{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:08:01Z","timestamp":1773479281017,"version":"3.50.1"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007948","name":"Deutscher Akademischer Austausch Dienst Kairo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.chroma.2019.460795","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T01:59:28Z","timestamp":1576461568000},"page":"460795","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Optimization of a sensitive and robust strategy for micellar electrokinetic chromatographic analysis of sofosbuvir in combination with its co-formulated hepatitis C antiviral drugs"],"prefix":"10.1016","volume":"1616","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1359-3071","authenticated-orcid":false,"given":"Azza H.","family":"Rageh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma A.M.","family":"Abdel-aal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5461-0707","authenticated-orcid":false,"given":"Ute","family":"Pyell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.chroma.2019.460795_bib0001","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1478-3231.2008.01934.x","article-title":"The global burden of hepatitis C","volume":"29","author":"Lavanchy","year":"2009","journal-title":"Liver Int"},{"key":"10.1016\/j.chroma.2019.460795_bib0002","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1038\/srep04765","article-title":"Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA","volume":"4","author":"Ascher","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chroma.2019.460795_bib0003","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(11)61097-0","article-title":"Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews","volume":"378","author":"Nelson","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.chroma.2019.460795_bib0004","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.1128\/JVI.00215-11","article-title":"Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action","volume":"85","author":"Targett-Adams","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.chroma.2019.460795_bib0005","doi-asserted-by":"crossref","first-page":"5368","DOI":"10.1128\/AAC.00763-16","article-title":"Clinical resistance to velpatasvir (GS-5816), a novel pan-genotypic inhibitor of the hepatitis C virus NS5A protein","volume":"60","author":"Lawitz","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chroma.2019.460795_bib0006","unstructured":"https:\/\/www.verywellhealth.com\/list-of-approved-hepatitis-c-drugs-3576465(accessed 18\/9\/2019)."},{"key":"10.1016\/j.chroma.2019.460795_bib0007","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.5740\/jaoacint.16-0295","article-title":"Comparative validation of the determination of sofosbuvir in pharmaceuticals by several inexpensive ecofriendly chromatographic, electrophoretic, and spectrophotometric methods","volume":"100","author":"El-Yazbi","year":"2017","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.chroma.2019.460795_bib0008","first-page":"391","article-title":"Development and validation of three novel UV spectrophotometric methods for determination of newly discovered combination for the treatment of hepatitis C and their comparison using ANOVA","volume":"6","author":"Meshram","year":"2018","journal-title":"Int. J. Pharm. Drug Anal."},{"key":"10.1016\/j.chroma.2019.460795_bib0009","article-title":"Silver nanoparticles synthesis for sensitive spectrophotometric determination of sofosbuvir, lamivudine, and ritonavir in pure forms and pharmaceutical dosage forms","author":"Saraya","year":"2019","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.chroma.2019.460795_bib0010","doi-asserted-by":"crossref","first-page":"32909","DOI":"10.1039\/C8RA06588H","article-title":"Selective and sensitive spectrofluorimetric quantification of velpatasvir in presence of sofosbuvir. Application to their co-formulated tablet","volume":"8","author":"Elgamal","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.chroma.2019.460795_bib0011","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jpba.2018.01.038","article-title":"Ultrasensitive spectrofluorimetric method for rapid determination of daclatasvir and ledipasvir in human plasma and pharmaceutical formulations","volume":"152","author":"bo-Zeid","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2019.460795_bib0012","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/bio.3542","article-title":"Study on fluorescence properties of HCV antiviral (velpatasvir) and its fluorimetric determination in presence of sofosbuvir; application to stability study and human plasma","volume":"33","author":"Omar","year":"2018","journal-title":"Luminescence"},{"key":"10.1016\/j.chroma.2019.460795_bib0013","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jchromb.2018.10.020","article-title":"Rapid bioanalytical LC-MS\/MS method for the simultaneous determination of sofosbuvir and velpatasvir in human plasma-application to a pharmacokinetic study in Egyptian volunteers","volume":"1102\u20131103","author":"Elkady","year":"2018","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2019.460795_bib0014","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jchromb.2019.01.024","article-title":"Quantification of second generation direct-acting antivirals daclatasvir, elbasvir, grazoprevir, ledipasvir, simeprevir, sofosbuvir and velpatasvir in human plasma by UPLC-MS\/MS","volume":"1110\u20131111","author":"van Seyen","year":"2019","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2019.460795_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchromb.2019.04.048","article-title":"A liquid chromatography-tandem mass spectrometry method for simultaneous determination of simeprevir, daclatasvir, sofosbuvir, and GS-331007 applied to a retrospective clinical pharmacological study","volume":"1120","author":"Ferrari","year":"2019","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2019.460795_bib0016","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1080\/03639045.2019.1593444","volume":"45","author":"Baker","year":"2019","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.chroma.2019.460795_bib0017","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/22297928.2017.1325331","article-title":"Application of TLC densitometric method for simultaneous estimation of the newly co-formulated antiviral agents ledipasvir and sofosbuvir in their tablet dosage form","volume":"7","author":"Salama","year":"2017","journal-title":"Anal. Chem. Lett."},{"key":"10.1016\/j.chroma.2019.460795_bib0018","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1556\/1006.2019.32.2.10","article-title":"Development of a high-performance thin-layer chromatographic method for the simultaneous determination of newly co-formulated antiviral drugs sofosbuvir and velpatasvir in their pure forms and tablet dosage form","volume":"32","author":"Saraya","year":"2019","journal-title":"J. Planar Chromatogr. -Mod. TLC."},{"key":"10.1016\/j.chroma.2019.460795_bib0019","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1002\/jssc.201800567","article-title":"Development of a highly sensitive high-performance thin-layer chromatography method for the screening and simultaneous determination of sofosbuvir, daclatasvir, and ledipasvir in their pure forms and their different pharmaceutical formulations","volume":"41","author":"Saraya","year":"2018","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2019.460795_bib0020","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.molliq.2018.08.105","volume":"271","author":"El-Wekil","year":"2018","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.chroma.2019.460795_bib0021","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00604-019-3647-7","article-title":"Modification of N,S co-doped graphene quantum dots with p-aminothiophenol-functionalized gold nanoparticles for molecular imprint-based voltammetric determination of the antiviral drug sofosbuvir","volume":"186","author":"Mahmoud","year":"2019","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.chroma.2019.460795_bib0022","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.aca.2018.07.018","article-title":"e-MnO2-modified graphite electrode as a novel electrochemical sensor for the ultrasensitive detection of the newly FDA approved hepatitis C antiviral drug ledipasvir","volume":"1038","author":"Abdel-aal","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2019.460795_bib0023","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.snb.2018.11.158","article-title":"Molecularly imprinted polymer\/reduced graphene oxide-based carbon-paste sensor for highly sensitive determination of the anti-HCV drug daclatasvir dihydrochloride","volume":"283","author":"Abdel Ghani","year":"2019","journal-title":"Sens. Actuat. B"},{"key":"10.1016\/j.chroma.2019.460795_bib0024","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jpba.2014.03.041","article-title":"Current applications of miniaturized chromatographic and electrophoretic techniques in drug analysis","volume":"101","author":"Aturki","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2019.460795_bib0025","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1002\/jssc.201400266","article-title":"Determination of impurities and counterions of pharmaceuticals by capillary electromigration methods","volume":"37","author":"Stepanova","year":"2014","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2019.460795_bib0026","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/elps.201600058","article-title":"Recent advances in capillary electrophoretic migration techniques for pharmaceutical analysis (2013-2015)","volume":"37","author":"El-Deeb","year":"2016","journal-title":"Electrophoresis"},{"key":"10.1016\/j.chroma.2019.460795_bib0027","doi-asserted-by":"crossref","first-page":"129","DOI":"10.20959\/wjpr20175-8386","article-title":"Validated capillary zone electrophoresis approach for simultaneous separation and determination of hepatitis C sofosbuvir and ledipasvir in tablet dosage form","author":"El-Tohamy","year":"2017","journal-title":"World J. Pharm. Res."},{"key":"10.1016\/j.chroma.2019.460795_bib0028","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/10826076.2018.1462203","article-title":"Application of different analytical techniques for determination of velpatsvir and sofosbuvir in the pharmaceutical preparation","volume":"41","author":"Attia","year":"2018","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.chroma.2019.460795_bib0029","doi-asserted-by":"crossref","first-page":"279R","DOI":"10.1021\/a19800141","article-title":"Capillary electrophoresis","volume":"70","author":"Beale","year":"1998","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2019.460795_bib0030","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/mcs.1220030310","article-title":"Free solution capillary electrophoresis of basic proteins in uncoated fused silica capillary tubing","volume":"3","author":"Bullock","year":"1991","journal-title":"J. Microcolumn Sep."},{"key":"10.1016\/j.chroma.2019.460795_bib0031","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0021-9673(93)83049-X","article-title":"Improved capillary zone electrophoretic separation of basic proteins in uncoated fused-silica capillary by using ethylene diamine as a buffer additive","volume":"657","author":"Song","year":"1993","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460795_bib0032","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0021-9673(94)85198-0","article-title":"Electrophoresis of proteins in uncoated capillaries with amines and amino sugars as electrolyte additives","volume":"661","author":"Corradini","year":"1994","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460795_bib0033","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/1522-2683(200102)22:4<603::AID-ELPS603>3.0.CO;2-N","article-title":"The state of the art of dynamic coatings","volume":"22","author":"Righetti","year":"2001","journal-title":"Electrophoresis"},{"key":"10.1016\/j.chroma.2019.460795_bib0034","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/elps.201300259","article-title":"Processes involved in sweeping as sample enrichment method in cyclodextrin-modified micellar electrokinetic chromatography of hydrophobic basic analytes","volume":"35","author":"El-Awady","year":"2014","journal-title":"Electrophoresis"},{"key":"10.1016\/j.chroma.2019.460795_bib0035","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1021\/ac961257b","article-title":"Mechanism of electrokinetic separations of hydrophobic compounds with sodium dodecyl sulfate in acetonitrile-water mixtures","volume":"69","author":"Seifar","year":"1997","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2019.460795_bib0036","first-page":"982","article-title":"Effects of methanol and urea on optical resolution of phenylthiohydantoin-DL-amino acids by micellar electrokinetic chromatography with sodium N-dodecanoyl-L-valinate","volume":"11","author":"Otsuka","year":"1990","journal-title":"Electrophoresis (Weinheim, Fed. Repub. Ger. )"},{"key":"10.1016\/j.chroma.2019.460795_bib0037","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0021-9673(01)88727-6","article-title":"Effect of urea addition in micellar electrokinetic chromatography","volume":"545","author":"Terabe","year":"1991","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.chroma.2019.460795_bib0038","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/elps.11501501193","article-title":"Effect of organic modifier on resolution of hydrophobic compounds by micellar electrokinetic chromatography","volume":"15","author":"Kaneta","year":"1994","journal-title":"Electrophoresis"},{"key":"10.1016\/j.chroma.2019.460795_bib0039","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0021-9673(95)00283-S","article-title":"Optimization of resolution in micellar electrokinetic chromatography via computer-aided simultaneous variation of concentrations of sodium dodecyl sulfate and urea as modifier","volume":"716","author":"Pyell","year":"1995","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460795_bib0040","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1002\/elps.1150191306","article-title":"Cyclodextrins as selectivity enhancers in capillary zone electrophoresis of proteins","volume":"19","author":"Rathore","year":"1998","journal-title":"Electrophoresis"},{"key":"10.1016\/j.chroma.2019.460795_bib0041","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1002\/elps.201000245","article-title":"Use of organic solvent to prevent protein adsorption in CE-MS experiments","volume":"31","author":"Staub","year":"2010","journal-title":"Electrophoresis"},{"key":"10.1016\/j.chroma.2019.460795_bib0042","doi-asserted-by":"crossref","first-page":"489A","DOI":"10.1021\/ac00032a721","article-title":"On-column sample concentration using field amplification in CZE","volume":"64","author":"Chien","year":"1992","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2019.460795_bib0043","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1126\/science.282.5388.465","article-title":"Exceeding 5000-fold concentration of dilute analytes in micellar electrokinetic chromatography","volume":"282","author":"Quirino","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.chroma.2019.460795_bib0044","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/elps.201000604","article-title":"Regulation of the retention factor for weak acids in micellar electrokinetic chromatography with cationic surfactant via variation of the chloride concentration","volume":"32","author":"Orentaite","year":"2011","journal-title":"Electrophoresis"},{"key":"10.1016\/j.chroma.2019.460795_bib0045","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.chroma.2013.04.069","article-title":"Sweeping as a multistep enrichment process in micellar electrokinetic chromatography: the retention factor gradient effect","volume":"1297","author":"El-Awady","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460795_bib0046","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s10337-017-3261-y","article-title":"The concept of stationary and moving boundaries modelled as accelerating or decelerating planes in the understanding of sweeping processes employed for online focusing in capillary zone electrophoresis and electrokinetic chromatography","volume":"80","author":"Pyell","year":"2017","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2019.460795_bib0047","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10337-018-3570-9","article-title":"\u201cPseudostationary ion-exchanger\u201d sweeping as an online enrichment technique in the determination of nucleosides in urine via micellar electrokinetic chromatography","volume":"82","author":"Rageh","year":"2019","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2019.460795_bib0048","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1002\/jssc.201100414","article-title":"Online sample pre-concentration via dynamic pH junction in capillary and microchip electrophoresis","volume":"34","author":"Kazarian","year":"2011","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2019.460795_bib0049","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/elps.201800261","article-title":"Recent progress of sample stacking in capillary electrophoresis (2016-2018)","volume":"40","author":"Slampova","year":"2019","journal-title":"Electrophoresis"},{"key":"10.1016\/j.chroma.2019.460795_bib0050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/elps.201800384","article-title":"Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries in microchips (2016-2018)","volume":"40","author":"Breadmore","year":"2019","journal-title":"Electrophoresis"},{"key":"10.1016\/j.chroma.2019.460795_bib0051","unstructured":"ICH Harmonised Tripartite Guidelines, Validation of analytical procedures: text and methodology Q2(R1). http:\/\/www.ich.org\/products\/guidelines\/quality\/article\/quality-guidelines.html."},{"key":"10.1016\/j.chroma.2019.460795_bib0052","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0021-9673(02)00048-1","article-title":"Improvement of the long-term stability of polyimide-coated fused-silica capillaries used in capillary electrophoresis and capillary electrochromatography","volume":"961","author":"Baeuml","year":"2002","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460795_bib0053","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1021\/ac9706281","article-title":"Online concentration of neutral analytes for micellar electrokinetic chromatography. 3. Stacking with reverse migrating micelles","volume":"70","author":"Quirino","year":"1998","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2019.460795_bib0054","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.chroma.2013.08.020","article-title":"Robust analysis of the hydrophobic basic analytes loratadine and desloratadine in pharmaceutical preparations and biological fluids by sweeping-cyclodextrin-modified micellar electrokinetic chromatography","volume":"1309","author":"El-Awady","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460795_bib0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.microc.2016.01.009","article-title":"Analysis of four antimigraine drugs in two ternary mixtures by sweeping-micellar electrokinetic chromatography with retention factor gradient effect and dynamic pH junction","volume":"127","author":"Belal","year":"2016","journal-title":"Microchem. J."},{"key":"10.1016\/j.chroma.2019.460795_bib0056","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1002\/elps.1150191603","article-title":"Strategies for capillary electrophoresis. Method development and validation for pharmaceutical and biological applications","volume":"19","author":"W\u00e4tzig","year":"1998","journal-title":"Electrophoresis"},{"key":"10.1016\/j.chroma.2019.460795_bib0057","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.chroma.2012.09.044","article-title":"Processes involved in sweeping under inhomogeneous electric field conditions as sample enrichment procedure in micellar electrokinetic chromatography","volume":"1264","author":"El-Awady","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2019.460795_bib0058","series-title":"Challenges in Analytical Quality Assurance","article-title":"Challenges in Analytical Quality Assurance","year":"2011"},{"key":"10.1016\/j.chroma.2019.460795_bib0059","doi-asserted-by":"crossref","first-page":"61","DOI":"10.22159\/ajpcr.2016.v9s3.14616","article-title":"Method development and validation of ultraviolet-visible spectroscopic method for the estimation of hepatitis-C drugs - daclatasvir and sofosbuvir in active pharmaceutical ingredient form","volume":"9","author":"Kumar","year":"2016","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"10.1016\/j.chroma.2019.460795_bib0060","first-page":"92","article-title":"Novel and facile spectrophotometric techniques for the determination of sofosbuvir and ledipasvir in their tablet dosage form","volume":"7","author":"Abdelfatah","year":"2018","journal-title":"J. Anal. Pharm. Res."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967319312439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967319312439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T05:52:12Z","timestamp":1758261132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967319312439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":60,"alternative-id":["S0021967319312439"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2019.460795","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimization of a sensitive and robust strategy for micellar electrokinetic chromatographic analysis of sofosbuvir in combination with its co-formulated hepatitis C antiviral drugs","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2019.460795","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"460795"}}