{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:43:52Z","timestamp":1790595832515,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42107412"],"award-info":[{"award-number":["42107412"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["2021GDASYL-20210103006"],"award-info":[{"award-number":["2021GDASYL-20210103006"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["2022GDASZH-2022010105"],"award-info":[{"award-number":["2022GDASZH-2022010105"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA0910300"],"award-info":[{"award-number":["2021YFA0910300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["202201010224"],"award-info":[{"award-number":["202201010224"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.chroma.2023.464627","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T19:09:05Z","timestamp":1703963345000},"page":"464627","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Trace analysis of 47 psychotropic medications in environmental samples by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS\/MS)"],"prefix":"10.1016","volume":"1715","author":[{"given":"Anguo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinna","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihua","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7276-4219","authenticated-orcid":false,"given":"Meiying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2023.464627_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2013.11.107","article-title":"Illicit and pharmaceutical drug consumption estimated via wastewater analysis. Part A: chemical analysis and drug use estimates","volume":"487","author":"Baker","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2023.464627_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2012.07.042","article-title":"Distribution of antidepressant residues in wastewater and biosolids following different treatment processes by municipal wastewater treatment plants in Canada","volume":"46","author":"Lajeunesse","year":"2012","journal-title":"Water Res."},{"key":"10.1016\/j.chroma.2023.464627_bib0003","doi-asserted-by":"crossref","DOI":"10.1021\/acsestwater.0c00174","article-title":"Simultaneous occurrence of psychotropic pharmaceuticals in surface water of the megacity shanghai and implication for their ecotoxicological risks","volume":"1","author":"Liang","year":"2021","journal-title":"ACS ES&T Water"},{"key":"10.1016\/j.chroma.2023.464627_bib0004","article-title":"Occurrence and fate of emerging contaminants in municipal wastewater treatment plants from different geographical regions\u2014A review","volume":"133","author":"Ngoc Han","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.chroma.2023.464627_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141200","article-title":"Occurrence of pharmaceuticals, hazard assessment and ecotoxicological evaluation of wastewater treatment plants in Costa Rica","volume":"746","author":"Ramirez-Morales","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2023.464627_bib0006","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/476265a","article-title":"Drug waste harms fish","volume":"476","author":"Gilbert","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.chroma.2023.464627_bib0007","doi-asserted-by":"crossref","DOI":"10.1021\/acs.est.1c04724","article-title":"The potential for adverse effects in fish exposed to antidepressants in the aquatic environment","volume":"55","author":"Gould","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chroma.2023.464627_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106970","article-title":"Environmental occurrence and ecological risks of psychoactive substances","volume":"158","author":"Jin","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.chroma.2023.464627_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118878","article-title":"Occurrence, hazard, and risk of psychopharmaceuticals and illicit drugs in European surface waters","volume":"222","author":"Davey","year":"2022","journal-title":"Water Res."},{"key":"10.1016\/j.chroma.2023.464627_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138661","article-title":"Tracking the occurrence of psychotropic pharmaceuticals in Brazilian wastewater treatment plants and surface water, with assessment of environmental risks","volume":"727","author":"Pivetta","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2023.464627_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124974","article-title":"Environmentally relevant concentrations of sertraline disrupts behavior and the brain and liver transcriptome of juvenile yellow catfish (Tachysurus fulvidraco): implications for the feeding and growth axis","volume":"409","author":"Chen","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.chroma.2023.464627_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.136564","article-title":"Depressed, hypertense and sore: long-term effects of fluoxetine, propranolol and diclofenac exposure in a top predator fish","volume":"712","author":"Duarte","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2023.464627_bib0013","doi-asserted-by":"crossref","DOI":"10.1021\/es504808g","article-title":"Transgenerational effects of two antidepressants (sertraline and venlafaxine) on Daphnia magna life history traits","volume":"49","author":"Minguez","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chroma.2023.464627_bib0014","article-title":"Increased use of antidepressants in Wuhan, China: a retrospective study from 2006 to 2012","volume":"49","author":"Gao","year":"2013","journal-title":"Medicina-Lithuania"},{"key":"10.1016\/j.chroma.2023.464627_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2014.06.010","article-title":"Beliefs of people taking antidepressants about causes of depression and reasons for increased prescribing rates","volume":"168","author":"Read","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.chroma.2023.464627_bib0016","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.924609","article-title":"Comparison of prevalence and associated factors of anxiety and depression among people affected by versus people unaffected by quarantine during the COVID-9 epidemic in Southwestern China","volume":"26","author":"Lei","year":"2020","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.chroma.2023.464627_bib0017","unstructured":"World Health Organization, Mental Health and COVID-19: early evidence of the pandemic's impact: scientific brief. https:\/\/www.who.int\/publications\/i\/item\/WHO-2019-nCoV-Sci_Brief-Mental_health-2022.1, 2022 (accessed 2 March 2022)."},{"key":"10.1016\/j.chroma.2023.464627_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2011.08.002","article-title":"Emerging pollutants in wastewater: a review of the literature","volume":"214","author":"Deblonde","year":"2011","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.chroma.2023.464627_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2013.11.056","article-title":"Seasonal variation in the occurrence and removal of pharmaceuticals and personal care products in a wastewater treatment plant in Xiamen, China","volume":"277","author":"Sun","year":"2014","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.chroma.2023.464627_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2012.04.028","article-title":"Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment\u2014A review","volume":"429","author":"Verlicchi","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2023.464627_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2010.08.019","article-title":"Environmental toxicology and risk assessment of pharmaceuticals from hospital wastewater","volume":"45","author":"Escher","year":"2011","journal-title":"Water Res."},{"key":"10.1016\/j.chroma.2023.464627_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124729","article-title":"Antibiotics and antidepressants occurrence in surface waters and sediments collected in the north of Portugal","volume":"239","author":"Fernandes","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.chroma.2023.464627_bib0023","doi-asserted-by":"crossref","DOI":"10.1021\/es9022706","article-title":"Antidepressant pharmaceuticals in two US effluent-impacted streams: occurrence and fate in water and sediment, and selective uptake in fish neural tissue","volume":"44","author":"Schultz","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chroma.2023.464627_bib0024","doi-asserted-by":"crossref","DOI":"10.1021\/ac800162q","article-title":"Determination of basic antidepressants and their n-desmethyl metabolites in raw sewage and wastewater using solid-phase extraction and liquid chromatography\u2013Tandem mass spectrometry","volume":"80","author":"Lajeunesse","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2023.464627_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142648","article-title":"Occurrence, fate and mass loading of benzodiazepines and their transformation products in eleven wastewater treatment plants in Guangdong province, China","volume":"755","author":"Lei","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2023.464627_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2014.02.020","article-title":"Occurrence of antidepressant residues in the sewage-impacted Vistula and Utrata rivers and in tap water in Warsaw (Poland)","volume":"104","author":"Giebultowicz","year":"2014","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chroma.2023.464627_bib0027","article-title":"Occurrence and fate of psychiatric pharmaceuticals in wastewater treatment plants in Hong Kong: enantiomeric profiling and preliminary risk assessment","volume":"1","author":"Wu","year":"2020","journal-title":"ACS ES&T Water"},{"key":"10.1016\/j.chroma.2023.464627_bib0028","doi-asserted-by":"crossref","DOI":"10.1007\/s11356-017-9293-x","article-title":"Occurrence and risk assessment of antidepressants in Huangpu River of Shanghai, China","volume":"24","author":"Wu","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.chroma.2023.464627_bib0029","doi-asserted-by":"crossref","DOI":"10.1037\/a0034733","article-title":"Comorbidity of anxiety and depression in children and adolescents: 20 years after","volume":"140","author":"Cummings","year":"2014","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.chroma.2023.464627_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2007.09.007","article-title":"Comorbidity of depressive disorders among adolescents in community and clinical settings","volume":"158","author":"Essau","year":"2008","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.chroma.2023.464627_bib0031","doi-asserted-by":"crossref","DOI":"10.1007\/s10661-021-09069-z","article-title":"Determination of pharmaceuticals in solid samples in municipal wastewater treatment plants by online SPE LC\u2013MS\/MS using QuEChERS extraction","volume":"193","author":"Park","year":"2021","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.chroma.2023.464627_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2012.06.035","article-title":"QuEChERS: a new sample preparation approach for the determination of ibuprofen and its metabolites in soils","volume":"433","author":"Braganca","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2023.464627_bib0033","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16173026","article-title":"Distribution and chemical analysis of pharmaceuticals and personal care products (PPCPs) in the environmental systems: a review","volume":"16","author":"Ohoro","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.chroma.2023.464627_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2011.01.014","article-title":"Trace analysis of 28 steroids in surface water, wastewater and sludge samples by rapid resolution liquid chromatography-electrospray ionization tandem mass spectrometry","volume":"1218","author":"Liu","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2023.464627_bib0035","doi-asserted-by":"crossref","DOI":"10.1007\/s00216-022-04212-2","article-title":"Development and validation of a simultaneous method for the analysis of benzothiazoles and organic ultraviolet filters in various environmental matrices by GC\u2013MS\/MS","volume":"414","author":"Xiong","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2023.464627_bib0036","doi-asserted-by":"crossref","DOI":"10.1007\/s00216-015-9284-z","article-title":"Solid-phase extraction in combination with dispersive liquid-liquid microextraction and ultra-high performance liquid chromatography-tandem mass spectrometry analysis: the ultra-trace determination of 10 antibiotics in water samples","volume":"408","author":"Liang","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2023.464627_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2005.05.051","article-title":"Extraction and determination of sulfonamides, macrolides, and trimethoprim in sewage sludge","volume":"1085","author":"Gobel","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2023.464627_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117706","article-title":"Recovery of extracellular biopolymers from conventional activated sludge: potential, characteristics and limitation","volume":"205","author":"Li","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.chroma.2023.464627_bib0039","doi-asserted-by":"crossref","DOI":"10.1080\/10408347.2014.980775","article-title":"Biological matrix effects in quantitative tandem mass spectrometry-based analytical methods: advancing biomonitoring","volume":"46","author":"Panuwet","year":"2016","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.chroma.2023.464627_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2004.11.101","article-title":"Operational options to reduce matrix effects in liquid chromatography-electrospray ionization-mass spectrometry analysis of aqueous environmental samples","volume":"1067","author":"Kloepfer","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2023.464627_bib0041","doi-asserted-by":"crossref","DOI":"10.1021\/ac702154e","article-title":"Trace analysis of antidepressant pharmaceuticals and their select degradates in aquatic matrixes by LC\/ESI\/MS\/MS","volume":"80","author":"Schultz","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2023.464627_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.128104","article-title":"Assessment of the occurrence of 455 pharmaceutical compounds in sludge according to their physical and chemical properties: a review","volume":"426","author":"Sellier","year":"2022","journal-title":"J. Hazard. Mater."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002196732300852X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002196732300852X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T06:27:45Z","timestamp":1758263265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002196732300852X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":42,"alternative-id":["S002196732300852X"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2023.464627","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trace analysis of 47 psychotropic medications in environmental samples by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS\/MS)","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2023.464627","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"464627"}}