{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T06:07:47Z","timestamp":1772518067596,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003195","name":"Ministerie van Economische Zaken","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003195","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004349","name":"BASF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022615","name":"DSM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.chroma.2022.463758","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T20:46:54Z","timestamp":1672174014000},"page":"463758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Composition mapping of highly substituted cellulose-ether monomers by liquid chromatography\u2013mass spectrometry and probability-based data deconvolution"],"prefix":"10.1016","volume":"1689","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-6385","authenticated-orcid":false,"given":"Tijmen S.","family":"Bos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1847-7646","authenticated-orcid":false,"given":"Jessica S.","family":"Desport","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ab","family":"Buijtenhuijs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jindra","family":"Purmova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif","family":"Karlson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4558-3778","authenticated-orcid":false,"given":"Bob W.J.","family":"Pirok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Schoenmakers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4200-2015","authenticated-orcid":false,"given":"Govert W.","family":"Somsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2022.463758_bib0001","doi-asserted-by":"crossref","unstructured":"E. Doelker, Cellulose derivatives, in: Biopolym I, Springer-Verlag, Berlin, Heidelberg, n.d.: pp. 199\u2013265. 10.1007\/BFb0027554.","DOI":"10.1007\/BFb0027554"},{"key":"10.1016\/j.chroma.2022.463758_bib0002","series-title":"Chemical Structure Analysis of Starch and Cellulose Derivatives","first-page":"117","author":"Mischnick","year":"2010"},{"key":"10.1016\/j.chroma.2022.463758_bib0003","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/macp.201500431","article-title":"Block-structured 1,4- d -glucans by transglycosidation of cellulose ethers","volume":"217","author":"Rother","year":"2016","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.chroma.2022.463758_bib0004","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/macp.200600048","article-title":"Fractionation of methyl cellulose according to polarity \u2013 a tool to differentiate first and second order heterogeneity of the substituent distribution","volume":"207","author":"Adden","year":"2006","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.chroma.2022.463758_bib0005","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1021\/ac051484q","article-title":"Comprehensive analysis of the substituent distribution in the glucosyl units and along the polymer chain of hydroxyethylmethyl celluloses and statistical evaluation","volume":"78","author":"Adden","year":"2006","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2022.463758_bib0006","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0008-6215(88)84065-5","article-title":"Distribution of substituents in O-ethyl-O-(2-hydroxy-ethyl)cellulose","volume":"176","author":"Lindberg","year":"1988","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.chroma.2022.463758_bib0007","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0008-6215(91)84144-4","article-title":"Analysis of positions of substitution of O-carboxymethyl groups in partially O-carboxymethylated cellulose by the reductive-cleavage method","volume":"211","author":"Zeller","year":"1991","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.chroma.2022.463758_bib0008","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0008-6215(93)84084-J","article-title":"Structure of O-(2-hydroxyethyl) celluloses with high degrees of molar substitution: a critical evaluation","volume":"243","author":"Arisz","year":"1993","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.chroma.2022.463758_bib0009","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/mabi.200600028","article-title":"Comprehensive analysis of the substituent distribution in hydroxyethyl celluloses by quantitative MALDI-ToF-MS","volume":"6","author":"Adden","year":"2006","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.chroma.2022.463758_bib0010","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0008-6215(88)85046-8","article-title":"Analysis of positions of substitution of O-methyl or O-ethyl groups in partially methylated or ethylated cellulose by the reductive-cleavage method","volume":"177","author":"D'Ambra","year":"1988","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.chroma.2022.463758_bib0011","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0008-6215(84)85242-8","article-title":"A simple and rapid method for the permethylation of carbohydrates","volume":"131","author":"Ciucanu","year":"1984","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.chroma.2022.463758_bib0012","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1002\/1521-3935(20001001)201:15<1985::AID-MACP1985>3.0.CO;2-4","article-title":"Structure analysis of 1,4-glucan derivatives","volume":"201","author":"Mischnick","year":"2000","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.chroma.2022.463758_bib0013","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.carres.2011.11.016","article-title":"Simultaneous determination of substituent patterns in partially acid hydrolyzed O-Me\/O-Me-d3-cellulose and quantification of the obtained oligomers by HPLC-ESI-MS","volume":"348","author":"Cuers","year":"2012","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.chroma.2022.463758_bib0014","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1007\/s00216-020-02388-z","article-title":"1,4-d-Glucan block copolymers: synthesis and comprehensive structural characterization","volume":"412","author":"Hashemi","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2022.463758_bib0015","doi-asserted-by":"crossref","first-page":"9021","DOI":"10.1007\/s00216-013-7065-0","article-title":"Critical investigation of the substituent distribution in the polymer chains of hydroxypropyl methylcelluloses by (LC-)ESI-MS","volume":"405","author":"Cuers","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2022.463758_bib0016","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1002\/macp.201300070","article-title":"A new method for the analysis of the substitution pattern of hydroxyethyl(methyl)-celluloses along the polysaccharide chain","volume":"214","author":"Mischnick","year":"2013","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.chroma.2022.463758_bib0017","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1021\/acs.biomac.2c00336","article-title":"Degradation of cellulose derivatives in laboratory, man-made, and natural environments","volume":"23","author":"Erdal","year":"2022","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.chroma.2022.463758_bib0018","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.carbpol.2017.02.089","article-title":"Enzymic degradation of hydroxyethyl cellulose and analysis of the substitution pattern along the polysaccharide chain","volume":"169","author":"Diao","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.chroma.2022.463758_bib0019","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.aca.2003.08.005","article-title":"Characterisation of the substituent distribution in starch and cellulose derivatives","volume":"497","author":"Richardson","year":"2003","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2022.463758_bib0020","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1021\/bm0509422","article-title":"New approaches to the analysis of enzymatically hydrolyzed methyl cellulose. Part 2. Comparison of various enzyme preparations","volume":"7","author":"Melander","year":"2006","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.chroma.2022.463758_bib0021","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1021\/ma951177u","article-title":"Application of regioselectively substituted methylcelluloses to characterize the reaction mechanism of cellulase","volume":"29","author":"Nojiri","year":"1996","journal-title":"Macromolecules"},{"key":"10.1016\/j.chroma.2022.463758_bib0022","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/masy.200950605","article-title":"The applicability of enzymes in cellulose ether analysis","volume":"280","author":"Adden","year":"2009","journal-title":"Macromol. Symp."},{"key":"10.1016\/j.chroma.2022.463758_bib0023","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.O111.011379","article-title":"mz5: space- and time-efficient storage of mass spectrometry data sets","volume":"11","author":"Wilhelm","year":"2012","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.chroma.2022.463758_bib0024","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chroma.2022.463758_bib0025","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1007\/s00216-022-04095-3","article-title":"Impact of instrumental settings in electrospray ionization ion trap mass spectrometry on the analysis of O-methoxyethyl-O-methyl cellulose: a comprehensive quantitative evaluation","volume":"414","author":"Schleicher","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2022.463758_bib0026","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1021\/ja01877a070","article-title":"Arrangement of substituents in cellulose derivatives","volume":"61","author":"Spurlin","year":"1939","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.chroma.2022.463758_bib0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0008-6215(83)88129-4","article-title":"Analysis of the carbon-13 n.m.r. spectrum of hydrolyzed O-(carboxymethyl)cellulose: monomer composition and substitution patterns","volume":"115","author":"Reuben","year":"1983","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.chroma.2022.463758_bib0028","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0008-6215(87)84002-8","article-title":"Analysis of the carbon-13 n.m.r. spectrum of methanolyzed O-ethylcellulose: monomer composition and models for its description","volume":"161","author":"Reuben","year":"1987","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.chroma.2022.463758_bib0029","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0008-6215(86)85069-8","article-title":"Analysis of the 13C-n.m.r. spectra of hydrolyzed and methanolyze O-methylcelluloses: monomer compositions and models for their description","volume":"157","author":"Reuben","year":"1986","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.chroma.2022.463758_bib0030","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1021\/bm000093c","article-title":"A new model for the substitution patterns in the polymer chain of polysaccharide derivatives","volume":"2","author":"Mischnick","year":"2001","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.chroma.2022.463758_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0008-6215(95)00039-V","article-title":"Substituent distribution along the cellulose backbone in O-methylcelluloses using GC and FAB-MS for monomer and oligomer analysis","volume":"271","author":"Arisz","year":"1995","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.chroma.2022.463758_bib0032","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0008-6215(87)80168-4","article-title":"Distribution of substituents in O-(2-hydroxyethyl)cellulose: A13C-N.M.R. approach","volume":"163","author":"Reuben","year":"1987","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.chroma.2022.463758_bib0033","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/macp.1994.021950503","article-title":"Nuclear magnetic resonance spectroscopic characterization of carboxymethylcellulose","volume":"195","author":"Baar","year":"1994","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.chroma.2022.463758_bib0034","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0021-9673(92)85297-7","article-title":"Composition analysis of carboxymethylcellulose by high- pH anion-exchange chromatography with pulsed amperometric detection","volume":"623","author":"Kragten","year":"1992","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2022.463758_bib0035","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1021\/ac50056a032","article-title":"Proton nuclear magnetic resonance spectrometry for determination of substituents and their distribution in carboxymethylcellulose","volume":"52","author":"Ho","year":"1980","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2022.463758_bib0036","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3390\/polysaccharides2040051","article-title":"Analysis of the heterogeneities of first and second order of cellulose derivatives: a complex challenge","volume":"2","author":"Mischnick","year":"2021","journal-title":"Polysaccharides"},{"key":"10.1016\/j.chroma.2022.463758_bib0037","article-title":"Composition mapping of highly substituted cellulose-ether monomers by LC-MS and probability-based data deconvolution","author":"Bos","year":"2022","journal-title":"Tool"},{"key":"10.1016\/j.chroma.2022.463758_bib0038","doi-asserted-by":"crossref","DOI":"10.1002\/rcm.8652","article-title":"MSPolyCalc: a web-based App for polymer mass spectrometry data interpretation. The case study of a pharmaceutical excipient","volume":"34","author":"Desport","year":"2020","journal-title":"Rapid Commun. Mass Spectrom."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967322009499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967322009499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T06:20:38Z","timestamp":1758262838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967322009499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":38,"alternative-id":["S0021967322009499"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2022.463758","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Composition mapping of highly substituted cellulose-ether monomers by liquid chromatography\u2013mass spectrometry and probability-based data deconvolution","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2022.463758","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"463758"}}