{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:54:31Z","timestamp":1789700071185,"version":"4.0.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.chroma.2023.464436","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T11:48:25Z","timestamp":1696592905000},"page":"464436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Determination of tobacco-specific nitrosamines in tobacco and mainstream cigarette smoke using one-step clean-up coupled with liquid chromatography- tandem mass spectrometry"],"prefix":"10.1016","volume":"1710","author":[{"given":"Yong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1466-6033","authenticated-orcid":false,"given":"Zhongbang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3687-7886","authenticated-orcid":false,"given":"He","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2023.464436_bib0001","series-title":"Smokeless Tobacco Products","first-page":"151","article-title":"Chapter Seven - Metabolism and DNA adduct formation of carcinogenic tobacco-specific nitrosamines found in smokeless tobacco products","author":"Hecht","year":"2020"},{"key":"10.1016\/j.chroma.2023.464436_bib0002","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1021\/tx900281u","article-title":"Analysis of 23 Polycyclic Aromatic Hydrocarbons in Smokeless Tobacco by Gas Chromatography-Mass Spectrometry","volume":"23","author":"Stepanov","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.chroma.2023.464436_bib0003","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.toxrep.2020.05.008","article-title":"Variability of TSNA in U.S. Tobacco and Moist Smokeless Tobacco Products","volume":"7","author":"Oldham","year":"2020","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.chroma.2023.464436_bib0004","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/10408449109017910","article-title":"Analytical studies on tobacco-specific N-nitrosamines in tobacco and tobacco smoke","volume":"21","author":"Brunnemann","year":"1991","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.chroma.2023.464436_bib0005","series-title":"Smokeless Tobacco and Some Tobacco-Specific N-Nitrosamines","year":"2007"},{"key":"10.1016\/j.chroma.2023.464436_bib0006","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1021\/ac030135y","article-title":"Simultaneous determination of five tobacco-specific nitrosamines in mainstream cigarette smoke by isotope dilution liquid chromatography\/electrospray ionization tandem mass spectrometry","volume":"75","author":"Wu","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2023.464436_bib0007","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.186.4160.265","article-title":"N'-Nitrosonornicotine in Tobacco","volume":"186","author":"Hoffmann","year":"1974","journal-title":"Science"},{"key":"10.1016\/j.chroma.2023.464436_bib0008","first-page":"145","article-title":"Improved method for the determination of tobacco-specific nitrosamines (TSNA) in tobacco smoke","volume":"14","author":"Fischer","year":"1989","journal-title":"Beitrige Tab. Int."},{"key":"10.1016\/j.chroma.2023.464436_bib0009","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1021\/ac60362a037","article-title":"Determination of N\u2019-nitrosonornicotine in tobacco by high speed liquid chromatography","volume":"47","author":"Hecht","year":"1975","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2023.464436_bib0010","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1021\/ac9810821","article-title":"Supercritical fluid extraction and gas chromatography\/mass spectrometry for the analysis of tobacco-specific nitrosamines in cigarettes","volume":"71","author":"Song","year":"1999","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2023.464436_bib0011","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.chroma.2016.07.018","volume":"1460","author":"Luo","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2023.464436_bib0012","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1021\/ac048887v","article-title":"Development of a quantitative method for the analysis of tobacco-specific nitrosamines in mainstream cigarette smoke using isotope dilution liquid chromatography\/electrospray ionization tandem mass spectrometry","volume":"77","author":"Wagner","year":"2005","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2023.464436_bib0013","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.chroma.2013.03.035","article-title":"Determination of tobacco-specific nitrosamines in replacement liquids of electronic cigarettes by liquid chromatography-tandem mass spectrometry","volume":"1291","author":"Kim","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2023.464436_bib0014","first-page":"1730","article-title":"Simultaneous determination of alkaloids and their related tobacco-specific nitrosamines in tobacco leaves using LC-MS-MS","volume":"53","author":"Li","year":"2015","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.chroma.2023.464436_bib0015","first-page":"2505","article-title":"Assessment of Tobacco-specific N-Nitrosamines in Tobacco Products","volume":"39","author":"Hoffmann","year":"1979","journal-title":"Cancer Res."},{"key":"10.1016\/j.chroma.2023.464436_bib0016","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/carcin\/8.3.465","article-title":"Identification and analysis of a new tobacco-specific iV-nitrosamine, 4-(methylnitrosamino)-4-(3-pyridyl)-l-butanol","volume":"8","author":"D.Brunnemann","year":"1987","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.chroma.2023.464436_bib0017","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1093\/carcin\/10.9.1725","article-title":"Identification and analysis of a nicotine-derived iV-nitrosamino acid and other nitrosamino acids in tobacco","volume":"10","author":"V.Djordjevic","year":"1989","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.chroma.2023.464436_bib0018","first-page":"192","article-title":"A Collaborative Study for the Determination of Tobacco Specific Nitrosamines in Tobacco","volume":"21","author":"Morgan","year":"2004","journal-title":"Contrib. Tob. Nicotine Res."},{"key":"10.1016\/j.chroma.2023.464436_bib0019","series-title":"International Standard ISO 21766: Tobacco and tobacco products - Determination of tobacco-specific nitrosamines in tobacco products - Method using LC-MS\/MS","year":"2021"},{"key":"10.1016\/j.chroma.2023.464436_bib0020","series-title":"CORESTA Recommended Method No. 75: Determination of tobacco specific nitrosamines in mainstream smoke by LC-MS\/MS","year":"2022"},{"key":"10.1016\/j.chroma.2023.464436_bib0021","series-title":"CORESTA Recommended Method No. 72: Determination of tobacco specific nitrosamines in tobacco and tobacco products by LC-MS\/MS","year":"2017"},{"key":"10.1016\/j.chroma.2023.464436_bib0022","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.aca.2010.06.011","article-title":"Simultaneous determination of four tobacco-specific N-nitrosamines in mainstream smoke for Chinese Virginia cigarettes by liquid chromatography tandem mass spectrometry and validation under ISO and \"Canadian intense\" machine smoking regimes","volume":"674","author":"Xiong","year":"2010","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2023.464436_bib0023","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.aca.2019.04.073","volume":"1075","author":"Ishizaki","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2023.464436_bib0024","first-page":"597","article-title":"determination of tobacco specific N-nitrosamines in mainstream cigarette smoke by gas chromatography\/mass spectrometry using online solid phase extraction","volume":"35","author":"Liu","year":"2019","journal-title":"J. Anal. Sci."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967323006611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967323006611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T06:27:14Z","timestamp":1758263234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967323006611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":24,"alternative-id":["S0021967323006611"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2023.464436","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determination of tobacco-specific nitrosamines in tobacco and mainstream cigarette smoke using one-step clean-up coupled with liquid chromatography- tandem mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2023.464436","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"464436"}}