{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:13:29Z","timestamp":1790446409322,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004801","name":"Shota Rustaveli National Science Foundation","doi-asserted-by":"publisher","award":["FR-22\\u2013971"],"award-info":[{"award-number":["FR-22\\u2013971"]}],"id":[{"id":"10.13039\/501100004801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.chroma.2024.465062","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T17:48:19Z","timestamp":1718214499000},"page":"465062","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Separation of isotopologues of amphetamine with various degree of deuteration on achiral and polysaccharide-based chiral columns in high-performance liquid chromatography"],"prefix":"10.1016","volume":"1730","author":[{"given":"Giorgia","family":"Sprega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgi","family":"Kobidze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo Fabrizio","family":"Lo Faro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Sechi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Peluso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tivadar","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Paolo","family":"Busard\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bezhan","family":"Chankvetadze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2024.465062_bib0001","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/anie.201704146","article-title":"Deuterium-and tritium-labelled compounds: applications in the life sciences","volume":"57","author":"Atzrodt","year":"2018","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.chroma.2024.465062_bib0002","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nbt0617-493","article-title":"First deuterated drug approved","volume":"35","author":"Schmidt","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chroma.2024.465062_bib0003","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1007\/s40265-021-01603-0","article-title":"Donafenib: first approval","volume":"81","author":"Keam","year":"2021","journal-title":"Drugs"},{"key":"10.1016\/j.chroma.2024.465062_bib0004","doi-asserted-by":"crossref","first-page":"8973","DOI":"10.1021\/acs.jmedchem.9b00444","article-title":"Highly selective inhibition of tyrosine kinase 2 (TYK2) for the treatment of autoimmune diseases: discovery of the allosteric inhibitor BMS-986165","volume":"62","author":"Wrobleski","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.chroma.2024.465062_bib0005","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41573-023-00703-8","article-title":"Deuterium in drug discovery: progress, opportunities and challenges","volume":"22","author":"Di Martino","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.chroma.2024.465062_bib0006","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1063\/1.1746492","article-title":"Calculation of equilibrium constants for isotopic exchange reactions","volume":"261","author":"Bigeleisen","year":"1947","journal-title":"Int. J. Chem. Phys."},{"key":"10.1016\/j.chroma.2024.465062_bib0007","doi-asserted-by":"crossref","first-page":"545","DOI":"10.4155\/bio-2020-0058","article-title":"Evaluation, identification and impact assessment of abnormal internal standard response variability in regulated LC\u2212MS bioanalysis","volume":"12","author":"Fu","year":"2020","journal-title":"Bioanalysis"},{"key":"10.1016\/j.chroma.2024.465062_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113578","article-title":"A homologous series of internal standards for near universal application in the discovery LC-MS\/MS bioanalytical laboratory","volume":"190","author":"Heinle","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2024.465062_bib0009","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1126\/science.126.3277.748","article-title":"Isotope effects in gas-liquid chromatography","volume":"126","author":"Wilzbach","year":"1957","journal-title":"Science"},{"key":"10.1016\/j.chroma.2024.465062_bib0010","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1246\/bcsj.31.770","article-title":"Gas chromatographic separation of hydrogen isotopes D2 and HD","volume":"31","author":"Ohkoshi","year":"1958","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"10.1016\/j.chroma.2024.465062_bib0011","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1021\/ac60234a035","article-title":"Gas chromatography of isotopic molecules on open tubular columns","volume":"38","author":"Bruner","year":"1966","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2024.465062_bib0012","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0021-9673(93)83377-5","article-title":"Gas chromatographic separation of pairs of isotopic molecules","volume":"654","author":"Shi","year":"1993","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2024.465062_bib0013","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.chroma.2016.12.023","article-title":"Isotopic separation of acetaldehyde and methanol from their deuterated isotopologues on a porous layer open tubular column allows quantification by stable isotope dilution without mass spectrometric detection","volume":"1481","author":"Schmarr","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2024.465062_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.338490","article-title":"Evaluation of gas chromatography for the separation of a broad range of isotopic compounds","volume":"1165","author":"Thakur","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2024.465062_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.124857","article-title":"Effect of position of deuterium atoms on gas chromatographic isotope effects","volume":"265","author":"Aslani","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2024.465062_bib0016","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/jat\/bkaa170","article-title":"Use of lisdexamfetamine or amphetamine? Interpretation of chiral amphetamine analyses","volume":"46","author":"Cherm\u00e1","year":"2022","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.chroma.2024.465062_bib0017","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/196829a0","article-title":"A tritium isotope effect on ion exchange chromatography","volume":"196","author":"Gottschling","year":"1962","journal-title":"Nature"},{"key":"10.1016\/j.chroma.2024.465062_bib0018","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/chromsci\/42.7.383","article-title":"Evaluation of deuterium isotope effects in normal-phase LC-MS-MS separations using a molecular modeling approach","volume":"42","author":"Iyer","year":"2004","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.chroma.2024.465062_bib0019","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/000456328602300305","article-title":"Isotope dilution analysis using chromatographic separation of isotopic forms of the compound to be measured","volume":"23","author":"Pratt","year":"1986","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.chroma.2024.465062_bib0020","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1021\/ac00170a029","article-title":"Separation of deuteriated isotopomers of dopamine by ion-pair reversed-phase high-performance liquid chromatography","volume":"60","author":"Masters","year":"1988","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2024.465062_bib0021","doi-asserted-by":"crossref","first-page":"13836","DOI":"10.1021\/ja036006g","article-title":"Deuterium isotope effects on hydrophobic interactions: the importance of dispersion interactions in the hydrophobic phase","volume":"125","author":"Turowski","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.chroma.2024.465062_bib0022","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1021\/acs.analchem.9b05672","article-title":"Tunable liquid chromatographic separation of H\/D isotopologues enabled by aromatic \u03c0 interactions","volume":"92","author":"Kanao","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2024.465062_bib0023","doi-asserted-by":"crossref","first-page":"7033","DOI":"10.1021\/ac501309s","article-title":"Application of screening experimental designs to assess chromatographic isotope effect upon isotope-coded derivatization for quantitative liquid chromatography-mass spectrometry","volume":"86","author":"Szarka","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2024.465062_bib0024","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1515\/CCLM.2003.245","article-title":"Automated LC-MS method for the fast stereoselective determination of methadone in plasma","volume":"41","author":"Souverain","year":"2003","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.chroma.2024.465062_bib0025","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.chroma.2006.03.078","article-title":"Secondary isotope effects in liquid chromatography behaviour of 2H and 3H labelled solutes and solvents","volume":"1116","author":"Valleix","year":"2006","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.chroma.2024.465062_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.464709","article-title":"Separation of undeuterated and partially deuterated enantioisotopologues of some amphetamine derivatives on achiral and polysaccharide-based chiral columns in high-performance liquid chrom (atography","volume":"1718","author":"Kobidze","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2024.465062_bib0027","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1021\/ac00180a022","article-title":"Separation of dansylated Methylamine and dansylated methyl-d3-amine by micellar electrokinetic capillary chromatography with methanol-modified mobile phase","volume":"61","author":"Bushey","year":"1989","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2024.465062_bib0028","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/mcs.1220010304","article-title":"Effects of methanol-modified mobile phase on the separation of isotopically substituted compounds by micellar electrokinetic capillary chromatography","volume":"1","author":"Bushey","year":"1989","journal-title":"J. Microcol. Sep."},{"key":"10.1016\/j.chroma.2024.465062_bib0029","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1039\/B517914A","article-title":"Advances in methods and algorithms in a modern quantum chemistry program package","volume":"8","author":"Shao","year":"2006","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.chroma.2024.465062_bib0030","unstructured":"Gaussian 16, Revision C.01, M.J. Frisch, G.W. Trucks, H.B. Schlegel, G.E. Scuseria, M.A. Robb, J.R. Cheeseman, G. Scalmani, V. Barone, G.A. Petersson, H. Nakatsuji, X. Li, M. Caricato, A.V. Marenich, J. Bloino, B.G. Janesko, R. Gomperts, B. Mennucci, H.P. Hratchian, J.V. Ortiz, A.F. Izmaylov, J.L. Sonnenberg, D. Williams-Young, F. Ding, F. Lipparini, F. Egidi, J. Goings, B. Peng, A. Petrone, T. Henderson, D. Ranasinghe, V.G. Zakrzewski, J. Gao, N. Rega, G. Zheng, W. Liang, M. Hada, M. Ehara, K. Toyota, R. Fukuda, J. Hasegawa, M. Ishida, T. Nakajima, Y. Honda, O. Kitao, H. Nakai, T. Vreven, K. Throssell, J.A. Montgomery Jr., J.E. Peralta, F. Ogliaro, M.J. Bearpark, J.J. Heyd, E.N. Brothers, K.N. Kudin, V.N. Staroverov, T.A. Keith, R. Kobayashi, J. Normand, K. Raghavachari, A.P. Rendell, J.C. Burant, S.S. Iyengar, J. Tomasi, M. Cossi, J.M. Millam, M. Klene, C. Adamo, R. Cammi, J.W. Ochterski, R.L. Martin, K. Morokuma, O. Farkas, J.B. Foresman, D.J. Fox, Gaussian, Inc., Wallingford CT, (2016)."},{"key":"10.1016\/j.chroma.2024.465062_bib0031","doi-asserted-by":"crossref","DOI":"10.1063\/1.3382344","article-title":"A consistent and accurate ab initio parameterization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu","volume":"132","author":"Grimme","year":"2010","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.chroma.2024.465062_bib0032","doi-asserted-by":"crossref","first-page":"6378","DOI":"10.1021\/jp810292n","article-title":"Universal solvation model based on solute electron density and a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions","volume":"113","author":"Marenich","year":"2009","journal-title":"J. Phys Chem. B"},{"key":"10.1016\/j.chroma.2024.465062_bib0033","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/jcc.22885","article-title":"Multiwfn: a multifunctional wavefunction analyser","volume":"33","author":"Lu","year":"2012","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.chroma.2024.465062_bib0034","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jmgm.2012.07.004","article-title":"Quantitative analysis of molecular surface based on improved Marching Tetrahedra algorithm","volume":"38","author":"Lu","year":"2012","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.chroma.2024.465062_bib0035","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1002\/jcc.21759","article-title":"Effect of the damping function in dispersion corrected density functional theory","volume":"32","author":"Grimme","year":"2011","journal-title":"J. Comp. Chem."},{"key":"10.1016\/j.chroma.2024.465062_bib0036","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0021-9673(01)00958-X","article-title":"Enantioseparation of selected chiral sulfoxides using polysaccharide-type chiral stationary phases and polar organic, polar aqueous-organic and normal-phase eluents","volume":"922","author":"Chankvetadze","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2024.465062_bib0037","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1002\/jssc.201200443","article-title":"HPLC separation of dihydropyridine derivatives enantiomers with emphasis on elution order using polysaccharide-based chiral columns","volume":"35","author":"Jibuti","year":"2012","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2024.465062_bib0038","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.chroma.2016.12.064","article-title":"Separation of enantiomers of chiral weak acids with polysaccharide-based chiral columns and aqueous-organic mobile phases in high-performance liquid chromatography: typical reversed-phase behavior?","volume":"1483","author":"Matarashvili","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2024.465062_bib0039","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.chroma.2013.12.051","article-title":"Effect of the water content on the retention and enantioselectivity of albendazole and fenbendazole sulfoxides using amylose-based chiral stationary phases in organic-aqueous conditions","volume":"1327","author":"Materazzo","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2024.465062_bib0040","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1021\/ac970338k","article-title":"Direct chromatographic separation of racemates on the basis of isotopic chirality","volume":"69","author":"Kimata","year":"1997","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2024.465062_bib0041","article-title":"Viability of hydrogen isotopes separation via heterolytic dissociation-driven Chemical Affinity Quantum Sieving on inexpensive alkali-earth oxides","volume":"657","author":"Puricelli","year":"2024","journal-title":"Appl. Surf. Chem."},{"key":"10.1016\/j.chroma.2024.465062_bib0042","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s42004-019-0242-0","article-title":"Polarizability and isotope effects on dispersion interactions in water","volume":"2","author":"Zhan","year":"2019","journal-title":"Commun. Chem."},{"key":"10.1016\/j.chroma.2024.465062_bib0043","doi-asserted-by":"crossref","first-page":"14306","DOI":"10.1021\/ja305788p","article-title":"Do deuteriums form stronger CH-\u03c0 interactions?","volume":"134","author":"Zhao","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.chroma.2024.465062_bib0044","doi-asserted-by":"crossref","first-page":"13286","DOI":"10.1002\/chem.200902526","article-title":"Noncovalent isotope effect for guest encapsulation in self-assembled molecular capsules","volume":"15","author":"Haino","year":"2009","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.chroma.2024.465062_bib0045","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1351\/PAC-REP-10-01-01","article-title":"Defining the hydrogen bond: an account (IUPAC Technical Report)","volume":"83","author":"Arunan","year":"2011","journal-title":"Pure Appl. Chem."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967324004369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967324004369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T22:15:28Z","timestamp":1721686528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967324004369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":45,"alternative-id":["S0021967324004369"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2024.465062","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Separation of isotopologues of amphetamine with various degree of deuteration on achiral and polysaccharide-based chiral columns in high-performance liquid chromatography","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2024.465062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"465062"}}