{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T12:38:27Z","timestamp":1771591107786,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010234","name":"Swedish Asthma and Allergy Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010234","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.chroma.2018.06.056","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T17:53:04Z","timestamp":1529689984000},"page":"102-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["A two-dimensional non-comprehensive reversed\/normal phase high-performance liquid chromatography\/tandem mass spectrometry system for determination of limonene and linalool hydroperoxides"],"prefix":"10.1016","volume":"1566","author":[{"given":"Ahmed","family":"Ramzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1598-7093","authenticated-orcid":false,"given":"Ioannis","family":"Sadiktsis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0137-2071","authenticated-orcid":false,"given":"Ulrika","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2018.06.056_bib0005","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/bjd.14167","article-title":"Prevalence of contact allergy in the general population in different European regions","volume":"174","author":"Diepgen","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.chroma.2018.06.056_bib0010","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1111\/bjd.14151","article-title":"Prevalence of fragrance contact allergy in the general population of five European countries: a cross-sectional study","volume":"173","author":"Diepgen","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.chroma.2018.06.056_bib0015","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1365-2133.2008.09022.x","article-title":"Contact sensitization to fragrances in the general population: a Koch\u2019s approach may reveal the burden of disease","volume":"160","author":"Thyssen","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.chroma.2018.06.056_bib0020","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2340\/0001555572456460","article-title":"Allergic contact sensitization in an unselected Danish population","volume":"72","author":"Nielsen","year":"1992","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.chroma.2018.06.056_bib0025","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1021\/tx7002239","article-title":"Allergic contact dermatitis--formation, structural requirements, and reactivity of skin sensitizers","volume":"21","author":"Karlberg","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.chroma.2018.06.056_bib0030","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/cod.12127","article-title":"Activation of non-sensitizing or low-sensitizing fragrance substances into potent sensitizers - prehaptens and prohaptens","volume":"69","author":"Karlberg","year":"2013","journal-title":"Contact Dermat."},{"key":"10.1016\/j.chroma.2018.06.056_bib0035","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1067\/mjd.2002.124817","article-title":"Oxidized citrus oil (R-limonene): a frequent skin sensitizer in Europe","volume":"47","author":"Matura","year":"2002","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.chroma.2018.06.056_bib0040","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1600-0536.2006.00939.x","article-title":"Not only oxidized r-(+)- but also S-(-)-limonene is a common cause of contact allergy in dermatitis patients in Europe","volume":"55","author":"Matura","year":"2006","journal-title":"Contact Dermat."},{"key":"10.1016\/j.chroma.2018.06.056_bib0045","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.0105-1873.2005.00605.x","article-title":"Selected oxidized fragrance terpenes are common contact allergens","volume":"52","author":"Matura","year":"2005","journal-title":"Contact Dermat."},{"key":"10.1016\/j.chroma.2018.06.056_bib0050","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/cod.12545","article-title":"Oxidized limonene and oxidized linalool - concomitant contact allergy to common fragrance terpenes","volume":"74","author":"Br\u00e5red Christensson","year":"2016","journal-title":"Contact Dermat."},{"key":"10.1016\/j.chroma.2018.06.056_bib0055","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1021\/tx049831z","article-title":"Contact allergens formed on air exposure of linalool. Identification and quantification of primary and secondary oxidation products and the effect on skin sensitization","volume":"17","author":"Sk\u00f6ld","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.chroma.2018.06.056_bib0060","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1600-0536.2008.01442.x","article-title":"Limonene hydroperoxide analogues differ in allergenic activity","volume":"59","author":"Christensson","year":"2008","journal-title":"Contact Dermat."},{"key":"10.1016\/j.chroma.2018.06.056_bib0065","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00370734","article-title":"Hydroperoxides in oxidized d-limonene identified as potent contact allergens","volume":"286","author":"Karlberg","year":"1994","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.chroma.2018.06.056_bib0070","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/cod.12714","article-title":"Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC(*) prospective study","volume":"76","author":"Deza","year":"2017","journal-title":"Contact Dermat."},{"key":"10.1016\/j.chroma.2018.06.056_bib0075","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1021\/tx800104c","article-title":"Carbon- and oxygen-centered radicals are equally important haptens of allylic hydroperoxides in allergic contact dermatitis","volume":"21","author":"Johansson","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.chroma.2018.06.056_bib0080","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/jssc.201300843","article-title":"Determination of allergenic hydroperoxides in essential oils using gas chromatography with electron ionization mass spectrometry","volume":"37","author":"Rudb\u00e4ck","year":"2014","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2018.06.056_bib0085","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/jssc.201200855","article-title":"A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry","volume":"36","author":"Rudb\u00e4ck","year":"2013","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2018.06.056_bib0090","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.1007\/s00216-014-8066-3","article-title":"Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products","volume":"406","author":"Kern","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2018.06.056_bib0095","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/ffj.3210","article-title":"Stability of limonene and monitoring of a hydroperoxide in fragranced products","volume":"29","author":"Kern","year":"2014","journal-title":"Flavour Fragr. J."},{"key":"10.1016\/j.chroma.2018.06.056_bib0100","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ffj.3232","article-title":"An HPLC method for hydroperoxides derived from limonene and linalool in citrus oils, using post-column luminol-mediated chemiluminescence detection","volume":"30","author":"Calandra","year":"2015","journal-title":"Flavour Fragr. J."},{"key":"10.1016\/j.chroma.2018.06.056_bib0105","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/tx700017v","article-title":"Fragrance compound geraniol forms contact allergens on air exposure. Identification and quantification of oxidation products and effect on skin sensitization","volume":"20","author":"Hagvall","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.chroma.2018.06.056_bib0110","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-0536.2007.01262.x","article-title":"Autoxidation of linalyl acetate, the main component of lavender oil, creates potent contact allergens","volume":"58","author":"Sk\u00f6ld","year":"2008","journal-title":"Contact Dermat."},{"key":"10.1016\/j.chroma.2018.06.056_bib0115","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1021\/ac7022662","article-title":"Comprehensive off-line, two-dimensional liquid chromatography. Application to the separation of peptide digests","volume":"80","author":"Marchetti","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2018.06.056_bib0120","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.chroma.2008.01.086","article-title":"Implementations of two-dimensional liquid chromatography","volume":"1189","author":"Guiochon","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2018.06.056_bib0125","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1021\/acs.analchem.6b03506","article-title":"Two-dimensional liquid chromatography: a state of the art tutorial","volume":"89","author":"Stoll","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2018.06.056_bib0130","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.chroma.2016.06.008","article-title":"On-line comprehensive two-dimensional normal-phase liquid chromatography\u00d7reversed-phase liquid chromatography for preparative isolation of toad venom","volume":"1456","author":"Li","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2018.06.056_bib0135","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1021\/ac0352981","article-title":"Comprehensive two-dimensional normal-phase (adsorption)-reversed-phase liquid chromatography","volume":"76","author":"Dugo","year":"2004","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2018.06.056_bib0140","series-title":"FDA Guidance for Industry, Bioanalytical Method Validation","author":"U.D.o. Health","year":"2001"},{"key":"10.1016\/j.chroma.2018.06.056_bib0145","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.1039\/C4AN00567H","article-title":"Establishing ion ratio thresholds based on absolute peak area for absolute protein quantification using protein cleavage isotope dilution mass spectrometry","volume":"139","author":"Loziuk","year":"2014","journal-title":"Analyst"},{"key":"10.1016\/j.chroma.2018.06.056_bib0150","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/bmc.3407","article-title":"Design and development of a two-dimensional system based on hydrophilic and reversed-phase liquid chromatography with on-line sample treatment for the simultaneous separation of excreted xenobiotics and endogenous metabolites in urine","volume":"29","author":"Garcia-G\u00f3mez","year":"2015","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.chroma.2018.06.056_bib0155","first-page":"1","article-title":"Retention behavior of oligomeric proanthocyanidins in hydrophilic interaction chromatography","volume":"2","author":"Yanagida","year":"2007","journal-title":"J. Chromatogr A"},{"key":"10.1016\/j.chroma.2018.06.056_bib0160","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF02269653","article-title":"Analysis of contact allergenic compounds in oxidized d-limonene","volume":"42","author":"Nilsson","year":"1996","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2018.06.056_bib0165","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/cod.12163","article-title":"Air-oxidized linalool elicits eczema in allergic patients - a repeated open application test study","volume":"70","author":"Andersch Bjorkman","year":"2014","journal-title":"Contact Dermat."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967318308136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967318308136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T09:17:37Z","timestamp":1693732657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967318308136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":33,"alternative-id":["S0021967318308136"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2018.06.056","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A two-dimensional non-comprehensive reversed\/normal phase high-performance liquid chromatography\/tandem mass spectrometry system for determination of limonene and linalool hydroperoxides","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2018.06.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}