{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:09:20Z","timestamp":1790417360344,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007566","name":"City, University of London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007566","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"publisher","award":["IP-2014-09-7031"],"award-info":[{"award-number":["IP-2014-09-7031"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.chroma.2017.06.005","type":"journal-article","created":{"date-parts":[[2017,6,3]],"date-time":"2017-06-03T02:16:26Z","timestamp":1496456186000},"page":"60-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"special_numbering":"C","title":["Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography\u2013tandem mass spectrometry"],"prefix":"10.1016","volume":"1509","author":[{"given":"Ivan","family":"Senta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivona","family":"Krizman-Matasic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senka","family":"Terzic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijan","family":"Ahel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2017.06.005_bib0005","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0048-9697(98)00337-4","article-title":"Occurrence of antibiotics in the aquatic environment","volume":"225","author":"Hirsch","year":"1999","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2017.06.005_bib0010","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chemosphere.2008.11.086","article-title":"Antibiotics in the aquatic environment\u2014a review \u2212part I","volume":"75","author":"K\u00fcmmerer","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.chroma.2017.06.005_bib0015","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1289\/ehp.11776","article-title":"Review of the occurrence of anti-infectives in contaminated wastewaters and natural and drinking waters","volume":"117","author":"Segura","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chroma.2017.06.005_bib0020","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1016\/j.scitotenv.2008.11.059","article-title":"The occurrence of antibiotics in an urban watershed: from wastewater to drinking water","volume":"407","author":"Watkinson","year":"2009","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2017.06.005_bib0025","first-page":"951","article-title":"Occurrence transformation, and fate of antibiotics in municipal wastewater treatment plants","volume":"41","author":"Zhang","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chroma.2017.06.005_bib0030","unstructured":"Review on Antimicrobial Resistance, Tackling drug-resistant infections globally: Final report and recommendations, London, 2016. Available at: https:\/\/amr-review.org\/sites\/default\/files\/160518_Final%20paper_with%20cover.pdf (Accessed 10 February 2017)."},{"key":"10.1016\/j.chroma.2017.06.005_bib0035","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.copbio.2008.05.006","article-title":"Antibiotics and antibiotic resistance in water environments","volume":"19","author":"Baquero","year":"2008","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.chroma.2017.06.005_bib0040","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.aca.2009.07.031","article-title":"An overview of analytical methodologies for the determination of antibiotics in environmental waters","volume":"649","author":"Seifrtov\u00e1","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2017.06.005_bib0045","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.scitotenv.2013.03.010","article-title":"Occurrence and fate of eleven classes of antibiotics in two typical wastewater treatment plants in South China","volume":"452\u2013453","author":"Zhou","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2017.06.005_bib0050","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1021\/ac0496603","article-title":"Trace determination of macrolide and sulfonamide antimicrobials a human sulfonamide metabolite, and trimethoprim in wastewater using liquid chromatography coupled to electrospray tandem mass spectrometry","volume":"76","author":"G\u00f6bel","year":"2004","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2017.06.005_bib0055","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1007\/s11356-013-2464-5","article-title":"Investigation of pharmaceutical metabolites in environmental waters by LC\u2013MS\/MS","volume":"21","author":"Gracia-Lor","year":"2014","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.chroma.2017.06.005_bib0060","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S1473-3099(14)70780-7","article-title":"Global antibiotic consumption 2000\u20132010: an analysis of national pharmaceutical sales data","volume":"14","author":"Van Boeckel","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chroma.2017.06.005_bib0065","series-title":"European Centre for Disease Prevention and Control (ECDC), Summary of the Latest Data on Antibiotic Consumption in the European Union, ESAC-Net Surveillance Data","year":"2015"},{"key":"10.1016\/j.chroma.2017.06.005_bib0070","series-title":"Center for Disease Dynamics, Economics & Policy, State of the World\u2019s Antibiotics","year":"2015"},{"key":"10.1016\/j.chroma.2017.06.005_bib0075","series-title":"Disposition of Toxic Drugs and Chemicals in Man","author":"Baselt","year":"2004"},{"key":"10.1016\/j.chroma.2017.06.005_bib0080","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s00216-009-3318-3","article-title":"Fate of antibacterial spiramycin in river waters","volume":"396","author":"Calza","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2017.06.005_bib0085","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.chemosphere.2010.12.025","article-title":"Photodegradation of azithromycin in various aqueous systems under simulated and natural solar radiation: kinetics and identification of photoproducts","volume":"83","author":"Tong","year":"2011","journal-title":"Chemosphere"},{"issue":"470","key":"10.1016\/j.chroma.2017.06.005_bib0090","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.scitotenv.2013.09.057","article-title":"Photodegradation of antibiotics under simulated solar radiation: implications for their environmental fate","volume":"470\u2013471","author":"Batchu","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2017.06.005_bib0095","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/dta.2007","article-title":"Environmental impact assessment of veterinary drug on fish aquaculture for food safety","volume":"8","author":"Kwon","year":"2016","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.chroma.2017.06.005_bib0100","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.scitotenv.2016.03.210","article-title":"Reduced persistence of the macrolide antibiotics erythromycin, clarithromycin and azithromycin in agricultural soil following several years of exposure in the field","volume":"562","author":"Topp","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2017.06.005_bib0105","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jhazmat.2016.03.078","article-title":"UHPLC-QTOF MS screening of pharmaceuticals and their metabolites in treated wastewater samples from Athens","volume":"323","author":"Ib\u00e1\u00f1ez","year":"2017","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.chroma.2017.06.005_bib0110","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.envpol.2010.10.009","article-title":"Nontarget analysis of polar contaminants in freshwater sediments influenced by pharmaceutical industry using ultra-high-pressure liquid chromatography\u2014quadrupole time-of-flight mass spectrometry","volume":"159","author":"Terzic","year":"2011","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chroma.2017.06.005_bib0115","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00216-011-5060-x","article-title":"Identification of biotransformation products of antimicrobials in membrane bioreactor treatment by ultrahigh-performance liquid chromatography\/quadrupole time-of-flight mass spectrometry","volume":"40","author":"Terzic","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2017.06.005_bib0120","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1351\/pac199870040993","article-title":"Guidelines for calibration in analytical chemistry. Part 1. Fundamentals and single component calibration","volume":"70","author":"Danzer","year":"1998","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.chroma.2017.06.005_bib0125","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.aca.2015.01.017","article-title":"Practical guidelines for reporting results in single- and multicomponent analytical calibration: a tutorial","volume":"868","author":"Olivieri","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2017.06.005_bib0130","series-title":"Macrolide Antibiotics","article-title":"Azithromycin and novel azalides","author":"Sch\u00f6nfeld","year":"2002"},{"key":"10.1016\/j.chroma.2017.06.005_bib0135","doi-asserted-by":"crossref","first-page":"10098","DOI":"10.1021\/jp073030y","article-title":"Mechanism for the degradation of erythromycin A and erythromycin A 2\u00a2-ethyl succinate in acidic aqueous solution","volume":"111","author":"Hassanzadeh","year":"2007","journal-title":"J. Phys. Chem. A"},{"key":"10.1016\/j.chroma.2017.06.005_bib0140","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.chroma.2004.02.084","article-title":"Solid-phase extraction-high-performance liquid chromatography-ion trap mass spectrometry for analysis of trace concentrations of macrolide antibiotics in natural and waste water matrices","volume":"1038","author":"Yang","year":"2004","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2017.06.005_bib0145","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1365\/s10337-008-0780-6","article-title":"Simultaneous determination of sulfonamides, fluoroquinolones macrolides and trimethoprim in wastewater and river water by LC\u2013tandem\u2013MS","volume":"68","author":"Senta","year":"2008","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2017.06.005_bib0150","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1056\/NEJMc1212055","article-title":"U.S. outpatient antibiotic prescribing, 2010","volume":"368","author":"Hicks","year":"2013","journal-title":"Engl. J. Med."},{"key":"10.1016\/j.chroma.2017.06.005_bib0155","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.scitotenv.2016.03.119","article-title":"Biodegradation of carbamazepine and clarithromycin by Trichoderma harzianum and Pleurotus ostreatus investigated by liquid chromatography\u2014high-resolution tandem mass spectrometry (FTICR MS-IRMPD)","volume":"557","author":"Buchicchio","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2017.06.005_bib0160","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.watres.2012.10.041","article-title":"Occurrence and fate of dissolved and particulate antimicrobials in municipal wastewater treatment","volume":"47","author":"Senta","year":"2013","journal-title":"Water Res."},{"key":"10.1016\/j.chroma.2017.06.005_bib0165","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.trac.2007.01.009","article-title":"A practical guide to analytical method validation, including measurement uncertainty and accuracy profiles","volume":"26","author":"Gustavo Gonz\u00e1lez","year":"2007","journal-title":"TrAC-Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2017.06.005_bib0170","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.talanta.2016.06.006","article-title":"Simultaneous analysis of multiple classes of antimicrobials in environmental water samples using SPE coupled with UHPLC-ESI\u2013MS\/MS and isotope dilution","volume":"159","author":"Tran","year":"2016","journal-title":"Talanta"}],"updated-by":[{"DOI":"10.1016\/j.chroma.2017.09.020","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T00:00:00Z","timestamp":1509062400000}}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967317308385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967317308385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T05:44:07Z","timestamp":1758260647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967317308385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":34,"alternative-id":["S0021967317308385"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2017.06.005","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography\u2013tandem mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2017.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}