{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:19:57Z","timestamp":1791429597566,"version":"4.3.3"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81527806"],"award-info":[{"award-number":["81527806"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.chroma.2021.462583","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T15:04:56Z","timestamp":1632927896000},"page":"462583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Advantages of rectangular horizontal tubing in the semi-preparative counter-current chromatography bobbin"],"prefix":"10.1016","volume":"1657","author":[{"given":"Shunjie","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodie","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanjuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2021.462583_bib0001","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/chromsci\/8.6.315","article-title":"Countercurrent chromatography: liquid-liquid partition chromatography without solid support","volume":"8","author":"Ito","year":"1970","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.chroma.2021.462583_bib0002","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.chroma.2004.12.044","article-title":"Golden rules and pitfalls in selecting optimum conditions for high-speed counter-current chromatography","volume":"1065","author":"Ito","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462583_bib0003","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-61779-624-1_9","article-title":"Separation of natural products by countercurrent chromatography","volume":"864","author":"Mcalpine","year":"2012","journal-title":"Method Mol. Biol."},{"key":"10.1016\/j.chroma.2021.462583_bib0004","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.chroma.2006.09.098","article-title":"Rapid purification and scale-up of honokiol and magnolol using high-capacity high-speed counter-current chromatography","volume":"1142","author":"Chen","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462583_bib0005","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.chroma.2007.01.143","article-title":"Recent progress on the industrial scale-up of counter-current chromatography","volume":"1151","author":"Sutherland","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462583_bib0006","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.chroma.2008.04.049","article-title":"How to realize the linear scale-up process for rapid purification using high-performance counter-current chromatography","volume":"1194","author":"Yuan","year":"2008","journal-title":"J. Chromatogr. A"},{"issue":"01","key":"10.1016\/j.chroma.2021.462583_bib0007","article-title":"Comparative studies on performance of CCC and preparative RP-HPLC in separation and purification of steroid saponins from Dioscorea zingiberensis C.H.Wright","volume":"6","author":"Zhang","year":"2015","journal-title":"J Steroids Horm Sci"},{"key":"10.1016\/j.chroma.2021.462583_bib0008","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.aca.2015.04.055","article-title":"Tubing modifications for countercurrent chromatography (CCC): stationary phase retention and separation efficiency","volume":"884","author":"Englert","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2021.462583_bib0009","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1081\/JLC-120021255","article-title":"Spiral disk assembly for HSCCC: column design and basic studies on chromatographic resolution and stationary phase retention","volume":"26","author":"Ito","year":"2003","journal-title":"J. Liq. Chromatogr. Rel. Technol."},{"key":"10.1016\/j.chroma.2021.462583_bib0010","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/jssc.201600927","article-title":"Spiral counter-current chromatography: design, development, application, and challenges","volume":"40","author":"Huang","year":"2017","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2021.462583_bib0011","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.chroma.2013.02.079","article-title":"Conical coils counter-current chromatography for preparative isolation and purification of tanshinones from Salvia miltiorrhiza Bunge","volume":"1288","author":"Liang","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462583_bib0012","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.chroma.2015.10.009","article-title":"Surface modification of polytetrafluoroethylene column for two-stationary phase separations by counter-current chromatography","volume":"1422","author":"Quan","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462583_bib0013","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.chroma.2018.10.046","article-title":"The effect of increasing centrifugal acceleration\/force and flow rate for varying column aspect ratios on separation efficiency in counter-current chromatography","volume":"1581-1582","author":"Peng","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462583_bib0014","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.chroma.2018.10.012","article-title":"How changes in column geometry and packing ratio can increase sample load and throughput by a factor of fifty in counter-current chromatography","volume":"1580","author":"Peng","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462583_bib0015","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1016\/j.chroma.2008.11.013","article-title":"Advantages of a small-volume counter-current chromatography column","volume":"1216","author":"Berthod","year":"2009","journal-title":"J. Chromatogr. A"},{"issue":"12","key":"10.1016\/j.chroma.2021.462583_bib0016","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1081\/JLC-120021766","article-title":"Large convoluted tubing for scale-up of slow rotary countercurrent chromatograph","volume":"26","author":"Du","year":"2003","journal-title":"J. Liq. Chromatogr. Rel. Technol."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002196732100707X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002196732100707X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T06:09:09Z","timestamp":1758262149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002196732100707X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":16,"alternative-id":["S002196732100707X"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2021.462583","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advantages of rectangular horizontal tubing in the semi-preparative counter-current chromatography bobbin","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2021.462583","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"462583"}}