{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:58:04Z","timestamp":1787893084509,"version":"build-2784847793"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.chroma.2021.462406","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T23:36:32Z","timestamp":1626219392000},"page":"462406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Simultaneous enantio- and diastereo-selective high-performance liquid chromatography separation of paroxetine on an immobilized amylose-based chiral stationary phase under green reversed-phase conditions"],"prefix":"10.1016","volume":"1653","author":[{"given":"Alessia","family":"Rosetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosella","family":"Ferretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3253-3608","authenticated-orcid":false,"given":"Claudio","family":"Villani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4030-8205","authenticated-orcid":false,"given":"Marco","family":"Pierini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6346-1953","authenticated-orcid":false,"given":"Roberto","family":"Cirilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2021.462406_bib0001","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1527-3458.2001.tb00189.x","article-title":"Paroxetine: a review","volume":"7","author":"Bourin","year":"2001","journal-title":"CNS Drug Rev"},{"key":"10.1016\/j.chroma.2021.462406_bib0002","doi-asserted-by":"crossref","first-page":"495","DOI":"10.15171\/apb.2017.061","article-title":"Chirality of modern antidepressants: an overview","volume":"7","author":"Bud\u0103u","year":"2017","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.chroma.2021.462406_bib0003","series-title":"Monograph: Paroxetine Hydrochloride Hemihydrate 01\/2017:2018","first-page":"3490","year":"2020"},{"key":"10.1016\/j.chroma.2021.462406_bib0004","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0731-7085(90)80129-D","article-title":"\u03b11-Acid glycoprotein column in the high-performance liquid chromatographic analysis of some groups of chiral drugs","volume":"8","author":"G\u00f6r\u00f6g","year":"1990","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2021.462406_bib0005","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1002\/jssc.201000627","article-title":"New approaches of LC-MS compatible method development on \u03b11-acid glycoprotein-based stationary phase for resolution of enantiomers by HPLC","volume":"33","author":"Michishita","year":"2010","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2021.462406_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bmc.4730","article-title":"Enantioselective LC analysis and determination of selective serotonin reuptake inhibitors","volume":"34","author":"Sethi","year":"2020","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.chroma.2021.462406_bib0007","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/chir.10250","article-title":"Chiral HPLC method for chiral purity determination of paroxetine drug substance","volume":"31","author":"Zukowski","year":"2003","journal-title":"Chirality"},{"key":"10.1016\/j.chroma.2021.462406_bib0008","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jpba.2016.02.043","article-title":"Mechanistic considerations of enantiorecognition on novel Cinchona alkaloid-based zwitterionic chiral stationary phases from the aspect of the separation of trans-paroxetine enantiomers as model compounds","volume":"124","author":"Grecs\u00f3","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2021.462406_bib0009","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0378-4347(98)00098-X","article-title":"L. Validated chiral high-performance liquid chromatographic method for the determination of trans-(\u2212)-paroxetine and its enantiomer in bulk and pharmaceutical formulations","volume":"710","author":"Ferretti","year":"1998","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2021.462406_bib0010","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1007\/s00216-013-7565-y","article-title":"New validated HPLC methodology for the determination of (\u2212)-trans-paroxetine and its enantiomer in pharmaceutical formulations with use of ovomucoid chiral stationary phase","volume":"406","author":"Lisowska-Ku\u017amicz","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2021.462406_bib0011","doi-asserted-by":"crossref","first-page":"8394","DOI":"10.1016\/j.chroma.2011.09.052","article-title":"Application of 3 \u03bcm particle-based amylose-derived chiral stationary phases for the enantioseparation of potential histone deacetylase inhibitors","volume":"1218","author":"Ferrettia","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462406_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.121151","article-title":"Direct HPLC enantioseparation of chemopreventive chiral isothiocyanates sulforaphane and iberin on immobilized amylose-based chiral stationary phases under normal-phase, polar organic and aqueous conditions","volume":"218","author":"Panusa","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2021.462406_bib0013","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1002\/jssc.200900272","article-title":"The acetonitrile shortage: Is reversed HILIC with water an alternative for the analysis of highly polar ionizable solutes?","volume":"32","author":"Pereira","year":"2009","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2021.462406_bib0014","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.microc.2019.04.074","article-title":"Green RP-HPLC method for simultaneous determination of moxifloxacin combinations: Investigation of the greenness for the proposed method","volume":"148","author":"Ibrahim","year":"2019","journal-title":"Microchem. J."},{"key":"10.1016\/j.chroma.2021.462406_bib0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0021-9673(01)95357-9","article-title":"Chromatographic resolution of 1,2-amino alcohols on a chiral stationary phase containing N,N\u2032-(3,5-dinitrobenzoyl)-trans-1,2-diaminocyclohexane: Theoretical and practical aspects","volume":"539","author":"Gasparrini","year":"1991","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.chroma.2021.462406_bib0016","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/jssc.201701191","article-title":"Development of a high-performance liquid chromatography method for the simultaneous determination of chiral impurities and assay of (S)-clopidogrel using a cellulose-based chiral stationary phase in methanol\/water mode","volume":"41","author":"Ferretti","year":"2018","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2021.462406_bib0017","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/jssc.201501329","article-title":"Green high-performance liquid chromatography enantioseparation of lansoprazole using a cellulose-based chiral stationary phase under ethanol\/water mode","volume":"39","author":"Ferretti","year":"2016","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2021.462406_bib0018","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jpha.2019.04.002","article-title":"Temperature and eluent composition effects on enantiomer separation of carvedilol by high-performance liquid chromatography on immobilized amylose-based chiral stationary phases","volume":"9","author":"Panella","year":"2019","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.chroma.2021.462406_bib0019","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/anie.198901921","article-title":"Temperature dependent inversion of elution sequence in the resolution of \u03b1-amino acid enantiomers on chiral diamide selectors","volume":"28","author":"Watabe","year":"1989","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.chroma.2021.462406_bib0020","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/anie.198407473","article-title":"Gas-chromatographic separation of enantiomers on optically-active metal-complex free stationary phases","volume":"23","author":"Schurig","year":"1984","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.chroma.2021.462406_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0021-9673(91)80106-Q","article-title":"Unusual effect of temperature on the retention of enantiomers on a chiral column","volume":"558","author":"Pirkle","year":"1991","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.chroma.2021.462406_bib0022","article-title":"Study of enantioseparation of \u03b2-blockers using amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions","volume":"1634","author":"D\u00edaz Merino","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462406_bib0023","series-title":"Monograph: Paroxetine Hydrochloride Hemihydrate 01\/2017:2283","first-page":"3488","year":"2020"}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967321005306?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967321005306?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T06:08:23Z","timestamp":1758262103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967321005306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":23,"alternative-id":["S0021967321005306"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2021.462406","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous enantio- and diastereo-selective high-performance liquid chromatography separation of paroxetine on an immobilized amylose-based chiral stationary phase under green reversed-phase conditions","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2021.462406","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"462406"}}