{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T18:56:20Z","timestamp":1758394580938,"version":"3.44.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.chroma.2021.462683","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T01:20:32Z","timestamp":1636852832000},"page":"462683","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Detailed computational fluid dynamics study of the parameters contributing to the viscous heating band broadening in liquid chromatography at pressures up to 2500\u00a0bar in 2.1 mm columns"],"prefix":"10.1016","volume":"1661","author":[{"given":"Ali","family":"Moussa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sander","family":"Deridder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Broeckhoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"Desmet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2021.462683_bib0001","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/BF02265631","article-title":"Van den berg, temperature gradients in HPLC columns due to viscous heat dissipation","volume":"14","author":"Poppe","year":"1981","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2021.462683_bib0002","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0021-9673(00)91617-0","article-title":"Influence of thermal conditions on the efficiency of high-performance liquid chromatographic columns","volume":"282","author":"Poppe","year":"1983","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0003","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF02688476","article-title":"Miniaturisation in pressure and electroendosmotically driven liquid chromatography: some theoretical considerations","volume":"24","author":"Knox","year":"1987","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2021.462683_bib0004","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.chroma.2006.01.120","article-title":"Influence of frictional heating on temperature gradients in ultra-high-pressure liquid chromatography on 2.1mm I.D. columns","volume":"1113","author":"de Villiers","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0005","doi-asserted-by":"crossref","first-page":"6575","DOI":"10.1016\/j.chroma.2009.07.049","article-title":"Modeling of thermal processes in high pressure liquid chromatography: II. Thermal heterogeneity at very high pressures","volume":"1216","author":"Kaczmarski","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0006","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1021\/ac802632x","article-title":"Influence of viscous friction heating on the efficiency of columns operated under very high pressures","volume":"81","author":"Gritti","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462683_bib0007","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.chroma.2014.10.075","article-title":"Observation of enhanced heat dissipation in columns packed with superficially porous particles","volume":"1371","author":"Grinias","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0008","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.chroma.2008.09.021","article-title":"Investigation of the effect of pressure on retention of small molecules using reversed-phase ultra-high-pressure liquid chromatography","volume":"1209","author":"Fallas","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0009","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.chroma.2012.10.056","article-title":"The effect of pressure and mobile phase velocity on the retention properties of small analytes and large biomolecules in ultra-high pressure liquid chromatography","volume":"1270","author":"Fekete","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.trac.2014.06.024","article-title":"The impact of pressure and frictional heating on retention, selectivity and efficiency in ultra-high-pressure liquid chromatography","volume":"63","author":"McCalley","year":"2014","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462683_bib0011","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.chroma.2014.07.030","article-title":"Estimation of the effects of longitudinal temperature gradients caused by frictional heating on the solute retention using fully porous and superficially porous sub-2\u00b5m materials","volume":"1359","author":"Fekete","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0012","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.chroma.2015.03.023","article-title":"estimation of pressure-, temperature- and frictional heating-related effects on proteins\u2019 retention under ultra-high-pressure liquid","volume":"1393","author":"Fekete","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0013","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.chroma.2014.04.056","article-title":"Extending the limits of operating pressure of narrow-bore column liquid chromatography instrumentation","volume":"1347","author":"De Pauw","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0014","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.trac.2014.08.007","article-title":"Current and future trends in UHPLC","volume":"63","author":"Fekete","year":"2014","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462683_bib0015","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.chroma.2014.09.022","article-title":"Temperature effects in supercritical fluid chromatography: a trade-off between viscous heating and decompression cooling","volume":"1365","author":"De Pauw","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0016","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1021\/acs.analchem.5b04381","article-title":"Advances in ultrahigh-pressure liquid chromatography technology and system design","volume":"88","author":"De Vos","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462683_bib0017","article-title":"Liquid chromatography above 20,000 PSI","volume":"124","author":"Sorensen","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0018","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.chroma.2017.07.040","article-title":"Considerations for the use of ultra-high pressures in liquid chromatography for 2.1mm inner diameter columns","volume":"1523","author":"Broeckhoven","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0019","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.microc.2018.05.004","article-title":"Protocol for the visualisation of axial temperature gradients in ultra-high performance liquid chromatography using infrared cameras","volume":"141","author":"Vera","year":"2018","journal-title":"Microchem. J."},{"key":"10.1016\/j.chroma.2021.462683_bib0020","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.microc.2018.11.037","article-title":"Visualisation of axial temperature gradients and heat transfer process of different solvent compositions in ultra high performance liquid chromatography using thermography","volume":"145","author":"Vera","year":"2019","journal-title":"Microchem. J."},{"key":"10.1016\/j.chroma.2021.462683_bib0021","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.chroma.2014.08.084","article-title":"Estimations of temperature deviations in chromatographic columns using isenthalpic plots. I. Theory for isocratic systems","volume":"1366","author":"Tarafder","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0022","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.chroma.2018.08.056","article-title":"Numerical and analytical investigation of the possibilities to enhance the thermal conductivity of core-shell particle packed beds","volume":"1575","author":"Deridder","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2020.461022","article-title":"A multiscale modelling study on the sense and nonsense of thermal conductivity enhancement of liquid chromatography packings and other potential solutions for viscous heating effects","volume":"1620","author":"Deridder","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2020.461076","article-title":"Evaluating the advantages of higher heat conductivity in a recently developed type of core-shell diamond stationary phase particle in UHPLC","volume":"1625","author":"Le\u015bko","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0025","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.chroma.2016.03.070","article-title":"Achieving quasi-adiabatic thermal environment to maximize resolution power in very high-pressure liquid chromatography: theory, models, and experiments","volume":"1444","author":"Gritti","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0026","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.chroma.2016.06.029","article-title":"Quasi-adiabatic vacuum-based column housing for very high-pressure liquid chromatography","volume":"1456","author":"Gritti","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0027","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.chroma.2016.12.057","article-title":"The Joule-Thomson coefficient as a criterion for efficient operating conditions in supercritical fluid chromatography","volume":"1482","author":"Poe","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0028","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.chroma.2016.11.050","article-title":"A practical approach for predicting retention time shifts due to pressure and temperature gradients in ultra-high-pressure liquid chromatography","volume":"1479","author":"\u00c5sberg","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0029","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.chroma.2015.05.002","article-title":"Method transfer from high-pressure liquid chromatography to ultra-high-pressure liquid chromatography. II. Temperature and pressure effects","volume":"1401","author":"\u00c5sberg","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0030","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.chroma.2015.07.043","article-title":"High-speed isocratic and gradient liquid-chromatography separations at 1500bar","volume":"1409","author":"De Vos","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0031","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.chroma.2016.10.008","article-title":"On the feasibility to conduct gradient liquid chromatography separations in narrow-bore columns at pressures up to 2000bar","volume":"1473","author":"De Pauw","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2021.462452","article-title":"Computational fluid dynamics study of potential solutions to alleviate viscous heating band broadening in 2.1 mm liquid chromatography columns","volume":"1654","author":"Moussa","year":"2021","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0033","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.chroma.2008.09.056","article-title":"Influence of pressure and temperature on the physico-chemical properties of mobile phase mixtures commonly used in high-performance liquid chromatography","volume":"1210","author":"Billen","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0034","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.chroma.2006.03.024","article-title":"Theoretical calculation of the retention enthalpy effect on the viscous heat dissipation band broadening in high performance liquid chromatography columns with a fixed wall temperature","volume":"1116","author":"Desmet","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0035","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1021\/acs.analchem.9b04278","article-title":"Advances and Challenges in Extremely High-Pressure Liquid Chromatography in Current and Future Analytical Scale Column Formats","volume":"92","author":"Broeckhoven","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462683_bib0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0021-9673(92)80197-3","article-title":"Variance of a zone migrating in a non-uniform time invariant linear medium","volume":"596","author":"Blumberg","year":"1992","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.chroma.2021.462683_bib0037","first-page":"67","article-title":"On the dispersion of a solute in a fluid flowing through a tube","volume":"235","author":"Aris","year":"1956","journal-title":"Proc R Soc Lond A Math Phys Sci"},{"key":"10.1016\/j.chroma.2021.462683_bib0038","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0021-9673(00)81641-6","article-title":"Peak width in solvent-programmed chromatography: I. General description of peak broadening in solvent-programmed elution","volume":"204","author":"Poppe","year":"1981","journal-title":"J. Chromatogr. A"},{"year":"1965","series-title":"Dynamics of Chromatography: Principles and Theory","author":"Giddings","key":"10.1016\/j.chroma.2021.462683_bib0039"},{"key":"10.1016\/j.chroma.2021.462683_bib0040","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.chroma.2005.06.005","article-title":"Effects of high pressure in liquid chromatography","volume":"1090","author":"Martin","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462683_bib0041","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.chroma.2008.12.065","article-title":"Numerical and analytical solutions for the column length-dependent band broadening originating from axisymmetrical trans-column velocity gradients","volume":"1216","author":"Broeckhoven","year":"2009","journal-title":"J. Chromatogr. A"}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967321008050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967321008050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T06:12:05Z","timestamp":1758262325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967321008050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":41,"alternative-id":["S0021967321008050"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2021.462683","relation":{},"ISSN":["0021-9673"],"issn-type":[{"type":"print","value":"0021-9673"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detailed computational fluid dynamics study of the parameters contributing to the viscous heating band broadening in liquid chromatography at pressures up to 2500\u00a0bar in 2.1 mm columns","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2021.462683","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"462683"}}