{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:24:16Z","timestamp":1792697056309,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.chroma.2014.11.044","type":"journal-article","created":{"date-parts":[[2014,11,29]],"date-time":"2014-11-29T09:02:33Z","timestamp":1417251753000},"page":"238-246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["On the method development of immobilized polysaccharide chiral stationary phases in supercritical fluid chromatography using an extended range of modifiers"],"prefix":"10.1016","volume":"1374","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8372-9598","authenticated-orcid":false,"given":"James","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.T.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Barendt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony Q.","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7588-474X","authenticated-orcid":false,"given":"Yun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7949-3340","authenticated-orcid":false,"given":"Frank","family":"Riley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hardink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Bradow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2014.11.044_bib0005","series-title":"Packed Column Supercritical Fluid Chromatography","author":"Berger","year":"1995"},{"key":"10.1016\/j.chroma.2014.11.044_bib0010","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.chroma.2012.05.025","article-title":"Preparative enantioseparations using supercritical fluid chromatography","volume":"1250","author":"Miller","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2014.11.044_bib0015","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1021\/ac202892w","article-title":"Chiral separations: a review of current topics and trends","volume":"84","author":"Ward","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2014.11.044_bib0020","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0021-9673(94)80399-4","article-title":"Chiral separations by packed-column super- and subcritical fluid chromatography","volume":"666","author":"Anton","year":"1994","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2014.11.044_bib0025","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/chir.20357","article-title":"Solving multicomponent chiral separation challenges using a new SFC tandem column screening tool","volume":"19","author":"Welch","year":"2007","journal-title":"Chirality"},{"key":"10.1016\/j.chroma.2014.11.044_bib0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.chroma.2004.12.038","article-title":"Screening approach for chiral separation of pharmaceuticals: part III. Supercritical fluid chromatography for analysis and purification in drug discovery","volume":"1088","author":"Maftouh","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2014.11.044_bib0035","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jchromb.2008.06.044","article-title":"Preparative chromatographic resolution of racemates using HPLC and SFC in a pharmaceutical discovery environment","volume":"875","author":"Miller","year":"2008","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2014.11.044_bib0040","series-title":"LC-GC Application Notes","first-page":"15","article-title":"A screening process for development of enantioselective supercritical fluid chromatography separation methods","author":"Cox","year":"2008"},{"key":"10.1016\/j.chroma.2014.11.044_bib0045","series-title":"The Application Notebook","first-page":"24","article-title":"Resolution of flurbiprofen enantiomers by preparative chiral supercritical fluid chromatography, LC-GC North America","author":"Cox","year":"2002"},{"key":"10.1016\/j.chroma.2014.11.044_bib0050","series-title":"Chiral Separations, Methods and Protocols","first-page":"113","article-title":"Common screening approaches for efficient analytical method development in LC and SFC on columns packed with immobilized polysaccharide-derived chiral stationary phases","author":"Franco","year":"2013"},{"key":"10.1016\/j.chroma.2014.11.044_bib0055","series-title":"Agilent Application Note","article-title":"Separation of enantiomers and conformers of tofisopam","author":"Zhang","year":"2011"},{"key":"10.1016\/j.chroma.2014.11.044_bib0060","series-title":"Agilent Application Note","article-title":"Enantiomer separation of nonsteroidal anti-inflammatory drugs","author":"Zhang","year":"2011"},{"key":"10.1016\/j.chroma.2014.11.044_bib0065","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.chroma.2012.07.090","article-title":"Enantioselectivity of polysaccharide-based chiral stationary phases in supercritical fluid chromatography using methanol-containing carbon dioxide mobile phases","volume":"1269","author":"De Klerck","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2014.11.044_bib0070","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0021-9673(00)00952-3","article-title":"Enantioseparations in super- and subcritical fluid chromatography","volume":"906","author":"Terfloth","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2014.11.044_bib0075","article-title":"Enantiomer separation of acidic compounds using Daicel CHIRALPAK QN-AX and QD-AX columns","author":"Zhang","year":"2011","journal-title":"Agilent Application Note"},{"key":"10.1016\/j.chroma.2014.11.044_bib0080","series-title":"A Practical Approach to Chiral Separations by Liquid Chromatography","first-page":"115","article-title":"Polysaccharide phases in enantioseparations","author":"Dingenen","year":"1994"},{"key":"10.1016\/j.chroma.2014.11.044_bib0085","series-title":"Chiral Separations, Applications and Technology","first-page":"271","article-title":"Chromatography as a separation tool for the preparative resolution of racemic compounds","author":"Francotte","year":"1997"},{"key":"10.1016\/j.chroma.2014.11.044_bib0090","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/(SICI)1521-3773(19980504)37:8<1020::AID-ANIE1020>3.0.CO;2-5","article-title":"Polysaccharide derivatives for chromatographic separation of enantiomers","volume":"37","author":"Okamoto","year":"1998","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.chroma.2014.11.044_bib0095","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0021-9673(00)00532-X","article-title":"Separation of enantiomers: needs, challenges, perspectives","volume":"906","author":"Maier","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2014.11.044_bib0100","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0021-9673(00)00951-1","article-title":"Enantioselective chromatography as a powerful alternative for the preparation of drug enantiomers","volume":"906","author":"Francotte","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2014.11.044_bib0105","series-title":"Chiral Separation Techniques: A Practical Approach","year":"2001"},{"key":"10.1016\/j.chroma.2014.11.044_bib0110","series-title":"Preparative Enantioselective Chromatography","year":"2005"},{"key":"10.1016\/j.chroma.2014.11.044_bib0115","series-title":"Chiral Separation Techniques: A Practical Approach","first-page":"99","article-title":"Analytical and preparative potential of immobilised polysaccharide-derived chiral stationary phases","author":"Zhang","year":"2007"},{"key":"10.1016\/j.chroma.2014.11.044_bib0120","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.chroma.2012.09.071","article-title":"Complementary enantiorecognition patterns and specific method optimization aspects on immobilized polysaccharide-derived chiral stationary phases","volume":"1269","author":"Zhang","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2014.11.044_bib0125","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jchromb.2008.06.051","article-title":"Common approaches for efficient method development with immobilised polysaccharide-derived chiral stationary phases","volume":"875","author":"Franco","year":"2008","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2014.11.044_bib0130","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jchromb.2008.06.057","article-title":"Analysis and purification of alcohol-sensitive chiral compounds using 2,2,2-trifluoroethanol as a modifier in supercritical fluid chromatography","volume":"875","author":"Byrne","year":"2008","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2014.11.044_bib0135","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.chroma.2012.07.079","article-title":"Evaluation of non-traditional modifiers for analytical and preparative enantioseparations using supercritical fluid chromatography","volume":"1256","author":"Miller","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2014.11.044_bib0140","series-title":"On the method development of immobilized polysaccharide chiral stationary phases in SFC using an extended range of co-solvents, Presentation at the SFC2013","author":"Watts","year":"2013"},{"key":"10.1016\/j.chroma.2014.11.044_bib0145","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.chroma.2013.12.073","article-title":"Evaluation of non-conventional polar modifiers on immobilized chiral stationary phases for improved resolution of enantiomers by supercritical fluid chromatography","volume":"1328","author":"DaSilva","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2014.11.044_bib0150","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.chroma.2013.12.044","article-title":"Pharmaceutical-enantiomers resolution using immobilized polysaccharide-based chiral stationary phases in supercritical fluid chromatography","volume":"1328","author":"De Klerck","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2014.11.044_bib0155","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/chir.20348","article-title":"Investigation of the stability of Chiralpak AD chiral stationary phase under various solvent conditions and development of a method to identify stationary phase-derived polymer contamination","volume":"19","author":"Welch","year":"2007","journal-title":"Chirality"}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967314018020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967314018020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T06:23:14Z","timestamp":1538029394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967314018020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":31,"alternative-id":["S0021967314018020"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2014.11.044","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"On the method development of immobilized polysaccharide chiral stationary phases in supercritical fluid chromatography using an extended range of modifiers","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2014.11.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}