{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:53:34Z","timestamp":1768517614974,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Science Fund of China","award":["81403073"],"award-info":[{"award-number":["81403073"]}]},{"name":"National Science Fund of China","award":["81530097"],"award-info":[{"award-number":["81530097"]}]},{"name":"Quality guarantee system of Chinese herbal medicines","award":["201507002"],"award-info":[{"award-number":["201507002"]}]},{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","award":["2016-JYB-XJQ004"],"award-info":[{"award-number":["2016-JYB-XJQ004"]}],"id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006469","name":"Macao Science and Technology Development Fund","doi-asserted-by":"crossref","award":["007\/2014\/AMJ"],"award-info":[{"award-number":["007\/2014\/AMJ"]}],"id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.chroma.2017.04.034","type":"journal-article","created":{"date-parts":[[2017,4,15]],"date-time":"2017-04-15T15:46:17Z","timestamp":1492271177000},"page":"39-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"special_numbering":"C","title":["Simultaneous determination of components with wide polarity and content ranges in Cistanche tubulosa using serially coupled reverse phase-hydrophilic interaction chromatography-tandem mass spectrometry"],"prefix":"10.1016","volume":"1501","author":[{"given":"Yu","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqing","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yitao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongxiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuelin","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2017.04.034_bib0005","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.chroma.2015.06.041","article-title":"Large-scale qualitative and quantitative characterization of components in Shenfu injection by integrating hydrophilic interaction chromatography reversed phase liquid chromatography, and tandem mass spectrometry","volume":"1407","author":"Song","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2017.04.034_bib0010","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.chroma.2015.12.045","article-title":"An integrated strategy to quantitatively differentiate chemome between Cistanche deserticola and C. tubulosa using high performance liquid chromatography-hybrid triple quadrupole-linear ion trap mass spectrometry","volume":"1429","author":"Song","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2017.04.034_bib0015","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1093\/mp\/sst080","article-title":"A novel integrated method for large-scale detection, identification, and quantification of widely targeted metabolites: application in the study of rice metabolomics","volume":"6","author":"Chen","year":"2013","journal-title":"Mol. Plant"},{"key":"10.1016\/j.chroma.2017.04.034_bib0020","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/S0031-9422(02)00708-2","article-title":"Plant metabolomics: large-scale phytochemistry in the functional genomics era","volume":"62","author":"Sumner","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.chroma.2017.04.034_bib0025","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/nprot.2007.95","article-title":"Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry","volume":"2","author":"De Vos","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.chroma.2017.04.034_bib0030","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1111\/j.1469-8137.2005.01632.x","article-title":"Plant metabolomics: from holistic hope to hype, to hot topic","volume":"169","author":"Hall","year":"2006","journal-title":"New Phytol."},{"key":"10.1016\/j.chroma.2017.04.034_bib0035","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.tplants.2006.08.007","article-title":"Plant metabolomics: towards biological function and mechanism","volume":"11","author":"Schauer","year":"2006","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.chroma.2017.04.034_bib0040","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aca.2016.03.040","article-title":"Stationary phase modulation in liquid chromatography through the serial coupling of columns: a review","volume":"923","author":"Alvarez-Segura","year":"2016","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2017.04.034_bib0045","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1021\/acs.analchem.6b03506","article-title":"Two-dimensional liquid chromatography: a state of the art tutorial","volume":"89","author":"Stoll","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2017.04.034_bib0050","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.chroma.2014.01.078","article-title":"Qualitative analysis and enantiospecific determination of angular-type pyranocoumarins in Peucedani Radix using achiral and chiral liquid chromatography coupled with tandem mass spectrometry","volume":"1338","author":"Song","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2017.04.034_bib0055","doi-asserted-by":"publisher","first-page":"1258A","DOI":"10.1021\/ac00276a003","article-title":"Two-dimensional separations: concept and promise","volume":"56","author":"Giddings","year":"1984","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2017.04.034_bib0060","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/jssc.201301112","article-title":"Robustness of a method based on the serial coupling of reversed-phase and zwitterionic hydrophilic interaction LC-MS for the analysis of phenols","volume":"37","author":"Greco","year":"2014","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2017.04.034_bib0065","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1002\/jssc.201200920","article-title":"Serial coupling of reversed-phase and zwitterionic hydrophilic interaction LC\/MS for the analysis of polar and nonpolar phenols in wine","volume":"36","author":"Greco","year":"2013","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2017.04.034_bib0070","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.aca.2016.01.062","article-title":"Simultaneous screening for lipophilic and hydrophilic toxins in marine harmful algae using a serially coupled reversed-phase and hydrophilic interaction liquid chromatography separation system with high-resolution mass spectrometry","volume":"914","author":"Chen","year":"2016","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2017.04.034_bib0075","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.chroma.2008.08.058","article-title":"Serial coupling of reversed-phase and hydrophilic interaction liquid chromatography to broaden the elution window for the analysis of pharmaceutical compounds","volume":"1208","author":"Louw","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2017.04.034_bib0080","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1007\/s11306-014-0770-7","article-title":"Serially coupling hydrophobic interaction and reversed-phase chromatography with simultaneous gradients provides greater coverage of the metabolome","volume":"11","author":"Haggarty","year":"2015","journal-title":"Metabolomics"},{"key":"10.1016\/j.chroma.2017.04.034_bib0085","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1002\/jssc.201300562","article-title":"Serial coupling of RP and zwitterionic hydrophilic interaction LC-MS: Suspects screening of diclofenac transformation products by oxidation with a boron-doped diamond electrode","volume":"36","author":"Rajab","year":"2013","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2017.04.034_bib0090","doi-asserted-by":"publisher","first-page":"8831","DOI":"10.1021\/jf2051569","article-title":"A versatile targeted metabolomics method for the rapid quantification of multiple classes of phenolics in fruits and beverages","volume":"60","author":"Vrhovsek","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.chroma.2017.04.034_bib0095","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.chroma.2016.07.008","article-title":"An integrated platform for directly widely-targeted quantitative analysis of feces part II: An application for steroids, eicosanoids, and porphyrins profiling","volume":"1460","author":"Song","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2017.04.034_bib0100","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.aca.2016.11.066","article-title":"Integrated work-flow for quantitative metabolome profiling of plants, Peucedani Radix as a case","volume":"953","author":"Song","year":"2017","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2017.04.034_bib0105","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1016\/j.chroma.2008.04.040","article-title":"Differentiation of Herba Cistanches by fingerprint with high-performance liquid chromatography-diode array detection-mass spectrometry","volume":"1216","author":"Jiang","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2017.04.034_bib0110","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1016\/j.chroma.2008.07.031","article-title":"Analysis of chemical constituents in Cistanche species","volume":"1216","author":"Jiang","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2017.04.034_bib0115","first-page":"526","article-title":"An integrated method for the extraction of effective substances from Cistanche deserticola","volume":"21","author":"Ouyang","year":"2003","journal-title":"Wu Han Zhi Wu Xue Yan Jiu"},{"key":"10.1016\/j.chroma.2017.04.034_bib0120","first-page":"556","article-title":"Active antisenile constituents in Cistanche deserticola Y. C. Ma","volume":"20","author":"Xue","year":"1995","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.chroma.2017.04.034_bib0125","first-page":"359","article-title":"A study on quality standard for herba cistanches","volume":"25","author":"Zhang","year":"2000","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.chroma.2017.04.034_bib0130","doi-asserted-by":"publisher","first-page":"57372","DOI":"10.1039\/C5RA09429A","article-title":"Potential of hyphenated ultra-high performance liquid chromatography-scheduled multiple reaction monitoring algorithm for large-scale quantitative analysis of traditional Chinese medicines","volume":"5","author":"Song","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.chroma.2017.04.034_bib0135","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1002\/jssc.200700663","article-title":"Simultaneous separation of hydrophilic and hydrophobic compounds by using an online HILIC-RPLC system with two detectors","volume":"31","author":"Wang","year":"2008","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2017.04.034_bib0140","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1021\/ac503031d","article-title":"New and vintage solutions to enhance the plasma metabolome coverage by LC-ESI\u2013MS untargeted metabolomics: the not-so-simple process of method performance evaluation","volume":"87","author":"Tulipani","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2017.04.034_bib0145","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.jpba.2007.02.006","article-title":"Recent advances in high-throughput quantitative bioanalysis by LC-MS\/MS","volume":"44","author":"Xu","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2017.04.034_bib0150","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.chroma.2013.10.069","article-title":"A novel stop-flow two-dimensional liquid chromatography-mass spectrometry method for lipid analysis","volume":"1321","author":"Wang","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2017.04.034_bib0155","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.chroma.2013.07.008","article-title":"Use of on-line stop-flow heart-cutting two-dimensional high performance liquid chromatography for simultaneous determination of 12 major constituents in tartary buckwheat (Fagopyrum tataricum Gaertn)","volume":"1304","author":"Ren","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2017.04.034_bib0160","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s00216-014-8219-4","article-title":"On-line stop-flow two-dimensional liquid chromatography-mass spectrometry method for the separation and identification of triterpenoid saponins from ginseng extract","volume":"407","author":"Wang","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2017.04.034_bib0165","first-page":"198","article-title":"A chemical profiling solution for Chinese medicine formulas using comprehensive and loop-based multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry","volume":"2016","author":"Qiao","year":"1438","journal-title":"J. Chromatogr. A."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967317305885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967317305885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T15:04:36Z","timestamp":1601910276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967317305885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":33,"alternative-id":["S0021967317305885"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2017.04.034","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous determination of components with wide polarity and content ranges in Cistanche tubulosa using serially coupled reverse phase-hydrophilic interaction chromatography-tandem mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2017.04.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}