{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:13:25Z","timestamp":1793276005593,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.chroma.2020.461201","type":"journal-article","created":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T01:52:44Z","timestamp":1589680364000},"page":"461201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Rendering A Chiral Screening Step In Supercritical Fluid Chromatography Mass-Spectrometry Compatible"],"prefix":"10.1016","volume":"1624","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0961-1786","authenticated-orcid":false,"given":"Sven","family":"Declerck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvan","family":"Vander Heyden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby","family":"Mangelings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2020.461201_bib0001","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jpba.2017.07.008","article-title":"The market of chiral drugs: Chiral switches versus de novo enantiomerically pure compounds","volume":"147","author":"Calcaterra","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2020.461201_bib0002","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jpba.2015.03.007","article-title":"Supercritical fluid chromatography in pharmaceutical analysis","volume":"113","author":"Desfontaine","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2020.461201_bib0003","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10337-018-3606-1","article-title":"Recent Achievements and Future Challenges in Supercritical Fluid Chromatography for the Enantioselective Separation of Chiral Pharmaceuticals","volume":"82","author":"Felletti","year":"2019","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2020.461201_bib0004","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.jbiosc.2012.12.008","article-title":"History of supercritical fluid chromatography: Instrumental development","volume":"115","author":"Saito","year":"2013","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.chroma.2020.461201_bib0005","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.chroma.2014.12.083","article-title":"The many faces of packed column supercritical fluid chromatography - A critical review","volume":"1382","author":"Lesellier","year":"2015","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0006","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.chroma.2012.10.005","article-title":"Comparison of ultra-high performance supercritical fluid chromatography and ultra-high performance liquid chromatography for the analysis of pharmaceutical compounds","volume":"1266","author":"Grand-Guillaume Perrenoud","year":"2012","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0007","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.chroma.2005.03.073","article-title":"Integration of supercritical fluid chromatography into drug discovery as a routine support tool: Part I. Fast chiral screening and purification","volume":"1074","author":"White","year":"2005","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0008","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.chroma.2016.07.050","article-title":"Preparative supercritical fluid chromatography: A powerful tool for chiral separations","volume":"1467","author":"Speybrouck","year":"2016","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0009","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.aca.2016.11.002","article-title":"General screening and optimization strategy for fast chiral separations in modern supercritical fluid chromatography","volume":"950","author":"Nov\u00e1kov\u00e1","year":"2017","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2020.461201_bib0010","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.supflu.2013.04.003","article-title":"Updating a generic screening approach in sub- or supercritical fluid chromatography for the enantioresolution of pharmaceuticals","volume":"80","author":"De Klerck","year":"2013","journal-title":"J. Supercrit. Fluids."},{"key":"10.1016\/j.chroma.2020.461201_bib0011","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1016\/j.chroma.2011.03.066","article-title":"A high throughput approach to purifying chiral molecules using 3\u03bcm analytical chiral stationary phases via supercritical fluid chromatography","volume":"1218","author":"Hamman","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2020.461201_bib0012","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.chroma.2013.07.046","article-title":"The evaluation of 25 chiral stationary phases and the utilization of sub-2.0 \u03bcm coated polysaccharide chiral stationary phases via supercritical fluid chromatography","volume":"1305","author":"Hamman","year":"2013","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0013","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jchromb.2018.02.006","article-title":"Supercritical fluid chromatography-photodiode array detection-electrospray ionization mass spectrometry as a framework for impurity fate mapping in the development and manufacture of drug substances","volume":"1080","author":"Pirrone","year":"2018","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.chroma.2020.461201_bib0014","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.chroma.2012.05.068","article-title":"Metabolic profiling of lipids by supercritical fluid chromatography\/mass spectrometry","volume":"1250","author":"Bamba","year":"2012","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0015","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.trac.2018.12.023","article-title":"Recent developments in supercritical fluid chromatography \u2013 mass spectrometry: Is it a viable option for analysis of complex samples?","volume":"112","author":"Pila\u0159ov\u00e1","year":"2019","journal-title":"TrAC Trends Anal. Chem"},{"key":"10.1016\/j.chroma.2020.461201_bib0016","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jchromb.2018.03.010","article-title":"What are the current solutions for interfacing supercritical fluid chromatography and mass spectrometry?","volume":"1083","author":"Guillarme","year":"2018","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.chroma.2020.461201_bib0017","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jchromb.2018.05.017","article-title":"Splitless hyphenation of SFC with MS by APCI, APPI, and ESI exemplified by steroids as model compounds","volume":"1091","author":"Parr","year":"2018","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.chroma.2020.461201_bib0018","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.chroma.2015.07.037","article-title":"Development of an achiral supercritical fluid chromatography method with ultraviolet absorbance and mass spectrometric detection for impurity profiling of drug candidates. Part I: Optimization of mobile phase composition","volume":"1408","author":"Lemasson","year":"2015","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0019","series-title":"HPLC for Pharmaceutical Scientists","year":"2007"},{"key":"10.1016\/j.chroma.2020.461201_bib0020","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jchromb.2005.01.011","article-title":"Simple means to alleviate sensitivity loss by trifluoroacetic acid (TFA) mobile phases in the hydrophilic interaction chromatography-electrospray tandem mass spectrometric (HILIC-ESI\/MS\/MS) bioanalysis of basic compounds","volume":"825","author":"Shou","year":"2005","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.chroma.2020.461201_bib0021","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/1044-0305(95)00571-4","article-title":"Signal enhancement for gradient reverse-phase high-performance liquid chromatography-electrospray ionization mass spectrometry analysis with trifluoroacetic and other strong acid modifiers by postcolumn addition of propionic acid and isopropanol","volume":"6","author":"Kuhlmann","year":"1995","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.chroma.2020.461201_bib0022","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0021-9673(02)00345-X","article-title":"Effect of the mobile phase composition on the separation and detection of intact proteins by reversed-phase liquid chromatography-electrospray mass spectrometry","volume":"957","author":"Garc\u00eda","year":"2002","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0023","series-title":"Handb. Metab. Phenotyping","first-page":"619","article-title":"SFC-MS in Metabolic Phenotyping","author":"Wilson","year":"2018"},{"key":"10.1016\/j.chroma.2020.461201_bib0024","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.chroma.2016.04.040","article-title":"Analysis of polar urinary metabolites for metabolic phenotyping using supercritical fluid chromatography and mass spectrometry","volume":"1449","author":"Sen","year":"2016","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0025","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/ijms20235957","article-title":"N-butylamine for improving the efficiency of untargeted mass spectrometry analysis of plasma metabolite composition","volume":"20","author":"Maslov","year":"2019","journal-title":"Int. J. Mol. Sci"},{"key":"10.1016\/j.chroma.2020.461201_bib0026","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.chroma.2015.01.084","article-title":"Exploring the enantioseparation of amino-naphthol analogues by supercritical fluid chromatography","volume":"1387","author":"F\u00fcl\u00f6p","year":"2015","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0027","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.chroma.2012.05.023","article-title":"Potential of chiral anion-exchangers operated in various subcritical fluid chromatography modes for resolution of chiral acids","volume":"1245","author":"Pell","year":"2012","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0028","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jpba.2018.08.061","article-title":"SFC for chiral separations in bioanalysis","volume":"162","author":"Harps","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2020.461201_bib0029","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.forsciint.2017.01.025","article-title":"Enantioseparation of methamphetamine by supercritical fluid chromatography with cellulose-based packed column","volume":"273","author":"Segawa","year":"2017","journal-title":"Forensic Sci. Int"},{"key":"10.1016\/j.chroma.2020.461201_bib0030","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jchromb.2017.07.009","article-title":"Enantiomeric separation and quantification of citalopram in serum by ultra-high performance supercritical fluid chromatography-tandem mass spectrometry","volume":"1061\u20131062","author":"Hegstad","year":"2017","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.chroma.2020.461201_bib0031","first-page":"380","article-title":"Rapid chiral separation of racemic cetirizine in human plasma using subcritical fluid chromatography-tandem mass spectrometry","volume":"117","author":"Kang","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2020.461201_bib0032","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.chroma.2015.07.067","article-title":"Response surface methodology for the enantioseparation of dinotefuran and its chiral metabolite in bee products and environmental samples by supercritical fluid chromatography\/tandem mass spectrometry","volume":"1410","author":"Chen","year":"2015","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0033","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.chroma.2008.01.050","article-title":"Development of a supercritical fluid chromatography high-resolution separation method suitable for pharmaceuticals using cyanopropyl silica","volume":"1185","author":"Brunelli","year":"2008","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0034","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0021-9673(03)00725-8","article-title":"Rapid method development for chiral separation in drug discovery using sample pooling and supercritical fluid chromatography-mass spectrometry","volume":"1003","author":"Zhao","year":"2003","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jpba.2012.01.021","article-title":"Supercritical fluid chromatography for the enantioseparation of pharmaceuticals","volume":"69","author":"De Klerck","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2020.461201_bib0036","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.chroma.2013.12.052","article-title":"Exploratory data analysis as a tool for similarity assessment and clustering of chiral polysaccharide-based systems used to separate pharmaceuticals in supercritical fluid chromatography","volume":"1326","author":"De Klerck","year":"2014","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0037","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/bmc.3071","article-title":"Three versus five micrometer chlorinated polysaccharide-based packings in chiral capillary electrochromatography: efficiency and precision evaluation","volume":"28","author":"Hendrickx","year":"2014","journal-title":"Biomed. Chromatogr"},{"key":"10.1016\/j.chroma.2020.461201_bib0038","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.chroma.2004.12.038","article-title":"Screening approach for chiral separation of pharmaceuticals: Part III. Supercritical fluid chromatography for analysis and purification in drug discovery","volume":"1088","author":"Maftouh","year":"2005","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0039","first-page":"3947","article-title":"In Situ Formation of Alkylcarbonic Acids with CO2","volume":"105","author":"Griffith","year":"2007","journal-title":"J. Phys. Chem. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0040","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.chroma.2017.02.066","article-title":"Unravelling the effects of mobile phase additives in supercritical fluid chromatography. Part I: Polarity and acidity of the mobile phase","volume":"1492","author":"West","year":"2017","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0041","doi-asserted-by":"crossref","first-page":"6441","DOI":"10.1016\/j.chroma.2009.07.022","article-title":"Effect of increasing concentration of ammonium acetate as an additive in supercritical fluid chromatography using CO2-methanol mobile phase","volume":"1216","author":"Cazenave-Gassiot","year":"2009","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2020.461201_bib0042","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jpba.2016.04.005","article-title":"Screening study of SFC critical method parameters for the determination of pharmaceutical compounds","volume":"125","author":"Dispas","year":"2016","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967320304659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967320304659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T05:56:06Z","timestamp":1758261366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967320304659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":42,"alternative-id":["S0021967320304659"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2020.461201","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rendering A Chiral Screening Step In Supercritical Fluid Chromatography Mass-Spectrometry Compatible","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2020.461201","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"461201"}}