{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T08:34:59Z","timestamp":1786437299176,"version":"build-2736575974"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003170","name":"Stiftelsen f\u00f6r Kunskaps- och Kompetensutveckling","doi-asserted-by":"publisher","award":["20170059"],"award-info":[{"award-number":["20170059"]}],"id":[{"id":"10.13039\/501100003170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2015-04627"],"award-info":[{"award-number":["2015-04627"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.chroma.2021.462541","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T22:52:31Z","timestamp":1631227951000},"page":"462541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Experimental and theoretical investigation of high- concentration elution bands in ion-pair chromatography"],"prefix":"10.1016","volume":"1656","author":[{"given":"Marek","family":"Le\u015bko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rgen","family":"Samuelsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9209-1418","authenticated-orcid":false,"given":"Krzysztof","family":"Kaczmarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7123-2066","authenticated-orcid":false,"given":"Torgny","family":"Fornstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2021.462541_bib0001","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/10408340802038882","article-title":"Ion pairing chromatography","volume":"38","author":"Cecchi","year":"2008","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462541_bib0002","doi-asserted-by":"crossref","first-page":"10294","DOI":"10.1002\/anie.201611914","article-title":"New modalities for challenging targets in drug discovery","volume":"56","author":"Valeur","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.chroma.2021.462541_bib0003","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00216-019-02236-9","article-title":"Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair reagents","volume":"412","author":"Enmark","year":"2020","journal-title":"Anal Bioanal. Chem."},{"key":"10.1016\/j.chroma.2021.462541_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2021.462269","article-title":"Selectivity limits of and opportunities for ion pair chromatographic separation of oligonucleotides","volume":"1651","author":"Enmark","year":"2021","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462541_bib0005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0021-9673(00)82234-7","article-title":"Soap chromatography\u2014a new high-performance liquid chromatographic technique for separation of ionizable materials: dyestuff intermediates","volume":"122","author":"Knox","year":"1976","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2021.462541_bib0006","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1021\/ac50022a048","article-title":"Enhancement of retention by ion-pair formation in liquid chromatography with nonpolar stationary phases","volume":"49","author":"Horvath","year":"1977","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462541_bib0007","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1021\/ac50022a030","article-title":"Reversed phase high performance liquid chromatographic separations of nucleotides in the presence of solvophobic ions","volume":"49","author":"Hoffman","year":"1977","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462541_bib0008","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1021\/ac50043a045","article-title":"Retention behavior of carboxylic acids and their quaternary ammonium ion pairs in reversed phase chromatography with acetonitrile as organic modifier in the mobile phase","volume":"51","author":"Tilly-Melin","year":"1979","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462541_bib0009","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1021\/ac50009a044","article-title":"Liquid chromatography of ionogenic substances with nonpolar stationary phases","volume":"49","author":"Horvath","year":"1977","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462541_bib0010","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0731-7085(84)80066-7","article-title":"Retention model for ion-pair chromatography based on double-layer ionic adsorption and exchange","volume":"2","author":"Cantwell","year":"1984","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2021.462541_bib0011","first-page":"255","article-title":"Electrostatic retention model of reversed-phase ion-pair chromatography","volume":"668","author":"Bartha","year":"1994","journal-title":"9th Danube Symp. Chromatogr."},{"key":"10.1016\/j.chroma.2021.462541_bib0012","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1021\/ac00169a024","article-title":"Adsorption isotherm of tetrabutylammonium ion and its relation to the mechanism of ion pair chromatography","volume":"60","author":"St\u00e5hlberg","year":"1988","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462541_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2016.01.008","article-title":"System peaks and their impact in liquid chromatography","author":"Fornstedt","year":"2016","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462541_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2020.461048","article-title":"Systematic investigations of peak distortions due to additives in supercritical fluid chromatography","volume":"1621","author":"Glenne","year":"2020","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2021.462541_bib0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0021-9673(02)00228-5","article-title":"Measurement and modeling of the equilibrium behavior of the Troger's base enantiomers on an amylose-based chiral stationary phase","volume":"955","author":"Mihlbachler","year":"2002","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2021.462541_bib0016","series-title":"Encyclopedia of Chromatography","article-title":"Analyte-analyte interactions, effect on TLC band formation","author":"Kaczmarski","year":"2004"},{"key":"10.1016\/j.chroma.2021.462541_bib0017","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s10337-017-3298-y","article-title":"Estimation of nonlinear adsorption isotherms in gradient elution RP-LC of peptides in the presence of an adsorbing additive","volume":"80","author":"\u00c5sberg","year":"2017","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2021.462541_bib0018","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.chroma.2017.03.041","article-title":"The importance of ion-pairing in peptide purification by reversed-phase liquid chromatography","volume":"1496","author":"\u00c5sberg","year":"2017","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2021.462541_bib0019","series-title":"Fundamentals of Preparative and Nonlinear Chromatography","author":"Guiochon","year":"2006"},{"key":"10.1016\/j.chroma.2021.462541_bib0020","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0021-9673(00)91485-7","article-title":"The Gouy\u2014Chapman theory in combination with a modified Langmuir isotherm as a theoretical model for ion-pair chromatography","volume":"356","author":"St\u00e5hlberg","year":"1986","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2021.462541_bib0021","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0098-1354(96)00300-6","article-title":"Modeling fixed-bed adsorption columns through orthogonal collocations on moving finite elements","volume":"21","author":"Kaczmarski","year":"1997","journal-title":"Comput. Chem. Eng."},{"key":"10.1016\/j.chroma.2021.462541_bib0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9673(99)00901-2","article-title":"Calculation of chromatographic band profiles with an implicit isotherm","volume":"862","author":"Kaczmarski","year":"1999","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2021.462541_bib0023","first-page":"20","article-title":"Use of simulated annealing for optimization of chromatographic separations","volume":"17","author":"Kaczmarski","year":"2006","journal-title":"Acta Chromatogr."},{"key":"10.1016\/j.chroma.2021.462541_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2007.06.026","article-title":"Thermodynamic characterization of separations on alkaline-stable silica-based C18 columns: Why basic solutes may have better capacity and peak performance at higher pH","volume":"1163","author":"Samuelsson","year":"2007","journal-title":"J. Chromatogr. A."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967321006658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967321006658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T06:07:42Z","timestamp":1758262062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967321006658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":24,"alternative-id":["S0021967321006658"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2021.462541","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experimental and theoretical investigation of high- concentration elution bands in ion-pair chromatography","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2021.462541","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"462541"}}