title":"Multi-analyte procedures for screening for and quantification of drugs in blood, plasma, or serum by liquid chromatography-single stage or tandem mass spectrometry (LC-MS or LC-MS\/MS) relevant to clinical and forensic toxicology","volume":"38","author":"Maurer","year":"2005","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.chroma.2014.06.069_bib0010","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1007\/s00216-012-6035-2","article-title":"Aspects of matrix effects in applications of liquid chromatography-mass spectrometry to forensic and clinical toxicology--a review","volume":"403","author":"Peters","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2014.06.069_bib0015","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00216-007-1248-5","article-title":"Current role of liquid chromatography-mass spectrometry in clinical and forensic toxicology","volume":"388","author":"Maurer","year":"2007","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2014.06.069_bib0020","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/mas.20097","article-title":"Matrix effects in quantitative pesticide analysis using liquid chromatography-mass spectrometry","volume":"25","author":"Niessen","year":"2006","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.chroma.2014.06.069_bib0025","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/S1044-0305(03)00574-9","article-title":"Matrix effect in bio-analysis of illicit drugs with LC-MS\/MS: Influence of ionization type, sample preparation, and biofluid","volume":"14","author":"Dams","year":"2003","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.chroma.2014.06.069_bib0030","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.talanta.2013.07.043","article-title":"Simultaneous quantification of antimicrobial agents for multidrug-resistant bacterial infections in human plasma by ultra-high-pressure liquid chromatography\u2013tandem mass spectrometry","volume":"116","author":"Tsai","year":"2013","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2014.06.069_bib0035","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1016\/j.jchromb.2009.01.003","article-title":"Validation of bioanalytical LC-MS\/MS assays: evaluation of matrix effects","volume":"877","author":"Van Eeckhaut","year":"2009","journal-title":"J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.chroma.2014.06.069_bib0040","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1002\/rcm.4736","volume":"24","author":"Remane","year":"2010","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.chroma.2014.06.069_bib0045","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/mas.20298","article-title":"An overview of matrix effects in liquid chromatography-mass spectrometry","volume":"30","author":"Trufelli","year":"2011","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.chroma.2014.06.069_bib0050","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00204-003-0522-3","article-title":"Di(2-ethylhexyl)phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP","volume":"78","author":"Koch","year":"2004","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chroma.2014.06.069_bib0055","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/jms.1050","article-title":"Identification of isomeric flavonoid glucuronides in urine and plasma by metal complexation and LC-ESI-MS\/MS","volume":"41","author":"Davis","year":"2006","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.chroma.2014.06.069_bib0060","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.jchromb.2010.01.003","article-title":"Simultaneous quantification of the organophosphorus pesticides dimethoate and omethoate in porcine plasma and urine by LC-ESI-MS\/MS and flow-injection-ESI-MS\/MS","volume":"878","author":"John","year":"2010","journal-title":"J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.chroma.2014.06.069_bib0065","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/j.jchromb.2011.07.012","article-title":"Determination of vandetanib in human plasma and cerebrospinal fluid by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS\/MS)","volume":"879","author":"Bai","year":"2011","journal-title":"J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.chroma.2014.06.069_bib0070","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10337-011-2042-2","article-title":"LC\u2013MS\u2013MS Quantitative determination of gefitinib in human serum and cerebrospinal fluid","volume":"74","author":"Zheng","year":"2011","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2014.06.069_bib0075","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1021\/ac990312o","article-title":"Postcolumn introduction of an internal standard for quantitative LC-MS analysis","volume":"71","author":"Choi","year":"1999","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2014.06.069_bib0080","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.aca.2008.06.012","article-title":"Analysis of steroids in yeast-mediated cell culture by on-line solid-phase extraction coupled high-performance liquid chromatography electrospray-ionization\/mass spectrometry and novel continuous postcolumn infusion of internal standard technique","volume":"623","author":"Cheng","year":"2008","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2014.06.069_bib0085","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/neuonc\/nop066","article-title":"Prevalence estimates for primary brain tumors in the United States by age, gender, behavior, and histology","volume":"12","author":"Porter","year":"2010","journal-title":"Neuro-Oncol."},{"key":"10.1016\/j.chroma.2014.06.069_bib0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0169-409X(02)00171-0","article-title":"Drug-drug interaction mediated by inhibition and induction of P-glycoprotein","volume":"55","author":"Lin","year":"2003","journal-title":"Adv. Drug Delivery Rev."},{"key":"10.1016\/j.chroma.2014.06.069_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/jns.1998.88.1.0001","article-title":"Survival rates in patients with primary malignant brain tumors stratified by patient age and tumor histological type: an analysis based on Surveillance, Epidemiology, and End Results (SEER) data, 1973\u20131991","volume":"88","author":"Davis","year":"1998","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.chroma.2014.06.069_bib0100","first-page":"920509","article-title":"Blood-brain barrier integrity and breast cancer metastasis to the brain","volume":"2011","author":"Arshad","year":"2010","journal-title":"Pathol. Res. Int."},{"key":"10.1016\/j.chroma.2014.06.069_bib0105","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1359-6446(00)01632-9","article-title":"Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1)","volume":"6","author":"Kusuhara","year":"2001","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.chroma.2014.06.069_bib0110","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1136\/bmj.327.7413.478","article-title":"Children and young people who die from cancer: epidemiology and place of death in England (1995-9)","volume":"327","author":"Higginson","year":"2003","journal-title":"Br. Med. J."},{"key":"10.1016\/j.chroma.2014.06.069_bib0115","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.chroma.2013.12.066","article-title":"Using a postcolumn-infused internal standard for correcting the matrix effects of urine specimens in liquid chromatography-electrospray ionization mass spectrometry","volume":"1327","author":"Liao","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2014.06.069_bib0120","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/jms.173","article-title":"Simultaneous determination of etoposide and its catechol metabolite in the plasma of pediatric patients by liquid chromatography\/tandem mass spectrometry","volume":"36","author":"Pang","year":"2001","journal-title":"J. Mass Spectrom.: JMS"},{"key":"10.1016\/j.chroma.2014.06.069_bib0125","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF00257521","article-title":"Drug-monitoring of etoposide (Vp16-213) .1. A combined method of liquid-chromatography and mass-spectrometry","volume":"15","author":"Danigel","year":"1985","journal-title":"Cancer Chemother. Pharmacol."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967314010127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967314010127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T20:55:38Z","timestamp":1538427338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967314010127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":25,"alternative-id":["S0021967314010127"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2014.06.069","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantification of target analytes in various biofluids using a postcolumn infused-internal standard method combined with matrix normalization factors in liquid chromatography\u2013electrospray ionization mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2014.06.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}