{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:08:09Z","timestamp":1774436889962,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.chroma.2019.460378","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T11:53:38Z","timestamp":1564055618000},"page":"460378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Rapid quantitation and identification of the chemical constituents in Danhong Injection by liquid chromatography coupled with orbitrap mass spectrometry"],"prefix":"10.1016","volume":"1606","author":[{"given":"Lu-lu","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan-peng","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Bo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-lei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2019.460378_bib0005","article-title":"Analysis of anaphylactic shock caused by 17 types of traditional Chinese medicine injections used to treat cardiovascular and cerebrovascular diseases","author":"Guo","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.chroma.2019.460378_bib0010","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.chroma.2015.06.041","article-title":"Large-scale qualitative and quantitative characterization of components in Shenfu injection by integrating hydrophilic interaction chromatography, reversed phase liquid chromatography, and tandem mass spectrometry","volume":"1407","author":"Song","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460378_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2017.00833","article-title":"A Comprehensive strategy to evaluate compatible stability of Chinese medicine injection and infusion solutions based on chemical analysis and bioactivity assay","volume":"8","author":"Li","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.chroma.2019.460378_bib0020","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.phrs.2018.11.006","article-title":"Danhong injection in cardiovascular and cerebrovascular diseases: pharmacological actions, molecular mechanisms, and therapeutic potential","volume":"139","author":"Feng","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.chroma.2019.460378_bib0025","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1039\/C5AY03173G","article-title":"A novel and improved UHPLC-QTOF\/MS method for the rapid analysis of the chemical constituents of Danhong Injection","volume":"8","author":"Tang","year":"2016","journal-title":"Anal. Methods"},{"key":"10.1016\/j.chroma.2019.460378_bib0030","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1142\/S0192415X16500130","article-title":"Phytochemistry and pharmacology of Carthamus tinctorius L","volume":"44","author":"Zhang","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.chroma.2019.460378_bib0035","first-page":"59","article-title":"Danshen: a phytochemical and pharmacological overview","volume":"17","author":"Mei","year":"2019","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.chroma.2019.460378_bib0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2017.00361","article-title":"Specific combination of salvianolic acids as core active ingredients of Danhong Injection for treatment of arterial thrombosis and its derived dry gangrene","volume":"8","author":"Zhao","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.chroma.2019.460378_bib0045","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8259280","article-title":"Hydroxysafflor yellow A: a promising therapeutic agent for a broad spectrum of diseases","author":"Ao","year":"2018","journal-title":"Evid.-Based Complement. Alternat. Med."},{"key":"10.1016\/j.chroma.2019.460378_bib0050","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/313471","article-title":"Near-infrared spectroscopy as an analytical process technology for the on-line quantification of water precipitation processes during Danhong Injection","author":"Liu","year":"2015","journal-title":"Int. J. Anal. Chem."},{"key":"10.1016\/j.chroma.2019.460378_bib0055","first-page":"147","article-title":"Rapid separation and identification of multiple constituents in Danhong Injection by ultra-high performance liquid chromatography coupled to electrospray ionization quadrupole time-of-flight tandem mass spectrometry","volume":"14","author":"Zhang","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.chroma.2019.460378_bib0060","doi-asserted-by":"crossref","first-page":"6285","DOI":"10.14233\/ajchem.2013.14389","article-title":"Chemical fingerprint and metabolic fingerprint of Danhong Injection by HPLC-UV and HPLC-MS","volume":"25","author":"Zhou","year":"2013","journal-title":"Asian. J. Chem."},{"key":"10.1016\/j.chroma.2019.460378_bib0065","article-title":"Precursor ion scan enhanced rapid identification of the chemical constituents of Danhong injection by liquid chromatography\u2013tandem mass spectrometry: an integrated strategy","author":"Li","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460378_bib0070","first-page":"333","article-title":"Study on flavonoids in the flower of Carthamus tinctorius L","volume":"46","author":"Fan","year":"2011","journal-title":"Chin. Pharm. J."},{"key":"10.1016\/j.chroma.2019.460378_bib0075","first-page":"76","volume":"Vol. I","author":"Chinese Pharmacopeia Commission","year":"2015"},{"key":"10.1016\/j.chroma.2019.460378_bib0080","first-page":"223","article-title":"Anti-apoptotic effects and mechanisms of salvianolic acid A on cardiomyocytes in ischemia-reperfusion injury","volume":"34","author":"Qian","year":"2019","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.chroma.2019.460378_bib0085","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1007\/s00253-015-6395-6","article-title":"Production and applications of rosmarinic acid and structurally related compounds","volume":"99","author":"Kim","year":"2015","journal-title":"Appl. Microbiol. Biot."},{"key":"10.1016\/j.chroma.2019.460378_bib0090","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejphar.2008.01.044","article-title":"Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors","volume":"584","author":"Yilmaz","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.chroma.2019.460378_bib0095","unstructured":"http:\/\/www.ich.org\/fleadmin\/Public_Web_Site\/ICH_Products\/Guidelines\/Quality\/Q2_R1\/Step4\/Q2_R1_Guideline.pdf."},{"key":"10.1016\/j.chroma.2019.460378_bib0100","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1021\/cr200058f","article-title":"Constituents from Salvia species and their biological activities","volume":"112","author":"Wu","year":"2012","journal-title":"Chem. Rev."},{"key":"10.1016\/j.chroma.2019.460378_bib0105","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.chroma.2015.11.078","article-title":"Qualitative and quantitative characterization of phenolic and diterpenoid constituents in Danshen (Salvia miltiorrhiza) by comprehensive two-dimensional liquid chromatography coupled with hybrid linear ion trap Orbitrap mass","volume":"1427","author":"Cao","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460378_bib0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/molecules21010051","article-title":"Chemical analysis of the herbal medicine Salviae miltiorrhizae Radix et Rhizoma (Danshen)","volume":"21","author":"Pang","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.chroma.2019.460378_bib0115","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1556\/AChrom.27.2015.4.9","article-title":"UPLC\/Q-TOF-MS analysis for identification of hydrophilic phenolics and lipophilic diterpenoids from Radix Salviae Miltiorrhizae","volume":"27","author":"Yang","year":"2015","journal-title":"Acta Chromatogr."},{"key":"10.1016\/j.chroma.2019.460378_bib0120","first-page":"449","article-title":"Salviaflaside and salviaflaside methyl ester, two new depsidic glycosides from Salvia flava","volume":"7","author":"Zhao","year":"1996","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.chroma.2019.460378_bib0125","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.foodchem.2014.07.154","article-title":"A comprehensive characterisation of beer polyphenols by high resolution mass spectrometry (LC-ESI-LTQ-Orbitrap-MS)","volume":"169","author":"Quifer-Rada","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.chroma.2019.460378_bib0130","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1039\/C5RA23744K","article-title":"Selective and comprehensive characterization of the quinochalcone C-glycoside homologs in Carthamus tinctorius L. by offline comprehensive two-dimensional liquid chromatography\/LTQ-Orbitrap MS coupled with versatile data mining strategies","volume":"16","author":"Yang","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.chroma.2019.460378_bib0135","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.chroma.2017.02.041","volume":"1491","author":"Yao","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460378_bib0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.5246\/jcps.2011.01.007","article-title":"Stability and degradation of hydroxysafflor yellow A and anhydrosafflor yellow B in the Safflower injection studied by HPLC-DAD-ESI-MSn","volume":"20","author":"Fan","year":"2011","journal-title":"J. Chin. Pharm. Sci."},{"key":"10.1016\/j.chroma.2019.460378_bib0145","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.1039\/C4AN01707B","article-title":"Characterization of the herb-derived components in rats following oral administration of Carthamus tinctorius extract by extracting diagnostic fragment ions (DFIs) in the MSn chromatograms","volume":"139","author":"Chen","year":"2014","journal-title":"Analyst"},{"key":"10.1016\/j.chroma.2019.460378_bib0150","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.fitote.2012.06.015","article-title":"Chemical conversions of salvianolic acid B by decoction in aqueous solution","volume":"83","author":"Lee","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.chroma.2019.460378_bib0155","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.fitote.2010.10.008","article-title":"Isolation and identification of degradation products of salvianolic acid A by NMR and LC-MS","volume":"82","author":"Xu","year":"2011","journal-title":"Fitoterapia"},{"key":"10.1016\/j.chroma.2019.460378_bib0160","first-page":"2734","article-title":"Reaction kinetics and pathways for salvianolic acid B in high temperature water","volume":"3","author":"Cheng","year":"2018","journal-title":"Chem. Select"},{"key":"10.1016\/j.chroma.2019.460378_bib0165","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1021\/acs.jafc.5b05617","article-title":"Determination of nonanthocyanin phenolic compounds using high-resolution mass spectrometry (UHPLC-Orbitrap-MS\/MS) and impact of storage conditions in a beverage made from strawberry by fermentation","volume":"64","author":"\u00c1lvarez-Fern\u00e1ndez","year":"2016","journal-title":"J. Agric. Food Chem."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967319307629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967319307629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T05:52:03Z","timestamp":1758261123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967319307629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":33,"alternative-id":["S0021967319307629"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2019.460378","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapid quantitation and identification of the chemical constituents in Danhong Injection by liquid chromatography coupled with orbitrap mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2019.460378","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"460378"}}