{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:43:47Z","timestamp":1793259827129,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008094","name":"The Women's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009968","name":"State of Tyrol","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.chroma.2024.465432","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T05:59:41Z","timestamp":1728539981000},"page":"465432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Determination of anthraquinones in Frangula alnus by Supercritical Fluid Chromatography"],"prefix":"10.1016","volume":"1737","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0245-6146","authenticated-orcid":false,"given":"Michael","family":"Zwerger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Deisl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Hammerle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7407-9060","authenticated-orcid":false,"given":"Markus","family":"Ganzera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2024.465432_bib0001","unstructured":"B. Zecchin, G. Caudullo, D. de Rigo, Frangula alnus in Europe: distribution, habitat, usage and threats, 2016, p. 96."},{"issue":"1","key":"10.1016\/j.chroma.2024.465432_bib0002","first-page":"20","article-title":"Comparing of effects of hydro-alcoholic, ethanolic, and methanolic extracts of the Frangula alnus: chemical composition, antimicrobial, and synergism","volume":"6","author":"Nejabatdoust","year":"2020","journal-title":"J. Genet. Resour."},{"issue":"20","key":"10.1016\/j.chroma.2024.465432_bib0003","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.3390\/plants11202719","article-title":"Extracts from Frangula alnus Mill. and their effects on environmental and probiotic bacteria","volume":"11","author":"Kledecka","year":"2022","journal-title":"Plants"},{"issue":"4","key":"10.1016\/j.chroma.2024.465432_bib0004","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.foodchem.2011.09.094","article-title":"Anthraquinone profiles, antioxidant and antimicrobial properties of Frangula rupestris (Scop.) Schur and Frangula alnus Mill. bark","volume":"131","author":"Kremer","year":"2012","journal-title":"Food Chem."},{"issue":"3","key":"10.1016\/j.chroma.2024.465432_bib0005","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.yrtph.2015.09.025","article-title":"Toxicity and antioxidant capacity of Frangula alnus Mill. bark and its active component emodin","volume":"73","author":"Brkanac","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.chroma.2024.465432_bib0006","first-page":"e05090","article-title":"Safety of hydroxyanthracene derivatives for use in food","volume":"16","author":"Younes","year":"2018","journal-title":"EFSA J."},{"key":"10.1016\/j.chroma.2024.465432_bib0007","series-title":"Frangulae Cortex","year":"2019"},{"issue":"2","key":"10.1016\/j.chroma.2024.465432_bib0008","first-page":"108","article-title":"Quantitative analysis of glucofrangulins and phenolic compounds in Croatian Rhamnus and Frangula species","volume":"52","author":"\u017deljan","year":"2010","journal-title":"Acta Biol. Crac. Ser. Bot."},{"issue":"2","key":"10.1016\/j.chroma.2024.465432_bib0009","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3109\/13880209209053982","article-title":"HPLC analysis of the anthraquinones from Rhamnus species growing in Turkey","volume":"30","author":"Co\u015fkun","year":"1992","journal-title":"Int. J. Pharmacogn."},{"key":"10.1016\/j.chroma.2024.465432_bib0010","first-page":"40","article-title":"High-performance liquid chromatographic method for the simultaneous separation of emodin-type oxidized and reduced anthranoids","volume":"37","author":"Dernirezer","year":"1994","journal-title":"Extraction"},{"issue":"3","key":"10.1016\/j.chroma.2024.465432_bib0011","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1021\/np400736s","article-title":"Validated method for the analysis of frangulins A and B and glucofrangulins A and B using HPLC and UHPLC","volume":"77","author":"Rosenthal","year":"2014","journal-title":"J. Nat. Prod."},{"issue":"4","key":"10.1016\/j.chroma.2024.465432_bib0012","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s11101-015-9410-8","article-title":"Phytochemical evaluation and HPTLC investigation of bark and extracts of Rhamnus frangula Linn","volume":"14","author":"\u0162ebrencu","year":"2015","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.chroma.2024.465432_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2021.116463","article-title":"Analysis of natural products by SFC\u2013applications from 2015 to 2021","volume":"145","author":"Ganzera","year":"2021","journal-title":"TrAC Trends Anal. Chem."},{"issue":"6\u201307","key":"10.1016\/j.chroma.2024.465432_bib0014","first-page":"361","article-title":"Supercritical fluid chromatography in natural product analysis\u2013an update","volume":"84","author":"Gibitz Eisath","year":"2018","journal-title":"Planta Med."},{"issue":"8","key":"10.1016\/j.chroma.2024.465432_bib0015","first-page":"396","article-title":"Green chromatography (part 2): the role of GC and SFC","volume":"23","author":"Sandra","year":"2010","journal-title":"LCGC Eur."},{"issue":"4","key":"10.1016\/j.chroma.2024.465432_bib0016","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3390\/separations10040239","article-title":"SFC and CE\u2013a comparison of two orthogonal methods for the analysis of dihydrochalcones in apple leaves","volume":"10","author":"Zwerger","year":"2023","journal-title":"Separations"},{"key":"10.1016\/j.chroma.2024.465432_bib0017","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.chroma.2017.02.066","article-title":"Unravelling the effects of mobile phase additives in supercritical fluid chromatography. Part I: polarity and acidity of the mobile phase","volume":"1492","author":"West","year":"2017","journal-title":"J. Chromatogr. A"},{"issue":"17","key":"10.1016\/j.chroma.2024.465432_bib0018","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1055\/s-0035-1545911","article-title":"Supercritical fluid chromatography\u2013theoretical background and applications on natural products","volume":"81","author":"Hartmann","year":"2015","journal-title":"Planta Med."},{"issue":"18","key":"10.1016\/j.chroma.2024.465432_bib0019","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.1039\/C9AN00826H","article-title":"Supercritical fluid chromatography\u2013a technical overview and its applications in medicinal plant analysis: an update covering 2012\u20132018","volume":"144","author":"He","year":"2019","journal-title":"Analyst"},{"issue":"6","key":"10.1016\/j.chroma.2024.465432_bib0020","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.jbiosc.2012.12.008","article-title":"History of supercritical fluid chromatography: instrumental development","volume":"115","author":"Saito","year":"2013","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.chroma.2024.465432_bib0021","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.talanta.2015.08.011","article-title":"Analysis of anthraquinones in rhubarb (Rheum palmatum and Rheum officinale) by supercritical fluid chromatography","volume":"144","author":"Aichner","year":"2015","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2024.465432_bib0022","series-title":"Faulbaumrinde, Pharmakognosie-Phytopharmazie","first-page":"1193","author":"H\u00e4nsel","year":"2009"},{"key":"10.1016\/j.chroma.2024.465432_bib0023","unstructured":"ICH, Q2(R1) Validation of analytical procedures, (2005) 411\u2013421."},{"key":"10.1016\/j.chroma.2024.465432_bib0024","unstructured":"Committee on Herbal Medicinal Products (HMPC), Assessment report on Rhamnus frangula L. cortex, 2019."},{"issue":"6","key":"10.1016\/j.chroma.2024.465432_bib0025","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/0031-9422(90)85060-S","article-title":"Anthraquinone glycosides from Rhamnus libanoticus","volume":"29","author":"Co\u015fkun","year":"1990","journal-title":"Phytochemistry"},{"issue":"2","key":"10.1016\/j.chroma.2024.465432_bib0026","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/14786419.2018.1446135","article-title":"Isolation and identification of new anthraquinones from Rhamnus alaternus L. and evaluation of their free radical scavenging activity","volume":"33","author":"Ben Ammar","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.chroma.2024.465432_bib0027","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.chroma.2016.02.052","article-title":"An improved classification of stationary phases for ultra-high performance supercritical fluid chromatography","volume":"1440","author":"West","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2024.465432_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2019.460385","article-title":"An analytical strategy for accurate, rapid and sensitive quantitative analysis of isoflavones in traditional Chinese medicines using ultra-high performance supercritical fluid chromatography: take Radix Puerariae as an example","volume":"1606","author":"Wu","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2024.465432_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.supflu.2019.03.017","article-title":"Comprehensive analysis and quality assessment of Herba Epimedii from multiple botanical origins based on ultra-high performance supercritical fluid chromatography coupled with quadrupole time-of-flight mass spectrometry and photodiode array detector","volume":"149","author":"Sun","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.chroma.2024.465432_bib0030","unstructured":"EDQM, Frangula bark (Knowledge database), 2023."},{"issue":"11","key":"10.1016\/j.chroma.2024.465432_bib0031","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.3390\/molecules22111838","article-title":"In-silico UHPLC method optimization for aglycones in the herbal laxatives Aloe barbadensis Mill., Cassia angustifolia Vahl pods, Rhamnus frangula L. bark, Rhamnus purshianus DC. bark, and Rheum palmatum L. roots","volume":"22","author":"Meier","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.chroma.2024.465432_bib0032","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.aca.2019.06.046","article-title":"Two-dimensional qNMR of anthraquinones in Frangula alnus (Rhamnus frangula) using surrogate standards and delay time adaption","volume":"1081","author":"\u00c7i\u00e7ek","year":"2019","journal-title":"Anal. Chim. Acta"},{"issue":"5","key":"10.1016\/j.chroma.2024.465432_bib0033","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/pca.3353","article-title":"Simultaneous high-performance liquid chromatography analysis of anthraquinones in sicklepod sprouts with \u03b1-glucosidase inhibitory activity","volume":"35","author":"Muraoka","year":"2024","journal-title":"Phytochem. Anal."},{"issue":"6","key":"10.1016\/j.chroma.2024.465432_bib0034","doi-asserted-by":"crossref","first-page":"e5368","DOI":"10.1002\/bmc.5368","article-title":"Quality evaluation of different varieties of rhubarb based on multicomponents and bioactivity: application to quality control in the production of rhubarb decoction pieces","volume":"36","author":"Liang","year":"2022","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.chroma.2024.465432_bib0035","article-title":"On-line identification of the chemical constituents of Polygoni multiflori radix by UHPLC-Q-ToF MS\/MS","volume":"11","author":"Wang","year":"2023","journal-title":"Front. Chem."},{"issue":"4","key":"10.1016\/j.chroma.2024.465432_bib0036","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/chromsci\/bmad009","volume":"61","author":"Yan","year":"2023","journal-title":"J. Chromatogr. Sci."},{"issue":"8","key":"10.1016\/j.chroma.2024.465432_bib0037","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/pca.3176","article-title":"Simultaneous determination of seven anthraquinones in Cassiae semen by natural deep eutectic solvent extraction","volume":"33","author":"Xu","year":"2022","journal-title":"Phytochem. Anal."},{"issue":"3","key":"10.1016\/j.chroma.2024.465432_bib0038","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3390\/foods11030386","article-title":"Ultrasonic solvent extraction followed by dispersive solid phase extraction (d-SPE) cleanup for the simultaneous determination of five anthraquinones in Polygonum multiflorum by UHPLC-PDA","volume":"11","author":"Xu","year":"2022","journal-title":"Foods"},{"issue":"11","key":"10.1016\/j.chroma.2024.465432_bib0039","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/S1044-0305(99)00088-4","article-title":"Electrospray ionization mass spectrometric analysis of microcystins, cyclic heptapeptide hepatotoxins: modulation of charge states and [M + H]+ to [M + Na]+ ratio","volume":"10","author":"Yuan","year":"1999","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"5","key":"10.1016\/j.chroma.2024.465432_bib0040","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.jpba.2004.06.017","article-title":"HPLC-DAD and LC-ESI-MS analysis of doxycycline and related impurities in doxipan mix, a medicated premix for incorporation in medicated feedstuff","volume":"37","author":"Fiori","year":"2005","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"5","key":"10.1016\/j.chroma.2024.465432_bib0041","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s13361-017-1626-y","article-title":"Adduct formation in ESI\/MS by mobile phase additives","volume":"28","author":"Kruve","year":"2017","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"3","key":"10.1016\/j.chroma.2024.465432_bib0042","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/rcm.8352","article-title":"Optimization of flow splitting and make-up flow conditions in liquid chromatography\/electrospray ionization mass spectrometry","volume":"33","author":"Liigand","year":"2019","journal-title":"Rapid Commun. Mass Spectrom."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967324008069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967324008069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T13:04:11Z","timestamp":1730898251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967324008069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":42,"alternative-id":["S0021967324008069"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2024.465432","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determination of anthraquinones in Frangula alnus by Supercritical Fluid Chromatography","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2024.465432","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"465432"}}