{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:26:28Z","timestamp":1790403988907,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T00:00:00Z","timestamp":1612051200000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004795","name":"Institut Universitaire de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004562","name":"Minist\u00e8re de l'Education Nationale, de l'Enseignement Superieur et de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.chroma.2019.460689","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T21:05:33Z","timestamp":1573247133000},"page":"460689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Cinchona-based zwitterionic stationary phases: Exploring retention and enantioseparation mechanisms in supercritical fluid chromatography with a fragmentation approach"],"prefix":"10.1016","volume":"1612","author":[{"given":"Adrien","family":"Raimbault","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cam Mai Anh","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Ferri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"B\u00e4urer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6485-138X","authenticated-orcid":false,"given":"Pascal","family":"Bonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9640-9665","authenticated-orcid":false,"given":"St\u00e9phane","family":"Bourg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"L\u00e4mmerhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7595-6777","authenticated-orcid":false,"given":"Caroline","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2019.460689_bib0001","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1016\/S0040-4039(00)98298-4","article-title":"Cinchona alkaloids for preparing new, easily accessible chiral stationary phases.I. 11-(10,11-Dihydro-6\u2032-methoxy-cinchonan-9-OL)-tiopropylsilanized silica","volume":"26","author":"Rosini","year":"1985","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.chroma.2019.460689_bib0002","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0021-9673(96)00137-9","article-title":"Quinine and quinidine derivatives as chiral selectors I. Brush type chiral stationary phases for high-performance liquid chromatography based on cinchonan carbamates and their application as chiral anion exchangers","volume":"741","author":"L\u00e4mmerhofer","year":"1996","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0003","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.aca.2017.02.005","article-title":"Quinine bonded to superficially porous particles for high-efficiency and ultrafast liquid and supercritical fluid chromatography","volume":"963","author":"Patel","year":"2017","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2019.460689_bib0004","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.chroma.2012.05.023","article-title":"Potential of chiral anion-exchangers operated in various subcritical fluid chromatography modes for resolution of chiral acids","volume":"1245","author":"Pell","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0005","doi-asserted-by":"crossref","first-page":"8780","DOI":"10.1021\/ac801384f","article-title":"Synergistic effects on enantioselectivity of zwitterionic chiral stationary phases for separations of chiral acids, bases, and amino acids by HPLC","volume":"80","author":"Hoffmann","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2019.460689_bib0006","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/jssc.201400149","article-title":"Zwitterionic chiral stationary phases based on cinchona and chiral sulfonic acids for the direct stereoselective separation of amino acids and other amphoteric compounds: liquid chromatography","volume":"37","author":"Zhang","year":"2014","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2019.460689_bib0007","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/jssc.201400078","article-title":"Effect of mobile phase composition on the liquid chromatographic enantioseparation of bulky monoterpene-based \u03b2-amino acids by applying chiral stationary phases based on cinchona alkaloid: liquid chromatography","volume":"37","author":"Pataj","year":"2014","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2019.460689_bib0008","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.chroma.2012.06.094","article-title":"Versatility of cinchona-based zwitterionic chiral stationary phases: enantiomer and diastereomer separations of non-protected oligopeptides utilizing a multi-modal chiral recognition mechanism","volume":"1269","author":"Wernisch","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0009","doi-asserted-by":"crossref","first-page":"8611","DOI":"10.1021\/ja020203i","article-title":"Elucidation of the chiral recognition mechanism of cinchona alkaloid carbamate-type receptors for 3,5-Dinitrobenzoyl amino acids","volume":"124","author":"Maier","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.chroma.2019.460689_bib0010","first-page":"191","article-title":"Method development and optimization on cinchona and chiral sulfonic acid\u2013based zwitterionic stationary phases for enantiomer separations of free amino acids by high-performance liquid chromatography","volume":"1363","author":"Zhang","year":"2014","journal-title":"Enantioseparations"},{"key":"10.1016\/j.chroma.2019.460689_bib0011","doi-asserted-by":"crossref","DOI":"10.4137\/IJTR.S20381","article-title":"Enantiomeric separation of monosubstituted tryptophan derivatives and metabolites by hplc with a cinchona alkaloid-based zwitterionic chiral stationary phase and its application to the evaluation of the optical purity of synthesized 6-Chloro-L-Tryptophan","volume":"8","author":"Fukushima","year":"2015","journal-title":"Int. J. Tryptophan Res."},{"key":"10.1016\/j.chroma.2019.460689_bib0012","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/chir.22458","article-title":"High-Performance liquid chromatographic enantioseparation of cyclic \u03b2; -Amino acids on zwitterionic chiral stationary phases based on cinchona alkaloids: hplc enantioseparation of cyclic \u03b2; -Amino acids","volume":"27","author":"Ilisz","year":"2015","journal-title":"Chirality"},{"key":"10.1016\/j.chroma.2019.460689_bib0013","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1007\/s00726-015-2006-1","article-title":"High-performance liquid chromatographic separation of unusual \u03b23-amino acid enantiomers in different chromatographic modes on cinchona alkaloid-based zwitterionic chiral stationary phases","volume":"47","author":"Ilisz","year":"2015","journal-title":"Amino Acids"},{"key":"10.1016\/j.chroma.2019.460689_bib0014","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0021-9673(00)00172-2","article-title":"tert.-Butylcarbamoylquinine as chiral ion-pair agent in non-aqueous enantioselective capillary electrophoresis applying the partial filling technique","volume":"892","author":"L\u00e4mmerhofer","year":"2000","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1520-667X(1996)8:2<145::AID-MCS8>3.0.CO;2-1","article-title":"Quinine as a chiral additive in nonaqueous capillary zone electrophoresis","volume":"8","author":"Stalcup","year":"1996","journal-title":"J. Microcolumn Sep."},{"key":"10.1016\/j.chroma.2019.460689_bib0016","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1002\/elps.200305527","article-title":"Macroporous monolithic chiral stationary phases for capillary electrochromatography: new chiral monomer derived from cinchona alkaloid with enhanced enantioselectivity","volume":"24","author":"L\u00e4mmerhofer","year":"2003","journal-title":"Electrophoresis"},{"key":"10.1016\/j.chroma.2019.460689_bib0017","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1021\/ac000323d","article-title":"Chiral monolithic columns for enantioselective capillary electrochromatography prepared by copolymerization of a monomer with quinidine functionality. 2. effect of chromatographic conditions on the chiral separations","volume":"72","author":"L\u00e4mmerhofer","year":"2000","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2019.460689_bib0018","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2174\/1573411011410010009","article-title":"Enantioselective separations with supercritical fluids - review","volume":"10","author":"West","year":"2014","journal-title":"Curr. Anal. Chem."},{"key":"10.1016\/j.chroma.2019.460689_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2019.115648","article-title":"Recent trends in chiral supercritical fluid chromatography","volume":"120","author":"West","year":"2019","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2019.460689_bib0020","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.chroma.2017.12.047","article-title":"Simultaneous determination of inorganic anions and cations by supercritical fluid chromatography using evaporative light scattering detection","volume":"1534","author":"Foulon","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0021","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1134\/S1990793118070059","article-title":"Effect of the mobile phase composition on selectivity in supercritical fluid chromatography in the separation of salbutamol enantiomers","volume":"12","author":"Kostenko","year":"2018","journal-title":"Russ. J. Phys. Chem. B"},{"key":"10.1016\/j.chroma.2019.460689_bib0022","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.chroma.2015.08.009","article-title":"An attempt to estimate ionic interactions with phenyl and pentafluorophenyl stationary phases in supercritical fluid chromatography","volume":"1412","author":"West","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0023","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.chroma.2016.02.052","article-title":"An improved classification of stationary phases for ultra-high performance supercritical fluid chromatography","volume":"1440","author":"West","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2019.02.002","article-title":"Unravelling the effects of mobile phase additives in supercritical fluid chromatography. part II: adsorption on the stationary phase","author":"West","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0025","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.chroma.2015.08.058","article-title":"Application of cinchona alkaloid-based zwitterionic chiral stationary phases in supercritical fluid chromatography for the enantioseparation of n\u03b1-protected proteinogenic amino acids","volume":"1415","author":"Lajk\u00f3","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0026","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/chir.22700","article-title":"Liquid and subcritical fluid chromatographic enantioseparation of n \u03b1 -Fmoc proteinogenic amino acids on quinidine -based zwitterionic and anion-exchanger type chiral stationary phases. A comparative study","volume":"29","author":"Lajk\u00f3","year":"2017","journal-title":"Chirality"},{"key":"10.1016\/j.chroma.2019.460689_bib0027","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.chroma.2018.05.064","article-title":"Dedicated comparisons of diverse polysaccharide- and zwitterionic cinchona alkaloid-based chiral stationary phases probed with basic and ampholytic indole analogs in liquid and subcritical fluid chromatography mode","volume":"1563","author":"Bajtai","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0028","doi-asserted-by":"crossref","DOI":"10.1007\/s00216-019-01783-5","article-title":"A chiral unified chromatography\u2013mass spectrometry method to analyze free amino acids","author":"Raimbault","year":"2019","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2019.460689_bib0029","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.chroma.2012.08.006","article-title":"Mechanistic investigations of cinchona alkaloid-based zwitterionic chiral stationary phases","volume":"1269","author":"Pell","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0030","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jpba.2018.06.045","article-title":"Liquid chromatographic enantiomer separations applying chiral ion-exchangers based on cinchona alkaloids","volume":"159","author":"Ilisz","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2019.460689_bib0031","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.chroma.2017.08.022","article-title":"Consequences of transition from liquid chromatography to supercritical fluid chromatography on the overall performance of a chiral zwitterionic ion-exchanger","volume":"1517","author":"Wolrab","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0032","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.chroma.2009.10.022","article-title":"Chiral recognition by enantioselective liquid chromatography: mechanisms and modern chiral stationary phases","volume":"1217","author":"L\u00e4mmerhofer","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0033","article-title":"Fragment-based design of zwitterionic, strong cation- and weak anion-exchange type mixed-mode liquid chromatography ligands and their chromatographic exploration","author":"Ferri","year":"2019","journal-title":"Submitt. Publ. J Chromatogr A"},{"key":"10.1016\/j.chroma.2019.460689_bib0034","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.chroma.2010.11.084","article-title":"Insights into chiral recognition mechanisms in supercritical fluid chromatography. I. non-enantiospecific interactions contributing to the retention on tris-(3,5-dimethylphenylcarbamate) amylose and cellulose stationary phases","volume":"1218","author":"West","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0035","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.chroma.2010.11.085","article-title":"Insights into chiral recognition mechanisms in supercritical fluid chromatography. II. Factors contributing to enantiomer separation on tris-(3,5-dimethylphenylcarbamate) of amylose and cellulose stationary phases","volume":"1218","author":"West","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0036","first-page":"5939","article-title":"Investigations on the chromatographic behaviour of zwitterionic stationary phases used in hydrophilic interaction chromatography","volume":"1218","author":"Chirita","year":"2011","journal-title":"Hydrophilic Interact. Chromatogr."},{"key":"10.1016\/j.chroma.2019.460689_bib0037","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.chroma.2014.06.084","article-title":"Insights into chiral recognition mechanism in supercritical fluid chromatography III. Non-halogenated polysaccharide stationary phases","volume":"1363","author":"Khater","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0038","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.chroma.2014.06.026","article-title":"Insights into chiral recognition mechanism in supercritical fluid chromatography IV. Chlorinated polysaccharide stationary phases","volume":"1363","author":"Khater","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2019.460485","article-title":"Characterization of three macrocyclic glycopeptide stationary phases in supercritical fluid chromatography","volume":"1604","author":"Khater","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0040","article-title":"Mixed-mode chromatography characteristics of chiralpak ZWIX(+) and ZWIX(\u2212) and elucidation of their chromatographic orthogonality for LC\u202f\u00d7\u202fLC application","author":"B\u00e4urer","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2019.460689_bib0041","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.aca.2019.06.006","article-title":"Electrostatic attraction-repulsion model with cinchona alkaloid-based zwitterionic chiral stationary phases exemplified for zwitterionic analytes","volume":"1078","author":"Mimini","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2019.460689_bib0042","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.chroma.2006.01.109","article-title":"Characterisation of stationary phases in subcritical fluid chromatography with the solvation parameter model: III. Polar stationary phases","volume":"1110","author":"West","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460689_bib0043","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.chroma.2006.02.002","article-title":"Characterisation of stationary phases in subcritical fluid chromatography by the solvation parameter model: II. Comparison tools","volume":"1110","author":"West","year":"2006","journal-title":"J. Chromatogr. A"}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967319311185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967319311185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T05:52:10Z","timestamp":1758261130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967319311185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":43,"alternative-id":["S0021967319311185"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2019.460689","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cinchona-based zwitterionic stationary phases: Exploring retention and enantioseparation mechanisms in supercritical fluid chromatography with a fragmentation approach","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2019.460689","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"460689"}}