{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:47:23Z","timestamp":1790783243738,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.chroma.2021.462793","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T11:08:51Z","timestamp":1640862531000},"page":"462793","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Development and validation of a quantitative method for 15 antiviral drugs in poultry muscle using liquid chromatography coupled to tandem mass spectrometry"],"prefix":"10.1016","volume":"1665","author":[{"given":"Cl\u00e9ment","family":"Douillet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Moloney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Di Rocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Danaher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.chroma.2021.462793_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-018-0002-y","article-title":"Influenza","volume":"4","author":"Krammer","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.chroma.2021.462793_bib0002","doi-asserted-by":"crossref","first-page":"i6258","DOI":"10.1136\/bmj.i6258","article-title":"Influenza","volume":"355","author":"Ghebrehewet","year":"2016","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.chroma.2021.462793_bib0003","doi-asserted-by":"crossref","first-page":"441","DOI":"10.4161\/viru.25710","article-title":"Genetic changes that accompanied shifts of low pathogenic avian influenza viruses toward higher pathogenicity in poultry","volume":"4","author":"Abdelwhab","year":"2013","journal-title":"Virulence"},{"issue":"7","key":"10.1016\/j.chroma.2021.462793_bib0004","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1016\/S1473-3099(16)00153-5","article-title":"Global epidemiology of avian influenza A H5N1 virus infection in humans, 1997\u20132015: a systematic review of individual case data","volume":"16","author":"Lai","year":"2016","journal-title":"Lancet Infect. Dis."},{"issue":"7","key":"10.1016\/j.chroma.2021.462793_bib0005","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.disamonth.2007.05.006","article-title":"Avian influenza: the next pandemic?","volume":"53","author":"McFee","year":"2007","journal-title":"Disease-a-month: DM"},{"key":"10.1016\/j.chroma.2021.462793_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinf.2021.06.021","article-title":"The whole genome analysis for the first human infection with H10N3 influenza virus in China","author":"Wang","year":"2021","journal-title":"J. Infect."},{"issue":"12","key":"10.1016\/j.chroma.2021.462793_bib0007","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nrd2400","article-title":"The war against influenza: discovery and development of sialidase inhibitors","volume":"6","author":"von Itzstein","year":"2007","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"16","key":"10.1016\/j.chroma.2021.462793_bib0008","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1017\/S0950268815001570","article-title":"The pandemic potential of avian influenza A(H7N9) virus: a review","volume":"143","author":"Tanner","year":"2015","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.chroma.2021.462793_bib0009","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bcp.2016.09.029","article-title":"Antivirals against animal viruses","volume":"133","author":"Villa","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.chroma.2021.462793_bib0010","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jpba.2017.06.071","article-title":"Current antiviral drugs and their analysis in biological materials\u2013Part I: antivirals against respiratory and herpes viruses","volume":"147","author":"Novakova","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"7045","key":"10.1016\/j.chroma.2021.462793_bib0011","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/4351009a","article-title":"China\u2019s chicken farmers under fire for antiviral abuse","volume":"435","author":"Cyranoski","year":"2005","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.chroma.2021.462793_bib0012","doi-asserted-by":"crossref","first-page":"7062","DOI":"10.1039\/C4AY00516C","article-title":"Simultaneous determination of amantadine, rimantadine and chlorpheniramine in animal-derived food by liquid chromatography-tandem mass spectrometry after fast sample preparation","volume":"6","author":"Zhao","year":"2014","journal-title":"Anal. Methods"},{"issue":"20","key":"10.1016\/j.chroma.2021.462793_bib0013","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1002\/jssc.201600490","article-title":"Chromatography column comparison and rapid pretreatment for the simultaneous analysis of amantadine, rimantadine, acyclovir, ribavirin, and moroxydine in chicken muscle by ultra high performance liquid chromatography and tandem mass spectrometry","volume":"39","author":"Zhang","year":"2016","journal-title":"J. Sep. Sci."},{"issue":"1","key":"10.1016\/j.chroma.2021.462793_bib0014","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.antiviral.2007.08.007","article-title":"Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China","volume":"77","author":"He","year":"2008","journal-title":"Antiviral Res."},{"issue":"31","key":"10.1016\/j.chroma.2021.462793_bib0015","doi-asserted-by":"crossref","first-page":"6968","DOI":"10.1021\/acs.jafc.5b02416","article-title":"Determination and Confirmation of the Antiviral Drug Amantadine and Its Analogues in Chicken Jerky Pet Treats","volume":"63","author":"Turnipseed","year":"2015","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.chroma.2021.462793_bib0016","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1378\/chest.105.5.1630a","article-title":"Toxic Effects of Amantadine in Patients With Renal Failure","volume":"105","author":"Miller","year":"1994","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.chroma.2021.462793_bib0017","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jhep.2015.07.041","article-title":"Liver toxicity associated with sofosbuvir, an NS5A inhibitor and ribavirin use","volume":"64","author":"Dyson","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.chroma.2021.462793_bib0018","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.meegid.2013.09.004","article-title":"Perspective on emergence and re-emergence of amantadine resistant influenza A viruses in domestic animals in China","volume":"20","author":"Wan","year":"2013","journal-title":"Infect. Genet. Evol."},{"issue":"10","key":"10.1016\/j.chroma.2021.462793_bib0019","doi-asserted-by":"crossref","first-page":"e986","DOI":"10.1371\/journal.pone.0000986","article-title":"Antiviral Oseltamivir Is not Removed or Degraded in Normal Sewage Water Treatment: implications for Development of Resistance by Influenza A Virus","volume":"2","author":"Fick","year":"2007","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.chroma.2021.462793_bib0020","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1289\/ehp.9574","article-title":"Potential risks associated with the proposed widespread use of Tamiflu","volume":"115","author":"Singer","year":"2007","journal-title":"Environ. Health Perspect."},{"issue":"7","key":"10.1016\/j.chroma.2021.462793_bib0021","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1080\/19440049.2021.1914868","article-title":"Development of a molecularly imprinted microspheres-based microplate fluorescence method for detection of amantadine and rimantadine in chicken","volume":"38","author":"Zhang","year":"2021","journal-title":"Food Additives & Contaminants: Part A"},{"key":"10.1016\/j.chroma.2021.462793_bib0022","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-35080-5","article-title":"A Lateral Flow Immunochromato-graphic Strip Test for Rapid Detection of Oseltamivir Phosphate in Egg and Chicken Meat","volume":"8","author":"Yang","year":"2018","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.chroma.2021.462793_bib0023","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1111\/1750-3841.15789","article-title":"Synthesis of hapten, production of monoclonal antibody, and development of immunoassay for ribavirin detection in chicken","volume":"86","author":"Zhu","year":"2021","journal-title":"J. Food Sci."},{"issue":"1","key":"10.1016\/j.chroma.2021.462793_bib0024","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s12161-017-1000-5","article-title":"New Hapten Synthesis, Antibody Production, and Indirect Competitive Enzyme-Linked Immnunosorbent Assay for Amantadine in Chicken Muscle","volume":"11","author":"Wang","year":"2018","journal-title":"Food Anal Methods"},{"key":"10.1016\/j.chroma.2021.462793_bib0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jchromb.2013.08.020","article-title":"Determination of amantadine and rimantadine in chicken muscle by QuEChERS pretreatment method and UHPLC coupled with LTQ Orbitrap mass spectrometry","volume":"938","author":"Yan","year":"2013","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2021.462793_bib0026","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jchromb.2014.06.038","article-title":"Simultaneous determination of amantadine, rimantadine and memantine in chicken muscle using multi-walled carbon nanotubes as a reversed-dispersive solid phase extraction sorbent","volume":"965","author":"Wu","year":"2014","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2021.462793_bib0027","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jchromb.2017.01.014","article-title":"Simultaneous determination of amantadine, rimantadine, and memantine in processed products, chicken tissues, and eggs by liquid chromatography with tandem mass spectrometry","volume":"1044","author":"Tsuruoka","year":"2017","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2021.462793_bib0028","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jchromb.2016.04.036","article-title":"Simultaneous determination of 14 antiviral drugs and relevant metabolites in chicken muscle by UPLC\u2013MS\/MS after QuEChERS preparation","volume":"1023-1024","author":"Mu","year":"2016","journal-title":"J. Chromatogr. B"},{"issue":"1","key":"10.1016\/j.chroma.2021.462793_bib0029","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.aca.2010.11.015","article-title":"Screening method for the analysis of antiviral drugs in poultry tissues using zwitterionic hydrophilic interaction liquid chromatography\/tandem mass spectrometry","volume":"700","author":"Chan","year":"2011","journal-title":"Anal. Chim. Acta"},{"issue":"4","key":"10.1016\/j.chroma.2021.462793_bib0030","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/s00216-011-5581-3","article-title":"Quantitative trace analysis of a broad range of antiviral drugs in poultry muscle using column-switch liquid chromatography coupled to tandem mass spectrometry","volume":"402","author":"Berendsen","year":"2012","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.chroma.2021.462793_bib0031","first-page":"84","volume":"L180","year":"2021","journal-title":"Official Journal of the European Union"},{"key":"10.1016\/j.chroma.2021.462793_bib0032","unstructured":"Parra, N., Taylor, L. (2014). \"Why Instrument Detection Limit (IDL) is a Better Metric for Determining The Sensitivity of Triple Quadrupole LC\/MS Systems.\" (accessed on 13\/12\/2021)."},{"issue":"1","key":"10.1016\/j.chroma.2021.462793_bib0033","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.antiviral.2008.01.003","article-title":"Current and future antiviral therapy of severe seasonal and avian influenza","volume":"78","author":"Beigel","year":"2008","journal-title":"Antiviral Res."},{"key":"10.1016\/j.chroma.2021.462793_bib0034","doi-asserted-by":"crossref","first-page":"e15874","DOI":"10.1371\/journal.pone.0015874","article-title":"Mechanism of Inhibition of Enveloped Virus Membrane Fusion by the Antiviral Drug Arbidol","volume":"6","author":"Teissier","year":"2011","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.chroma.2021.462793_bib0035","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1128\/AAC.02282-12","article-title":"Pharmacokinetics, Metabolism, and Excretion of the Antiviral Drug Arbidol in Humans","volume":"57","author":"Deng","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chroma.2021.462793_bib0036","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.chemosphere.2016.11.102","article-title":"Fate of new three anti-influenza drugs and one prodrug in the water environment","volume":"169","author":"Azuma","year":"2017","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.chroma.2021.462793_bib0037","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s13361-016-1563-1","article-title":"pH Effects on Electrospray Ionization Efficiency","volume":"28","author":"Liigand","year":"2017","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.chroma.2021.462793_bib0038","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jpba.2017.05.003","article-title":"An atmospheric pressure ionization source using a high voltage target compared to electrospray ionization for the LC\/MS analysis of pharmaceutical compounds","volume":"142","author":"Lubin","year":"2017","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.chroma.2021.462793_bib0039","article-title":"Tandem mass spectrometry of small-molecule antiviral drugs: 3. antiviral agents against herpes, influenza and other viral infections","volume":"455","author":"Niessen","year":"2020","journal-title":"Int J Mass Spectrom"},{"issue":"1","key":"10.1016\/j.chroma.2021.462793_bib0040","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.chroma.2004.01.018","article-title":"Evaluation of an embedded polar C4 phase for hydrophobic protein analysis by reversed-phase liquid chromatography","volume":"1043","author":"Hamada","year":"2004","journal-title":"J. Chromatogr. A"},{"issue":"3","key":"10.1016\/j.chroma.2021.462793_bib0041","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s00216-017-0688-9","article-title":"Simultaneous analysis of aminoglycosides with many other classes of drug residues in bovine tissues by ultrahigh-performance liquid chromatography\u2013tandem mass spectrometry using an ion-pairing reagent added to final extracts","volume":"410","author":"Lehotay","year":"2018","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.chroma.2021.462793_bib0042","series-title":"Hydrophilic Interaction Liquid Chromatography (HILIC) and Advanced Applications","first-page":"47","article-title":"HILIC Behavior of Reversed-Phase\/Ion-Exchange Mixed-Mode Stationary Phases and Their Applications","author":"Liu","year":"2011"},{"key":"10.1016\/j.chroma.2021.462793_bib0043","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.chroma.2015.09.035","article-title":"Systematic evaluation of matrix effects in hydrophilic interaction chromatography versus reversed phase liquid chromatography coupled to mass spectrometry","volume":"1439","author":"Periat","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2021.462793_bib0044","unstructured":"Anastassiades, M., Kolberg, D.I., Eichhorn, E., Benkenstein, A., Luka\u010devi\u0107, S., Mack, D., Wildgrube, C., Sigalov, I., D\u00f6rk, D., Barth, A. (2016). \"Quick Method for the Analysis of Residues of numerous Highly Polar Pesticides in Food Commodities involving Simultaneous Extraction with Methanol and Determination via LC-MS\/MS (QuPPe-AO-Method). II. Food of Animal Origin.\" Available online: https:\/\/www.eurl-pesticides.eu\/userfiles\/file\/EurlSRM\/EurlSrm_meth_QuPPe_AO_V2.pdf (accessed on 20\/10\/2021)."},{"key":"10.1016\/j.chroma.2021.462793_bib0045","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.chroma.2017.04.022","article-title":"Development and validation of a quantitative confirmatory method for 30 \u03b2-lactam antibiotics in bovine muscle using liquid chromatography coupled to tandem mass spectrometry","volume":"1500","author":"Di Rocco","year":"2017","journal-title":"J. Chromatogr. A"},{"issue":"26","key":"10.1016\/j.chroma.2021.462793_bib0046","doi-asserted-by":"crossref","first-page":"6913","DOI":"10.1007\/s00216-019-02062-z","article-title":"Vibrational extraction QuEChERS for analysis of antiparasitic agents in fish by liquid chromatography coupled with tandem mass spectrometry","volume":"411","author":"de Oliveira","year":"2019","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.chroma.2021.462793_bib0047","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jchromb.2017.12.022","article-title":"Determination of pyrethrin and pyrethroid residues in animal fat using liquid chromatography coupled to tandem mass spectrometry","volume":"1077-1078","author":"Moloney","year":"2018","journal-title":"J. Chromatogr. B"}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967321009158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967321009158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T06:10:56Z","timestamp":1758262256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967321009158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":47,"alternative-id":["S0021967321009158"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2021.462793","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of a quantitative method for 15 antiviral drugs in poultry muscle using liquid chromatography coupled to tandem mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2021.462793","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"462793"}}