{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:33:03Z","timestamp":1782538383928,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFC1905500"],"award-info":[{"award-number":["2019YFC1905500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21922409"],"award-info":[{"award-number":["21922409"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.chroma.2021.462786","type":"journal-article","created":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T09:44:36Z","timestamp":1640511876000},"page":"462786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Surface-up construction of quinine bridged functional cyclodextrin for single-column versatile enantioseparation"],"prefix":"10.1016","volume":"1664","author":[{"given":"Xinling","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2021.462786_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2021.116332","article-title":"Application of enantioselective separation techniques to bioanalysis of chiral drugs and their metabolites","volume":"143","author":"Chankvetadze","year":"2021","journal-title":"TrAC-Trends. Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462786_bib0002","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s11426-014-5239-z","article-title":"Stereoselective interactions of chiral dipeptides on amylose based chiral stationary phases","volume":"58","author":"Ali","year":"2014","journal-title":"Sci. China: Chem."},{"key":"10.1016\/j.chroma.2021.462786_bib0003","first-page":"83","article-title":"Recent advances in pharmaceutical separations with supercritical fluid chromatography using chiral stationary phases, TrAC-Trend","volume":"37","author":"Wang","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462786_bib0004","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.trac.2017.05.013","article-title":"Chiral separations in food analysis","volume":"96","author":"D'Orazio","year":"2017","journal-title":"TrAC-Trends. Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462786_bib0005","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1021\/acs.chemrev.8b00246","article-title":"Column characterization and selection systems in reversed-phase high-performance liquid chromatography","volume":"119","author":"Zuvela","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.chroma.2021.462786_bib0006","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/j.cclet.2020.11.022","article-title":"In-situ and one-step preparation of protein film in capillary column for open tubular capillary electrochromatography enantioseparation","volume":"32","author":"Li","year":"2021","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.chroma.2021.462786_bib0007","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.chroma.2019.04.053","article-title":"Graphene quantum dots functionalized \u03b2-cyclodextrin and cellulose chiral stationary phases with enhanced enantioseparation performance","volume":"1600","author":"Wu","year":"2019","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2021.462786_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2020.115808","article-title":"Gas chromatographic separation of enantiomers on novel chiral stationary phases","volume":"124","author":"Xie","year":"2020","journal-title":"TrAC-Trends. Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462786_bib0009","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1021\/ac202892w","article-title":"Chiral separations: a review of current topics and trends","volume":"84","author":"Ward","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462786_bib0010","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1021\/ac1010926","article-title":"Chiral Separations: fundamental Review 2010","volume":"82","author":"Ward","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462786_bib0011","doi-asserted-by":"crossref","first-page":"7742","DOI":"10.1002\/anie.201002215","article-title":"Strong detrimental effect of a minute enantiomeric impurity of a chiral selector on the enantioselectivity factor","volume":"49","author":"Levkin","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.chroma.2021.462786_bib0012","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.chroma.2012.08.049","article-title":"Recent development of cyclodextrin chiral stationary phases and their applications in chromatography","author":"Xiao","year":"2012","journal-title":"J. Chromatogr. A. 1269"},{"key":"10.1016\/j.chroma.2021.462786_bib0013","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.chroma.2009.01.039","article-title":"Enantioseparation of a novel \"click\" chemistry derived native beta-cyclodextrin chiral stationary phase for high-performance liquid chromatography","volume":"1216","author":"Wang","year":"2009","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2021.462786_bib0014","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1021\/acs.analchem.6b00897","article-title":"Engineering thiol-ene click chemistry for the fabrication of novel structurally well-defined multifunctional cyclodextrin separation materials for enhanced enantioseparation","volume":"88","author":"Yao","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462786_bib0015","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.cclet.2018.10.013","article-title":"Preparation of polar group derivative \u03b2-cyclodextrin bonded hydride silica chiral stationary phases and their chromatography separation performances","volume":"30","author":"Zhao","year":"2019","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.chroma.2021.462786_bib0016","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1021\/ac00219a009","article-title":"Retention behavior and chiral recognition mechanism of several cyclodextrin-bonded stationary phases for dansyl amino acids","volume":"62","author":"Fujimura","year":"1990","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462786_bib0017","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.talanta.2018.03.065","article-title":"Polarity tuned perphenylcarbamoylated cyclodextrin separation materials for achiral and chiral differentiation","volume":"185","author":"Li","year":"2018","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2021.462786_bib0018","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1021\/ac00254a009","article-title":"Retention behavior of some aromatic compounds on chemically bonded cyclodextrin silica stationary phase in liquid chromatography","volume":"55","author":"Fujlmura","year":"1983","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462786_bib0019","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1021\/ac00262a005","article-title":"Chemically bonded cyclodextrin stationary phases for liquid chromatographic separation of aromatic compounds","volume":"55","author":"Kawaguchi","year":"1983","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462786_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2021.462338","article-title":"Anhydride-linked \u03b2-cyclodextrin-bonded silica stationary phases with enhanced chiral separation ability in liquid chromatography","volume":"1651","author":"Wang","year":"2021","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2021.462786_bib0021","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/chir.23174","article-title":"Preparation and evaluation of biselector bonded-type multifunctional chiral stationary phase based on dialdehyde cellulose and 6-monodeoxy-6-monoamino-beta-cyclodextrine derivatives","volume":"32","author":"Gao","year":"2020","journal-title":"Chirality"},{"key":"10.1016\/j.chroma.2021.462786_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.121160","article-title":"gamma-Cyclodextrin metal-organic framework supported by polydopamine as stationary phases for electrochromatographic enantioseparation","volume":"218","author":"Li","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2021.462786_bib0023","doi-asserted-by":"crossref","first-page":"36297","DOI":"10.1039\/C7RA06558B","article-title":"\u03b3-Cyclodextrin metal\u2013organic framework for efficient separation of chiral aromatic alcohols","volume":"7","author":"Yang","year":"2017","journal-title":"RSC Adv"},{"key":"10.1016\/j.chroma.2021.462786_bib0024","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/chir.23227","article-title":"beta-Cyclodextrin-modified covalent organic framework as chiral stationary phase for the separation of amino acids and beta-blockers by capillary electrochromatography","volume":"32","author":"Li","year":"2020","journal-title":"Chirality"},{"key":"10.1016\/j.chroma.2021.462786_bib0025","first-page":"1619","article-title":"Preparation and evaluation of an ethylenediamine dicarboxyethyl diamido-bridged bis(beta-cyclodextrin)-bonded chiral stationary phase for high performance liquid chromatography","volume":"460937","author":"Shuang","year":"2020","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2021.462786_bib0026","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/chir.20904","article-title":"The comparison in enantioseparation ability of the chiral stationary phases with single and mixed selector\u2013the selectors derived from two d-tartrates","volume":"23","author":"Chen","year":"2011","journal-title":"Chirality"},{"key":"10.1016\/j.chroma.2021.462786_bib0027","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/chir.20799","article-title":"Preparation and enantioseparation of a mixed selector chiral stationary phase derived from benzoylated tartaric acid and 1,2-diphenylethylenediamine","volume":"22","author":"Wei","year":"2010","journal-title":"Chirality"},{"key":"10.1016\/j.chroma.2021.462786_bib0028","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.chroma.2014.03.061","article-title":"Surface-up constructed tandem-inverted bilayer cyclodextrins for enhanced enantioseparation and adsorption","volume":"1343","author":"Zhao","year":"2014","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2021.462786_bib0029","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.chroma.2015.01.008","article-title":"Click' preparation of a novel 'native-phenylcarbamoylated' bilayer cyclodextrin stationary phase for enhanced chiral differentiation","volume":"1381","author":"Zhao","year":"2015","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2021.462786_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9673(99)00803-1","article-title":"Quinine versus carbamoylated quinine-based chiral anion exchangers: a comparison regarding enantioselectivity for N-protected amino acids and other chiral acids","volume":"858","author":"Mandl","year":"1999","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2021.462786_bib0031","doi-asserted-by":"crossref","first-page":"8780","DOI":"10.1021\/ac801384f","article-title":"Synergistic effects on enantioselectivity of Zwitterionic chiral stationary phases for separations of chiral acids, bases, and amino acids by HPLC","volume":"80","author":"Hoffmann","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2021.462786_bib0032","first-page":"438","article-title":"Preparation and application of quinine-functionalized poly (1-vinylimidazole)-modified silica stationary phase in hydrophilic interaction chromatography","volume":"38","author":"Zhou","year":"2020","journal-title":"Chin. J. Chromatogr."},{"key":"10.1016\/j.chroma.2021.462786_bib0033","first-page":"1270","article-title":"Click preparation and application of chiral stationary phase based on intrinsic recongnition ability of cyclodextrin","volume":"38","author":"Chen","year":"2020","journal-title":"Chin. J. Chromatogr."},{"key":"10.1016\/j.chroma.2021.462786_bib0034","doi-asserted-by":"crossref","first-page":"10979","DOI":"10.1002\/chem.201802564","article-title":"beta-cyclodextrin covalent organic framework for selective molecular adsorption","volume":"24","author":"Wang","year":"2018","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.chroma.2021.462786_bib0035","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1039\/D1AN00145K","article-title":"Click preparation of multiple-thioether bridged cyclodextrin chiral materials for efficient enantioseparation in high-performance liquid chromatography","volume":"146","author":"Chen","year":"2021","journal-title":"Analyst"},{"key":"10.1016\/j.chroma.2021.462786_bib0036","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3184\/174751913X13735527483211","article-title":"Facile synthesis of 3-aryl-5-(2-oxopyrrolidin-1-yl)- and 5-(pyridin-4-yl)-4,5-dihydroisoxazoles via 1,3-dipolar cycloaddition under mild conditions","volume":"8","author":"Gong","year":"2013","journal-title":"J. Chem. Res."},{"key":"10.1016\/j.chroma.2021.462786_bib0037","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0021-9673(95)00269-S","article-title":"Retention and selectivity of flavanones on homopolypeptide-bonded stationary phases in both normal- and reversed-phase liquid chromatography","volume":"704","author":"Siles","year":"1995","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2021.462786_bib0038","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.chroma.2016.06.074","article-title":"Thioether bridged cationic cyclodextrin stationary phases: effect of spacer length, selector concentration and rim functionalities on the enantioseparation","volume":"1467","author":"Li","year":"2016","journal-title":"J. Chromatogr. A."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967321009080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967321009080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T18:00:17Z","timestamp":1762192817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967321009080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":38,"alternative-id":["S0021967321009080"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2021.462786","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surface-up construction of quinine bridged functional cyclodextrin for single-column versatile enantioseparation","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2021.462786","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"462786"}}