{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:42:51Z","timestamp":1792204971254,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["314061271-TRR205-1\/2"],"award-info":[{"award-number":["314061271-TRR205-1\/2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.chroma.2022.463021","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T01:56:28Z","timestamp":1649123788000},"page":"463021","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Liquid chromatography-tandem mass spectrometry based quantification of arginine metabolites including polyamines in different sample matrices"],"prefix":"10.1016","volume":"1671","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9003-3409","authenticated-orcid":false,"given":"Mathias","family":"Langner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6150-9175","authenticated-orcid":false,"given":"Ivona","family":"Mateska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6932-333X","authenticated-orcid":false,"given":"Nicole","family":"Bechmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4923-2596","authenticated-orcid":false,"given":"Ben","family":"Wielockx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Triantafyllos","family":"Chavakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3935-8985","authenticated-orcid":false,"given":"Vasileia Ismini","family":"Alexaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2472-675X","authenticated-orcid":false,"given":"Mirko","family":"Peitzsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2022.463021_bib0001","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00726-019-02719-0","article-title":"The role of polyamines in the regulation of macrophage polarization and function","volume":"52","author":"Latour","year":"2020","journal-title":"Amino Acids"},{"key":"10.1016\/j.chroma.2022.463021_bib0002","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrd2243","article-title":"Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases","volume":"6","author":"Casero","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.chroma.2022.463021_bib0003","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00726-007-0500-9","article-title":"S-adenosylmethionine and its products","volume":"34","author":"Grillo","year":"2008","journal-title":"Amino Acids"},{"key":"10.1016\/j.chroma.2022.463021_bib0004","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/jb\/mvj035","article-title":"Genetic manipulation of polyamine catabolism in rodents","volume":"139","author":"J\u00e4nne","year":"2006","journal-title":"J. Biochem."},{"key":"10.1016\/j.chroma.2022.463021_bib0005","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1007\/s00018-021-03828-4","article-title":"Arginine-dependent immune responses","volume":"78","author":"Mart\u00ed i L\u00edndez","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.chroma.2022.463021_bib0006","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.cell.2016.09.031","article-title":"L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity","volume":"167","author":"Geiger","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chroma.2022.463021_bib0007","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.cmet.2020.01.001","article-title":"Macrophage metabolism of apoptotic cell-derived arginine promotes continual efferocytosis and resolution of injury","volume":"31","author":"Yurdagul","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.chroma.2022.463021_bib0008","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fnut.2019.00024","article-title":"Dietary and gut microbiota polyamines in obesity- and age-related diseases","volume":"6","author":"Ramos-Molina","year":"2019","journal-title":"Front. Nutr."},{"key":"10.1016\/j.chroma.2022.463021_bib0009","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nature13198","article-title":"Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity","volume":"508","author":"Kraus","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chroma.2022.463021_bib0010","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1128\/MCB.02034-06","article-title":"Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism","volume":"27","author":"Pirinen","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.chroma.2022.463021_bib0011","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2020.1832857","article-title":"Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice","volume":"12","author":"Ma","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.chroma.2022.463021_bib0012","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1158\/0008-5472.CAN-16-3462","article-title":"Spermidine prolongs lifespan and prevents liver fibrosis and hepatocellular carcinoma by activating MAP1S-mediated autophagy","volume":"77","author":"Yue","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.chroma.2022.463021_bib0013","doi-asserted-by":"crossref","first-page":"948","DOI":"10.3389\/fimmu.2018.00948","article-title":"Spermine alleviates acute liver injury by inhibiting liver-resident macrophage pro-inflammatory response through ATG5-dependent autophagy","volume":"9","author":"Zhou","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chroma.2022.463021_bib0014","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3390\/metabo10040168","article-title":"Distinguishing NASH histological severity using a multiplatform metabolomics approach","volume":"10","author":"Ioannou","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.chroma.2022.463021_bib0015","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.14336\/AD.2021.0603","article-title":"New insights into the roles and mechanisms of spermidine in aging and age-related diseases","volume":"12","author":"Ni","year":"2021","journal-title":"Aging Dis."},{"key":"10.1016\/j.chroma.2022.463021_bib0016","doi-asserted-by":"crossref","DOI":"10.1172\/JCI126299","article-title":"Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology","volume":"131","author":"Sandusky-Beltran","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.chroma.2022.463021_bib0017","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/ana.25516","article-title":"A metabolic profile of polyamines in Parkinson disease: a promising biomarker","volume":"86","author":"Saiki","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.chroma.2022.463021_bib0018","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.foodchem.2009.02.018","article-title":"Determination of biogenic amines in foods using ultra-performance liquid chromatography (UPLC)","volume":"116","author":"Dad\u00e1kov\u00e1","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.chroma.2022.463021_bib0019","doi-asserted-by":"crossref","first-page":"9174","DOI":"10.1016\/j.chroma.2011.10.040","article-title":"Simultaneous determination of 23 amino acids and 7 biogenic amines in fermented food samples by liquid chromatography\/quadrupole time-of-flight mass spectrometry","volume":"1218","author":"Jia","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2022.463021_bib0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10068-011-0017-6","article-title":"Determination of biogenic amines in Cheonggukjang using ultra high pressure liquid chromatography coupled with mass spectrometry","volume":"20","author":"Lee","year":"2011","journal-title":"Food Sci. Biotechnol."},{"key":"10.1016\/j.chroma.2022.463021_bib0021","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.chroma.2013.12.061","article-title":"Polyamines in biological samples: rapid and robust quantification by solid-phase extraction online-coupled to liquid chromatography\u2013tandem mass spectrometry","volume":"1331","author":"Magnes","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2022.463021_bib0022","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1021\/acs.analchem.6b04623","article-title":"High-speed quantitative UPLC-MS analysis of multiple amines in human plasma and serum via precolumn derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate: application to acetaminophen-induced liver failure","volume":"89","author":"Gray","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2022.463021_bib0023","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.chroma.2008.02.038","article-title":"A new hydrophilic interaction liquid chromatography tandem mass spectrometry method for the simultaneous determination of seven biogenic amines in cheese","volume":"1185","author":"Gianotti","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2022.463021_bib0024","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.1021\/jf200455r","article-title":"Simultaneous quantification of eight biogenic amine compounds in tuna by matrix solid-phase dispersion followed by HPLC\u2013orbitrap mass spectrometry","volume":"59","author":"Self","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.chroma.2022.463021_bib0025","doi-asserted-by":"crossref","first-page":"e8646","DOI":"10.1002\/rcm.8646","article-title":"Targeted ultra-performance liquid chromatography\/tandem mass spectrometric quantification of methylated amines and selected amino acids in biofluids","volume":"34","author":"Roggensack","year":"2020","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.chroma.2022.463021_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2021.462005","article-title":"Quantification of endogenous aminoacids and aminoacid derivatives in urine by hydrophilic interaction liquid chromatography tandem mass spectrometry","volume":"1642","author":"Virgiliou","year":"2021","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2022.463021_bib0027","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.foodchem.2012.10.056","article-title":"A review of the liquid chromatographic methods for the determination of biogenic amines in foods","volume":"138","author":"\u00d6nal","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.chroma.2022.463021_bib0028","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5814389","article-title":"The importance of derivatizing reagent in chromatography applications for biogenic amine detection in food and beverages","volume":"2020","author":"Munir","year":"2020","journal-title":"J. Anal. Methods Chem."},{"key":"10.1016\/j.chroma.2022.463021_bib0029","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1373\/clinchem.2009.138602","article-title":"Pitfalls associated with the use of liquid chromatography\u2013tandem mass spectrometry in the clinical laboratory","volume":"56","author":"Vogeser","year":"2010","journal-title":"Clin. Chem."},{"key":"10.1016\/j.chroma.2022.463021_bib0030","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.chroma.2014.04.020","article-title":"Evaluation of 13C- and 2H-labeled internal standards for the determination of amphetamines in biological samples, by reversed-phase ultra-high performance liquid chromatography\u2013tandem mass spectrometry","volume":"1344","author":"Berg","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2022.463021_bib0031","doi-asserted-by":"crossref","first-page":"9366","DOI":"10.1016\/j.chroma.2011.10.081","article-title":"13C labelled internal standards\u2014a solution to minimize ion suppression effects in liquid chromatography\u2013tandem mass spectrometry analyses of drugs in biological samples?","volume":"1218","author":"Berg","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2022.463021_bib0032","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.chroma.2012.08.087","article-title":"Challenges in the development of bioanalytical liquid chromatography\u2013mass spectrometry method with emphasis on fast analysis","volume":"1295","author":"Nov\u00e1kov\u00e1","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2022.463021_bib0033","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/bmc.3502","article-title":"Stable isotope dilution HILIC-MS\/MS method for accurate quantification of glutamic acid, glutamine, pyroglutamic acid, GABA and theanine in mouse brain tissues","volume":"30","author":"Inoue","year":"2016","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.chroma.2022.463021_bib0034","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1017\/S0007114513001402","article-title":"Dietary arginine affects energy metabolism through polyamine turnover in juvenile Atlantic salmon (Salmo salar)","volume":"110","author":"Andersen","year":"2013","journal-title":"Br. J. Nutr."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967322002163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967322002163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:10:21Z","timestamp":1777385421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967322002163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":34,"alternative-id":["S0021967322002163"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2022.463021","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liquid chromatography-tandem mass spectrometry based quantification of arginine metabolites including polyamines in different sample matrices","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2022.463021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"463021"}}